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Postinflammatory Hyperpigmentation

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41. Guideline for the Treatment of Acne

and inflammatory lesions including papules, pustules and nodules. Scarring and post inflammatory hyperpigmentation are frequently seen clinical signs in acne. It also commonly affects the back (60 %) and chest (15 %) [2]. Seborrhoea is a frequent feature [3]. The clinical picture embraces a spectrum of signs, ranging from mild comedonal acne, with or without sparse inflammatory lesions (IL), to acne conglobate or aggressive fulminate disease with deep-seated inflammation, nodules and in some cases associated (...) and the use of both disease and quality of life scores is suggested [21]. Persisting hyperpigmentation after active acne has settled is of great concern to many patients. An instrument to measure this has been described, the post acne hyperpigmentation index (PAHPI) [22]. 2.1.1.2 Global assessment techniques Global assessment scales incorporate the entirety of the clinical presentation into a single category of severity. Each category is defined by either photographs with a corresponding numeric scale

2016 European Dermatology Forum

42. Acne clinical guideline Full Text available with Trip Pro

, complementary/alternative therapies, and the role of diet will be reviewed. This guideline does not examine the treatment of acne sequelae (eg, scarring or postinflammatory dyschromia). Methods A work group of 17 recognized acne experts, 1 general practitioner, 1 pediatrician, and 1 patient was convened to determine the scope of the guideline and identify clinical questions ( Table I ) in the diagnosis and management of AV. Work group members completed a disclosure of interests, which was periodically

2016 American Academy of Dermatology

43. Compression stockings as an effective treatment for erythema nodosum: Case series Full Text available with Trip Pro

effects or require a change in lifestyle. We investigated the effects of moderate 20 mmHg to 30 mmHg compression stockings as an alternative treatment method in two female patients with recurrent erythema nodosum. In both cases, the patients wore the compression stockings daily. At the follow-up visit, the EN lesions were no longer tender to the touch, and postinflammatory hyperpigmentation changes had started. Both patients had a lasting clinical resolution.

2017 International journal of women's dermatology

44. A review of laser and light therapy in melasma Full Text available with Trip Pro

a benefit. Vascular-specific lasers do not appear to be effective for the treatment of melasma. Ablative fractionated lasers should be used with caution because they have a very high risk for postinflammatory hypo- and hyperpigmentation. The use of nonablative fractionated laser treatments compared with other laser and light options may result in slightly longer remission intervals. Picosecond lasers, fractional radiofrequency, and laser-assisted drug delivery are promising future approaches to treat (...) . Intense pulsed light, low fluence Q-switched lasers, and non-ablative fractionated lasers are the most common lasers and light treatments that are currently performed. They all appear effective but there is a high level of recurrence with time and some techniques are associated with an increased risk for postinflammatory hyper- or hypopigmentation. The number and frequency of treatments varies by device type but overall, Q-switched lasers require the greatest number of treatment applications to see

2017 International journal of women's dermatology

45. Low-fluence Q-switched Nd:YAG 1064-nm laser versus Q-switched Nd:YAG 532-nm laser in the treatment of hyperpigmented lips: a prospective, randomized, controlled, evaluator-blinded trial. (Abstract)

average mean of photographic evaluation percentage changes from the baseline than the LFQS 1064-nm group (p < 0.001 and p < 0.001, respectively). The adverse effects were less likely to occur in the LFQS 1064-nm group. Few cases of scale, hypopigmentation, bleb formation, postinflammatory hyperpigmentation, and labial edema occurred only in the QS 532-nm group. (...) Low-fluence Q-switched Nd:YAG 1064-nm laser versus Q-switched Nd:YAG 532-nm laser in the treatment of hyperpigmented lips: a prospective, randomized, controlled, evaluator-blinded trial. Lip hyperpigmentation is an esthetic problem. Clinical data from controlled comparative studies is insufficient to support the efficacy of laser treatments for hyperpigmented lips. This study is aimed to compare the efficacy of low-fluence Q-switched Nd:YAG 1064-nm laser (LFQS 1064-nm) versus Q-switched Nd:YAG

2019 Lasers in medical science Controlled trial quality: uncertain

46. The effect of human umbilical cord blood-derived mesenchymal stem cell media containing serum on recovery after laser treatment: A double-blinded, randomized, split-face controlled study. (Abstract)

The effect of human umbilical cord blood-derived mesenchymal stem cell media containing serum on recovery after laser treatment: A double-blinded, randomized, split-face controlled study. Ablative CO2 fractional laser (AFL) is a common cosmetic procedure to improve skin laxity. However, due to prolonged downtime and the risk of postinflammatory hyperpigmentation, laser-assisted delivery of active ingredients as post-laser treatment has gained interest in past years. Among various active

