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Postherpetic Neuralgia

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2. Safety and effectiveness of the herpes zoster vaccine to prevent postherpetic neuralgia: 2014 update and consensus statement from the Canadian Pain Society

Safety and effectiveness of the herpes zoster vaccine to prevent postherpetic neuralgia: 2014 update and consensus statement from the Canadian Pain Society Safety and effectiveness of the herpes zoster vaccine to prevent postherpetic neuralgia: 2014 Update and consensus statement from the Canadian Pain Society Warning: The NCBI web site requires JavaScript to function. Search database Search term Search PMC4325890 Safety and effectiveness of the herpes zoster vaccine to prevent postherpetic (...) by the varicella zoster virus. The virus remains dormant in the dorsal root and the trigeminal ganglia until it is reactivated under certain conditions, causing herpes zoster (HZ, commonly known as shingles). Approximately 20% of Canadians are expected to develop HZ at some point in their lives. In Canada, 130,000 new cases of shingles are reported each year. Of these, about 17,000 will go on to develop postherpetic neuralgia (PHN). The estimated annual direct health care cost for HZ and PHN in Canada

2015 CPG Infobase

3. Efficacy of Pain Relief in Different Postherpetic Neuralgia Therapies: A Network Meta-Analysis

Efficacy of Pain Relief in Different Postherpetic Neuralgia Therapies: A Network Meta-Analysis Postherpetic neuralgia (PHN) is a nerve pain disease usually controlled by different therapies, i.e., topical therapies, antiepileptics, analgesics, antipsychotics, antidepressants, anti-dementia drugs, antivirals, amitriptyline, fluphenazine, and magnesium sulfate. It is believed that different therapies may lead to different levels of pain relief.We proposed this study to compare the efficacy of PHN (...) effects (gabapentin and carisbamate) with different mechanisms (opioids and ketamine) on reducing pain, and some agents were hard to find in literatures and were not involved in our study, which may influence our results.Analgesics were preferable to other treatments with respect to pain relief for PHN, while antivirals appeared to be less effective than other therapies.Postherpetic neuralgia, topical agents, antiepileptics, analgesics, antipsychotics, antidepressants.

2018 EvidenceUpdates

4. Antiviral treatment for preventing postherpetic neuralgia. (PubMed)

Antiviral treatment for preventing postherpetic neuralgia. Postherpetic neuralgia (PHN) is a painful and refractory complication of herpes zoster. Treatments are either partially or totally ineffective for many people with PHN. Antiviral agents, used at the time of the rash, have been proposed as an intervention to prevent the development of PHN. This is the first update since the first publication of the review in 2009.To assess the effectiveness of antiviral agents in preventing PHN.On 26 (...) ). In four of the trials (692 participants), there was some evidence for a reduction in the incidence of pain four weeks after the onset of rash. In the trial of famciclovir versus placebo, neither 500 mg nor 750 mg doses of famciclovir reduced the incidence of herpetic neuralgia significantly. The most commonly reported adverse events were nausea, vomiting, diarrhoea and headache for aciclovir, and headache and nausea for famciclovir. For neither treatment was the incidence of adverse events

2014 Cochrane

5. The Analgesic and Emotional Response to Intravenous Lidocaine Infusion in the Treatment of Postherpetic Neuralgia: A Randomized, Double-Blinded, Placebo-controlled Study

The Analgesic and Emotional Response to Intravenous Lidocaine Infusion in the Treatment of Postherpetic Neuralgia: A Randomized, Double-Blinded, Placebo-controlled Study This study evaluated the analgesic efficacy and emotional response to intravenous lidocaine infusion compared with placebo in patients with postherpetic neuralgia (PHN).In this randomized, double-blinded study, patients with PHN received 5 mg/kg intravenous lidocaine infusion or placebo. The primary outcome was pain measured

2018 EvidenceUpdates

6. Ultrasound-guided Pulsed Radiofrequency in the Management of Thoracic Postherpetic Neuralgia: A Randomized, Double-blinded, Controlled Trial

Ultrasound-guided Pulsed Radiofrequency in the Management of Thoracic Postherpetic Neuralgia: A Randomized, Double-blinded, Controlled Trial This study was designed to evaluate the efficacy and safety of ultrasound-guided pulsed radiofrequency (PRF) for the intercostal nerves (ICNs) in the management of thoracic postherpetic neuralgia.After 2 weeks of treatment by pregabalin 150 mg/12 hours, patients were randomly allocated into 2 groups. The PRF group, after ultrasound-guided localization (...) the study period except for the physical role which displayed nonsignificant improvement.Ultrasound-guided PRF for ICNs in combination with pharmacotherapy seems to be a safe and effective treatment modality for postherpetic neuralgia.

