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Podophyllin Resin

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21. Papillomavirus (Follow-up)

the same dosage schedule to treat up to 5 additional condylomata per course of treatment. Patients with more than 10 condylomata may receive additional sequences, depending on how many condylomata are present. Podofilox In a nonpregnant patient, podofilox gel or solution is the authors’ first choice. This antimitotic agent is either chemically synthesized or purified from naturally occurring podophyllin resin. Podofilox is used in the treatment of external genital warts or condyloma acuminatum (...) Podophyllin, a resin derived from the May apple ( Podophyllum peltatum Linné ), contains the active agent podophyllotoxin, which is a cytotoxic agent that arrests mitosis in metaphase. It is a physician-applied medicine used in the treatment of external genital warts and condyloma acuminatum. It can be applied weekly for up to 6 weeks. Warts visible after 6 treatments usually do not respond to further therapy. [ ] Podophyllin is applied directly to warts, but no more than 0.5 mL should be used with 1

2014 eMedicine.com

22. Warts, Nongenital (Follow-up)

), and diphencyclopropenone (DCP) are contact sensitizers. Trichloroacetic acid is a caustic compound that causes tissue necrosis. Podophyllin is a cytotoxic compound used more commonly in the treatment of genital warts. Aminolevulinic acid (ALA) is a photosensitizer that has been successfully used topically in combination with blue light to treat flat warts. [ ] Several prescription medications have proven beneficial in treating warts. These can be applied at home by the patient. Imiquimod is an immune response modifier (...) approved for the treatment of genital warts. Reports indicate successful treatment of common warts. [ ] Cidofovir is an antiviral agent used for the treatment of cytomegalovirus infection in HIV patients. Several reports describe successful treatment of recalcitrant warts using various concentrations of topical cidofovir. [ , , , , ] Podophyllotoxin is a purified ingredient of podophyllin. Since it tends to work better on mucosal surfaces, it is used primarily to treat genital warts. Little information

2014 eMedicine.com

23. Warts, Genital (Follow-up)

the same dosage schedule to treat up to 5 additional condylomata per course of treatment. Patients with more than 10 condylomata may receive additional sequences, depending on how many condylomata are present. Podofilox In a nonpregnant patient, podofilox gel or solution is the authors’ first choice. This antimitotic agent is either chemically synthesized or purified from naturally occurring podophyllin resin. Podofilox is used in the treatment of external genital warts or condyloma acuminatum (...) Podophyllin, a resin derived from the May apple ( Podophyllum peltatum Linné ), contains the active agent podophyllotoxin, which is a cytotoxic agent that arrests mitosis in metaphase. It is a physician-applied medicine used in the treatment of external genital warts and condyloma acuminatum. It can be applied weekly for up to 6 weeks. Warts visible after 6 treatments usually do not respond to further therapy. [ ] Podophyllin is applied directly to warts, but no more than 0.5 mL should be used with 1

2014 eMedicine.com

24. Hairy Leukoplakia (Follow-up)

resin 25% solution usually achieves resolution after 1-2 treatment applications. The treatments may temporarily cause local pain, discomfort, and alteration of taste. Podophyllin has cellular cytotoxic effects, but the mechanism of action in resolving hairy leukoplakia is not known. Again, hairy leukoplakia often recurs several weeks after successful podophyllin therapy. [ ] Topical therapy with retinoic acid (tretinoin) has been reported to resolve hairy leukoplakia. Retinoic acids are known (...) requires high doses (800 mg 5 times per day) to achieve therapeutic levels. [ ] Valacyclovir (1000 mg 3 times a day) and famciclovir (500 mg 3 times a day) are newer antiviral drugs with higher oral bioavailability than acyclovir and can be dosed less often. Antiviral drugs inhibit productive Epstein-Barr virus (EBV) replication but do not eliminate the latent state of infection. Hairy leukoplakia often recurs several weeks after the cessation of antiviral therapy. Topical therapy with podophyllin

2014 eMedicine.com

25. Human Papillomavirus (Follow-up)

the same dosage schedule to treat up to 5 additional condylomata per course of treatment. Patients with more than 10 condylomata may receive additional sequences, depending on how many condylomata are present. Podofilox In a nonpregnant patient, podofilox gel or solution is the authors’ first choice. This antimitotic agent is either chemically synthesized or purified from naturally occurring podophyllin resin. Podofilox is used in the treatment of external genital warts or condyloma acuminatum (...) Podophyllin, a resin derived from the May apple ( Podophyllum peltatum Linné ), contains the active agent podophyllotoxin, which is a cytotoxic agent that arrests mitosis in metaphase. It is a physician-applied medicine used in the treatment of external genital warts and condyloma acuminatum. It can be applied weekly for up to 6 weeks. Warts visible after 6 treatments usually do not respond to further therapy. [ ] Podophyllin is applied directly to warts, but no more than 0.5 mL should be used with 1

