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Polyarteritis Nodosa

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2. Polyarteritis nodosa

Polyarteritis nodosa Polyarteritis nodosa - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Polyarteritis nodosa Last reviewed: February 2019 Last updated: January 2018 Summary Rare form of systemic vasculitis that affects only medium-sized vessels (i.e., small and medium-sized arteries). Hepatitis B virus (HBV)-related PAN has become very rare since the introduction of effective immunisation programmes against (...) clearly, be sincere, act calmly: Adolf Kussmaul (February 22, 1822-May 28, 1902) and his relevance to medicine in the 21st century. Curr Opin Rheumatol. 2003;15:29-34. http://www.ncbi.nlm.nih.gov/pubmed/12496507?tool=bestpractice.com Since then, the name has changed to polyarteritis nodosa (PAN) and the definition has been refined to: "Necrotising inflammation of medium-sized or small arteries without glomerulonephritis or vasculitis in arterioles, capillaries, or venules." This definition

2018 BMJ Best Practice

3. Hybrid Surgery to Treat Multiple Visceral Aneurysms Secondary to Polyarteritis Nodosa (PubMed)

Hybrid Surgery to Treat Multiple Visceral Aneurysms Secondary to Polyarteritis Nodosa A 57-year-old woman presented to vascular surgery clinic with visceral artery aneurysms that were incidentally detected during regular check-up. Imaging studies revealed occlusion of the celiac axis and severe stenosis of the superior mesenteric artery and 3 aneurysms along the posterior and inferior pancreaticoduodenal arteries, as well as the right gastroepiploic artery. Endovascular embolization of all (...) aneurysms was rejected because of the risk of hepatic ischemia. These complicated lesion caused by polyarteritis nodosa were successfully treated using a hybrid operation with coil embolization, aneurysm resection, and antegrade aorto-celiac-superior mesentery artery bypass.

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2018 Vascular specialist international

4. Thirty Years of Followup in 3 Patients with Familial Polyarteritis Nodosa due to Adenosine Deaminase 2 Deficiency. (PubMed)

Thirty Years of Followup in 3 Patients with Familial Polyarteritis Nodosa due to Adenosine Deaminase 2 Deficiency. Three sisters of Northern European descent provided an opportunity to examine the longterm course and possible familial aspects of a rare disease, polyarteritis nodosa (PAN). Approval and consent was obtained from each patient.

2019 Journal of Rheumatology

5. Inpatient burden and association with comorbidities of polyarteritis nodosa: National Inpatient Sample 2014. (PubMed)

Inpatient burden and association with comorbidities of polyarteritis nodosa: National Inpatient Sample 2014. To characterize inpatient burden, expenditures and association with comorbidities of polyarteritis nodosa (PAN).Patients with PAN were identified from the Nationwide Inpatient Sample (NIS) database for the year 2014 using ICD-9 diagnostic codes. The primary outcome was determining the inpatient prevalence of PAN in hospitalized patients in the US. Secondary outcomes included determining

2019 Seminars in arthritis and rheumatism

6. Adding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors: A Randomized, Controlled Trial

Adding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors: A Randomized, Controlled Trial In most patients with nonsevere systemic necrotizing vasculitides (SNVs), remission is achieved with glucocorticoids alone, but one-third experience a relapse within 2 years. This study was undertaken to determine whether the addition of azathioprine (AZA (...) ) to glucocorticoids could achieve a higher sustained remission rate of newly diagnosed nonsevere eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA), microscopic polyangiitis (MPA), or polyarteritis nodosa (PAN).All patients included in this double-blind trial received glucocorticoids, gradually tapered over 12 months, and were randomized to receive AZA or placebo for 12 months, with stratification according to SNV (EGPA or MPA/PAN). The primary end point was the combined rate of remission

2017 EvidenceUpdates

7. Hepatitis B viremia manifesting as polyarteritis nodosa and secondary membranous nephropathy (PubMed)

Hepatitis B viremia manifesting as polyarteritis nodosa and secondary membranous nephropathy Renal involvement in hepatitis B-polyarteritis nodosa (HBV-PAN) usually occurs in the form of hypertension, microscopic hematuria, proteinuria but nephrotic range proteinuria or renal failure is very uncommon. A 60-year-old man had abdominal pain for 15 days which was followed by bilateral pedal edema in a day and in next three days he had sudden onset bilateral foot drop with numbness. He had weight (...) was normal. Prednisolone (60 mg/day), plasmapheresis (5 courses) and entecavir (0.5 mg/ every second day) were started. At 2 months follow up, patient improved in the form of grade 3/5 power in both lower limbs with sensory improvement. Twenty-four hours proteinuria decreased to 800 mg/day and serum creatinine reached to 1.5 mg/dl. Polyarteritis nodosa was due to HBV infection, but the etiology of MN was uncertain, as it has rarely been described in PAN. Proteinuria responded to nucleoside analogue

