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Podophyllin Resin

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1. Podophyllin Resin

Podophyllin Resin Podophyllin Resin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Podophyllin Resin Podophyllin Resin Aka (...) : Podophyllin Resin , Podophyllin From Related Chapters II. Indications III. Background Use by clinicians started in the 1940s is a purified form of Podophyllin IV. Preparation Podophyllin 15-25% solution in tincture of Benzoin V. Technique Apply with cotton applicator Apply test first to small area of warts Allow solution to dry after application Wash off in 1-4 hours (earlier if burning) Repeat application at 1 week intervals for 3-6 weeks VI. Precautions Perform only in office, not at home Do not apply

2018 FP Notebook

2. Podophyllin Resin

Podophyllin Resin Podophyllin Resin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Podophyllin Resin Podophyllin Resin Aka (...) : Podophyllin Resin , Podophyllin From Related Chapters II. Indications III. Background Use by clinicians started in the 1940s is a purified form of Podophyllin IV. Preparation Podophyllin 15-25% solution in tincture of Benzoin V. Technique Apply with cotton applicator Apply test first to small area of warts Allow solution to dry after application Wash off in 1-4 hours (earlier if burning) Repeat application at 1 week intervals for 3-6 weeks VI. Precautions Perform only in office, not at home Do not apply

2015 FP Notebook

3. Guidelines for the Management of Genital, Anal and Throat HPV Infection in New Zealand

bicarbonate. TCA solution has a low viscosity (comparable to that of water), and if over-applied can spread rapidly and ‘run’, damaging a significant area of normal tissue. Contraindications: Nil, but most suitable for small moist warts. Can be used in pregnancy. The following treatments are not recommended because of side effects, toxicity and difficulty in application: • Podophyllin resin • 5% flurouracil cream • Systemic interferon Selecting treatment(s) for individual patients (see Table 3, page 13 (...) is likely to be negligible. Podophyllotoxin Podophyllotoxin is dispensed as a 0.5% solution (Condyline TM ). The 0.15% cream is not available in New Zealand. These contain purified podophyllin in a more standardised form. Podophyllotoxin has been extensively studied in randomised and placebo- controlled trials. It is licensed for 4- to 5-week courses and supervision by medical staff is recommended when the lesion area is greater than 4cm 2 . Mechanism of action: The active moiety is an antimitotic

2017 New Zealand Sexual Health Society

4. Jeffrey Aronson: When I use a word . . . Liquorice and glycyrrhetinic acid

, contained, not what it said on the bottle, but liquorice, senna, aniseed, and ammonium chloride; Beecham’s Cough Pills had similar contents plus a small amount of morphine; and Keating’s Cough Lozenges contained morphine, liquorice, and ipecacuanha. Doan’s Backache Kidney Pills came in boxes of 40 kidney pills and four “dinner” pills; the contained oil of peppermint, podophyllin, aloin, jalap resin, powdered capsicum, maize starch, acacia gum, extract of henbane, and powdered liquorice. A cachou

2018 The BMJ Blog

5. Jeffrey Aronson: When I use a word . . . Dropsies

, feeling discouraged was asserted to be one of the symptoms of the disease! The dinner pills contained, as far as the authors of (BMA, 1909) could discover, oil of peppermint, podophyllin, aloin, jalap resin, powdered capsicum, powdered liquorice, maize starch, acacia gum, and extract of henbane. The materials for 50 pills cost one old penny—price, one and three ha’pence (about 6p). The kidney pills contained oil of juniper, podophyllin, hemlock pitch, potassium nitrate, powdered fenugreek, wheat flour

2017 The BMJ Blog

6. Topical Antiviral and Antifungal Medications in Pregnancy: A Review of Safety Profiles. (PubMed)

on utilizing topical antiviral and antifungal medications in pregnancy. For antiviral medications, acyclovir and trichloroacetic acid are safe to use in pregnancy. Docosanol, imiquimod and penciclovir are likely safe, but should be utilized as second-line agents. Podofilox and podophyllin resin should be avoided. For antifungal medications, clotrimazole, miconazole and nystatin are considered first-line agents. Butenafine, ciclopirox, naftifine, oxiconazole and terbinafine may be utilized after the above

2017 Journal of the European Academy of Dermatology and Venereology

7. Podophyllotoxin

of the plant Podophyllum peltatum. This agent is formulated for topical applications. (NCI04) Definition (MSH) A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. Concepts Organic (...) only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See for financial assistance information. Ontology: podofilox (C0032334) Definition (NCI) A pure, stabilized form of podophyllin, in which only the biologically active portion of the compound is present. Podophyllotoxin is a toxic, polycyclic antimitotic agent isolated primarily from the rhizome

