How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,023 results for

Platelet Function Closure Time

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. Clinical utility of closure times using the Platelet Function Analyzer (PFA)-100/200. (PubMed)

Clinical utility of closure times using the Platelet Function Analyzer (PFA)-100/200. The "platelet function analyzer" (PFA)-100 was first introduced to us in 1995. Since then, the instrument has appeared in over 50 reviews and almost 1000 publications. Recently, the PFA-100 has been "upgraded" to the PFA-200, which has transformed the user interface and electronic management, but retained the fundamental mechanics, and essentially provides the same results. The PFA-100/200 has conceivable (...) clinical utility to screen for von Willebrand Disease (VWD) and platelet disorders, and in monitoring desmopressin (DDAVP) therapy in both, and possibly anti-platelet therapy. Its great strengths are its usage simplicity and sensitivity to conditions affecting primary hemostasis. However, as a "global" test, its limitation is that closure time (CT) test results are neither predictive of, nor specific for, any individual disorder. However, utilized properly, the PFA-100/200 reflects a valuable addition

Full Text available with Trip Pro

2016 American journal of hematology

2. Platelet Function Closure Time

Platelet Function Closure Time Platelet Function Closure Time Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Platelet Function (...) Closure Time Platelet Function Closure Time Aka: Platelet Function Closure Time , Platelet Function Analyzer , PFCT , PFA-100 From Related Chapters II. Indication Replaced by von specific tests (Willebrand Factor Activity, , Factor VIII Level) Historical indications Replaced to assess platelet function Personal or of easy or bleeding Post-operative bleeding III. Protocol: Sample Citrate anticoagulated whole blood IV. Mechanism Rapid quantitation of platelet function for hemostasis Blood passed through

2018 FP Notebook

3. Platelet closure time in anesthetized Greyhounds with hemorrhagic shock treated with hydroxyethyl starch 130/0.4 or 0.9% sodium chloride infusions. (PubMed)

Platelet closure time in anesthetized Greyhounds with hemorrhagic shock treated with hydroxyethyl starch 130/0.4 or 0.9% sodium chloride infusions. To measure platelet closure time (PCT) in dogs during controlled hemorrhagic shock and after fluid resuscitation with hydroxyethyl starch (HES) 130/0.4 or 0.9% sodium chloride.Experimental interventional study.University veterinary teaching hospital.Eleven healthy Greyhounds.Dogs were anesthetized and had 48 mL/kg of blood removed to induce (...) hemorrhagic shock. Dogs received 20 mL/kg of HES 130/0.4 (n = 6) or 80 mL/kg of 0.9% sodium chloride (NaCl; n = 5) intravenously over 20 minutes. PCT was measured using the Platelet Function Analyzer-100 with collagen and adenosine-diphosphate cartridges at: T0 = 60 minutes after induction of anesthesia prior to hemorrhage, T1 = during hemorrhagic shock, and T2 = 40 minutes after completion of fluid bolus. Packed cell volume and platelet count were concurrently measured.Hemorrhagic shock did

2017 Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

4. Inhibition of platelet function after ocular administration of non-steroidal anti-inflammatory drugs. (PubMed)

production were evaluated before and after eyedrop therapy.AA (0.1-0.2 mM)-induced LTA was significantly reduced after ocular indomethacin but not after diclofenac. PFA-100® C-EPI closure time was also significantly prolonged in the indomethacin group but not in the diclofenac group. Circulating platelet P-selectin expression was significantly reduced after treatment with indomethacin compared with diclofenac. Finally, treatment with eyedrop indomethacin, but not with diclofenac, strikingly suppressed AA (...) Inhibition of platelet function after ocular administration of non-steroidal anti-inflammatory drugs. The use of topical NSAIDs is frequent in ophthalmology to reduce the local inflammatory reaction resulting from surgical procedures. Ocular use of some drugs was previously found to lead to significant systemic absorption with possible systemic effects. NSAIDs may enhance the hemorrhagic risk of anticoagulant and antiplatelet drugs. Aim of our study was to evaluate the systemic effects of two

