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1. PON-P and PON-P2 predictor performance in CAGI challenges: Lessons learned (PubMed)

PON-P and PON-P2 predictor performance in CAGI challenges: Lessons learned Computational tools are widely used for ranking and prioritizing variants for characterizing their disease relevance. Since numerous tools have been developed, they have to be properly assessed before being applied. Critical Assessment of Genome Interpretation (CAGI) experiments have significantly contributed toward the assessment of prediction methods for various tasks. Within and outside the CAGI, we have addressed

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2017 Human mutation

2. Cytomegalovirus Infection in One Fetus with Hypoplasia of the Pons in a Diamniotic-Dichorionic Twin Pregnancy (PubMed)

Cytomegalovirus Infection in One Fetus with Hypoplasia of the Pons in a Diamniotic-Dichorionic Twin Pregnancy 29984350 2019 02 26 2509-596X 4 2 2018 Apr Ultrasound international open Ultrasound Int Open Cytomegalovirus Infection in One Fetus with Hypoplasia of the Pons in a Diamniotic-Dichorionic Twin Pregnancy. E52-E53 10.1055/a-0591-5981 Altmann Reinhard R Department of Gynecology, Obstetrics and Gynecological Endocrinology, Kepler University Hospital, Johannes Kepler University Linz, Linz

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2018 Ultrasound international open

3. Increased PON lactonase activity in morbidly obese patients is associated with impaired lipid profile. (PubMed)

Increased PON lactonase activity in morbidly obese patients is associated with impaired lipid profile. The paraoxonase-1 (PON1) enzyme could play an important role in the anti-oxidant capacity of high-density lipoprotein. However, there are no studies which analyse the evolution of the three activities of PON1 (PON arylesterase, PON paraoxonase and PON lactonase) after Roux-en-Y Gastric Bypass (RYGB) in morbidly obese subjects. We analysed the association of PON concentration and activities (...) with the evolution of morbidly obese subjects who underwent RYGB, and its relationship with biochemical variables and different atherogenic indices.Twenty-seven non-obese and 82 morbidly obese subjects were studied before and 6 months after RYGB.Before RYGB, morbidly obese subjects had a lower PON1 concentration (P < 0.05) and higher PON lactonase activity (P < 0.001) than non-obese subjects, with no differences in PON arylesterase and PON paraoxonase activities. After RYGB, PON1 concentration (P < 0.05) and PON

2019 International journal of clinical practice

4. Lower Urinary Tract Dysfunction and Associated Pons Volume in Wolfram Syndrome. (PubMed)

Lower Urinary Tract Dysfunction and Associated Pons Volume in Wolfram Syndrome. Wolfram syndrome is a neurodegenerative disorder characterized by childhood onset diabetes mellitus, optic nerve atrophy, diabetes insipidus, hearing impairment, and commonly bladder and bowel dysfunction. We hypothesized that there is an association between a smaller pons, which contains the pontine micturition center, and abnormal lower urinary tract function.Patients with genetically confirmed Wolfram syndrome (...) attended an annual multidisciplinary research clinic. Subjects underwent noninvasive urodynamic testing and brain magnetic resonance imaging, and completed validated patient reported outcome measures. Bowel and bladder diaries were completed before visits. Age and gender corrected linear and logistic mixed effects models were used to correlate pons volume, corrected for whole brain size, to urodynamic and patient reported outcomes.A total of 36 patients attended 142 visits between 2010 and 2016. Mean

2018 Journal of Urology

5. Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance (PubMed)

Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance Paraoxonase-1 (PON1) is a high-density lipoprotein-associated esterase and is speculated to play a role in several human diseases including diabetes mellitus and atherosclerosis. Low PON1 activity has been associated with increased risk of major cardiovascular events, therefore a variety of studies have been conducted to establish the cardioprotective properties and clinical relevance of PON1

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2018 Vascular health and risk management

6. PON-tstab: Protein Variant Stability Predictor. Importance of Training Data Quality (PubMed)

PON-tstab: Protein Variant Stability Predictor. Importance of Training Data Quality Several methods have been developed to predict effects of amino acid substitutions on protein stability. Benchmark datasets are essential for method training and testing and have numerous requirements including that the data is representative for the investigated phenomenon. Available machine learning algorithms for variant stability have all been trained with ProTherm data. We noticed a number of issues (...) with the contents, quality and relevance of the database. There were errors, but also features that had not been clearly communicated. Consequently, all machine learning variant stability predictors have been trained on biased and incorrect data. We obtained a corrected dataset and trained a random forests-based tool, PON-tstab, applicable to variants in any organism. Our results highlight the importance of the benchmark quality, suitability and appropriateness. Predictions are provided for three categories

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2018 International journal of molecular sciences

7. Correction to: A suggestion to introduce the diagnosis of "diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)". (PubMed)

Correction to: A suggestion to introduce the diagnosis of "diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)". The citation of the original publication in PubMed contains an error. The seventh author name is wrongly cited.