2018 FP Notebook

8. Urethral Warts (Diagnosis)

of invasive cervical cancer. Previous Next: Pharmacologic Therapy Treatment of urethral warts is aimed at inducing a wart-free state and reducing the amount of infectious virus present. Medical treatment is useful for urethral warts located at accessible sites. Podophyllin resin and podofilox , an antimitotic plant compound (10-25% solution in ethanol or tincture of benzoin), is applied with a cotton-tipped swab, allowed to dry, and washed off completely after 1-4 hours. Applications may be administered (...) once or twice weekly for as many as 6 weeks. Do not treat pregnant patients with podophyllin. 0.5% solution or gel (purified from podophyllin resin) has a stable shelf life, need not be washed off after use, and is less likely to cause systemic toxicity. However, podofilox has not been approved for urethral, rectal, perianal, vaginal, or cervical warts. Imiquimod 5% cream stimulates the production of interferon and other cytokines and is topically applied 3 times weekly for as many as 16 weeks

2014 eMedicine.com

9. Condyloma Acuminatum (Follow-up)

the same dosage schedule to treat up to 5 additional condylomata per course of treatment. Patients with more than 10 condylomata may receive additional sequences, depending on how many condylomata are present. Podofilox In a nonpregnant patient, podofilox gel or solution is the authors’ first choice. This antimitotic agent is either chemically synthesized or purified from naturally occurring podophyllin resin. Podofilox is used in the treatment of external genital warts or condyloma acuminatum (...) Podophyllin, a resin derived from the May apple ( Podophyllum peltatum Linné ), contains the active agent podophyllotoxin, which is a cytotoxic agent that arrests mitosis in metaphase. It is a physician-applied medicine used in the treatment of external genital warts and condyloma acuminatum. It can be applied weekly for up to 6 weeks. Warts visible after 6 treatments usually do not respond to further therapy. [ ] Podophyllin is applied directly to warts, but no more than 0.5 mL should be used with 1

2014 eMedicine.com

11. Condyloma Acuminatum (Treatment)

the same dosage schedule to treat up to 5 additional condylomata per course of treatment. Patients with more than 10 condylomata may receive additional sequences, depending on how many condylomata are present. Podofilox In a nonpregnant patient, podofilox gel or solution is the authors’ first choice. This antimitotic agent is either chemically synthesized or purified from naturally occurring podophyllin resin. Podofilox is used in the treatment of external genital warts or condyloma acuminatum (...) Podophyllin, a resin derived from the May apple ( Podophyllum peltatum Linné ), contains the active agent podophyllotoxin, which is a cytotoxic agent that arrests mitosis in metaphase. It is a physician-applied medicine used in the treatment of external genital warts and condyloma acuminatum. It can be applied weekly for up to 6 weeks. Warts visible after 6 treatments usually do not respond to further therapy. [ ] Podophyllin is applied directly to warts, but no more than 0.5 mL should be used with 1

2014 eMedicine.com

12. Hairy Leukoplakia (Treatment)

resin 25% solution usually achieves resolution after 1-2 treatment applications. The treatments may temporarily cause local pain, discomfort, and alteration of taste. Podophyllin has cellular cytotoxic effects, but the mechanism of action in resolving hairy leukoplakia is not known. Again, hairy leukoplakia often recurs several weeks after successful podophyllin therapy. [ ] Topical therapy with retinoic acid (tretinoin) has been reported to resolve hairy leukoplakia. Retinoic acids are known (...) requires high doses (800 mg 5 times per day) to achieve therapeutic levels. [ ] Valacyclovir (1000 mg 3 times a day) and famciclovir (500 mg 3 times a day) are newer antiviral drugs with higher oral bioavailability than acyclovir and can be dosed less often. Antiviral drugs inhibit productive Epstein-Barr virus (EBV) replication but do not eliminate the latent state of infection. Hairy leukoplakia often recurs several weeks after the cessation of antiviral therapy. Topical therapy with podophyllin

2014 eMedicine.com

13. Warts, Genital (Treatment)

the same dosage schedule to treat up to 5 additional condylomata per course of treatment. Patients with more than 10 condylomata may receive additional sequences, depending on how many condylomata are present. Podofilox In a nonpregnant patient, podofilox gel or solution is the authors’ first choice. This antimitotic agent is either chemically synthesized or purified from naturally occurring podophyllin resin. Podofilox is used in the treatment of external genital warts or condyloma acuminatum (...) Podophyllin, a resin derived from the May apple ( Podophyllum peltatum Linné ), contains the active agent podophyllotoxin, which is a cytotoxic agent that arrests mitosis in metaphase. It is a physician-applied medicine used in the treatment of external genital warts and condyloma acuminatum. It can be applied weekly for up to 6 weeks. Warts visible after 6 treatments usually do not respond to further therapy. [ ] Podophyllin is applied directly to warts, but no more than 0.5 mL should be used with 1