2019 Thrombosis research

5. Patent Foramen Ovale (PFO) Closure at the Time of Endovascular Cardiac Electronic Device Implantation

Patent Foramen Ovale (PFO) Closure at the Time of Endovascular Cardiac Electronic Device Implantation Patent Foramen Ovale (PFO) Closure at the Time of Endovascular Cardiac Electronic Device Implantation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Patent Foramen Ovale (PFO) Closure at the Time of Endovascular Cardiac Electronic Device Implantation (PFOCUS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03232450

2017 Clinical Trials

6. Platelet function analyser (PFA)-100® closure time in the evaluation of non-steroidal anti-inflammatory drug-induced platelet dysfunction in children with bleeding symptoms (PubMed)

Platelet function analyser (PFA)-100® closure time in the evaluation of non-steroidal anti-inflammatory drug-induced platelet dysfunction in children with bleeding symptoms 22507864 2013 04 19 2018 11 13 1723-2007 10 4 2012 Oct Blood transfusion = Trasfusione del sangue Blood Transfus Platelet function analyser (PFA)-100 closure time in the evaluation of non-steroidal anti-inflammatory drug-induced platelet dysfunction in children with bleeding symptoms. 545-6 10.2450/2012.0125-11 Akin Mehmet (...) M Polat Yusuf Y eng Evaluation Studies Letter 2012 03 29 Italy Blood Transfus 101237479 1723-2007 0 Anti-Inflammatory Agents, Non-Steroidal IM Adolescent Anti-Inflammatory Agents, Non-Steroidal administration & dosage adverse effects Blood Platelet Disorders blood chemically induced Child Child, Preschool Female Hemorrhage blood Humans Male Platelet Activation drug effects Platelet Function Tests instrumentation 2011 10 06 2011 11 16 2012 4 18 6 0 2012 4 18 6 0 2013 4 23 6 0 ppublish 22507864

Full Text available with Trip Pro

2012 Blood Transfusion

7. Association between coagulation function and patients with primary angle closure glaucoma: a 5-year retrospective case-control study. (PubMed)

Association between coagulation function and patients with primary angle closure glaucoma: a 5-year retrospective case-control study. To evaluate the association between coagulation function and patients with primary angle closure glaucoma (PACG).A retrospective, hospital-based, case-control study.Shanghai, China.A total of 1778 subjects were recruited from the Eye & ENT Hospital of Fudan University from January 2010 to December 2015, including patients with PACG (male=296; female=569 (...) thromboplastin time (APTT) of the PACG group was approximately 4% shorter (p<0.001) than that of the control group. The prothrombin time (PT) was approximately 2.40% shorter (p<0.001) in patients with PACG compared with the control group. The thrombin time was also approximately 2.14% shorter (p<0.001) in patients with PACG compared with the control group. The level of D-dimer was significantly higher (p=0.042) in patients with PACG. Moreover, the mean platelet volume (MPV) of the PACG group

Full Text available with Trip Pro

2017 BMJ open

8. Left Atrial Function Changes After Left Atrial Appendage Closure in Patients With Persistent Atrial Fibrillation

. These patients will receive left atrial appendage closure(LAAC), radiofrequency ablation under the guidance of 3D mapping and LAAC combined with radiofrequency ablation, respectively (allocation ratio, 1:1:1). Real-time 3D ultrasound and 2D ultrasound examinations and measurement of left ventricle(LV) and left atrial(LA) function are carried out for all patients before the operation, and at 1, 2, 3 and 4 weeks and 2, 3, 6, 9 and 12 months after the operation. All ultrasound data will be stored (...) treatment at the same time, the transcatheter occlusion of left atrial appendage opening Outcome Measures Go to Primary Outcome Measures : Left atrial function of postoperative left atrial appendage occlusion detected [ Time Frame: 1-12 month ] Transthoracic ultrasound Secondary Outcome Measures : Plasma biomarkers of inflammation assessed [ Time Frame: 1-12 month ] Blood samples are extracted in all patients for the detection of the C reactive protein, white blood cell,red blood cell, Platelets