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2018 Acta neuropathologica

8. Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division (PubMed)

Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division Uneven distribution and local concentration of protein complexes on distinct membrane cortices is a fundamental property in numerous biological processes, including Drosophila neuroblast (NB) asymmetric cell divisions and cell polarity in general. In NBs, the cell fate determinant Numb forms a basal crescent together with Pon and is segregated into the basal daughter cell to initiate (...) its differentiation. Here we discover that Numb PTB domain, using two distinct binding surfaces, recognizes repeating motifs within Pon in a previously unrecognized mode. The multivalent Numb-Pon interaction leads to high binding specificity and liquid-liquid phase separation of the complex. Perturbations of the Numb/Pon complex phase transition impair the basal localization of Numb and its subsequent suppression of Notch signaling during NB asymmetric divisions. Such phase-transition-mediated

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2018 Nature communications

9. Optical pulse width modulation based TDM-PON monitoring with asymmetric loop in ONUs (PubMed)

Optical pulse width modulation based TDM-PON monitoring with asymmetric loop in ONUs We propose a time division multiplexing passive optical network (TDM-PON) monitoring scheme based on the optical pulse width modulation (OPWM) by using a simple asymmetric loop (AL) located near the optical network unit (ONU). Various pulse widths can be easily obtained by configuring the appropriate length of the patchcord used to generate the path difference between two branches of a 1 × 2 splitter. Different (...) wavelengths can be assigned to the same pulse width, which can further increase the network size. The optimized parameters of the AL are investigated and analysis models are established. The calculation results show that the proposed scheme has smaller correlation distance (CD) and lower multiple-customers interference probability (MCIP) than the periodic coding (PC) scheme. A simplified PON system with 8 ONUs is set up to experimentally demonstrate the feasibility of the proposed scheme. The network

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2018 Scientific reports

10. PoNS Clinical Experience Program (TBI)

PoNS Clinical Experience Program (TBI) PoNS Clinical Experience Program (TBI) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. PoNS Clinical Experience Program (TBI) The safety and scientific validity (...) Information provided by (Responsible Party): Neurohabilitation Corporation Study Details Study Description Go to Brief Summary: - Brief Summary: Prospective, cohort, open-label study. The cohort consists of people who have a chronic balance dysfunction due to a mild to moderate traumatic brain injury (TBI). All participants will participate in a 14-week PoNS Treatment protocol - a combination of symptom specific physical exercises and repeated use of the PoNS device. Subjects who meet the initial

2018 Clinical Trials

11. A Meta-Analysis on the Relationship of the PON Genes and Alzheimer Disease. (PubMed)

A Meta-Analysis on the Relationship of the PON Genes and Alzheimer Disease. This study aimed to evaluate the association of the paraoxonase (PON) gene variants and Alzheimer disease (AD) using meta-analysis.Relevant studies were identified by searching English and Chinese databases extensively. Allele and genotype frequencies for each included study were extracted. Newcastle-Ottawa Scale (NOS) was employed to assess the quality of included studies. The odds ratio (OR) with 95% confidence (...) (OR = 0.82, 95% CI: 0.68-0.99, P = .04), and the A allele of PON1 rs705379 polymorphism was positively related to AD in Caucasian population (OR = 1.21, 95% CI: 1.05-1.39, P = .009) as well as the GG genotype decreased AD risk significantly in Caucasians (OR = 0.7, 95% CI: 0.56-0.88, P = .002). However, there was no significant relationship between other 3 genetic variants of PON genes (L55 M, Q192 R, and -161C/T of PON1 gene) and AD.Existing evidence indicates that the S311C polymorphism (SS genotype

2017 Journal of Geriatric Psychiatry and Neurology

12. Microsurgical anatomy and approaches around the lateral recess with special reference to entry into the pons. (PubMed)

Microsurgical anatomy and approaches around the lateral recess with special reference to entry into the pons. OBJECTIVE The lateral recess is a unique structure communicating between the ventricle and cistern, which is exposed when treating lesions involving the fourth ventricle and the brainstem with surgical approaches such as the transcerebellomedullary fissure approach. In this study, the authors examined the microsurgical anatomy around the lateral recess, including the fiber tracts (...) , and analyzed their findings with respect to surgical exposure of the lateral recess and entry into the lower pons. METHODS Ten cadaveric heads were examined with microsurgical techniques, and 2 heads were examined with fiber dissection to clarify the anatomy between the lateral recess and adjacent structures. The lateral and medial routes directed to the lateral recess in the transcerebellomedullary fissure approach were demonstrated. A morphometric study was conducted in the 10 cadaveric heads (20 sides

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2017 Journal of Neurosurgery

13. The cholesterol-lowering effect of statins is potentiated by whole grains intake. The Polish Norwegian Study (PONS). (PubMed)

The cholesterol-lowering effect of statins is potentiated by whole grains intake. The Polish Norwegian Study (PONS). Hypercholesterolemia treatment guidelines emphasize an adequate whole grains (WG) intake, alone or complementary to pharmacological treatment. We conducted this study to compare the prevalence of adequate WG intake and levels of blood lipids according to the statin/WG intake status.This cross-sectional analysis of a community-based study included 12,754 men and women, age 45-64