2014 eMedicine.com

14. Warts, Nongenital (Treatment)

), and diphencyclopropenone (DCP) are contact sensitizers. Trichloroacetic acid is a caustic compound that causes tissue necrosis. Podophyllin is a cytotoxic compound used more commonly in the treatment of genital warts. Aminolevulinic acid (ALA) is a photosensitizer that has been successfully used topically in combination with blue light to treat flat warts. [ ] Several prescription medications have proven beneficial in treating warts. These can be applied at home by the patient. Imiquimod is an immune response modifier (...) approved for the treatment of genital warts. Reports indicate successful treatment of common warts. [ ] Cidofovir is an antiviral agent used for the treatment of cytomegalovirus infection in HIV patients. Several reports describe successful treatment of recalcitrant warts using various concentrations of topical cidofovir. [ , , , , ] Podophyllotoxin is a purified ingredient of podophyllin. Since it tends to work better on mucosal surfaces, it is used primarily to treat genital warts. Little information

2014 eMedicine.com

15. Papillomavirus (Treatment)

the same dosage schedule to treat up to 5 additional condylomata per course of treatment. Patients with more than 10 condylomata may receive additional sequences, depending on how many condylomata are present. Podofilox In a nonpregnant patient, podofilox gel or solution is the authors’ first choice. This antimitotic agent is either chemically synthesized or purified from naturally occurring podophyllin resin. Podofilox is used in the treatment of external genital warts or condyloma acuminatum (...) Podophyllin, a resin derived from the May apple ( Podophyllum peltatum Linné ), contains the active agent podophyllotoxin, which is a cytotoxic agent that arrests mitosis in metaphase. It is a physician-applied medicine used in the treatment of external genital warts and condyloma acuminatum. It can be applied weekly for up to 6 weeks. Warts visible after 6 treatments usually do not respond to further therapy. [ ] Podophyllin is applied directly to warts, but no more than 0.5 mL should be used with 1

2014 eMedicine.com

16. Human Papillomavirus (Treatment)

the same dosage schedule to treat up to 5 additional condylomata per course of treatment. Patients with more than 10 condylomata may receive additional sequences, depending on how many condylomata are present. Podofilox In a nonpregnant patient, podofilox gel or solution is the authors’ first choice. This antimitotic agent is either chemically synthesized or purified from naturally occurring podophyllin resin. Podofilox is used in the treatment of external genital warts or condyloma acuminatum (...) Podophyllin, a resin derived from the May apple ( Podophyllum peltatum Linné ), contains the active agent podophyllotoxin, which is a cytotoxic agent that arrests mitosis in metaphase. It is a physician-applied medicine used in the treatment of external genital warts and condyloma acuminatum. It can be applied weekly for up to 6 weeks. Warts visible after 6 treatments usually do not respond to further therapy. [ ] Podophyllin is applied directly to warts, but no more than 0.5 mL should be used with 1

2014 eMedicine.com

17. Urethral Warts (Treatment)

of invasive cervical cancer. Previous Next: Pharmacologic Therapy Treatment of urethral warts is aimed at inducing a wart-free state and reducing the amount of infectious virus present. Medical treatment is useful for urethral warts located at accessible sites. Podophyllin resin and podofilox , an antimitotic plant compound (10-25% solution in ethanol or tincture of benzoin), is applied with a cotton-tipped swab, allowed to dry, and washed off completely after 1-4 hours. Applications may be administered (...) once or twice weekly for as many as 6 weeks. Do not treat pregnant patients with podophyllin. 0.5% solution or gel (purified from podophyllin resin) has a stable shelf life, need not be washed off after use, and is less likely to cause systemic toxicity. However, podofilox has not been approved for urethral, rectal, perianal, vaginal, or cervical warts. Imiquimod 5% cream stimulates the production of interferon and other cytokines and is topically applied 3 times weekly for as many as 16 weeks

2014 eMedicine.com

18. Urethral Warts (Overview)

of invasive cervical cancer. Previous Next: Pharmacologic Therapy Treatment of urethral warts is aimed at inducing a wart-free state and reducing the amount of infectious virus present. Medical treatment is useful for urethral warts located at accessible sites. Podophyllin resin and podofilox , an antimitotic plant compound (10-25% solution in ethanol or tincture of benzoin), is applied with a cotton-tipped swab, allowed to dry, and washed off completely after 1-4 hours. Applications may be administered (...) once or twice weekly for as many as 6 weeks. Do not treat pregnant patients with podophyllin. 0.5% solution or gel (purified from podophyllin resin) has a stable shelf life, need not be washed off after use, and is less likely to cause systemic toxicity. However, podofilox has not been approved for urethral, rectal, perianal, vaginal, or cervical warts. Imiquimod 5% cream stimulates the production of interferon and other cytokines and is topically applied 3 times weekly for as many as 16 weeks

2014 eMedicine.com

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