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Postinflammatory Hyperpigmentation

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21. Reliability assessment and validation of the postacne hyperpigmentation index (PAHPI), a new instrument to measure postinflammatory hyperpigmentation from acne vulgaris. (PubMed)

Reliability assessment and validation of the postacne hyperpigmentation index (PAHPI), a new instrument to measure postinflammatory hyperpigmentation from acne vulgaris. There are no validated outcome measures for postinflammatory hyperpigmentation (PIH).We sought to determine the reliability and validity of an outcome measure for PIH after acne in patients with skin of color.A postacne hyperpigmentation index (PAHPI) was developed. Six raters scored 21 patients with PIH twice. Reliability

2013 Journal of American Academy of Dermatology

22. The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split-face randomized controlled study. (PubMed)

of the topical EGF ointment on wound healing process and postinflammatory hyperpigmentation (PIH) prevention after fractional ablative laser resurfacing.This is a randomized split-face study. Nineteen healthy subjects were enrolled and completed follow up protocol. Patients received single treatment of fractional carbon dioxide laser on both cheeks. After randomization, each patient was assigned to apply one side of the face with topical EGF ointment and another side with petrolatum. Wound healing (...) The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split-face randomized controlled study. Epidermal growth factor (EGF) is one of the important peptides in wound healing process. The effects of EGF have been increasingly studied in various types of ulcers. However, data on postablative laser resurfacing wound is still limited.To evaluate the effects

2019 Journal of cosmetic dermatology

23. A focused review on acne-induced and aesthetic procedure-related postinflammatory hyperpigmentation in Asians. (PubMed)

A focused review on acne-induced and aesthetic procedure-related postinflammatory hyperpigmentation in Asians. Postinflammatory hyperpigmentation (PIH) is a common consequence following cutaneous inflammation in dark-skinned individuals with Fitzpatrick skin phototypes (SPTs) III-VI. The exact pathogenesis of this condition is unknown, but is believed to be an integral part of the normal response of the skin to inflammatory stimuli. PIH can last from months to years and may significantly impair

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2013 Journal of the European Academy of Dermatology and Venereology

24. Tranexamic Acid vs Fractional CO2 Laser in Post-acne Hyperpigmentation

hyperpigmentation [ Time Frame: 3 months ] the post-acne hyperpigmentation index (PAHPI) ranges from 6-22 with higher values showing worse outcome. It is a summation of three scores (Postinflammatory hyperpigmentation(PIH) lesion size, median lesion intensity compared with surrounding skin and the number of PIH lesions). Patient satisfaction score to assess change of post-acne hyperpigmentation [ Time Frame: 3 months ] It is a score ranging from 1-4 with improvement 0-25%=1, 26-50%= 2, 51-75%=3 and more than 75 (...) Tranexamic Acid vs Fractional CO2 Laser in Post-acne Hyperpigmentation Tranexamic Acid vs Fractional CO2 Laser in Post-acne Hyperpigmentation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tranexamic Acid

2018 Clinical Trials

25. Postinflammatory Hyperpigmentation After Skin Prick Testing (PubMed)

Postinflammatory Hyperpigmentation After Skin Prick Testing 23268476 2012 12 27 2019 02 11 1939-4551 5 5 2012 May The World Allergy Organization journal World Allergy Organ J Postinflammatory hyperpigmentation after skin prick testing. 57-8 10.1097/WOX.0b013e3182488069 Ludman Sian S Department of MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, Division of Asthma, Allergy and Lung Biology, King's College London, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Penagos

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2012 The World Allergy Organization journal

26. Postinflammatory Hyperpigmentation

Postinflammatory Hyperpigmentation Postinflammatory Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Postinflammatory (...) Hyperpigmentation Postinflammatory Hyperpigmentation Aka: Postinflammatory Hyperpigmentation From Related Chapters II. Definition response to inflammation on dark skin III. Pathophysiology Common complication following or inflammation in darker skin type (3 to 6) Local inflammation results in prostaglandin, leukotriene and thromboxane release Epidermal s hypertrophy, synthesizing IV. Causes: Common precipitating lesions Inflammation Laser therapy or V. Signs Irregular, dark s and patches at sites of injury