2017 European journal of internal medicine

14. TREATMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION PATIENTS WITH VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITORS IN EVERYDAY PRACTICE: Identification of Health Care Constraints in Germany-The PONS Study. (PubMed)

TREATMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION PATIENTS WITH VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITORS IN EVERYDAY PRACTICE: Identification of Health Care Constraints in Germany-The PONS Study. The PONS study was conceived to analyze the extent of nonpersistence (NP) and nonadherence (NA) in the treatment of patients with neovascular age-related macular degeneration in everyday clinical practice in Germany. Further objectives were to identify factors that can affect NP and NA

2017 Retina

15. Optimal Cut-Off Value for Locus Coeruleus-to-Pons Intensity Ratio as Clinical Biomarker for Alzheimer’s Disease: A Pilot Study (PubMed)

Optimal Cut-Off Value for Locus Coeruleus-to-Pons Intensity Ratio as Clinical Biomarker for Alzheimer’s Disease: A Pilot Study Studies using neuromelanin-sensitive-MRI have established the locus coeruleus (LC)-to-pons intensity ratio as a biomarker for diagnosis of Parkinson's and Alzheimer's diseases. More detailed analysis is needed for exploiting the highest clinical potential of this technique.The aim is to determine the location of the highest LC-to-pons ratio within the LC and develop

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2017 Journal of Alzheimer's Disease Reports

16. PON-SC – program for identifying steric clashes caused by amino acid substitutions (PubMed)

PON-SC – program for identifying steric clashes caused by amino acid substitutions Amino acid substitutions due to DNA nucleotide replacements are frequently disease-causing because of affecting functionally important sites. If the substituting amino acid does not fit into the protein, it causes structural alterations that are often harmful. Clashes of amino acids cause local or global structural changes. Testing structural compatibility of variations has been difficult due to the lack (...) of a dedicated method that could handle vast amounts of variation data produced by next generation sequencing technologies.We developed a method, PON-SC, for detecting protein structural clashes due to amino acid substitutions. The method utilizes side chain rotamer library and tests whether any of the common rotamers can be fitted into the protein structure. The tool was tested both with variants that cause and do not cause clashes and found to have accuracy of 0.71 over five test datasets.We developed

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2017 BMC bioinformatics

17. Television viewing time among statin users and non-users. The Polish Norwegian Study (PONS) (PubMed)

Television viewing time among statin users and non-users. The Polish Norwegian Study (PONS) Sedentary behavior has emerged as an independent cardiovascular disease risk factor. Uncertainty exists about the behaviors of statin users, who may exhibit either a healthy adherer or a false reassurance effect. We conducted this study in order to assess and compare TV viewing among statin users and nonusers. We used data from a cross-sectional study of 12,754 participants, from south-east Poland, age

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2017 Preventive medicine reports

18. Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat (PubMed)

Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat Several studies have shown that taste-responsive cells in the brainstem taste nuclei of rodents respond to sensory qualities other than gustation. Such data suggest that cells in the classical gustatory brainstem may be better tuned to respond to stimuli that engage multiple sensory modalities than to stimuli that are purely gustatory. Here, we test (...) this idea by recording the electrophysiological responses to complex, naturalistic stimuli in single neurons in the parabrachial pons (PbN, the second neural relay in the central gustatory pathway) in awake, freely licking rats. Following electrode implantation and recovery, we presented both prototypical and naturalistic taste stimuli and recorded the responses in the PbN. Prototypical taste stimuli (NaCl, sucrose, citric acid, and caffeine) and naturalistic stimuli (clam juice, grape juice, lemon

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2016 Journal of neurophysiology

19. Identification of proliferative progenitors associated with prominent postnatal growth of the pons (PubMed)

Identification of proliferative progenitors associated with prominent postnatal growth of the pons The pons controls crucial sensorimotor and autonomic functions. In humans, it grows sixfold postnatally and is a site of paediatric gliomas; however, the mechanisms of pontine growth remain poorly understood. We show that the murine pons quadruples in volume postnatally; growth is fastest during postnatal days 0-4 (P0-P4), preceding most myelination. We identify three postnatal proliferative (...) compartments: ventricular, midline and parenchymal. We find no evidence of postnatal neurogenesis in the pons, but each progenitor compartment produces new astroglia and oligodendroglia; the latter expand 10- to 18-fold postnatally, and are derived mostly from the parenchyma. Nearly all parenchymal progenitors at P4 are Sox2(+)Olig2(+), but by P8 a Sox2(-) subpopulation emerges, suggesting a lineage progression from Sox2(+) 'early' to Sox2(-) 'late' oligodendrocyte progenitor. Fate mapping reveals that >90

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2016 Nature communications

20. Ideal cardiovascular health is associated with self-rated health status. The Polish Norwegian Study (PONS). (PubMed)

Ideal cardiovascular health is associated with self-rated health status. The Polish Norwegian Study (PONS). The concept of ideal cardiovascular health emphasizes a more integrative definition of health to include protective biological factors and behaviors but it has not been investigated in relation to individuals' perspectives on their own health.We used cross-sectional data of 10,687 participants, age 45-64years, free of cardiovascular diseases. Ideal cardiovascular health was defined

2016 International journal of cardiology

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