2017 Clinical Trials

9. The Effects of Cyclosporine and Aspirin on Platelet Function in Normal Dogs. (PubMed)

or the platelet function analyzer closure time between the low-dose aspirin group and the combined low-dose aspirin and cyclosporine group. On day 7, there was a significant difference in amplitude and closure time between the cyclosporine group and the combined low-dose aspirin and cyclosporine group. High-dose aspirin consistently inhibited platelet function. On both days, there was a significant difference in the urinary 11-dTXB2 -to-creatinine ratio between the cyclosporine group and the combined low-dose (...) The Effects of Cyclosporine and Aspirin on Platelet Function in Normal Dogs. Cyclosporine increases thromboxane synthesis in dogs, potentially increasing the thrombogenic properties of platelets.Our hypothesis was that the concurrent administration of low-dose aspirin and cyclosporine would inhibit cyclosporine-associated thromboxane synthesis without altering the antiplatelet effects of aspirin. The objective was to determine the effects of cyclosporine and aspirin on primary hemostasis.Seven

Full Text available with Trip Pro

2018 Journal of Veterinary Internal Medicine

10. Thromboelastometry and Platelet Function during Acclimatization to High Altitude. (PubMed)

acclimatization. Platelet function assays revealed evidence of platelet hyper-reactivity, with shortened PFA-100 closure times and increased platelet aggregation in response to adenosine diphosphate. Post-expedition results were consistent with the normalization of coagulation following descent to sea level. These robust findings indicate that hypoxia increases platelet reactivity and, with the exception of the paradoxical delay in thromboelastometry clotting time, suggest a prothrombotic phenotype (...) Thromboelastometry and Platelet Function during Acclimatization to High Altitude. Interaction between hypoxia and coagulation is important given the increased risk of thrombotic diseases in chronically hypoxic patients who reside at sea level and in residents at high altitude. Hypoxia alters the proteome of platelets favouring a prothrombotic phenotype, but studies of activation and consumption of specific coagulation factors in hypoxic humans have yielded conflicting results. We tested blood

Full Text available with Trip Pro

2018 Thrombosis and haemostasis

11. Platelet Function Analyzer-200 P2Y Results Are Predictive of the Risk of Major Adverse Cardiac Events in Korean Patients Receiving Clopidogrel Therapy Following Acute Coronary Syndrome (PubMed)

Platelet Function Analyzer-200 P2Y Results Are Predictive of the Risk of Major Adverse Cardiac Events in Korean Patients Receiving Clopidogrel Therapy Following Acute Coronary Syndrome Clopidogrel is one of the most commonly used anti-platelet agents in cardiovascular diseases. We analyzed the relationship between the platelet function analyzer (PFA)-200 P2Y (INNOVANCE PFA-200 System, Siemens Healthcare, Germany) results and occurrence of major adverse cardiac events (MACEs) in Korean patients (...) with recent-onset acute coronary syndrome (ACS) taking clopidogrel.Between August 2013 and June 2016, we prospectively enrolled 106 patients with recent-onset ACS who had been treated with clopidogrel. We obtained blood samples and measured closure time (CT) using the PFA-200 P2Y test. Patients were divided into two groups on the basis of a CT cut-off value of 106 seconds. We compared patient characteristics and various MACEs that occurred during the follow-up period.The CTs for 78 patients exceeded

Full Text available with Trip Pro

2018 Annals of laboratory medicine

12. Dark chocolate modulates platelet function with a mechanism mediated by flavan-3-ol metabolites. (PubMed)

conjugates and phenyl-γ-valerolactones and their conjugates, at different times.The aims of this study were to explore the effect of dark chocolate on platelet function and to investigate the relationship between this interplay and flavan-3-ol derived metabolites.Eighteen healthy male volunteers ingested 50 g of 90% cocoa chocolate within 5 minutes. Blood samples were collected immediately before chocolate ingestion (T0) and 4 hours afterwards (T1). Platelet function analyzer (PFA)-100 closure time (...) Dark chocolate modulates platelet function with a mechanism mediated by flavan-3-ol metabolites. Cocoa is a rich source bioactive compounds, i.e., flavan-3-ols, and its consumption has been associated with several beneficial effects, such as the positive modulation of the hemostasis targeted by the platelet function. However, these phenolic compounds have a very low bioavailability and extensively undergo phase I and II metabolism, with the appearing into the bloodstream of (epi)catechin