2015 FP Notebook

27. Sun-protective behaviors in patients with cutaneous hyperpigmentation: A cross-sectional study. (PubMed)

was conducted with 404 adults who complained of cutaneous hyperpigmentation.About 67.5% reported using a product containing sunscreen, and 91% endorsed using one with a sun protection factor of 21 or higher. Among the participants, 48.5% were not sure if their sunscreen provided broad-spectrum protection, and only 7.6% reapplied every 2 hours. The odds of a patient with melasma using sunscreen were 6.7 times the odds of a patient with postinflammatory hyperpigmentation using sunscreen (P < .001). Additional (...) predictors for sunscreen use were female sex (OR = 3.8, P = .0004) and disease duration of ≥1 year (OR = 2.1, P = .003). In a multivariate analysis, the odds ratio of sunscreen use among African Americans compared to whites was 0.31 (P = .008).Limitations included recall bias, question misinterpretation, and reporter bias.Patients diagnosed with postinflammatory hyperpigmentation, men, and those with disease duration <1 year reported lower sunscreen usage. These groups might benefit from increased

2017 Journal of American Academy of Dermatology

28. A prospective randomized controlled study of oral tranexamic acid for preventing postinflammatory hyperpigmentation after Q-switched ruby laser. (PubMed)

A prospective randomized controlled study of oral tranexamic acid for preventing postinflammatory hyperpigmentation after Q-switched ruby laser. Postinflammatory hyperpigmentation (PIH) is the most common skin complication in Asians after invasive cosmetic treatments.To determine whether oral tranexamic acid (TA) reduces the incidence of PIH after Q-switched ruby laser (QSRL) treatment.Thirty-two Japanese women underwent QSRL treatment for senile lentigines on the face. They were randomly

2011 Dermatologic Surgery

29. Commentary: use of oral therapy for the prevention of postinflammatory hyperpigmentation. (PubMed)

Commentary: use of oral therapy for the prevention of postinflammatory hyperpigmentation. 21518099 2011 07 26 2013 11 21 1524-4725 37 5 2011 May Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Use of oral therapy for the prevention of postinflammatory hyperpigmentation. 611 10.1111/j.1524-4725.2011.01958.x McDaniel David H DH Institute of Anti-Aging Research, Eastern Virginia Medical School, Virginia Beach, Virginia, USA. mail (...) @lsvcv.com eng Comment Journal Article United States Dermatol Surg 9504371 1076-0512 0 Antifibrinolytic Agents 6T84R30KC1 Tranexamic Acid IM Dermatol Surg. 2011 May;37(5):605-10 21457392 Administration, Oral Antifibrinolytic Agents administration & dosage therapeutic use Humans Hyperpigmentation etiology prevention & control Inflammation etiology prevention & control Japan Lasers adverse effects Tranexamic Acid administration & dosage therapeutic use 2011 4 27 6 0 2011 4 27 6 0 2011 7 27 6 0 ppublish

2011 Dermatologic Surgery

30. Postinflammatory hyperpigmentation: etiologic and therapeutic considerations. (PubMed)

Postinflammatory hyperpigmentation: etiologic and therapeutic considerations. Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis and sequela of a variety of inflammatory skin conditions. PIH can have a negative impact on a patient's quality of life, particularly for darker-skinned patients. Studies show that dyschromias, including PIH, are one of the most common presenting complaints of darker-skinned racial ethnic groups when visiting a dermatologist. This is likely due

2011 American journal of clinical dermatology

31. Non-ablative 1550 nm fractional laser therapy not effective for erythema dyschromicum perstans and postinflammatory hyperpigmentation: a pilot study. (PubMed)

