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Postpartum Endometritis

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341. Timing of prophylactic antibiotic at cesarean section: a double-blinded, randomized trial. Full Text available with Trip Pro

, a composite infectious outcome, which included endometritis, urinary tract infection, wound infection and pneumonia.Data on 896 women were analyzed; 449 randomized to skin incision, 447 to cord clamp. Postpartum infections were seen in a total of 8.4% of patients. Timing of antibiotic administration did not significantly affect any maternal postpartum infection rates or selected neonatal outcomes.Our results suggest that, in a largely non-laboring population, the timing of prophylactic antibiotic (...) Timing of prophylactic antibiotic at cesarean section: a double-blinded, randomized trial. The purpose was to determine the effect of the timing of prophylactic antibiotics for cesarean section on post-operative infectious complications.This was a prospective, double-blinded, randomized controlled trial in which patients were randomized to receive cefazolin or clindamycin either before skin incision or after cord clamp. The primary outcome was maternal infectious morbidity at 6 weeks postpartum

2013 Journal of perinatology : official journal of the California Perinatal Association Controlled trial quality: predicted high

342. Perioperative oxygen supplementation and surgical site infection after cesarean delivery: a randomized trial. Full Text available with Trip Pro

of oxygen used. Patients were evaluated for wound infection or endometritis during their hospital stay and by 6 weeks postpartum. The primary end point was a composite of either surgical site infection or endometritis.Eight hundred thirty-one patients were recruited. Of these, 415 participants received 30% oxygen perioperatively and 416 received 80% oxygen. The groups were well matched for age, race, parity, diabetes, number of previous cesarean deliveries, and scheduled compared with unscheduled (...) cesarean deliveries. An intention-to-treat analysis was used. There was no difference in the primary composite outcome (8.2% in women who received 30% oxygen compared with 8.2% in women who received 80% oxygen, P=.89), no difference in surgical site infection in the two groups (5.5% compared with 5.8%, P=.98), and no significant difference in endometritis in the two groups (2.7% compared with 2.4%, P=.66), respectively.Women who received 80% supplemental oxygen perioperatively did not have a lower rate

2013 Obstetrics and Gynecology Controlled trial quality: predicted high

343. Prophylactic administration of cefazolin prior to skin incision versus antibiotics at cord clamping in preventing postcesarean infectious morbidity: a systematic review and meta-analysis of randomized controlled trials. (Abstract)

prophylactic antibiotics with cefazolin for cesarean delivery given before the procedure versus at cord clamping.Six randomized controlled trials with high quality were included in this meta-analysis. Preoperative administration significantly reduced the risk of postpartum endometritis (RR: 0.57, 95% CI: 0.36-0.90, p = 0.02). Preoperative administration of cefazolin was not associated with a significant reduction in the risk of wound infection (RR: 0.70, 95% CI: 0.43-1.12) and urinary tract infection (RR (...) : 1.19, 95% CI: 0.53-2.63). Furthermore, preoperative administration of cefazolin did not significantly affect proven neonatal sepsis (RR: 0.82, 95% CI: 0.47-1.42), suspected neonatal sepsis that requires a workup (RR: 0.94, 95% CI: 0.72-1.22), or neonatal intensive care unit admissions (RR: 0.90, 95% CI: 0.62-1.28).Pooled results demonstrated that antibiotic prophylaxis with cefazolin for cesarean delivery that is given before skin incision can significantly decrease the incidence of postpartum

2013 Gynecologic and obstetric investigation

344. Clinical trial of treatment programs for purulent vaginal discharge in lactating dairy cattle in New Zealand. (Abstract)

Clinical trial of treatment programs for purulent vaginal discharge in lactating dairy cattle in New Zealand. Studies of treatment of postpartum endometritis in dairy cows indicate that prostaglandin (PGF2α) might result in similar outcomes as intrauterine antibiotics, but the effect might depend on the presence of a CL. The objective was to compare reproductive performance in cows with purulent vaginal discharge treated on the basis of having or not having a CL (CL-dependent treatment; CLdep