2014 eMedicine.com

26. Urethral Warts (Follow-up)

of invasive cervical cancer. Previous Next: Pharmacologic Therapy Treatment of urethral warts is aimed at inducing a wart-free state and reducing the amount of infectious virus present. Medical treatment is useful for urethral warts located at accessible sites. Podophyllin resin and podofilox , an antimitotic plant compound (10-25% solution in ethanol or tincture of benzoin), is applied with a cotton-tipped swab, allowed to dry, and washed off completely after 1-4 hours. Applications may be administered (...) once or twice weekly for as many as 6 weeks. Do not treat pregnant patients with podophyllin. 0.5% solution or gel (purified from podophyllin resin) has a stable shelf life, need not be washed off after use, and is less likely to cause systemic toxicity. However, podofilox has not been approved for urethral, rectal, perianal, vaginal, or cervical warts. Imiquimod 5% cream stimulates the production of interferon and other cytokines and is topically applied 3 times weekly for as many as 16 weeks

2014 eMedicine.com

27. Warts, Plantar (Follow-up)

), and diphencyclopropenone (DCP) are contact sensitizers. Trichloroacetic acid is a caustic compound that causes tissue necrosis. Podophyllin is a cytotoxic compound used more commonly in the treatment of genital warts. Aminolevulinic acid (ALA) is a photosensitizer that has been successfully used topically in combination with blue light to treat flat warts. [ ] Several prescription medications have proven beneficial in treating warts. These can be applied at home by the patient. Imiquimod is an immune response modifier (...) approved for the treatment of genital warts. Reports indicate successful treatment of common warts. [ ] Cidofovir is an antiviral agent used for the treatment of cytomegalovirus infection in HIV patients. Several reports describe successful treatment of recalcitrant warts using various concentrations of topical cidofovir. [ , , , , ] Podophyllotoxin is a purified ingredient of podophyllin. Since it tends to work better on mucosal surfaces, it is used primarily to treat genital warts. Little information

2014 eMedicine Emergency Medicine

28. Warts, Plantar (Treatment)

), and diphencyclopropenone (DCP) are contact sensitizers. Trichloroacetic acid is a caustic compound that causes tissue necrosis. Podophyllin is a cytotoxic compound used more commonly in the treatment of genital warts. Aminolevulinic acid (ALA) is a photosensitizer that has been successfully used topically in combination with blue light to treat flat warts. [ ] Several prescription medications have proven beneficial in treating warts. These can be applied at home by the patient. Imiquimod is an immune response modifier (...) approved for the treatment of genital warts. Reports indicate successful treatment of common warts. [ ] Cidofovir is an antiviral agent used for the treatment of cytomegalovirus infection in HIV patients. Several reports describe successful treatment of recalcitrant warts using various concentrations of topical cidofovir. [ , , , , ] Podophyllotoxin is a purified ingredient of podophyllin. Since it tends to work better on mucosal surfaces, it is used primarily to treat genital warts. Little information

2014 eMedicine Emergency Medicine

30. Podophyllotoxin

of the plant Podophyllum peltatum. This agent is formulated for topical applications. (NCI04) Definition (MSH) A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. Concepts Organic (...) only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See for financial assistance information. Ontology: podofilox (C0032334) Definition (NCI) A pure, stabilized form of podophyllin, in which only the biologically active portion of the compound is present. Podophyllotoxin is a toxic, polycyclic antimitotic agent isolated primarily from the rhizome

2015 FP Notebook

31. Systemic reactions to topically applied drugs. Howard Fox memorial lecture. (PubMed)

Triamcinolone 9000-55-9 Podophyllin IWW5FV6NK2 Hexachlorophene IM Administration, Topical Adolescent Age Factors Anti-Inflammatory Agents adverse effects pharmacology Boric Acids poisoning Child Child, Preschool Female Glucocorticoids Hexachlorophene poisoning Humans Infant Infant, Newborn Male Mercury Poisoning Permeability Phenols poisoning Pituitary-Adrenal System drug effects Podophyllin adverse effects Resins, Plant adverse effects Resorcinols adverse effects Salicylates poisoning Skin Absorption (...) Systemic reactions to topically applied drugs. Howard Fox memorial lecture. 4575969 1973 08 10 2018 11 13 0028-7091 49 7 1973 Jul Bulletin of the New York Academy of Medicine Bull N Y Acad Med Systemic reactions to topically applied drugs. Howard Fox memorial lecture. 613-27 Pascher F F eng Journal Article Review United States Bull N Y Acad Med 7505398 0028-7091 0 Anti-Inflammatory Agents 0 Boric Acids 0 Glucocorticoids 0 Phenols 0 Resins, Plant 0 Resorcinols 0 Salicylates 1ZK20VI6TY