2018 Medicine

13. Platelet Function Closure Time

Platelet Function Closure Time Platelet Function Closure Time Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Platelet Function (...) Closure Time Platelet Function Closure Time Aka: Platelet Function Closure Time , Platelet Function Analyzer , PFCT , PFA-100 From Related Chapters II. Indication Replaced by von specific tests (Willebrand Factor Activity, , Factor VIII Level) Historical indications Replaced to assess platelet function Personal or of easy or bleeding Post-operative bleeding III. Protocol: Sample Citrate anticoagulated whole blood IV. Mechanism Rapid quantitation of platelet function for hemostasis Blood passed through

2015 FP Notebook

14. Hemostatic properties of cold-stored whole blood leukoreduced using a platelet-sparing versus a non-platelet-sparing filter. (PubMed)

duration, on coagulation laboratory testing of WB.Ten units of LR WB-5 units manufactured with a Food and Drug Administration (FDA)-approved platelet (PLT)-sparing filter (WB-PS) and 5 units manufactured with an FDA-approved non-PLT-sparing filter (WB-NPS)-underwent complete blood count, PLT function analyzer (PFA [PFA-100]), thromboelastography (TEG), prothrombin time (PT), partial thromboplastin time (PTT), Factor (F)V activity, chromogenic FVIII, thrombin generation, and microparticle quantification (...) on Storage Days 3, 5, 7, 10, and 14.WB-PS contains more PLTs than WB-NPS (mean, 71 × 109 /L vs. 1 × 109 /L, p < 0.001). WB-PS yielded essentially normal TEG tracings, while TEG tracings of WB-NPS were grossly abnormal (mean reaction time, 7.0 min for WB-PS vs. 9.7 min for WB-NPS, p < 0.001; mean alpha-angle 54.9° vs. 38.1°, p < 0.001; mean maximum amplitude, 54.9 mm vs. 13.9 mm, p < 0.001). PFA-100 closure was more common among units of WB-PS compared to units of WB-NPS (72% vs. 4%, p < 0.001). PT, PTT

2019 Transfusion

15. Utility of preoperative in vitro platelet function tests for predicting bleeding risk in patients undergoing functional endoscopic sinus surgery (PubMed)

Utility of preoperative in vitro platelet function tests for predicting bleeding risk in patients undergoing functional endoscopic sinus surgery It is necessary to predict the bleeding risk in patients undergoing functional endoscopic sinus surgery (FESS). To evaluate the adequacy of primary hemostasis, preoperative hemostatic screening tests are used. In the present study, we determined whether there is a positive correlation between prolonged closure time (CT) with collagen/epinephrine (CT (...) -epi), prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT) and bleeding during FESS.We reviewed the medical records of 90 patients without bleeding histories who had undergone FESS from March 2013 to June 2014. More than 200 mL of blood loss was defined as moderate bleeding during surgery. With respect to bleeding during surgery, we determined the sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) of CT

Full Text available with Trip Pro

2016 Journal of blood medicine

16. Comparison of the effects of a balanced crystalloid-based and a saline-based tetrastarch solution on canine whole blood coagulation and platelet function. (PubMed)

for arthroscopy or imaging studies.Dogs received a 15 mL/kg intravenous bolus of HES-SAL (n = 13), HES-BAL (n = 14), or a modified Ringer's solution (n = 10) over 30-40 minutes. Coagulation was analyzed using a Platelet Function Analyzer-100 (closure time [CtPFA ]), and whole blood thromboelastometry (ROTEM) with extrinsically (ex-tem and fib-tem) and intrinsically (in-tem) activated assays, which assessed clotting time (CT), clot formation time (CFT), maximal clot firmness (MCF), and lysis index (LI (...) Comparison of the effects of a balanced crystalloid-based and a saline-based tetrastarch solution on canine whole blood coagulation and platelet function. To evaluate the effects of a 6% hydroxyethyl starch (130/0.42) solution in either a buffered, electrolyte-balanced (HES-BAL), or a saline (HES-SAL) carrier solution on canine platelet function and whole blood coagulation.Prospective, randomized study.University teaching hospital.Thirty-seven client-owned dogs undergoing general anesthesia

