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524 results for

Postpartum Endometritis

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521. Ciprofloxacin versus gentamicin/clindamycin for postpartum endometritis. (Abstract)

Ciprofloxacin versus gentamicin/clindamycin for postpartum endometritis. An open, randomized, comparative study of intravenous ciprofloxacin versus gentamicin and clindamycin was performed on women with postpartum endometritis. Ciprofloxacin alone successfully eradicated the infections in 35 of 49 patients (71%), while the combination of gentamicin/clindamycin cured 41 of 48 (85%) (P = .15). The microbiology and antibiotic sensitivity of the endometrial isolates confirmed the poor activity (...) of ciprofloxacin against anaerobic bacteria and less-than-optimal activity against Streptococcus faecalis. Ciprofloxacin, when used alone, may not be suitable for the treatment of postpartum endometritis.

1991 Journal of Reproductive Medicine Controlled trial quality: uncertain

522. The importance of wound infection in antibiotic failures in the therapy of postpartum endometritis. (Abstract)

The importance of wound infection in antibiotic failures in the therapy of postpartum endometritis. A prospective, randomized, double-blind trial was done to compare the efficacy of cefoxitin (2 grams given intravenously every six hours) with ceftizoxime (2 grams given intravenously every 12 hours) in the treatment of postpartum endometritis. Thirty-eight patients received cefoxitin and 43 received ceftizoxime. Demographic variables (age, gravidity, parity and estimated gestational age (...) of the antibiotic. With multiple logistic regression, only abdominal wound infection was associated with failure of the antibiotic (p = 0.0002). We conclude that cefoxitin and ceftizoxime are equally effective in the therapy of postpartum endometritis and that abdominal wound infection is primarily responsible for persistent fever and, therefore, failure of the antibiotic in patients with postpartum endometritis.

1992 Surgery, gynecology & obstetrics Controlled trial quality: uncertain

523. Comparative efficacy and safety of mezlocillin, cefoxitin, and clindamycin plus gentamicin in postpartum endometritis. (Abstract)

Comparative efficacy and safety of mezlocillin, cefoxitin, and clindamycin plus gentamicin in postpartum endometritis. The efficacy of mezlocillin versus cefoxitin versus clindamycin plus gentamicin was evaluated in 152 patients with postpartum endometritis. There were no statistically significant differences in rate of cure among the three groups (87% with mezlocillin, 82% with cefoxitin, and 92% with clindamycin-gentamicin). There were no severe adverse reactions observed in any of the three (...) treatment regimens. Mezlocillin is as safe and effective as cefoxitin and clindamycin-gentamicin for treatment of postpartum endometritis.

1987 Obstetrics and Gynecology

524. The pharmacokinetics of once-daily dosing with gentamicin in women with postpartum endometritis. Full Text available with Trip Pro

The pharmacokinetics of once-daily dosing with gentamicin in women with postpartum endometritis. To evaluate the pharmacokinetics and cost of once-daily dosing with gentamicin in women with postpartum endometritis.Gentamicin in a single daily dose of 4.5 mg/kg was administered intravenously to 10 women with postpartum endometritis. Peak and trough gentamicin levels were measured, and nephrotoxicity and clinical ototoxicity were monitored. Pharmacokinetic data were analyzed, and a cost analysis (...) of once-daily gentamicin administration was performed.The mean elimination constant was 0.105 +/- 0.008 L/h, and the mean volume of distribution was 0.34 +/- 0.07 L/kg. Mean peak gentamicin levels exceeded 11 mg/L, and all trough levels were < 0.3 mg/L. Cost savings of 44% were achieved with once-daily dosing of gentamicin, compared with traditional thrice-daily dosing.Once-daily dosing with gentamicin in women with postpartum endometritis achieves therapeutic peak levels without drug accumulation

1998 Infectious diseases in obstetrics and gynecology

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