Non-ablative 1550 nm fractional laser therapy not effective for erythema dyschromicum perstans and postinflammatory hyperpigmentation: a pilot study. Erythema dyschromicum perstans and postinflammatory hyperpigmentation (PIH) are characterized by papillary dermal pigmentation or pigment incontinence. To date, no standard treatment is available. Fractional laser therapy (FLT) was recently reported to improve different pigment disorders.To assess the efficacy and safety of non-ablative FLT (...) in the treatment of erythema dyschromicum perstans and PIH.Eight patients with erythema dyschromicum perstans and six patients with PIH were included. In each patient, two similar test regions were randomized to receive either five fractional laser treatments in combination with intermittent daily topical bleaching or the same intermittent regimen of topical bleaching alone. Three months after the last treatment, improvement of hyperpigmentation was assessed by melanin index, reflectance spectroscopy

2011 Journal of Dermatological Treatment

32. Periorbital Hyperpigmentation: A Comprehensive Review (PubMed)

Periorbital Hyperpigmentation: A Comprehensive Review Periorbital hyperpigmentation is a commonly encountered condition. There is very little scientific data available on the clinical profile and pathogenesis of periorbital hyperpigmentation. Periorbital hyperpigmentation is caused by various exogenous and endogenous factors. The causative factors include genetic or heredity, excessive pigmentation, postinflammatory hyperpigmentation secondary to atopic and allergic contact dermatitis (...) , periorbital edema, excessive vascularity, shadowing due to skin laxity and tear trough associated with aging. There are a number of treatment options available for periorbital hyperpigmentation. Among the available alternatives to treat dark circles are topical depigmenting agents, such as hydroquinone, kojic acid, azelaic acid, and topical retinoic acid, and physical therapies, such as chemical peels, surgical corrections, and laser therapy, most of which are tried scientifically for melasma, another

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2016 The Journal of clinical and aesthetic dermatology

33. Topical Corticosteroids Minimise the Risk of Postinflammatory Hyper-pigmentation After Ablative Fractional CO2 Laser Resurfacing in Asians. (PubMed)

Topical Corticosteroids Minimise the Risk of Postinflammatory Hyper-pigmentation After Ablative Fractional CO2 Laser Resurfacing in Asians. Postinflammatory hyperpigmentation (PIH) is the most common adverse effect of laser treatment in dark-skinned individuals. Little is known whether PIH can be prevented or minimised. The objective of this study was to investigate the effect of short-term application of topical corticosteroids on the incidence of PIH after ablative fractional resurfacing

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2014 Acta Dermato-Venereologica

34. Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Novel Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. (PubMed)

Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Novel Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. 20629692 2011 03 30 2011 02 14 1524-4725 36 9 2010 Sep Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Commentary: treatment of facial postinflammatory hyperpigmentation with facial acne in Asian patients using a novel Q-switched neodymium-doped yttrium aluminum garnet (...) laser. 1381 10.1111/j.1524-4725.2010.01644.x Metelitsa Andrei I AI SkinCare Physicians, Chestnut Hill, Massachusetts, USA. eng Comment Journal Article 2010 07 09 United States Dermatol Surg 9504371 1076-0512 IM Dermatol Surg. 2010 Sep;36(9):1374-80 20629693 Acne Vulgaris complications surgery Dermatitis etiology Face Humans Hyperpigmentation etiology surgery Lasers, Solid-State therapeutic use Skin Diseases etiology surgery 2010 7 16 6 0 2010 7 16 6 0 2011 3 31 6 0 ppublish 20629692 DSU1644 10.1111

2010 Dermatologic Surgery

35. Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. (PubMed)

Treatment of Facial Postinflammatory Hyperpigmentation with Facial Acne in Asian Patients Using a Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser. Postinflammatory hyperpigmentation (PIH) due to facial acne commonly occurs in Fitzpatrick skin types IV to VI and can have a considerable effect on quality of life. The sequelae in terms of pigmentation are often the main reason for consulting a dermatologist and take precedence over the acne itself.The purpose of this study was to evaluate

2010 Dermatologic Surgery

36. Efficacy and Safety of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel for the Treatment of Acne and Acne-induced Post-inflammatory Hyperpigmentation in Patients with Skin of Color. (PubMed)

