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Polypharmacy

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2601. Physician agreement with pharmacist-suggested drug therapy changes for elderly outpatients. (PubMed)

Relations Logistic Models Pharmacists Physicians Polypharmacy Referral and Consultation United States 1996 11 15 1996 11 15 0 1 1996 11 15 0 0 ppublish 8931817 10.1093/ajhp/53.22.2735

1997 American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists Controlled trial quality: uncertain

2602. Concurrent use of oral contraceptives with antidepressants for premenstrual syndromes. (PubMed)

Contraceptives, Oral QUC7NX6WMB Sertraline TG537D343B Desipramine IM Adolescent Adult Antidepressive Agents adverse effects therapeutic use Contraceptives, Oral adverse effects Desipramine adverse effects therapeutic use Double-Blind Method Drug Interactions Female Humans Middle Aged Polypharmacy Premenstrual Syndrome chemically induced drug therapy Sertraline adverse effects therapeutic use Severity of Illness Index 2001 10 11 10 0 2002 1 25 10 1 2001 10 11 10 0 ppublish 11593086

2002 Journal of Clinical Psychopharmacology Controlled trial quality: uncertain

2603. Gym and tonic: a profile of 100 male steroid users. (Full text)

steroids for various reasons, including additional anabolic effects, the minimisation of steroid related side effects, and withdrawal symptoms. Acne, striae, and gynaecomastia were the most commonly reported subjective side effects.Multiple steroids are combined in megadoses and self administered in a cyclical fashion. Polypharmacy is practised by over 80% of steroid users. Skeletal muscle hypertrophy along with acne, striae, and gynaecomastia are frequent physical signs associated with steroid use.

1997 British Journal of Sports Medicine

2604. Reduction of polypharmacy in the elderly: a systematic review of the role of the pharmacist

Reduction of polypharmacy in the elderly: a systematic review of the role of the pharmacist Reduction of polypharmacy in the elderly: a systematic review of the role of the pharmacist Reduction of polypharmacy in the elderly: a systematic review of the role of the pharmacist Rollason V, Vogt N CRD summary This review assessed the impact of pharmacists on the reduction of polypharmacy in the elderly. The authors concluded that intervention by a pharmacist can reduce the number of drugs (...) prescribed to elderly patients. Given the lack of methodological details, and that the evidence from non-randomised trials was not supported by the randomised controlled trials, the results should be treated with caution. Authors' objectives To determine the impact of pharmacists on the reduction of polypharmacy in the elderly. Searching MEDLINE (1996 to February 2003), EMBASE: Geriatrics and Gerontology (2002 edition; 1991 to December 2002), the Cochrane Library (up to February 2003) and International

2003 DARE.

2605. Polypharmacy in elderly patients

Polypharmacy in elderly patients Polypharmacy in elderly patients Polypharmacy in elderly patients Hajjar ER, Cafiero AC, Hanlon JT CRD summary This review concluded that various numbers of medications were associated with negative health outcomes, but more research was required to determine the consequences associated with unnecessary drug use. The conclusions did not address the apparent efficacy of interventions to reduce polypharmacy. Due to limitations in the methodology and reporting (...) of the review, the reliability of these results is unclear. Authors' objectives To review attempts to reduce polypharmacy in older adults and to assess adverse events associated with polypharmacy. The review also examined the epidemiology of polypharmacy (outside the scope of this abstract). Searching MEDLINE and International Pharmaceutical Abstracts were searched from 1986 to June 2007. Search terms were reported. References of identified studies and authors' files, book chapters and recent reviews were

2007 DARE.

2606. Long term antipsychotic polypharmacy is common among Medicaid recipients with schizophrenia

Long term antipsychotic polypharmacy is common among Medicaid recipients with schizophrenia Long term antipsychotic polypharmacy is common among Medicaid recipients with schizophrenia | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers (...) of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Long term antipsychotic polypharmacy is common among Medicaid recipients with schizophrenia Article Text Prevalence Long term antipsychotic polypharmacy is common among Medicaid recipients with schizophrenia Free