2013 Theriogenology Controlled trial quality: uncertain

345. A Randomized Trial of Induction Versus Expectant Management

: During labor and delivery ] Labor pain was scored according to a 10-point Likert scale, with higher scores indicating greater pain; included are women who had spontaneous labor, labor that started spontaneously but then was augmented, or induced labor. Number of Participants With Maternal Postpartum Infection [ Time Frame: delivery through discharge ] Defined as any of the following: Clinical diagnosis of endometritis Wound reopened for hematoma, seroma, infection or other reasons Cellulitis (...) (ICU) [ Time Frame: delivery through hospital discharge ] Admission of the participant to the intensive care unit (ICU) Number of Participants Experiencing Hypertensive Disorder of Pregnancy [ Time Frame: Randomization to hospital discharge ] Number of Participants With Postpartum Hemorrhage [ Time Frame: delivery through hospital discharge ] defined as any of the following: Transfusion Non-elective hysterectomy Use of two or more uterotonics other than oxytocin Other surgical interventions

2013 Clinical Trials

346. RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section

, 2015 Sponsor: Odense University Hospital Collaborators: Region of Southern Denmark University of Southern Denmark Hvidovre University Hospital Hospital of South West Jutland Information provided by (Responsible Party): Nana Hyldig, Odense University Hospital Study Details Study Description Go to Brief Summary: Background Women undergoing Caesarean Section (CS) have an increased risk of postpartum infections compared to women undergoing vaginal delivery. In Denmark the incidence of post-CS (...) infections is 7-10%. The most common infections are endometritis, Urinary tract infections (UTI) and wound infections (WI). Prophylactic antibiotics are effective in preventing postoperative infections and national guidelines recommend that antibiotics should be administered as a single dose immediately before surgical incision. CS is an exception to this pre-incision administration approach. National guidelines recommend administration of antibiotics after umbilical cord clamping to avoid exposure

2013 Clinical Trials

347. Monitoring With Ultrasound Imaging of Intrauterine Device (IUD) Position Placed Immediately After Giving Birth

IUD or levonorgestrel IUD Exclusion Criteria: Contraindications for IUD use (CDC MEDICAL Eligibility Criteria category 3 or 4 for specific IUD) Positive Chlamydia or gonorrhea cervical cultures in past 3 months Immediate postpartum hemorrhage Premature rupture of membranes (PROM) >12h or diagnosis of endometritis Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact (...) Last Update Posted : October 11, 2017 Sponsor: Icahn School of Medicine at Mount Sinai Collaborator: Teva Pharmaceuticals USA Information provided by (Responsible Party): Icahn School of Medicine at Mount Sinai Study Details Study Description Go to Brief Summary: Intrauterine devices (IUDs) are one of the most effective reversible forms of contraception, and are a good option in the postpartum period for women to avoid a rapid repeat pregnancy. IUDs can be placed immediately postpartum, after

2013 Clinical Trials

348. A Study on the Safety and Efficacy of the SCu300A IUB Compared to the TCu380 Copper IUD

A previously placed IUD that has not been removed Pregnancy or suspicion of pregnancy Use of other contraception method (condom for either male or female, oral contraceptives, diaphragms, spermicides, hormonal patches, injections or ring, cervical cap) History of pelvic inflammatory disease, recent or remote. Postpartum endometritis or post abortal endometritis in the past 3 month Mucopurulent cervicitis Endometrial thickness more than 12 mm on insertion date Known anemia History of previous IUD

2013 Clinical Trials

349. Multivariate Assessment of the IUB Intrauterine Device Compared With a T380A IUD

male or female, oral contraceptives, diaphragms, spermicides, hormonal patches, injections or ring, cervical cap) History of pelvic inflammatory disease, recent or remote. Postpartum endometritis or postabortal endometritis in the past 3 month Mucupurulent cervicitis Endometrial thickness more than 12 mm on insertion date Known anemia (except thalassemia, sickle cell, chronic anemia) Severe Mennorrhagia or severe Dysmenorrhea History of previous IUD complications Dysfunctional uterine bleeding

