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Postinflammatory Hyperpigmentation

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1. Insights on an in vivo model for postinflammatory hyperpigmentation. (PubMed)

Insights on an in vivo model for postinflammatory hyperpigmentation. Postinflammatory hyperpigmentation (PIH) can occur following a multitude of inflammatory skin conditions including acne vulgaris. It is more common in darker Fitzpatrick phototypes and represents a common skin complaint in dermatology offices. Despite its common occurrence, treatment options for PIH remain limited. Isedeh et al. published a validated in vivo model for PIH in which 35% trichloroacetic acid (TCA) solution

2019 British Journal of Dermatology

2. The ultraviolet B inflammation model: postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects. (PubMed)

The ultraviolet B inflammation model: postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects. Pain models are commonly used in drug development to demonstrate analgesic activity in healthy subjects and should therefore not cause long-term adverse effects. The ultraviolet B (UVB) model is a model for inflammatory pain in which three times the minimal erythema dose (3MED) is typically applied to induce sensitization (...) . Based on reports of long-lasting postinflammatory hyperpigmentation (PIH) associated with 3MED, it was decided to investigate the prevalence of PIH among subjects who were previously exposed to 3MED at our research centre. In addition, re-evaluation of the UVB inflammation model using a reduced exposure paradigm (2MED) was performed in healthy subjects.In the first study, all 142 subjects previously exposed to 3MED UVB were invited for a clinical evaluation of PIH. In the second study, 18 healthy

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2018 European Journal of Pain

3. Treatment of Postinflammatory Hyperpigmentation With a Combination of Glycolic Acid Peels and a Topical Regimen in Dark-Skinned Patients: A Comparative Study. (PubMed)

Treatment of Postinflammatory Hyperpigmentation With a Combination of Glycolic Acid Peels and a Topical Regimen in Dark-Skinned Patients: A Comparative Study. Facial postinflammatory hyperpigmentation (PIH) is challenging to manage in patients with skin of color because of the risk of subsequent treatment-related hyperpigmentation.To evaluate the safety and efficacy of combining glycolic acid (GA) peels with a modified Kligman formula (MKF) containing hydroquinone 2%, tretinoin 0.05 (...) %, and hydrocortisone 1% for the treatment of facial PIH in Indian patients.Thirty Indian patients (Fitzpatrick skin Types III-V) with facial PIH were randomly assigned to 2 groups of 15 each. One group received serial GA peels combined with an intervening topical regimen containing MKF. The other group received MKF alone. Results were evaluated by a clinical investigator at baseline and at the end of 21 weeks (3 weeks after treatment completion) using an objective scoring system, the Hyperpigmentation Area

2017 Dermatologic Surgery

4. Postinflammatory hyperpigmentation: A comprehensive overview: Epidemiology, pathogenesis, clinical presentation, and noninvasive assessment technique. (PubMed)

Postinflammatory hyperpigmentation: A comprehensive overview: Epidemiology, pathogenesis, clinical presentation, and noninvasive assessment technique. Postinflammatory hyperpigmentation (PIH) commonly occurs after various endogenous and exogenous stimuli, especially in dark-skinned individuals. PIH is one of the most common complications of procedures performed using laser and other light sources. The severity of PIH is determined by the inherent skin color, degree and depth of inflammation (...) , degree of dermoepidermal junction disruption, inflammatory conditions, and the stability of melanocytes, leading to epidermal and dermal melanin pigment deposition. The depth of melanin pigment is the key factor to predict prognosis and treatment outcome. Epidermal hyperpigmentation fades more rapidly than dermal hyperpigmentation. Various inflammatory disorders can eventually result in PIH. The evaluation of pigmentation using noninvasive tools helps define the level of pigmentation in the skin

2017 Journal of American Academy of Dermatology

5. Postinflammatory hyperpigmentation: A comprehensive overview: Treatment options and prevention. (PubMed)

Postinflammatory hyperpigmentation: A comprehensive overview: Treatment options and prevention. Postinflammatory hyperpigmentation (PIH) occurs after various dermatoses, exogenous stimuli, and dermatologic procedures. The clinical course of PIH is chronic and unpredictable, although the probability of resolution of epidermal hyperpigmentation is better than those of dermal hyperpigmentation. PIH can be prevented or alleviated. When it does occur, the underlying inflammatory conditions should (...) . The second article in this 2-part continuing medical education series on PIH specifically addresses the evidence that supports medical and procedural treatments of PIH and other forms of acquired hyperpigmentation. It also describes a PIH model and provides an algorithm for clinical practice along with discussion about the prevention of PIH.Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