2006 Evidence-Based Mental Health

2607. Effectiveness of telephone counselling by a pharmacist in reducing mortality in patients receiving polypharmacy: randomised controlled trial. (Full text)

Effectiveness of telephone counselling by a pharmacist in reducing mortality in patients receiving polypharmacy: randomised controlled trial. To investigate the effects of compliance and periodic telephone counselling by a pharmacist on mortality in patients receiving polypharmacy.Two year randomised controlled trial.Hospital medical clinic.502 of 1011 patients receiving five or more drugs for chronic disease found to be non-compliant at the screening visit were invited for randomisation (...) with compliance scores of 34-66% and 0-33%, respectively, compared with those who had a compliance score of 67% or more.In patients receiving polypharmacy, poor compliance was associated with increased mortality. Periodic telephone counselling by a pharmacist improved compliance and reduced mortality.International Standard Randomised Controlled Trial Number Register: SRCTN48076318.

2006 BMJ Controlled trial quality: predicted high

2608. Prevalence and predictors of polypharmacy among older primary care patients in Germany. (Full text)

Prevalence and predictors of polypharmacy among older primary care patients in Germany. Older people consume an increasing amount of medication. Polypharmacy is associated with an elevated risk of adverse health outcomes resulting in hospitalizations and sometimes death.To describe the prevalence of prescribed and over-the-counter (OTC) medications among older general practice patients living in the community. To determine predictors of polypharmacy (five or more prescribed drugs) from (...) assessment of patients' health and well-being enabled us to explore a variety of predictors of polypharmacy using logistic regression analysis with forward selection.Study participants consumed an average of 3.7 prescribed medicines and an additional 1.4 OTC drugs. In all, 26.7% of patients used five and more chronically prescribed drugs. A set of five determinants predicted polypharmacy best: breathlessness, hypertension, dependency on instrumental activities of daily living, low subjective health

2007 Family Practice Controlled trial quality: uncertain

2609. Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. (PubMed)

Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. Polypharmacy is a common cause of salivary hypofunction, producing symptoms of dry mouth or xerostomia, especially among older populations. As the number of older people continues to increase, polypharmacy-induced salivary hypofunction is becoming an increasing problem. Many over-the-counter products are available for relieving symptoms (...) , betaine and xylitol is safe and effective in relieving symptoms of dry mouth in a population with polypharmacy-induced xerostomia.

2007 Journal of oral rehabilitation Controlled trial quality: uncertain

2610. Incidence and costs of polypharmacy: data from a randomized, double-blind, placebo-controlled study of risperidone and quetiapine in patients with schizophrenia or schizoaffective disorder. (PubMed)

Incidence and costs of polypharmacy: data from a randomized, double-blind, placebo-controlled study of risperidone and quetiapine in patients with schizophrenia or schizoaffective disorder. The use of adjunctive psychotropics and the costs of polypharmacy in patients randomized to receive risperidone or quetiapine were compared in a placebo-controlled double-blind study conducted in India, Romania, and the United States.The efficacy and safety of risperidone, quetiapine, and placebo were (...) compared in a 14-day monotherapy phase in patients experiencing an acute exacerbation of symptoms of schizophrenia or schizoaffective disorder. This was followed by a 28-day, additive-therapy phase during which addition of antipsychotics or other psychotropic medications was permitted. Risperidone was received by 153 patients in the monotherapy phase and 133 in the additive therapy phase, quetiapine by 156 and 122, respectively, and placebo by 73 and 53. Rates of polypharmacy were examined using

2007 Current medical research and opinion Controlled trial quality: predicted high

2611. Treatment reviews of older people on polypharmacy in primary care: cluster controlled trial comparing two approaches. (Full text)