2013 Clinical Trials

350. Amnioinfusion for potential or suspected umbilical cord compression in labour. (Abstract)

: caesarean section overall (13 trials, 1493 participants; average risk ratio (RR) 0.62, 95% confidence interval (CI) 0.46 to 0.83); fetal heart rate (FHR) decelerations (seven trials, 1006 participants; average RR 0.53, 95% CI 0.38 to 0.74); Apgar score less than seven at five minutes (12 trials, 1804 participants; average RR 0.47, 95% CI 0.30 to 0.72); meconium below the vocal cords (three trials, 674 participants, RR 0.53, 95% CI 0.31 to 0.92); postpartum endometritis (six trials, 767 participants; RR (...) authors) in the amnioinfusion group (eight trials, 972 participants, average RR 0.58, 95% CI 0.29 to 1.14).The use of amnioinfusion for potential or suspected umbilical cord compression may be of considerable benefit to mother and baby by reducing the occurrence of variable FHR decelerations, improving short-term measures of neonatal outcome, reducing maternal postpartum endometritis and lowering the use of caesarean section, although there were methodological limitations to the trials reviewed here

2012 Cochrane database of systematic reviews (Online)

351. Therapeutic Equivalence Trial of Two Hormonal-IUDs in Patients With Heavy Menstrual Bleeding

Lower genital tract infection Current or recurrent PID (present or recurrent pelvis infection (including history of postpartum endometritis, infected miscarriage) during the past 3 months Uncontrolled hypertension Congenital or acquired valvular disease (including corrections with prosthetic valves) Known or suspected pregnancy Known or suspected hormone-dependent tumor BMI > 30 Abnormal Pap smear test or other evidence of cervical/endometrial mancy Unexplained amenorrhea Known hypersensitivity

2012 Clinical Trials

352. A Study to Evaluate the Safety and Initial Efficacy of a Novel Intrauterine Device

inflammatory disease Postpartum endometritis or postabortal endometritis in the past 3 months Known or suspected uterine or cervical malignancy Genital bleeding of unknown etiology Mucopurulent cervicitis Wilson's disease Allergy to any component of IUB™ A previously placed IUD that has not been removed Known intolerance or allergy to copper and/or copper IUDs Medication that may interfere with the subject's ability to complete the protocol Any other significant disease or condition that could interfere

2012 Clinical Trials

353. Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study. (Abstract)

-analysis.Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum (...) endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively).The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings.

2012 The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

354. Cervicitis

of the following is the most common cause of abnormal vaginal bleeding during the reproductive years? Anovulatory uterine bleeding Fibroids Polycystic ovary syndrome Polyps of the cervix NEWS & VIDEOS AAN: No Increased MS Relapse Risk in Postpartum Period FRIDAY, March 8, 2019 (HealthDay News) -- Women with multiple sclerosis (MS) seem not to suffer from pregnancy-related relapses in the early postpartum period, according to a study scheduled... 3D Model Vaginal Birth Video How to do and Repair an Episiotomy (...) treated empirically for chlamydial infection and gonorrhea. Acute cervicitis is usually caused by an infection; chronic cervicitis is usually not caused by an infection. Cervicitis may ascend and cause endometritis and (PID). The most common infectious cause of cervicitis is , followed by . Other causes include (HSV), Trichomonas vaginalis , and Mycoplasma genitalium . Often, a pathogen cannot be identified. The cervix may also be inflamed as part of vaginitis (eg, , ). Noninfectious causes

2013 Merck Manual (19th Edition)

355. Pelvic Inflammatory Disease (PID)

knowledge Vaginal Bleeding Which of the following is the most common cause of abnormal vaginal bleeding during the reproductive years? Anovulatory uterine bleeding Fibroids Polycystic ovary syndrome Polyps of the cervix NEWS & VIDEOS AAN: No Increased MS Relapse Risk in Postpartum Period FRIDAY, March 8, 2019 (HealthDay News) -- Women with multiple sclerosis (MS) seem not to suffer from pregnancy-related relapses in the early postpartum period, according to a study scheduled... 3D Model Vaginal Birth (...) of the cervix ( ) causes mucopurulent discharge. Infection of the fallopian tubes (salpingitis) and uterus (endometritis) tend to occur together. If severe, infection can spread to the ovaries (oophoritis) and then the peritoneum (peritonitis). Salpingitis with endometritis and oophoritis, with or without peritonitis, is often called salpingitis even though other structures are involved. Pus may collect in the tubes (pyosalpinx), and an abscess may form (tubo-ovarian abscess). Etiology PID results from

