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355 results for

Postinflammatory Hyperpigmentation

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341. The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells. (Abstract)

The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells. Alpha-hydroxy acids (AHAs) such as glycolic acid (GA) and lactic acid (LA) have been reported to be effective in treating pigmentary lesions such as melasma, solar lentigines, and postinflammatory hyperpigmentation. The mechanism of this effect might be due to epidermal remodeling and accelerated desquamation, which would result in quick pigment dispersion. However, the direct effect of AHAs

2003 Experimental Dermatology

342. Efficacy of pulsed dye laser treatment of port wine stain malformations of the lower limb. (Abstract)

and postinflammatory hyperpigmentation has been reported to be a significant problem.To review retrospectively patients who attended for PDL treatment of PWS affecting the lower limb and assess the efficacy and adverse effects with particular reference to skin site.A retrospective review was carried out of patients attending the Leeds Dermatology Laser Centre for treatment of a PWS on the lower limb with a 585-nm PDL.A total of 52 sites in 39 patients were treated: 17 on the thigh, 31 on the lower leg and four (...) on the foot. The mean number of sessions per patient was 14, with an excellent outcome in seven treatment sites (13.5%), good in 13 (25%), moderate in 21 (40.4%) and poor outcome in 11 (21.1%). Patients were generally pleased with their results with a mean improvement of 7 on a scale of 0-10. Perifollicular persistence of the PWS was observed in six sites (11.5%). Adverse effects occurred in 36 patients (92.3%), most commonly hyperpigmentation (87%). Six patients (15.4%) developed atrophic scarring

2003 British Journal of Dermatology

343. Combined therapy using Q-switched ruby laser and bleaching treatment with tretinoin and hydroquinone for acquired dermal melanocytosis. (Abstract)

Combined therapy using Q-switched ruby laser and bleaching treatment with tretinoin and hydroquinone for acquired dermal melanocytosis. Acquired dermal melanocytosis (ADM; acquired bilateral nevus of Ota-like macules) is known for its recalcitrance compared with Nevus of Ota, and we assume that one of the reasons is a higher rate and degree of postinflammatory hyperpigmentation (PIH) seen after laser treatments.Topical bleaching treatment with 0.1% tretinoin aqueous gel and 5% hydroquinone (...) patients showed good to excellent clearing after two to three sessions of QSR laser treatments. The total treatment period ranged from 3 to 13 (mean of 8.3) months. PIH was observed in 10.5% of the cases. Histologically, epidermal hyperpigmentation was observed in all specimens and was dramatically improved by the topical bleaching pretreatment.QSR laser combined with the topical bleaching pretreatment appeared to treat ADM consistently with a low occurrence rate of PIH and lessen the number of laser

2003 Dermatologic Surgery

344. The effect of combination treatment of the recalcitrant pigmentary disorders with pigmented laser and chemical peeling. (Abstract)

The effect of combination treatment of the recalcitrant pigmentary disorders with pigmented laser and chemical peeling. The pigmentary disorders including melasma, freckles, postinflammatory hyperpigmentation, or acquired bilateral nevus of Ota-like macules, etc. are usually resistant to all treatment modalities, and are therefore very frustrating to the patient and clinician.The purpose of this study was to demonstrate the effect of the combination treatment of recalcitrant pigmentary

2002 Dermatologic Surgery

345. Cosmetic color improvement of the nipple-areola complex by optimal use of tretinoin and hydroquinone. (Abstract)

average treatment period was 16.6 weeks. Improvement of NAC color was obtained in 12 patients (80%) by the physician's estimation, and 11 patients (73%) satisfied with their final results. The treatment was repeated after a 1-month interval of tretinoin application in 4 patients: 2 desired further improvement in color, and 2 had the second course conducted to treat the postinflammatory hyperpigmentation on the surrounding mound induced by the first course.This approach appeared to be most effective

2002 Dermatologic Surgery

346. Combined ultrapulse CO2 laser and Q-switched alexandrite laser compared with Q-switched alexandrite laser alone for refractory melasma: split-face design. (Abstract)

reduction was not significant. Two cases developed severe postinflammatory hyperpigmentation and were effectively treated with bleaching agents. Transient hypopigmentation and contact dermatitis were observed with the combination treatment side.: Combined Ultrapulse CO2 laser and QSAL showed a better result than QSAL alone but was associated with more frequent adverse effects. Long-term follow-up and a larger number of cases are required to determine its efficacy and safety for refractory melasma.