Treatment reviews of older people on polypharmacy in primary care: cluster controlled trial comparing two approaches. Older people are prone to problems related to use of medicines. As they tend to use many different medicines, monitoring pharmacotherapy for older people in primary care is important.To determine which procedure for treatment reviews (case conferences versus written feedback) results in more medication changes, measured at different moments in time. To determine the costs (...) and savings related to such an intervention.Randomised, controlled trial, randomisation at the level of the community pharmacy.Primary care; treatment reviews were performed by 28 pharmacists and 77 GPs concerning 738 older people (> or =75 years) on polypharmacy (>five medicines).In one group, pharmacists and GPs performed case conferences on prescription-related problems; in the other group, pharmacists provided results of a treatment review to GPs as written feedback. Number of medication changes

2007 British Journal of General Practice Controlled trial quality: uncertain

2612. Antipsychotic Polypharmacy: Prevalence, Background and Consequences

Antipsychotic Polypharmacy: Prevalence, Background and Consequences Antipsychotic Polypharmacy: Prevalence, Background and Consequences - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Antipsychotic (...) Polypharmacy: Prevalence, Background and Consequences The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00541398 Recruitment Status : Completed First Posted : October 10, 2007 Last Update Posted : November 2, 2009 Sponsor: Glostrup University Hospital, Copenhagen Collaborator: National Board of Health

2007 Clinical Trials

2613. Antipsychotic Polypharmacy in Schizophrenia

Antipsychotic Polypharmacy in Schizophrenia Antipsychotic Polypharmacy in Schizophrenia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Antipsychotic Polypharmacy in Schizophrenia The safety and scientific (...) of this study will subsequently serve to guide physicians in making appropriately informed decisions regarding the continuation of multiple antipsychotic drugs. Our primary hypothesis is that we expect to find no difference in the primary variable of interest (BPRS) following reduction to antipsychotic monotherapy (placebo group) versus continuing antipsychotic polypharmacy. This proposed study is the first study to systematically address the reduction of antipsychotic polypharmacy to monotherapy

2007 Clinical Trials

2614. Antipsychotic polypharmacy: is there evidence for its use? (PubMed)

Antipsychotic polypharmacy: is there evidence for its use? Antipsychotic polypharmacy occurs frequently in clinical practice; however, there is a lack of controlled clinical studies testing the efficacy of the combinations used. The purpose of this literature review was to examine studies and other reports that have assessed the incremental benefits and deficits of combination antipsychotic therapy versus monotherapy. A PUBMED search covering a 26-year period from 1976 to 2002 was conducted (...) combination was clozapine-risperidone. Of the clinical trials, 75% (3/4) of the double-blind studies and 69% (9/13) of the open-label trials found that combination therapy was effective in reducing symptoms, while 37% (13/35) of case reports documented an overall positive outcome. Currently, the clinical practice of antipsychotic polypharmacy is not evidence-based; however, there is also no evidence against its use. Expanded systematic research to assess this clinical practice is needed.

2005 Journal of psychiatric practice

2615. Reduction of polypharmacy in the elderly: a systematic review of the role of the pharmacist. (PubMed)

Reduction of polypharmacy in the elderly: a systematic review of the role of the pharmacist. Polypharmacy in the elderly complicates therapy, increases cost, and is a challenge for healthcare agencies. In the context of the evolving role of the pharmacist, this systematic review examines the effectiveness of interventions led by pharmacists in reducing polypharmacy. A computerised search was conducted using Medline, Embase geriatrics and gerontology (2001 edition), the Cochrane Library (...) and International Pharmaceutical Abstracts (IPA) databases. A manual search of articles on polypharmacy and the role of pharmacists in the therapy of the elderly and of the reference sections of all retrieved articles was also carried out. Search terms used were 'polypharmacy', 'elderly', 'aged', 'intervention' and 'pharmacist(s)'. Articles that fulfilled the following criteria were included: only elderly people were included in the study, or all ages were included but the study gave separate results