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

47. Patient-Reported Outcomes in Acne Patients With Skin of Color Using Adapalene 0.3%-Benzoyl Peroxide 2.5%: A Prospective Real-World Study (Abstract)

(GAI), postinflammatory hyperpigmentation (PIH; if present at baseline), and safety. Results: Fifty subjects were enrolled: 20 Asians, 17 black/African-Americans, and 13 Latin-Americans. Most had FST IV (74%) or V (22%), with moderate (70%; IGA 3) or severe (30%; IGA 4) acne. At week 16, 77% of subjects were satisfied or very satisfied with treatment, 56% of subjects had an IGA of 0 or 1 (clear/almost clear), and 87% had a good to excellent improvement in GAI. QoL improved throughout the study

2019 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

48. A randomized study to evaluate the efficacy and effectiveness of two sunscreen formulations on Indian skin types IV and V with pigmentation irregularities. Full Text available with Trip Pro

enrolled adult men and women (18-45 years) with Fitzpatrick skin phototypes IV (28° < individual typological angle <10°) and V (10° < individual typological angle < -30°) with pigmentary abnormalities seen on the face in adults (actinic lentigines and postinflammatory hyperpigmentation), who did not use sunscreens. Participants were randomized (1:1) to either of the two marketed sunscreen products, Product A (sun protection factor 50 PA+++) or Product B (sun protection factor 19 PA+++), applied twice

2019 Indian journal of dermatology, venereology and leprology Controlled trial quality: uncertain

49. Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split (Abstract)

evaluate the efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese (experimental cream) versus 0.02% Triamcinolone acetonide (TA) cream in decreasing adverse effects and downtime after FrCO2 laser, with wound healing improvement and prevention of certain steroid-related side effects like postinflammatory hyperpigmentation (PIH).We conducted a double-blinded, split face, randomized controlled trial in 20 subjects receiving FrCO2 laser on both sides

2019 Journal of cosmetic dermatology Controlled trial quality: uncertain

50. Development and accuracy of an artificial intelligence algorithm for acne grading from smartphone photographs. Full Text available with Trip Pro

Development and accuracy of an artificial intelligence algorithm for acne grading from smartphone photographs. We developed an artificial intelligence algorithm (AIA) for smartphones to determine the severity of facial acne using the GEA scale and to identify different types of acne lesion (comedonal, inflammatory) and postinflammatory hyperpigmentation (PIHP) or residual hyperpigmentation. Overall, 5972 images (face, right and left profiles) obtained with smartphones (IOS and/or Android) from

2019 Experimental Dermatology

51. The efficacy and safety of microneedle monopolar radiofrequency for the treatment of periorbital wrinkles. (Abstract)

treated with a short microneedle (SMN, 0.8 mm) were compared, significant improvement in the VISIA wrinkle score was observed only in those treated with the LMN. No serious adverse events, including scarring and postinflammatory hyperpigmentation, occurred. Conclusions: We demonstrated the efficacy and safety of the microneedle monopolar RF device in treating periorbital wrinkles. The LMN was superior to the SMN in reducing VISIA wrinkle score.

2019 Journal of Dermatological Treatment

52. Comparison of a picosecond alexandrite laser versus a Q-switched alexandrite laser for the treatment of nevus of Ota: A randomized, split-lesion, controlled trial. (Abstract)

5.61 vs QSAL 6.40). Patients were more satisfied with PSAL than QSAL (Likert scale, 4.5 vs 4.0). Occurrences of postinflammatory hyperpigmentation (PSAL 26% vs QSAL 34%) and hypopigmentation (PSAL 21% vs QSAL 47%) were also lower in PSAL than QSAL arm.Lack of objective assessments and outcome measures.PSAL demonstrated better clinical results and fewer adverse events than QSAL for the treatment of nevus of Ota.Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc. All

2019 Journal of American Academy of Dermatology Controlled trial quality: uncertain

53. Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology. Full Text available with Trip Pro

effective for treating many hyperpigmented lesions such as lentigos, dermal hypermelanocytosis or heavy metal depositions. In the other hand, they have to be considered with great caution for other disorders, such as café au lait macules, melasma or postinflammatory hyperpigmentation. After making the correct diagnosis, if lasers or IPLS are indicated, the optimal wavelengths and parameters will be chosen taking into account the skin phototype, origin and depth of the target pigments.Although

2019 Journal of the European Academy of Dermatology and Venereology

54. Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris: assessment of safety and tolerability in subgroups. (Abstract)

Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris: assessment of safety and tolerability in subgroups. Topical tretinoin's role in acne has been established through evidence-based guidelines. Cutaneous irritation and potential to cause or exacerbate postinflammatory hyperpigmentation (PIH) may limit use.Evaluate safety and tolerability of novel polymeric formulation of tretinoin 0.05% lotion in moderate-to-severe acne.One thousand six hundred

2019 Journal of Dermatological Treatment Controlled trial quality: uncertain

55. Efficacy of bleomycin application on periungual warts after treatment with ablative carbon dioxide fractional laser: a pilot study. (Abstract)

% improvement). The warts clearing completely did not recur over the follow-up period of 6 months. No significant long-term adverse effects occurred. One lesion showed postinflammatory hyperpigmentation, resolving within 1 month; five patients (29%) had short-term localized moderate pain after treatment.Bleomycin solution after ablative fractional CO2 laser is effective and safe to treat periungual warts. Further large controlled studies are necessary to validate effectiveness and find an optimal regimen.

2019 Journal of Dermatological Treatment

56. Q-switched double frequency Nd:YAG 532-nm nanosecond laser vs. double frequency Nd:YAG 532-nm picosecond laser for the treatment of solar lentigines in Asians. (Abstract)

Q-switched double frequency Nd:YAG 532-nm nanosecond laser vs. double frequency Nd:YAG 532-nm picosecond laser for the treatment of solar lentigines in Asians. Solar lentigines are common pigmentary lesions. Q-switched lasers are effective treatment options but postinflammatory hyperpigmentation (PIH) is common in darker skin. The objective of the study is to compare the efficacy and safety in solar lentigines of Asian skin treated by Q-switched potassium titanyl phosphate (KTP) 532-nm

2018 Lasers in medical science Controlled trial quality: uncertain

57. BPX-01 Minocycline Topical Gel Shows Promise for the Treatment of Moderate-to-severe Inflammatory Acne Vulgaris. (Abstract)

observed in the other endpoints. Across both studies, BPX-01 treatment was well-tolerated, with no photosensitivity, postinflammatory hyperpigmentation, or skin discoloration reported. A single subject (out of 259 study participants ) was identified to have detectable levels of plasma minocycline at low levels (42ng/mL) after 12 weeks of treatment but had no signs or symptoms associated with systemic administration of minocycline. Conclusion: BPX-01 appears to exhibit an effectiveness profile

2018 The Journal of clinical and aesthetic dermatology Controlled trial quality: uncertain

58. A pilot study of treatment of striae distensae with variable square pulse Erbium: YAG laser resurfacing. (Abstract)

both SP&SM and SP only group, volume of SD measured by Visioscan VC98 reduced significantly at 6-month follow-up visit (P=.017 and P=.034, respectively). There were no statistically significant differences in skin roughness (SER), skin smoothness (SESM), and surface measured by Visioscan VC98. Transient postinflammatory hyperpigmentation (PIH) is the common side effect found in patients with darker skin tone even in nonsun exposure areas and can last as long as 6 months.VSP Er:YAG laser resurfacing

2018 Journal of cosmetic dermatology Controlled trial quality: uncertain

59. Treating Acne in Patients With Skin of Color. Full Text available with Trip Pro

Treating Acne in Patients With Skin of Color. Patients with skin of color are more likely to develop acne and postinflammatory hyperpigmentation (PIH). Many therapies for acne have demonstrated efficacy in darker skin types and in the treatment of PIH. Semin Cutan Med Surg 37(supp3):S71-S73 © 2018 published by Frontline Medical Communications.2018 published by Frontline Medical Communications.

2018 Seminars in Cutaneous Medicine and Surgery

60. Dermoscopy in Diagnosis of Pigmentary Skin Lesions

, permenant or temporary, systemic or region restricted). Pigmentary disorders are include alarge number of heterogenous conditions that are usually characterized by altered melanocyte density, melanin concentration, or both, and result in altered pigmentation of the skin. Some of these disorders are extremely common such as (melisma and vitiligo), whereas others are rare Differential Diagnosis of Hyper and Hypopigmentation: Hyperpigmentation Hypopigmentation Postinflammatory hyperpigmentation (acne (...) , psoriasis, atopic and contact dermatitis, lichen planus, trauma, drugs, and fixed-drug eruptions) Melasma Solar lentigines Ephelides (freckles) Café-au-lait macules Nevi Melanoma and precursors Acquired (common) Vitiligo Pityriasis alba Tinea versicolor Postinflammatory hypopigmentation Congenital (uncommon) Albinism Piebaldism Tuberous sclerosis Hypomelanosis of Ito Several studies have shown that dermoscopy may come in very handy for assisting the noninvasive diagnosis of various general

2018 Clinical Trials

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