2017 Journal of American Academy of Dermatology

6. Postinflammatory Hyperpigmentation: Epidemiology, Clinical Presentation, Pathogenesis and Treatment. (PubMed)

Postinflammatory Hyperpigmentation: Epidemiology, Clinical Presentation, Pathogenesis and Treatment. Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis that develops following cutaneous inflammation. Common causes of PIH include intrinsic skin conditions (e.g., acne and eczema) as well as external insults to the skin, such as burn injuries and dermatologic procedures. PIH more commonly occurs in individuals with darker skin, for whom it is often a source of significant

2017 American journal of clinical dermatology

7. Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris

Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03361345 Recruitment

2017 Clinical Trials

8. Psychosocial Impact of Postinflammatory Hyperpigmentation in Patients with Acne Vulgaris (PubMed)

Psychosocial Impact of Postinflammatory Hyperpigmentation in Patients with Acne Vulgaris Background: Acne vulgaris is a common, often socially distressing skin condition primarily seen in young adults. Quality of life studies have shown that people with acne are more introverted with increased social setting anxiety compared to a control group. Unfortunately, patients with acne may have residual postinflammatory hyperpigmentation, amplifying impaired psychosocial effects. Objective: To quantify (...) the impact of postinflammatory hyperpigmentation in patients with acne using a psychometric scale. Design: A clinic-based survey was conducted among US adults with facial acne and postinflammatory hyperpigmentation. Outcomes included age, race, gender, and acne-related quality of life. A board-certified dermatologist rated each patient's acne severity and postinflammatory hyperpigmentation. Setting: Dermatology clinic, Anheuser Busch Institute and Des Peres Hospital, Saint Louis, Missouri. Participants

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2017 The Journal of clinical and aesthetic dermatology

9. Postinflammatory hyperpigmentation after human cold pain testing (PubMed)

Postinflammatory hyperpigmentation after human cold pain testing Changes in cold temperature sensitivity are often associated with chronic pain conditions. Progress in understanding the neurobiological mechanism underlying these changes and resulting development of effective therapies has been slowed by the accessibility and affordability of devices used to measure thermal sensitivity in humans. To address this gap, we developed an inexpensive method to measure cold pain thresholds in healthy (...) adult volunteers using dry ice and a thermode. However, early in preliminary testing, a subject presented with epidermal postinflammatory hyperpigmentation that lasted for >200 days. Although this response was unique among the small number of subjects in development of the assay, it raised questions as to the safety of the assay design.

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2016 Pain Reports

10. An In Vivo Model for Postinflammatory Hyperpigmentation

An In Vivo Model for Postinflammatory Hyperpigmentation An In Vivo Model for Postinflammatory Hyperpigmentation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An In Vivo Model for Postinflammatory (...) ) Estimated Enrollment : 30 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Other Official Title: An In Vivo Model for Postinflammatory Hyperpigmentation: Part II Study Start Date : February 2016 Estimated Primary Completion Date : December 2017 Estimated Study Completion Date : December 2017 Arms and Interventions Go to Arm Intervention/treatment Trichloroacetic Acid Intervention-Apply 4 concentrations of TCA (20%, 25%, 30%, 35%) to the buttocks to two

2016 Clinical Trials

11. Laser Treatments for Postinflammatory Hyperpigmentation: A Systematic Review. (PubMed)

Laser Treatments for Postinflammatory Hyperpigmentation: A Systematic Review. Lasers are gaining interest as a treatment option for postinflammatory hyperpigmentation (PIH) but can pose a clinical dilemma given the risk for laser-induced or exacerbated PIH.To assess the clinical evidence for the use of lasers in the treatment of PIH.A systematic review was performed by searching PubMed databases from January 1, 1990, through May 31, 2016. Included studies involved laser treatment for PIH

2016 JAMA dermatology

12. Postinflammatory Hyperpigmentation Associated with Treatment of Solar Lentigines using a Q-Switched 532-nm Nd: YAG Laser: A Multicenter Survey. (PubMed)

Postinflammatory Hyperpigmentation Associated with Treatment of Solar Lentigines using a Q-Switched 532-nm Nd: YAG Laser: A Multicenter Survey. To characterize the risk factors of Korean patients for postinflammatory hyperpigmentation (PIH) during treatment of solar lentigines using a Q-switched 532-nm Nd: YAG (QS 532 NY) laser.The present retrospective multicenter study was conducted at the dermatology clinics of five tertiary hospitals in Korea. Between October 2007 and January 2013, 516