2013 Merck Manual (19th Edition)

356. Amenorrhea

(eg, of , , , or ) Eating disorders (eg, , ) Exercise, if excessive Psychiatric disorders (eg, stress, , , ) Psychoactive drugs Pituitary dysfunction Aneurysms of the pituitary Hyperprolactinemia* Idiopathic hypogonadotropic hypogonadism Infiltrative disorders of the pituitary (eg, , Langerhans cell granulomatosis, sarcoidosis, TB) Isolated gonadotropin deficiency (hypogonadotropic hypogonadism with anosmia) Postpartum pituitary necrosis (Sheehan syndrome) Traumatic brain injury Tumors (...) abnormalities, such as endometrial scarring after instrumentation for postpartum hemorrhage or infection (Asherman syndrome), cause secondary ovulatory amenorrhea. Evaluation Girls are evaluated if They have no signs of puberty (eg, breast development, growth spurt) by age 13. Pubic hair is absent at age 14. Menarche has not occurred by age 16 or by 2 yr after the onset of puberty (development of secondary sexual characteristics). Women of reproductive age should have a pregnancy test after missing one

2013 Merck Manual (19th Edition)

357. Randomized clinical trial of antibiotic and prostaglandin treatments for uterine health and reproductive performance in dairy cows. Full Text available with Trip Pro

Randomized clinical trial of antibiotic and prostaglandin treatments for uterine health and reproductive performance in dairy cows. The objectives of this study were to assess the efficacy of antibiotic treatment for preventing postpartum uterine disease among cows at high risk of uterine disease, and to assess the efficacy of PGF(2α) for treating cytological endometritis (CYTO) and purulent vaginal discharge (PVD). A total of 2,178 Holstein cows in 6 herds were enrolled in a randomized (...) by CYTO or PVD at exam 1, 66 and 63%, respectively, had spontaneously cured at exam 2. Cows persistently affected at exam 2 had an increased time to pregnancy and were more likely to have both CYTO and PVD at exam 1. Administration of PGF(2α) at both 5 and 7 wk postpartum did not mitigate the effects of CYTO or PVD on reproductive performance. Clinical approaches to treatment of chronic postpartum reproductive tract infection and inflammation should be reassessed.Copyright © 2011 American Dairy

2011 Journal of dairy science Controlled trial quality: uncertain

358. Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy

until delivery (up to 42 weeks of gestation) ] Intrapartum chorioamnionitis is maternal temperature above 38.0 degrees Celsius and one or more of the following findings: fetal tachycardia; maternal tachycardia; uterine tenderness; purulent or malodorous amniotic fluid, or elevated maternal white blood cell count. Count of Participants With Endometritis [ Time Frame: From time of delivery up to 6 weeks postpartum ] Endometritis is a uterine (myometrial) infection. Count of Participants (...) of delivery, and postpartum serially up to 12 months. These swabs will be stored at -20 degrees Celsius or colder for additional microbiologic analyses. Additionally, placental tissue may be collected at time of delivery for possible future microbiome and/or other analyses. Women who suffer a premature rupture of the membranes, deliver before 36 weeks gestation, or go into labor before the GBS culture result is available, will receive the standard GBS antibiotic prophylaxis. Labor: The patient

2011 Clinical Trials

359. LCS12 Adolescent Study

the scheduled study visits and to comply with the study procedures Exclusion Criteria: Known or suspected pregnancy or is lactating Vaginal delivery, cesarean delivery, or abortion less than 6 weeks before Visit 1 History of ectopic pregnancies Infected abortion or postpartum endometritis less than 3 months before Visit 1 Abnormal uterine bleeding of unknown origin Any lower genital tract infection (until successfully treated) Acute or history of recurrent pelvic inflammatory disease Congenital or acquired

2011 Clinical Trials

360. Mirena Intrauterine System Timing of Insertion: A Randomized Controlled Trial

-placenta insertion focus on expulsion rates and do not report on symptoms and satisfaction rates. Condition or disease Intervention/treatment Phase Postpartum Period Device: Post-Placenta Mirena Insertion Device: Interval Insertion Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 53 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Prevention (...) Official Title: Randomized, Open-label, Controlled Trial of Immediate Postpartum Versus Interval Insertion of Mirena to Increase the Usage at 6 Months After Delivery Study Start Date : October 2010 Actual Primary Completion Date : December 2012 Actual Study Completion Date : December 2012 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Interval Insertion Will receive Mirena at 4-8 weeks

2011 Clinical Trials

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