2017 Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

17. Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis (PubMed)

and morphology. Platelet phenotyping showed: prolonged PFA-100 closure times; normal expression of major glycoprotein receptors; severely reduced platelet aggregation response to ADP and collagen (both patients); aggregation response to PAR1 and arachidonic acid markedly impaired in one patient; PMA-induced aggregation unaffected; platelet secretion, clot retraction, and spreading minimally affected. Genetic analysis identified two new homozygous variants in RASGRP2: c.706C>T (p.Q236X) and c.887G>A (p.C296Y (...) Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis The RASGRP2 gene encodes the Ca2+ and DAG-regulated guanine nucleotide exchange factor I (CalDAG-GEFI), which plays a key role in integrin activation in platelets and neutrophils. We here report two new RASGRP2 variants associated with platelet dysfunction and bleeding in patients. The homozygous patients had normal platelet and neutrophil counts

Full Text available with Trip Pro

2017 Platelets

18. Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies (PubMed)

the coimmunoprecipitation of GP VI-bound Lyn after convulxin stimulation. The surface plasmon resonance results revealed that honokiol binds directly to GP VI, with a KD of 289 μM. Platelet function analysis revealed that honokiol substantially prolonged the closure time in human whole blood and increased the occlusion time of thrombotic platelet plug formation in mice. In conclusion, honokiol acts as a potent antagonist of collagen GP VI in human platelets, and it has therapeutic potential in the prevention (...) Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies Honokiol, derived from Magnolia officinalis, has various pharmacological properties. Platelet activation plays a critical role in cardiovascular diseases. Honokiol has been reported to inhibit collagen-stimulated rabbit platelet aggregation. However, detailed further studies on the characteristics and functional activity of honokiol in platelet activation are relatively

Full Text available with Trip Pro

2017 Scientific reports

19. The Role of Platelet Function Analyzer Testing in Cardiac Surgery Transfusion Management (PubMed)

The Role of Platelet Function Analyzer Testing in Cardiac Surgery Transfusion Management Identifying high-risk patients for transfusion after cardiac operations would alter postoperative management. The aim of this study was to investigate closure time (CT) measured by platelet function analyzer (PFA) for prediction of bleeding and transfusions.66 patients were scheduled for coronary artery bypass graft (CABG) surgery and 30 patients for valve repair and replacement (non-CABG). Measurements (...) of PFA-100® CT for collagen and adenosine diphosphate (cADP) and collagen and epinephrine (cEPI) were performed 15 min after protamine administration. Blood loss was measured, and the amount of transfusion products was recorded postoperatively.The study demonstrated significant differences between CABG patients with cADP-CT ≥ 118 s and those with cADP-CT < 118 s with regard to blood loss for 24 h (p = 0.001) and blood loss for 25-48 h (p = 0.003) as well as fresh frozen plasma (p = 0.015), platelet

Full Text available with Trip Pro

2017 Transfusion Medicine and Hemotherapy

20. Laboratory investigation of heritable disorders of platelet function

disorders are currently the template BT and the Platelet Function Analyser (PFA‐100 ® ; Siemens Diagnostics) closure time. Other commercial platelet function assay systems are also available, including those designed to measure the effect of antiplatelet drugs ( ). Thromboelastography (TEG) and Rotational Thromboelastometry (ROTEM) provide global tests of haemostasis and platelet function and are mainly used within the surgical setting ( ). The utility of most of these assay systems including TEG/ROTEM (...) on operator technique, is subjective and is influenced by patient variables unrelated to haemostasis, such as age, gender, haematocrit, vascular pattern, skin thickness and skin temperature ( ; ). The BT therefore has poor reproducibility, sensitivity and specificity, as well as being invasive; for these reasons it is not recommended. Closure time by the platelet function analyser assay principle. The PFA‐100 ® device is a test system in which citrated whole blood is aspirated at high shear rates (5000

Full Text available with Trip Pro

2011 British Committee for Standards in Haematology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>