2018 EvidenceUpdates

7. Glucocorticoids combined with local anesthetics to prevent postherpetic neuralgia in patients with acute herpes zoster: a systematic review and meta-analysis

Glucocorticoids combined with local anesthetics to prevent postherpetic neuralgia in patients with acute herpes zoster: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

8. Premedication With Gabapentin Significantly Reduces the Risk of Postherpetic Neuralgia in Patients With Neuropathy. (PubMed)

Premedication With Gabapentin Significantly Reduces the Risk of Postherpetic Neuralgia in Patients With Neuropathy. Postherpetic neuralgia (PHN) is the most common complication of varicella zoster virus (VZV) reactivation and a cause of considerable physical and psychosocial morbidity. No known treatment effectively prevents the development of PHN in patients with VZV reactivation. In this study, our objective was to evaluate the efficacy of premedication with gabapentin for reducing the risk

2019 Mayo Clinic Proceedings

9. The Effect of Early Use of Supplemental Therapy on Preventing Postherpetic Neuralgia: A Systematic Review and Meta-analysis

The Effect of Early Use of Supplemental Therapy on Preventing Postherpetic Neuralgia: A Systematic Review and Meta-analysis Postherpetic neuralgia (PHN) is the most common and refractory complication of herpes zoster (HZ). Aggressive treatment of acute pain in HZ has the potential to prevent the development of PHN, but the preventive efficacy of supplemental therapy commonly used in clinical practice is controversial.Our aim is to examine the efficacy of supplemental therapy in preventing PHN.A (...) . The subgroup analysis shows that supplemental interventional procedures have a beneficial effect on preventing PHN, while supplemental systemic adjunct treatments do not. The early use of interventional procedures for acute pain may be a preferred choice for patients without contraindication, but evidence is moderate. More data from high-quality RCTs will be needed to confirm these results.Key words: Postherpetic neuralgia, systemic treatment, local anesthesia, analgesia, meta-analysis.

2017 EvidenceUpdates

10. Subcutaneous Injection of Triamcinolone and Lidocaine to Prevent Postherpetic Neuralgia

Subcutaneous Injection of Triamcinolone and Lidocaine to Prevent Postherpetic Neuralgia Herpes zoster (HZ) is associated with inflammation of the peripheral nerves, which is considered to be an important cause of postherpetic neuralgia (PHN). Interventions aimed at reducing this inflammation could prevent PHN. One option is the epidural administration of corticosteroid and local anesthetic. However, several authors have reported a risk of arachnoiditis with epidural corticosteroids (...) . No patient had major adverse events related to the subcutaneous injection.The main limitation of the study was the absence of a placebo subcutaneous injection in the standard group.Subcutaneous injection of triamcinolone and lidocaine in the acute phase of HZ can reduce ZAP more effectively than oral antivirals and analgesics alone, and may be a feasible method to prevent PHN.Subcutaneous injection, lidocaine, triamcinolone, postherpetic neuralgia, prevention.

2017 EvidenceUpdates

11. Sleep shortage is associated with postherpetic neuralgia development through hyperesthesia and acute pain intensity: a community-based prospective cohort study. (PubMed)

Sleep shortage is associated with postherpetic neuralgia development through hyperesthesia and acute pain intensity: a community-based prospective cohort study. There have been no community-based studies investigating the association between sleep duration and postherpetic neuralgia (PHN) development. The aim of the current study was to examine the association of sleep with herpes zoster (HZ) incidence and PHN.In total, 12,329 residents (ages 50 to 103 years) of Shozu County, Japan

2019 Pain Practice

12. Mirogabalin for the management of postherpetic neuralgia: a randomized, double-blind, placebo-controlled phase 3 study in Asian patients. (PubMed)

Mirogabalin for the management of postherpetic neuralgia: a randomized, double-blind, placebo-controlled phase 3 study in Asian patients. This study investigated the safety and efficacy of mirogabalin, a novel, potent, selective ligand of the α2δ subunit of voltage-dependent Ca channels, for the treatment of postherpetic neuralgia (PHN). In this multicenter, double-blind, placebo-controlled phase 3 study, Asian patients ≥20 years with PHN were randomized 2:1:1:1 to placebo or mirogabalin 15, 20

2019 Pain

13. Postherpetic Neuralgia and Trigeminal Neuralgia (PubMed)

Postherpetic Neuralgia and Trigeminal Neuralgia Postherpetic neuralgia (PHN) is an unpredictable complication of varicella zoster virus- (VZV-) induced herpes zoster (HZ) which often occurs in elderly and immunocompromised persons and which can induce psychosocial dysfunction and can negatively impact on quality of life. Preventive options for PHN include vaccination of high-risk persons against HZ, early use of antiviral agents, and robust management of pain during the early stage of acute (...) herpes zoster. If it does occur, PHN may persist for months or even years after resolution of the HZ mucocutaneous eruptions, and treatment is often only partially effective. Classical trigeminal neuralgia is a severe orofacial neuropathic pain condition characterized by unilateral, brief but recurrent, lancinating paroxysmal pain confined to the distribution of one or more of the branches of the trigeminal nerve. It may be idiopathic or causally associated with vascular compression of the trigeminal

