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Postpartum Endometritis

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61. Intrauterine Tamponade With a Belfort-Dildy Balloon in the Treatment of Severe Immediate Postpartum Hemorrhage

[ Time Frame: 8 days ] Assessed by : Proportion of women with a temperature >38°5C during postpartum hospitalization other Genital tract infection [ Time Frame: 8 days ] Assessed by : Proportion of women with endometritis during postpartum hospitalization. other Genital tract infection [ Time Frame: 6 weeks ] Assessed by : • Proportion of women who had endometritis at the 6 weeks postpartum visit. Other markers of severe hemorrhage [ Time Frame: 8 days ] Number of women who died in the postpartum (...) : August 27, 2014 Last Update Posted: August 28, 2018 Last Verified: August 2018 Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: No Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Assistance Publique - Hôpitaux de Paris: Immediate postpartum hemorrhage Intrauterine balloon tamponade Additional relevant MeSH terms: Layout table for MeSH terms Hemorrhage Postpartum Hemorrhage

2014 Clinical Trials

62. LNG-IUS at 2 Weeks Postpartum

of delivery No documented uterine rupture during delivery No active liver disease (resolved pre-eclampsia may enroll) No evidence of vaginal, cervical or uterine infection at time of LNG-IUS insertion No history of postpartum endometritis treated with antibiotics or a postpartum readmission for a dilation and curettage No pre-existing contraindication to a LNG-IUS as determined by the CDC's Medical Eligibility Criteria (MEC) category 3 or 4 Not currently incarcerated No known congenital or acquired (...) LNG-IUS at 2 Weeks Postpartum LNG-IUS at 2 Weeks Postpartum - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. LNG-IUS at 2 Weeks Postpartum (LNG-IUS) The safety and scientific validity of this study

2014 Clinical Trials

63. Recurrent secondary postpartum hemorrhages due to placental site vessel subinvolution and local uterine tissue coagulopathy. Full Text available with Trip Pro

are already discharged home. The causes of this pathology are severe inflammation (endometritis), inherited coagulation disorders, consumptive coagulopathy, and retained products of conceptions. Others are of rare occurrence, such as vessel subinvolution (VSI) of the placental implantation site, uterine artery pseudoaneurysm, or trauma.We present a rare form of recurrent secondary postpartum hemorrhage in a woman after uncomplicated cesarean delivery, with review of the literature linked to the management (...) Recurrent secondary postpartum hemorrhages due to placental site vessel subinvolution and local uterine tissue coagulopathy. Postpartum hemorrhage (PPH) represents a serious problem for women and obstetricians. Because of its association with hemorrhagic shock and predisposition to disseminated coagulopathy, it is a leading cause of maternal deaths worldwide. Furthermore, the jeopardy of PPH is rising with the secondary form of PPH occurring between 24 hours and 6 weeks postpartum, when women

2014 BMC Pregnancy and Childbirth

64. Inducing ovulation early postpartum influences uterine health and fertility in dairy cows. Full Text available with Trip Pro

Inducing ovulation early postpartum influences uterine health and fertility in dairy cows. The objective of the current study was to evaluate the effect of GnRH early postpartum on induction of ovulation, uterine health, and fertility in dairy cows. Holstein cows without a corpus luteum (CL) at 17 ± 3 DIM were assigned randomly to receive i.m. GnRH (n = 245) at 17 ± 3 and 20 ± 3 DIM or remain as controls (n = 245). Ovaries were scanned by ultrasonography twice weekly totaling 4 examinations (...) . Ovulation was characterized by the appearance of a CL ≥ 20 mm at any ultrasound or CL <20mm in 2 consecutive examinations. Clinical and cytological endometritis were diagnosed at 35 DIM. Compared with control, GnRH increased ovulation up to 3.5d after the last treatment (78.7 vs. 45.0%) and did not affect the prevalence of clinical endometritis (23.9 vs. 18.6%) or cytological endometritis (30.9 vs. 32.8%). Prevalence of clinical endometritis increased in cows that had calving problems (32.6 vs. 15.9

2014 Journal of dairy science Controlled trial quality: uncertain

65. Extensive pulmonary involvement with raltegravir-induced DRESS syndrome in a postpartum woman with HIV Full Text available with Trip Pro

Extensive pulmonary involvement with raltegravir-induced DRESS syndrome in a postpartum woman with HIV An 18-year-old postpartum woman with HIV, on lamivudine-zidovudine, lopinavir-ritonavir and raltegravir, presented with a 1-week history of rash and fevers. Initially admitted to obstetrics and gynaecology service for treatment of possible endometritis, she was transferred to the HIV medicine service for high fever, respiratory distress, hypotension and tachycardia. On admission, she