Efficacy and Safety of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel for the Treatment of Acne and Acne-induced Post-inflammatory Hyperpigmentation in Patients with Skin of Color. To assess the efficacy and safety of a topical gel containing clindamycin 1.2% and tretinoin 0.025% for the treatment of acne and acne-induced postinflammatory hyperpigmentation (PIH) in darker skinned patients.Randomized, double-blind, placebo-controlled study.Two United States clinical sites.Thirty-three (...) patients 12 years of age or older with skin types IV to VI, mild-to-moderate facial acne, and PIH were enrolled.Patients applied clindamycin phosphate/tretinoin gel or a nonmedicated vehicle each evening and a sun protection factor 30 sunscreen daily. Changes in skin erythema and hyperpigmentation were measured using a chromameter and photographic images. Efficacy was assessed using the Evaluators Global Acne Severity Scale, lesion counts, Post-inflammatory Hyperpigmentation Severity Scales

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2012 The Journal of clinical and aesthetic dermatology

37. Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation

(TEWL), colorimetry, clinically and by photography control. Condition or disease Intervention/treatment Phase Hyperpigmentation Drug: Desonide Drug: Niacinamide Drug: Placebo Phase 4 Detailed Description: Axillary hyperpigmentation is frequent in dark skin population, is possible a type of postinflammatory hyperpigmentation present in phototypes IV to VI. Previous reports have described increased intensity of Masson-Fontana, anti-tyrosinase and/or anti-TRP1 staining, indicative of melanocyte (...) Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2012 Clinical Trials

38. Periorbital Hyperpigmentation in Asians: An Epidemiologic Study and a Proposed Classification. (PubMed)

Skin Center were enrolled in the study to assess for POH, of whom 200 with POH were examined and investigated to define the cause of POH. The possible causes were determined according to a detailed history, clinical examination, and assessment by three dermatologists. The extent of the POH was measured using a mexameter.The commonest form of POH was the vascular type (41.8%), followed by constitutional (38.6%), postinflammatory hyperpigmentation (12%), and shadow effects (11.4%). The vascular type (...) Periorbital Hyperpigmentation in Asians: An Epidemiologic Study and a Proposed Classification. Periorbital hyperpigmentation (POH) presents with a dark area surrounding the eyelids. It is an ill-defined condition, and the pathogenesis can be multifactorial.This epidemiologic study was conducted to assess the prevalence of periorbital hyperpigmentation in Singapore in an attempt to propose a classification.One thousand consecutive patients attending the general dermatology clinic at the National

2011 Dermatologic Surgery

39. Hyperpigmentation

Education NOTE: This is the Professional Version. CONSUMERS: Topic Resources Hyperpigmentation has multiple causes and may be focal or diffuse. Most cases are due to an increase in melanin production and deposition. (See also .) Focal hyperpigmentation is most often postinflammatory in nature, occurring after injury (eg, and ) or other causes of inflammation (eg, , ). Focal linear hyperpigmentation is commonly due to phytophotodermatitis, which is a phototoxic reaction that results from ultraviolet (...) -gray discoloration (argyria), especially in sun-exposed areas In fixed drug eruptions, red plaques or blisters form at the same site each time a drug is taken; residual postinflammatory hyperpigmentation usually persists. Typical lesions occur on the face (especially the lips), hands, feet, and genitals. Typical inciting drugs include antibiotics (sulfonamides, tetracyclines, trimethoprim , and fluoroquinolones), NSAIDs, and barbiturates. Key Points Common causes of focal hyperpigmentation include

2013 Merck Manual (19th Edition)

40. Effectiveness, safety, and effect on quality of life of topical salicylic acid peels for treatment of postinflammatory hyperpigmentation in dark skin. (PubMed)

Effectiveness, safety, and effect on quality of life of topical salicylic acid peels for treatment of postinflammatory hyperpigmentation in dark skin. There are no randomized split-face model studies investigating treatments for postinflammatory hyperpigmentation (PIH) in dark skin.To assess the efficacy, safety, and effect on quality of life of salicylic acid peels for PIH in dark skin.Ten subjects with Fitzpatrick skin phototypes IV to VI were randomized to receive two 20% salicylic acid

2009 Dermatologic Surgery

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