2003 Dermatologic Surgery

347. Ethnic skin disorders overview. (Abstract)

include acne; pigmentary disorders such as postinflammatory hyperpigmentation and hypopigmentation, vitiligo, and melasma; and photoaging. Because the majority of the world's population already consists of people with pigmented skin and the population within the United States is approximately one-third non-Caucasian, physicians who practice in the field of dermatology today need a thorough understanding of non-Caucasian dermatoses.

2003 Journal of American Academy of Dermatology

348. Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment

Responsible Party: Worapong Manuskiatti, Mahidol University ClinicalTrials.gov Identifier: Other Study ID Numbers: 185/2005 First Posted: February 6, 2006 Last Update Posted: May 22, 2008 Last Verified: February 2007 Keywords provided by Mahidol University: Acquired bilateral nevus of Ota-like macules Postinflammatory hyperpigmentation Cold air cooling Additional relevant MeSH terms: Layout table for MeSH terms Hyperpigmentation Pigmentation Disorders Skin Diseases (...) Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2006 Clinical Trials

349. Congenital curvilinear palpable hyperpigmentation. (Abstract)

Congenital curvilinear palpable hyperpigmentation. We report two cases of congenital curvilinear palpable hyperpigmentation on the posterior aspect of bilateral legs in male infants. These lesions appeared shortly after birth and mimicked child abuse with looped cord or postinflammatory hyperpigmentation. Histopathologic features showed lentiginous melanocytic hyperplasia. One of the boys also had severe global developmental delay with abnormal findings from magnetic resonance imaging (...) of the brain. We believe that these lesions represent a new type of congenital hyperpigmentation that we termed "congenital curvilinear palpable hyperpigmentation." Although these lesions do not follow the lines of Blaschko, they may also be associated with neurologic and developmental abnormalities.

2005 Journal of American Academy of Dermatology

350. Post-inflammatory Hyperpigmentation of Skin

Cutan Aesthet Surg. 2013 Jan6(1):4-11. doi: 10.4103/0974-2077.110089. ; Novel technique to treat melasma in Chinese: The combination of 2940-nm fractional Er:YAG and 1064-nm Q-switched Nd:YAG laser. J Cosmet Laser Ther. 201618(2):72-4. doi: 10.3109/14764172.2015.1063662. Epub 2016 Feb 2. ; Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color. J Clin Aesthet Dermatol. 2010 Jul3(7):20-31. ; A review of acne in ethnic skin (...) : pathogenesis, clinical manifestations, and management strategies. J Clin Aesthet Dermatol. 2010 Apr3(4):24-38. ; DermNet NZ ; DermNet NZ ; My approach to superficial inflammatory dermatoses. J Clin Pathol. 2005 Dec58(12):1233-41. ; Low risk of postinflammatory hyperpigmentation in skin types 4 and 5 after treatment with fractional CO2 laser device. J Drugs Dermatol. 2008 Aug7(8):774-7. ; Lasers for treatment of melasma and post-inflammatory hyperpigmentation. J Cutan Aesthet Surg. 2012 Apr5(2):93-103. doi

2008 Mentor

351. Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled study. (Abstract)

Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled study. Previous investigations have reported the efficacy of tazarotene 0.1% cream for the treatment of dyschromia associated with photoaging and for acne vulgaris. The present investigation assessed tazarotene 0.1% cream for the treatment of postinflammatory hyperpigmentation (PIH) in a double-blind, randomized, vehicle-controlled study of 74 patients from (...) darker racial ethnic groups who had acne. Once-daily application of tazarotene cream was shown to be effective against PIH, achieving significantly greater reductions compared with vehicle in overall disease severity and in the intensity and area of hyperpigmentation within 18 weeks (P< or =.05). Mean levels of erythema, burning, and peeling were no more than trace in both groups throughout the study, and mean levels of dryness were no more than mild in both groups. In our study, tazarotene cream

2006 Cutis; cutaneous medicine for the practitioner Controlled trial quality: uncertain

352. Effect of cold air cooling on the incidence of postinflammatory hyperpigmentation after Q-switched Nd:YAG laser treatment of acquired bilateral nevus of Ota like macules. Full Text available with Trip Pro

Effect of cold air cooling on the incidence of postinflammatory hyperpigmentation after Q-switched Nd:YAG laser treatment of acquired bilateral nevus of Ota like macules. To investigate the effect of cold air cooling on the incidence of postinflammatory hyperpigmentation (PIH) after laser treatment in Asian patients.Randomized, controlled, split-face study.Skin laser center of a university hospital.Twenty-three Thai women with acquired bilateral nevus of Ota-like macules.Patients were treated

2007 Archives of Dermatology Controlled trial quality: uncertain

353. RALGA (Diacneal), a retinaldehyde and glycolic acid association and postinflammatory hyperpigmentation in acne--a review. (Abstract)

RALGA (Diacneal), a retinaldehyde and glycolic acid association and postinflammatory hyperpigmentation in acne--a review. Acne vulgaris affects 3 out of 4 adolescents and usually vanishes at the end of puberty with either no sequelae or mild to moderate sequelae, such as postinflammatory hyperpigmenation (PIH), which may result in psychological and emotional damages. The poor tolerability of the actual treatments (secondary inflammation) is a hindrance to therapy. Retinaldehyde (RAL

2005 Dermatology

354. Topical methimazole as a new treatment for postinflammatory hyperpigmentation: report of the first case. (Abstract)

Topical methimazole as a new treatment for postinflammatory hyperpigmentation: report of the first case. We have previously shown that the peroxidase inhibitor methimazole (1-methyl-2-mercapto imidazole; MMI) is a noncytotoxic inhibitor of melanin production in cultured B16 melanocytes. It was further demonstrated that the topical application of 5% MMI on brown guinea pig skin for 6 weeks causes a significant reduction in the amount of epidermal melanin, resulting in visually recognizable (...) cutaneous depigmentation. Herein, we report a 27-year-old male with postinflammatory hyperpigmentation (due to acid burn), successfully treated with topical MMI as a new skin depigmenting agent. Topical 5% MMI caused a moderate to marked improvement of the hyperpigmented lesions within 6 weeks of once-daily application. Topical MMI was well tolerated by the patient and did not affect the level of serum thyroid hormones (free thyroxin, free triiodothyronine and the thyroid-stimulating hormone). Unlike

2005 Dermatology

355. Glycolic acid peels for postinflammatory hyperpigmentation in black patients. A comparative study. (Abstract)

Glycolic acid peels for postinflammatory hyperpigmentation in black patients. A comparative study. Treatment of postinflammatory hyperpigmentation in patients of Fitzpatrick skin types IV, V, and VI is difficult. Glycolic acid peels are useful for pigment dyschromias in caucasians; however, there are no controlled studies examining their safety and efficacy in dark-complexioned individuals.To determine if serial glycolic acid peels provide additional improvement when compared with a topical (...) treatment groups demonstrated improvement, but the patients receiving the glycolic acid peels showed a trend toward more rapid and greater improvement. The peel group also experienced increased lightening of the normal skin.This pilot study demonstrates that serial glycolic acid peels provide an additional benefit, with minimal adverse effects, for the treatment of postinflammatory hyperpigmentation in dark-complexioned individuals.

1997 Dermatologic Surgery Controlled trial quality: uncertain

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