2014 BMJ case reports

66. Pregnancy, Postpartum Infections (Diagnosis)

is the single most important factor in the development of endometritis. [ ] The risk of endometritis increases dramatically after cesarean delivery. [ , ] However, there is some evidence that hospital readmission for management of postpartum endometritis occurs more often in those who delivered vaginally. [ ] Other risk factors include prolonged rupture of membranes, prolonged use of internal fetal monitoring, anemia, and lower socioeconomic status. [ ] Perioperative antibiotics have greatly decreased (...) United States statistics In a study by Yokoe et al in 2001, 5.5% of vaginal deliveries and 7.4% of cesarean deliveries resulted in a postpartum infection. [ ] The overall postpartum infection rate was 6.0%. Endometritis accounted for nearly half of the infections in patients following cesarean delivery (3.4% of cesarean deliveries). Mastitis and urinary tract infections together accounted for 5% of vaginal deliveries. [ ] A study by Bauer et al indicated that in the United States from 1998 to 2008

2014 eMedicine Emergency Medicine

67. Pregnancy, Postpartum Infections (Overview)

is the single most important factor in the development of endometritis. [ ] The risk of endometritis increases dramatically after cesarean delivery. [ , ] However, there is some evidence that hospital readmission for management of postpartum endometritis occurs more often in those who delivered vaginally. [ ] Other risk factors include prolonged rupture of membranes, prolonged use of internal fetal monitoring, anemia, and lower socioeconomic status. [ ] Perioperative antibiotics have greatly decreased (...) United States statistics In a study by Yokoe et al in 2001, 5.5% of vaginal deliveries and 7.4% of cesarean deliveries resulted in a postpartum infection. [ ] The overall postpartum infection rate was 6.0%. Endometritis accounted for nearly half of the infections in patients following cesarean delivery (3.4% of cesarean deliveries). Mastitis and urinary tract infections together accounted for 5% of vaginal deliveries. [ ] A study by Bauer et al indicated that in the United States from 1998 to 2008

2014 eMedicine Emergency Medicine

68. Pregnancy, Postpartum Infections (Follow-up)

. Outpatient follow-up All patients with a postpartum infection should undergo follow-up with an obstetrician. For patient education resources, see as well as . Previous Next: Prevention A Cochrane review found that for the prevention of post-caesarean endometritis, there was no clear difference between irrigation and intravenous antibiotic prophylaxis, however further research is necessary. [ ] Another Cochrane review reported that post uncomplicated vaginal birth, routine administration of antibiotics (...) monitoring, and administer oxygen. Next: Emergency Department Care Emergency Department care is focused on identifying the source of the infection, followed by appropriate antimicrobial therapy and referral. Postpartum endometritis treatment In most cases, initial antimicrobial treatment is a combination of an aminoglycoside and clindamycin. Alternatively, an aminoglycoside plus metronidazole with or without ampicillin may also be used. [ ] Mild cases of endometritis after vaginal delivery may be treated

2014 eMedicine Emergency Medicine

69. Pregnancy, Postpartum Hemorrhage (Follow-up)

administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet . 2017 May 27. 389 (10084):2105-2116. . Practice Bulletin No. 183 Summary: Postpartum Hemorrhage. Obstet Gynecol . 2017 Oct. 130 (4):923-925. . Quibel T, Ghout I, Goffinet F, Salomon LJ, Fort J, Javoise S, et al. Active Management of the Third Stage of Labor With a Combination of Oxytocin and Misoprostol to Prevent (...) . . Soriano D, Dulitzki M, Schiff E, Barkai G, Mashiach S, Seidman DS. A prospective cohort study of oxytocin plus ergometrine compared with oxytocin alone for prevention of postpartum haemorrhage. Br J Obstet Gynaecol . 1996 Nov. 103(11):1068-73. . Winikoff B, Dabash R, Durocher J, Darwish E, Nguyen TN, Leon W, et al. Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women not exposed to oxytocin during labour: a double-blind, randomised, non-inferiority trial. Lancet

2014 eMedicine Emergency Medicine

70. Pregnancy, Postpartum Infections (Treatment)

. Outpatient follow-up All patients with a postpartum infection should undergo follow-up with an obstetrician. For patient education resources, see as well as . Previous Next: Prevention A Cochrane review found that for the prevention of post-caesarean endometritis, there was no clear difference between irrigation and intravenous antibiotic prophylaxis, however further research is necessary. [ ] Another Cochrane review reported that post uncomplicated vaginal birth, routine administration of antibiotics (...) monitoring, and administer oxygen. Next: Emergency Department Care Emergency Department care is focused on identifying the source of the infection, followed by appropriate antimicrobial therapy and referral. Postpartum endometritis treatment In most cases, initial antimicrobial treatment is a combination of an aminoglycoside and clindamycin. Alternatively, an aminoglycoside plus metronidazole with or without ampicillin may also be used. [ ] Mild cases of endometritis after vaginal delivery may be treated