2016 Journal of Dermatological Treatment

13. Postinflammatory Hyperpigmentation

Postinflammatory Hyperpigmentation Postinflammatory Hyperpigmentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Postinflammatory (...) Hyperpigmentation Postinflammatory Hyperpigmentation Aka: Postinflammatory Hyperpigmentation From Related Chapters II. Definition response to inflammation on dark skin III. Pathophysiology Common complication following or inflammation in darker skin type (3 to 6) Local inflammation results in prostaglandin, leukotriene and thromboxane release Epidermal s hypertrophy, synthesizing IV. Causes: Common precipitating lesions Inflammation Laser therapy or V. Signs Irregular, dark s and patches at sites of injury

2018 FP Notebook

14. Treatment of Persistent Facial Postinflammatory Hyperpigmentation With Novel Pulse-in-Pulse Mode Intense Pulsed Light. (PubMed)

Treatment of Persistent Facial Postinflammatory Hyperpigmentation With Novel Pulse-in-Pulse Mode Intense Pulsed Light. Postinflammatory hyperpigmentation (PIH) is an acquired hypermelanosis induced by various causes including inflammatory dermatoses, injury, or cosmetic procedures, such as lasers or chemical peels, and it tends to affect dark-skinned people with greater frequency and severity. There are a variety of treatment options for PIH, including topical agents, chemical peels, laser

2016 Dermatologic Surgery

15. Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser

Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02492373 Recruitment Status : Completed First Posted : July 8, 2015 Last Update Posted : June 1, 2016 Sponsor

2015 Clinical Trials

16. An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits. (PubMed)

An in vivo model for postinflammatory hyperpigmentation: an analysis of histological, spectroscopic, colorimetric and clinical traits. Acne vulgaris is a common condition that occurs in all skin types. Postinflammatory hyperpigmentation (PIH) is often associated with acne in patients of darker skin types, making it a common complaint in dermatology offices. Despite this, there is limited understanding of and effective treatment options for PIH.The study objective was to validate an in vivo

2015 British Journal of Dermatology

17. Postinflammatory Hyperpigmentation (Overview)

Postinflammatory Hyperpigmentation (Overview) Postinflammatory Hyperpigmentation: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTE5MS1vdmVydmlldw== processing (...) > Postinflammatory Hyperpigmentation Updated: May 04, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Postinflammatory Hyperpigmentation Overview Background Postinflammatory hyperpigmentation (PIH) is a frequently encountered problem and represents the sequelae of various cutaneous disorders as well as therapeutic interventions. [ ] This acquired excess of pigment can be attributed to various preceding disease processes that affect

2014 eMedicine.com

18. Postinflammatory Hyperpigmentation (Treatment)

Postinflammatory Hyperpigmentation (Treatment) Postinflammatory Hyperpigmentation Treatment & Management: Medical Care, Surgical Care, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTE5MS10cmVhdG1lbnQ= processing > Postinflammatory Hyperpigmentation Treatment & Management Updated: May 04, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Postinflammatory Hyperpigmentation Treatment Medical Care The treatment of postinflammatory hyperpigmentation (PIH) tends to be a difficult and prolonged process that often takes 6-12 months to achieve the desired results of depigmentation. Each of these treatment options potentially

2014 eMedicine.com

19. Postinflammatory Hyperpigmentation (Follow-up)

Postinflammatory Hyperpigmentation (Follow-up) Postinflammatory Hyperpigmentation Treatment & Management: Medical Care, Surgical Care, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTE5MS10cmVhdG1lbnQ= processing > Postinflammatory Hyperpigmentation Treatment & Management Updated: May 04, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Postinflammatory Hyperpigmentation Treatment Medical Care The treatment of postinflammatory hyperpigmentation (PIH) tends to be a difficult and prolonged process that often takes 6-12 months to achieve the desired results of depigmentation. Each of these treatment options potentially

2014 eMedicine.com

20. Postinflammatory Hyperpigmentation (Diagnosis)

Postinflammatory Hyperpigmentation (Diagnosis) Postinflammatory Hyperpigmentation: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2OTE5MS1vdmVydmlldw== processing (...) > Postinflammatory Hyperpigmentation Updated: May 04, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Postinflammatory Hyperpigmentation Overview Background Postinflammatory hyperpigmentation (PIH) is a frequently encountered problem and represents the sequelae of various cutaneous disorders as well as therapeutic interventions. [ ] This acquired excess of pigment can be attributed to various preceding disease processes that affect

2014 eMedicine.com

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