Full Text available with Trip Pro

2017 Pain research and treatment

14. Do Corticosteroids Prevent Postherpetic Neuralgia?

Do Corticosteroids Prevent Postherpetic Neuralgia? Systematic Review Snapshot TAKE-HOME MESSAGE Although corticosteroids do not prevent postherpetic neuralgia, they may decrease the duration of acute zoster pain when given as a 3-week course. Do Corticosteroids Prevent Postherpetic Neuralgia? EBEM Commentators Jeremy Voros, MD Department of Emergency Medicine Denver Health Medical Center Denver, CO Alex Koyfman, MD Division of Emergency Medicine University of Illinois College of Medicine (...) at Peoria OSF Saint Francis Medical Center Peoria, IL Mark Foran, MD, MPH Department of Emergency Medicine New York University School of Medicine Bellevue Hospital Center New York, NY Results Estimates for potential bene?t and harm with corticosteroid therapy for shingles. Outcomes Estimated Risk in Control Estimated Risk With Corticosteroids (95% CI) Relative Risk (95% CI) No. of Studies (Participants) Quality of Evidence Presence of postherpetic neuralgia at 6 mo 193/1,000 183/1,000 (87–384) 0.95

2013 Annals of Emergency Medicine Systematic Review Snapshots

15. Effect of Repetitive Intracutaneous Injections with Local Anesthetics and Steroids for Acute Thoracic Herpes Zoster and Incidence of Postherpetic Neuralgia. (PubMed)

Effect of Repetitive Intracutaneous Injections with Local Anesthetics and Steroids for Acute Thoracic Herpes Zoster and Incidence of Postherpetic Neuralgia. Treatment of established postherpetic neuralgia (PHN) is difficult and often disappointing. In this study, we assessed the efficacy of repetitive intracutaneous injections with local anesthetics and steroids in acute thoracic herpes zoster (HZ) pain, herpetic eruption, and incidence of PHN.Ninety-three patients with acute thoracic HZ were

2018 Pain medicine (Malden, Mass.)

16. Effect of Single Intra-cutaneous Injection for Acute Thoracic Herpes Zoster and Incidence of Postherpetic Neuralgia. (PubMed)

Effect of Single Intra-cutaneous Injection for Acute Thoracic Herpes Zoster and Incidence of Postherpetic Neuralgia. The therapeutic effect of postherpetic neuralgia (PHN) is often disappointing and challenging. The role of intra-cutaneous injection of local anesthetic and steroids in preventing PHN remains unknown. The purpose of this study was to investigate the effect of a single intra-cutaneous injection of ropivacaine plus methylprednisolone on acute thoracic herpes zoster (HZ) pain

2018 Pain management nursing : official journal of the American Society of Pain Management Nurses

17. Subcutaneous Injection of Triamcinolone and Lidocaine to Prevent Postherpetic Neuralgia. (PubMed)

Subcutaneous Injection of Triamcinolone and Lidocaine to Prevent Postherpetic Neuralgia. Herpes zoster (HZ) is associated with inflammation of the peripheral nerves, which is considered to be an important cause of postherpetic neuralgia (PHN). Interventions aimed at reducing this inflammation could prevent PHN. One option is the epidural administration of corticosteroid and local anesthetic. However, several authors have reported a risk of arachnoiditis with epidural corticosteroids (...) . No patient had major adverse events related to the subcutaneous injection.The main limitation of the study was the absence of a placebo subcutaneous injection in the standard group.Subcutaneous injection of triamcinolone and lidocaine in the acute phase of HZ can reduce ZAP more effectively than oral antivirals and analgesics alone, and may be a feasible method to prevent PHN.Subcutaneous injection, lidocaine, triamcinolone, postherpetic neuralgia, prevention.

2018 Pain physician

18. Transdermal oxycodone patch for the treatment of postherpetic neuralgia: a randomized, double-blind, controlled trial. (PubMed)

Transdermal oxycodone patch for the treatment of postherpetic neuralgia: a randomized, double-blind, controlled trial. To evaluate the efficacy, systemic exposure, safety and tolerability of a transdermal oxycodone patch containing tocopheryl phosphate mixture (TPM) in patients with postherpetic neuralgia (PHN).The study was a Phase IIa, multicenter, randomized, double-blind, vehicle-controlled crossover study.While the TPM/oxycodone patch did not significantly improve 'average' Numeric Pain

2018 Pain management

19. Single Nucleotide Polymorphisms (SNPs) Associated With Postherpetic Neuralgia

Single Nucleotide Polymorphisms (SNPs) Associated With Postherpetic Neuralgia Single Nucleotide Polymorphisms (SNPs) Associated With Postherpetic Neuralgia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Single Nucleotide Polymorphisms (SNPs) Associated With Postherpetic Neuralgia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03708653 Recruitment Status : Recruiting First Posted : October 17, 2018 Last Update Posted

2018 Clinical Trials

20. Effectiveness of continuous epidural analgesia on acute herpes zoster and postherpetic neuralgia: A retrospective study. (PubMed)

Effectiveness of continuous epidural analgesia on acute herpes zoster and postherpetic neuralgia: A retrospective study. Despite early treatment of herpes zoster (HZ), postherpetic neuralgia (PHN) can persist. This study was designed to compare the therapeutic and pain relief effects of continuous epidural analgesia (CEA) on the chronic phase as well as the acute phase of HZ with standard medical treatment.Medical records of 227 patients with moderate to severe zoster-associated pain that had

Full Text available with Trip Pro

2018 Medicine

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