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2016 Journal of nephropharmacology

8. Clinical and Laboratory Markers Associated With Relapse in Cutaneous Polyarteritis Nodosa. (PubMed)

Clinical and Laboratory Markers Associated With Relapse in Cutaneous Polyarteritis Nodosa. In cutaneous polyarteritis nodosa (CPAN), less aggressive treatments can be selected, because CPAN is not associated with life-threatening or progressive outcomes. Although patients with a recurrent clinical course may require additional immunosuppressive therapies, no pretreatment factors associated with a worse prognosis in CPAN have been reported.To identify clinical or laboratory markers associated

2018 JAMA dermatology (Chicago, Ill.)

9. Adalimumab therapy in hepatitis B virus-negative polyarteritis nodosa: A case report. (PubMed)

Adalimumab therapy in hepatitis B virus-negative polyarteritis nodosa: A case report. Polyarteritis nodosa (PAN) is a difficult-to-treat rheumatology disorder, and biologic agents have been used in such patients with a treatment failure or the disease relapse.We report a 42-year-old male Han Chinese who received adalimumab (ADA) alone during his vasculitis relapse, manifesting with weight loss, ankle arthritis, testicular inflammation and new-onset hypertension. Under the ADA 40 mg biweekly

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2018 Medicine

10. Acute Necrotizing Vasculitic Neuropathy due to Polyarteritis Nodosa (PubMed)

Acute Necrotizing Vasculitic Neuropathy due to Polyarteritis Nodosa Necrotizing vasculitic neuropathy in polyarteritis nodosa can rarely present acutely and may mimic acute inflammatory neuropathies. A 53-year-old male presented with an acute neurological illness characterized by paresthesia and weakness of both lower limbs lasting six-days. He also had mild paresthesia of both hands. On examination, there were confluent, purpuric, and ecchymotic patches over the extensor aspects of both lower

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2018 Oman medical journal

11. Case Report: Polyarteritis nodosa or complicated Henoch-Schonlein purpura (IgAV), a rare case (PubMed)

Case Report: Polyarteritis nodosa or complicated Henoch-Schonlein purpura (IgAV), a rare case Background: Polyarteritis nodosa (PAN) is a vasculitis that affects medium-sized arteries. PAN is a rare disease and requires a high clinical suspicion for diagnosis. PAN and HSP (newly named Immunoglobulin A-associated vasculitis) have narrowing differential diagnosis. Here, we reported a case of PAN. Case presentation: Our patient was a 65-year-old woman that came to hospital due to abdominal pain

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2018 F1000Research

12. Nodules developing after radiofrequency ablation of varicosities: A potential clinical and histopathologic mimic of polyarteritis nodosa (PubMed)

Nodules developing after radiofrequency ablation of varicosities: A potential clinical and histopathologic mimic of polyarteritis nodosa 30246136 2019 02 26 2352-5126 4 8 2018 Sep JAAD case reports JAAD Case Rep Nodules developing after radiofrequency ablation of varicosities: A potential clinical and histopathologic mimic of polyarteritis nodosa. 814-816 10.1016/j.jdcr.2018.03.029 Helm Matthew F MF Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, Pennsylvania (...) , polyarteritis nodosa PDL, pulsed dye laser RFA, radiofrequency ablation polyarteritis nodosa radiofrequency ablation sclerotherapy varicosities 2018 9 25 6 0 2018 9 25 6 0 2018 9 25 6 1 epublish 30246136 10.1016/j.jdcr.2018.03.029 S2352-5126(18)30104-8 PMC6141695 Am J Dermatopathol. 2010 Oct;32(7):688-93 20647909 Am J Dermatopathol. 2013 Jun;35(4):463-71 23392132 Rheum Dis Clin North Am. 2015;41(1):33-46, vii 25399938 Nat Rev Rheumatol. 2017 Jun;13(6):381-386 28490787

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2018 JAAD Case Reports

13. Comparing childhood-versus adult-onset polyarteritis nodosa. Results from the French Vasculitis Study Group Registry. (PubMed)

Comparing childhood-versus adult-onset polyarteritis nodosa. Results from the French Vasculitis Study Group Registry. To investigate differences between childhood (cPAN)- and adult-onset polyarteritis nodosa (aPAN) patients.cPAN patients' clinical findings at onset and outcomes were compared to those of aPAN patients from the French Vasculitis Study Group registry matched for year of enrollment and initial systemic versus cutaneous disease. Their information on medications, disease activity

2018 Autoimmunity reviews

14. Ruptured hepatic aneurysm as first presenting symptom of polyarteritis nodosa (PubMed)

Ruptured hepatic aneurysm as first presenting symptom of polyarteritis nodosa Polyarteritis nodosa (PAN) is an inflammatory vasculitis that creates regions of stenosis and aneurysm formation. The authors describe a 66-year-old female with hepatic artery rupture as the first presentation of undiagnosed PAN, presenting with abdominal pain followed by hemorrhagic shock. This aneurysm was suture ligated with a successful outcome. A mesenteric arteriogram demonstrated lesions consistent with PAN