2003 Drugs & Aging

2616. Polypharmacy in patients with schizophrenia. (PubMed)

Polypharmacy in patients with schizophrenia. Polypharmacy in patients with schizophrenia is a common practice with little basis in well-controlled studies. The objective of this report is to describe the changes in prescription practices with psychotropic medications for patients diagnosed with schizophrenia in 1995 and 2000.The medical records of patients who were discharged from our facility in 1995 and 2000 with the diagnosis of schizophrenia (DSM-IV criteria) were reviewed. The psychotropic (...) in the use of divalproex. No patients were discharged on treatment with more than 1 antipsychotic in 1995, whereas in 2000, 15.9% of patients were. The most common antipsychotic combination was haloperidol and olanzapine. Paralleling the increased use of polypharmacy, there were significantly fewer adverse drug reactions in 2000 than in 1995 (p = .002). In addition, patients with schizophrenia who were discharged in 2000 had significantly shorter lengths of stay (p < .0001) and were significantly more

2003 Journal of Clinical Psychiatry

2617. Does antipsychotic polypharmacy increase the risk for metabolic syndrome? (Full text)

Does antipsychotic polypharmacy increase the risk for metabolic syndrome? To determine whether the coprescribing of two or more antipsychotics, a relatively frequent practice with little data to support its safety and efficacy, is associated with an increased prevalence of metabolic syndrome.364 newly admitted adults treated with second-generation antipsychotics underwent assessments evaluating antipsychotic polytherapy, and of the presence of metabolic syndrome and triglycerides/high-density (...) of aripiprazole treatment (r(2): 0.14, p<0.0001). Antipsychotic polypharmacy dropped out of both multivariate models.Compared with patients receiving antipsychotic monotherapy, patients on antipsychotic polytherapy have higher rates of metabolic syndrome and lipid markers of insulin resistance. However, antipsychotic polytherapy is not independently associated with the prevalence of these abnormalities, which are related to known demographic, clinical and anthropometric risk factors.

2007 Schizophrenia Research

2618. Prevalence, trends, and factors associated with antipsychotic polypharmacy among Medicaid-eligible schizophrenia patients, 1998-2000. (PubMed)

Prevalence, trends, and factors associated with antipsychotic polypharmacy among Medicaid-eligible schizophrenia patients, 1998-2000. To determine the prevalence, trends, and factors associated with antipsychotic polypharmacy categorized according to type of antipsychotic and duration of use and to contrast usage patterns with published treatment guidelines.A retrospective cohort study was designed, and Medicaid recipients > or = 16 years of age with a schizophrenia diagnosis (ICD-9-CM = 295.xx (...) ) between 1998 and 2000 were identified from the California (20% random sample) and Georgia Medicaid claims databases. Use of anti-psychotic polypharmacy was categorized based on duration (long-term polypharmacy was defined as lasting > 2 months), and long-term use was further categorized based on type of antipsychotic combinations (clozapine, conventional, and atypical). The prevalence, mean duration, and frequency of and yearwise trends in antipsychotic polypharmacy were estimated. A stepwise logistic

2004 Journal of Clinical Psychiatry

2619. Polypharmacy and prescribing quality in older people. (PubMed)

Polypharmacy and prescribing quality in older people. To evaluate the relationship between inappropriate prescribing, medication underuse, and the total number of medications used by patients.Cross-sectional study.Veterans Affairs Medical Center.One hundred ninety-six outpatients aged 65 and older who were taking five or more medications.Inappropriate prescribing was assessed using a combination of the Beers drugs-to-avoid criteria (2003 update) and subscales of the Medication Appropriateness

2006 Journal of the American Geriatrics Society

2620. Polypharmacy and excessive dosing: psychiatrists' perceptions of antipsychotic drug prescription. (Full text)

Polypharmacy and excessive dosing: psychiatrists' perceptions of antipsychotic drug prescription. Despite extensive research and recommendations regarding the optimal prescription of antipsychotic drugs, polypharmacy and excessive dosing still prevail.To identify the factors associated with the polypharmacy and excessive dosing phenomena.We studied 139 patients with schizophrenia, in 19 acute psychiatric units in Japanese hospitals, who were due to be discharged between October and December

2005 British Journal of Psychiatry

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