2014 eMedicine Emergency Medicine

71. Pregnancy, Postpartum Hemorrhage (Treatment)

administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet . 2017 May 27. 389 (10084):2105-2116. . Practice Bulletin No. 183 Summary: Postpartum Hemorrhage. Obstet Gynecol . 2017 Oct. 130 (4):923-925. . Quibel T, Ghout I, Goffinet F, Salomon LJ, Fort J, Javoise S, et al. Active Management of the Third Stage of Labor With a Combination of Oxytocin and Misoprostol to Prevent (...) . . Soriano D, Dulitzki M, Schiff E, Barkai G, Mashiach S, Seidman DS. A prospective cohort study of oxytocin plus ergometrine compared with oxytocin alone for prevention of postpartum haemorrhage. Br J Obstet Gynaecol . 1996 Nov. 103(11):1068-73. . Winikoff B, Dabash R, Durocher J, Darwish E, Nguyen TN, Leon W, et al. Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women not exposed to oxytocin during labour: a double-blind, randomised, non-inferiority trial. Lancet

2014 eMedicine Emergency Medicine

72. Treatment Utility of Postpartum Antibiotics in Chorioamnionitis

School of Medicine Collaborator: St. Louis University Information provided by (Responsible Party): Washington University School of Medicine Study Details Study Description Go to Brief Summary: To determine if prophylactic postpartum antibiotics are required post-cesarean delivery for pregnancies with treated chorioamnionitis. Condition or disease Intervention/treatment Phase The Primary Outcome of This Study Will be the Rate of Endometritis Drug: Postpartum Antibiotics Drug: No postpartum antibiotics (...) in terms of chorioamnionitis (fever pre-delivery). The groups will be managed identically if endometritis (post-partum fever) develops. Outcome Measures Go to Primary Outcome Measures : Number of Paricipants With Endometritis [ Time Frame: 7 days post-partum ] Endometritis is defined as uterine infection and is diagnosed by maternal temp > 38.0C on two occasions over a 4 hour period or any temp > 39.0C after delivery > 12 hours after delivery. Endometritis will be managed per currently accepted

2012 Clinical Trials

73. Pharmacokinetics and Safety of Ertapenem in the Postpartum Period

and Safety of Ertapenem in the Postpartum Period The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01587495 Recruitment Status : Terminated (study terminated due to low subject accrual) First Posted : April 30, 2012 Last Update Posted : May 20, 2015 Sponsor: Daniel Benjamin Information provided (...) of ertapenem in women diagnosed with postpartum endometritis. Subjects will include up to 24 women receiving treatment for a diagnosis of postpartum endometritis with ertapenem in the Duke University Hospital Labor & Delivery Unit. Each patient will participate in the study for approximately 7 days, though the total study duration is expected to be approximately 12 months. Descriptive statistics for the subjects will be calculated. The appropriate non-compartmental pharmacokinetic parameters

2012 Clinical Trials

74. Postpartum Levonorgestrel-releasing Intrauterine System and Breastfeeding

component of the LNG-IUS No genital bleeding of unknown etiology No history of solid organ transplantation Additional eligibility criteria for entry into the randomized trial, as assessed postpartum No endometritis or chorioamnionitis Membranes ruptured for less than 24 hours prior to delivery (O'Hanley, Hayes) No fever greater than or equal to 38°C during the intrapartum or postpartum period Did not receive medications other than pitocin and/or misoprostol to control postpartum bleeding Did not have (...) Postpartum Levonorgestrel-releasing Intrauterine System and Breastfeeding Postpartum Levonorgestrel-releasing Intrauterine System and Breastfeeding - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Postpartum

2012 Clinical Trials

75. Postpartum infections: occurrence, healthcare contacts and association with breastfeeding. (Abstract)

(12%) were most frequent, followed by wound (3%), airway (3%), vaginal (3%) and urinary tract infections (3%), endometritis (2%) and "other infections" (2%). Of the women with an infection, 66% (265 of 395) contacted their general practitioner, while 9% (37 of 395) had contact with a hospital. A significantly larger proportion of women with a postpartum infection stopped breastfeeding (21%) within the first four weeks after delivery compared with women without infection (12%; p < 0.001).Postpartum (...) Postpartum infections: occurrence, healthcare contacts and association with breastfeeding. To investigate the following: (i) the occurrence of postpartum infections; (ii) the frequency of contact with either a general practitioner or a hospital due to postpartum infections; and (iii) the association of postpartum infections with continuation of breastfeeding.Cross-sectional study.Department of Gynecology and Obstetrics Horsens Hospital, Horsens, Denmark.A total of 1871 women who gave birth