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1973 Bulletin of the New York Academy of Medicine

32. A new topical treatment protocol for oral hairy leukoplakia. (PubMed)

A new topical treatment protocol for oral hairy leukoplakia. The aim of this study was to present a new topical treatment protocol for oral hairy leukoplakia (OHL), consisting of a 25% podophyllin resin with a 1% penciclovir cream (PP), and to compare this topical treatment protocol's efficacy with that of 2 other topical treatment protocols: a 25% podophyllin resin (P) and a 25% podophyllin resin with a 5% acyclovir cream (PA).Forty-two human immunodeficiency virus-positive patients with 69

2010 Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics

33. Leukoplakia

with podophyllin resin 25% solution, which usually achieves resolution after 1-2 treatment applications. Topical therapy with retinoic acid (tretinoin), which has been reported to resolve hairy leukoplakia. Ablative therapy, which can also be considered for small hairy leukoplakia lesions. Cryotherapy has been reported as successful but is not widely used. Did you find this information useful? Thanks for your feedback! Why not subscribe to the newsletter? Email address * We'd love to send you our articles

2008 Mentor

34. Double-blind randomized clinical trial of self-administered podofilox solution versus vehicle in the treatment of genital warts. (PubMed)

penile warts and is well tolerated in a self-administered regimen. Podofilox 0.5% offers potential advantages in safety and cost over podophyllin resin therapy of genital warts.

1990 The American journal of medicine

35. A comparison of interferon alfa-2a and podophyllin in the treatment of primary condylomata acuminata. The Condylomata International Collaborative Study Group. (PubMed)

A comparison of interferon alfa-2a and podophyllin in the treatment of primary condylomata acuminata. The Condylomata International Collaborative Study Group. to compare the response to treatment and recurrence rate of condylomata accuminata using subcutaneous injection of interferon alfa 2a 1.5 million units three times weekly for four weeks, or podophyllin resin 25% applied to lesions twice weekly for up to six weeks.Randomised open study.Multicentre European study in genitourinary medicine (...) , dermatovenereology, and gynaecology departments.87 males and 67 females with condylomata acuminata for less than six months and no history of previous treatment.Complete clearance of lesions and evidence of recurrence at three months and nine months after treatment commenced.A complete response was achieved at three months in 15 of 64 (23%) in the interferon treated group, and 31 of 69 (45%) in the podophyllin treated group (p = 0.003). At nine months 10 of 13 patients in the interferon group and 22 of 30

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1991 Genitourinary medicine

36. A randomized trial of combination therapy with intralesional interferon alpha 2b and podophyllin versus podophyllin alone for the therapy of anogenital warts. (PubMed)

resin applied topically to each of three warts once weekly for 3 weeks. Maximal responses occurred within 2 weeks of therapy, and overall there was complete clearance of treated warts in 67% of interferon and podophyllin versus 42% of podophyllin recipients (P less than .05, chi 2). Clearance rates were greater in women, patients with warts of less than or equal to 12 months' duration, and HIV-seronegative patients. Of patients with complete clearance, 67% of interferon and podophyllin and 65 (...) A randomized trial of combination therapy with intralesional interferon alpha 2b and podophyllin versus podophyllin alone for the therapy of anogenital warts. To determine the value of combining interferon with standard local therapy in the treatment of human papillomavirus infection, 97 patients with anogenital warts were randomized to a short course of either interferon plus podophyllin or podophyllin alone. Interferon alpha 2b (1.5 x 10(6) IU) was injected intralesionally and podophyllin

1990 The Journal of infectious diseases

37. A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir cream (5%) in the treatment of oral hairy leukoplakia. (PubMed)

A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir cream (5%) in the treatment of oral hairy leukoplakia. The objective of this study was to assess the efficiency of topical applications of podophyllin resin (25%) (P) versus podophyllin resin (25%) together with acyclovir cream (5%) (PA) in the treatment of oral hairy leukoplakia (OHL) in accordance with the following criteria: (1

2007 Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics

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