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2018 Oxford Medical Case Reports

15. Involvement of the Peripheral Nervous System in Polyarteritis Nodosa and Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis. (PubMed)

Involvement of the Peripheral Nervous System in Polyarteritis Nodosa and Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis. Peripheral nerve involvement is common in polyarteritis nodosa and the antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides. The underlying mechanism is arteritis of the vasa nervorum, leading to ischemic neuropathy. The classic presentation is stepwise involvement of peripheral nerves with ongoing antecedent constitutional symptoms. This article

2017 Rheumatic Diseases Clinics of North America

16. The changing face of polyarteritis nodosa and necrotizing vasculitis. (PubMed)

The changing face of polyarteritis nodosa and necrotizing vasculitis. Polyarteritis nodosa (PAN) is a vasculitic disease characterized primarily by necrotizing vasculitis - inflammatory lesions in blood vessels that lead to vessel wall necrosis. Our understanding of PAN and necrotizing vasculitis has evolved over time. In addition to PAN, necrotizing vasculitis is now a recognized feature of a broad range of diseases with different aetiopathogenesis. For example, necrotizing vasculitis

2017 Nature reviews. Rheumatology

17. ADA2 deficiency (DADA2) as an unrecognised cause of early onset polyarteritis nodosa and stroke: a multicentre national study. (PubMed)

ADA2 deficiency (DADA2) as an unrecognised cause of early onset polyarteritis nodosa and stroke: a multicentre national study. To analyse the prevalence of CECR1 mutations in patients diagnosed with early onset livedo reticularis and/or haemorrhagic/ischaemic strokes in the context of inflammation or polyarteritis nodosa (PAN). Forty-eight patients from 43 families were included in the study.Direct sequencing of CECR1 was performed by Sanger analysis. Adenosine deaminase 2 (ADA2) enzymatic

2017 Annals of the Rheumatic Diseases

18. Cytomegalovirus-induced polyarteritis nodosa (PAN) in a liver transplant recipient. (PubMed)

Cytomegalovirus-induced polyarteritis nodosa (PAN) in a liver transplant recipient. Polyarteritis nodosa (PAN) is a necrotizing vasculitis that has been associated with viral infections, especially hepatitis B virus. We hereby report a case of tissue-invasive cytomegalovirus (CMV)-induced PAN in a liver transplant recipient presenting with acute kidney injury and active urinary sediment. Treatment directed against both PAN and CMV resulted in improvement in kidney function, normalization

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2017 American Journal of Transplantation

19. Coronary Artery Bypass Grafting in a Patient With Polyarteritis Nodosa. (PubMed)

Coronary Artery Bypass Grafting in a Patient With Polyarteritis Nodosa. A 38-year-old man with polyarteritis nodosa presented with exertional chest pain. Coronary angiography revealed 3-vessel coronary artery disease. We performed 2-vessel coronary artery bypass grafting with the saphenous vein because the left internal thoracic artery was in poor condition. Histological examination of the left internal thoracic artery showed a strong effect of polyarteritis nodosa.Copyright © 2017 The Society

2017 Annals of Thoracic Surgery

20. Cutaneous polyarteritis nodosa resulting from a paclitaxel-eluting balloon angioplasty (PubMed)

Cutaneous polyarteritis nodosa resulting from a paclitaxel-eluting balloon angioplasty 29387747 2019 02 26 2352-5126 4 1 2018 Jan JAAD case reports JAAD Case Rep Cutaneous polyarteritis nodosa resulting from a paclitaxel-eluting balloon angioplasty. 50-52 10.1016/j.jdcr.2017.09.024 Montgomery Allison A Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania. Kushner Jeffrey J Department of Dermatology, St. Joseph Mercy Hospital, Ypsilanti, Michigan. Altman David D Department (...) of Dermatology, St. Joseph Mercy Hospital, Ypsilanti, Michigan. eng Case Reports 2017 12 19 United States JAAD Case Rep 101665210 2352-5126 IL, interleukin angioplasty cPAN, cutaneous polyarteritis nodosa drug-eluting balloon pANCA, perinuclear antineutrophil cytoplasmic antibodies paclitaxel polyarteritis nodosa 2018 2 2 6 0 2018 2 2 6 0 2018 2 2 6 1 epublish 29387747 10.1016/j.jdcr.2017.09.024 S2352-5126(17)30233-3 PMC5771735 Ann Pharmacother. 2004 Feb;38(2):238-41 14742758 J Vasc Surg. 2014 Feb;59(2):520

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2017 JAAD Case Reports

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