2012 Acta Obstetricia et Gynecologica Scandinavica

76. Comparison of ampicillin with clindamycin plus gentamicin in the treatment of postpartum uterine infection. Full Text available with Trip Pro

Comparison of ampicillin with clindamycin plus gentamicin in the treatment of postpartum uterine infection. A prospective randomized study of the treatment of postpartum endometritis was conducted with 43 patients. The bacterial origin of the infection was determined by uterine aspiration. Treatment was successful in 17 of the 19 patients receiving ampicillin (12 g/d) and in 21 of the 24 patients receiving clindamycin (2.4 g/d) plus gentamicin (5.1 mg/kg daily).

1979 Canadian Medical Association journal Controlled trial quality: uncertain

77. Puerperal Endometritis

, rarely aided by culture. Treatment is with broad-spectrum antibiotics (eg, clindamycin plus gentamicin ). Incidence of postpartum endometritis is affected mainly by the mode of delivery: Vaginal deliveries: 1 to 3% Scheduled caesarean deliveries (done before labor starts): 5 to 15% Unscheduled caesarean deliveries (done after labor starts): 15 to 20% Patient characteristics also affect incidence. Etiology Endometritis may develop after chorioamnionitis during labor or postpartum. Predisposing (...) Gardnerella vaginalis, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis) . Uncommonly, peritonitis, pelvic abscess, (with risk of ), or a combination develops. Rarely, and its sequelae, including death, occur. Symptoms and Signs Typically, the first symptoms of puerperal endometritis are lower abdominal pain and uterine tenderness, followed by fever—most commonly within the first 24 to 72 h postpartum. Chills, headache, malaise, and anorexia are common. Sometimes the only symptom is a low

2013 Merck Manual (19th Edition)

78. Does Preoperative Vaginal Preparation With Povidone-iodine Before Cesarean Delivery Reduce the Risk of Endometritis?

of saved studies (100). Please remove one or more studies before adding more. Does Preoperative Vaginal Preparation With Povidone-iodine Before Cesarean Delivery Reduce the Risk of Endometritis? The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01437228 Recruitment Status : Completed First Posted (...) microorganisms as well as to remove certain species of bacteria. Condition or disease Intervention/treatment Phase Postpartum Endometritis Drug: povidone- iodine solution. Drug: placebo Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 668 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Prevention Study Start Date : October 2010 Actual Primary Completion Date

2011 Clinical Trials

79. Multiple square sutures for postpartum hemorrhage: results and hysteroscopic assessment. (Abstract)

by hysteroscopy at 3 months.Multiple square sutures stopped postpartum hemorrhage in 28 of 30 cases (93%). Twenty women underwent hysteroscopy after multiple square sutures. Eight women (40%) did not have intrauterine adhesions. Nine women (45%) had thin and localized intrauterine adhesions that were removed easily by the tip of the hysteroscope; 2 women had moderate intrauterine adhesions that were resected. One patient had endometritis followed by severe intrauterine adhesions.Multiple square sutures (...) Multiple square sutures for postpartum hemorrhage: results and hysteroscopic assessment. The purpose of this study was to evaluate the efficiency and morbidity of multiple square sutures in severe postpartum hemorrhage.A retrospective study encompassed 30 multiple square sutures that were performed for severe postpartum hemorrhage in 26,605 deliveries in a tertiary maternity center. The main outcome measures were the ability to stop hemorrhage and the assessment of the uterine cavity

2011 American Journal of Obstetrics and Gynecology

80. Postpartum Dyspareunia Resulting From Vaginal Atrophy

for their postpartum visit Criteria Inclusion Criteria: Healthy, puerperal women who will be willing to participate, over 18 years old. Exclusion Criteria: Patients with puerperal complications such as: bleeding, fever, endometritis. Patients with significant systemic diseases. Patients who conceive again during the study. Patients who are not willing to participate Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact (...) to Publications: Layout table for additonal information Responsible Party: Meir Medical Center ClinicalTrials.gov Identifier: Other Study ID Numbers: MMC11030-2011kCTIL First Posted: March 22, 2011 Last Update Posted: April 8, 2015 Last Verified: April 2012 Keywords provided by Meir Medical Center: Postpartum dyspareunia Vaginal atrophy Additional relevant MeSH terms: Layout table for MeSH terms Atrophy Dyspareunia Pathological Conditions, Anatomical Sexual Dysfunction, Physiological Genital Diseases, Male

2011 Clinical Trials

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