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161. Electric toothbrushes have greater efficacy in removing plaque compared to manual toothbrushes in children between four and seven.

Electric toothbrushes have greater efficacy in removing plaque compared to manual toothbrushes in children between four and seven. UTCAT2899, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Electric Toothbrushes Have Greater Efficacy in Removing Plaque Compared to Manual Toothbrushes in Children Between Four and Seven Clinical Question What is the efficacy of a power toothbrush compared to a manual toothbrush (...) in removing plaque in children between ages 4 and 7? Clinical Bottom Line In children ages 4 to 7, a power toothbrush removed significantly more plaque than a manual toothbrush Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Taschner/2012 68 patients between 4 and 7 years old with Quigley Hein plaque index of more than 1.8 Single-masked, randomized, split mouth clinical trial. Key results Overall Quigley Hein

2015 UTHSCSA Dental School CAT Library

162. Silver Nanoparticle (AgNP)-Containing Resin Bonding Systems Significantly Reduced the Viability of Caries-Related Bacteria and Plaque Biofilms

Silver Nanoparticle (AgNP)-Containing Resin Bonding Systems Significantly Reduced the Viability of Caries-Related Bacteria and Plaque Biofilms UTCAT2841, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Silver Nanoparticle (AgNP)-Containing Resin Bonding Systems Significantly Reduced the Viability of Caries-Related Bacteria and Plaque Biofilms Clinical Question In patients with class 1, class 2, or class 5 composite (...) restorations, is the incidence of secondary caries lower when using silver nanoparticle-incorporated resin bonding systems compared to conventional resin bonding systems? Clinical Bottom Line Studies performed in vitro demonstrated the inhibition of caries-related Streptococcus mutans and plaque-forming oral bacteria when AgNPs were incorporated into resin bonding systems. This is based on studies showing a reduction in metabolic activity, number of colony forming units (CFUs), and lactic acid production

2015 UTHSCSA Dental School CAT Library

163. Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone. Full Text available with Trip Pro

Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone. Recent studies have yielded conflicting results as to whether testosterone treatment increases cardiovascular risk.To test the hypothesis that testosterone treatment of older men with low testosterone slows progression of noncalcified coronary artery plaque volume.Double-blinded, placebo-controlled trial at 9 academic medical centers in the United States. The participants were 170 of 788 men aged 65 (...) years or older with an average of 2 serum testosterone levels lower than 275 ng/dL (82 men assigned to placebo, 88 to testosterone) and symptoms suggestive of hypogonadism who were enrolled in the Testosterone Trials between June 24, 2010, and June 9, 2014.Testosterone gel, with the dose adjusted to maintain the testosterone level in the normal range for young men, or placebo gel for 12 months.The primary outcome was noncalcified coronary artery plaque volume, as determined by coronary computed

2017 JAMA Controlled trial quality: predicted high

164. Tildrakizumab versus placebo or etanercept for chronic plaque psoriasis (reSURFACE 1 and reSURFACE 2): results from two randomised controlled, phase 3 trials. (Abstract)

Tildrakizumab versus placebo or etanercept for chronic plaque psoriasis (reSURFACE 1 and reSURFACE 2): results from two randomised controlled, phase 3 trials. Tildrakizumab is a high-affinity, humanised, IgG1 κ antibody targeting interleukin 23 p19 that represents an evolving treatment strategy in chronic plaque psoriasis. Previous research suggested clinical improvement with inhibition of interleukin 23 p19. We did two phase 3 trials to investigate whether tildrakizumab is superior to placebo (...) and etanercept in the treatment of chronic plaque psoriasis.We did two three-part, parallel group, double-blind, randomised controlled studies, reSURFACE 1 (at 118 sites in Australia, Canada, Japan, the UK, and the USA) and reSURFACE 2 (at 132 sites in Europe, Israel, and the USA). Participants aged 18 years or older with moderate-to-severe chronic plaque psoriasis (body surface area involvement ≥10%, Physician's Global Assessment [PGA] score ≥3, and Psoriasis Area and Severity Index [PASI] score ≥12) were

2017 Lancet Controlled trial quality: predicted high

165. Efficacy and safety of adalimumab every other week versus methotrexate once weekly in children and adolescents with severe chronic plaque psoriasis: a randomised, double-blind, phase 3 trial. (Abstract)

Efficacy and safety of adalimumab every other week versus methotrexate once weekly in children and adolescents with severe chronic plaque psoriasis: a randomised, double-blind, phase 3 trial. Adalimumab is indicated for the treatment of moderate to severe psoriasis in adults. We assessed the efficacy and safety of adalimumab in children and adolescents with severe plaque psoriasis.This randomised, double-blind, multiperiod, phase 3 trial was done at 38 clinics in 13 countries. Patients (aged ≥4 (...) to <18 years) with severe plaque psoriasis who had not responded to topical therapy were randomly assigned with an interactive voice or web-response system (1:1:1) to receive adalimumab 0·8 mg/kg or 0·4 mg/kg subcutaneously at week 0, then every other week starting at week 1, or oral methotrexate once weekly (0·1-0·4 mg/kg) for 16 weeks. Randomisation was stratified by history of etanercept treatment, with a block size of three. Responders were withdrawn from treatment (for up to 36 weeks) and re

2017 Lancet Controlled trial quality: predicted high

166. Risankizumab versus Ustekinumab for Moderate-to-Severe Plaque Psoriasis. (Abstract)

Risankizumab versus Ustekinumab for Moderate-to-Severe Plaque Psoriasis. Interleukin-23 is thought to be critical to the pathogenesis of psoriasis. We compared risankizumab (BI 655066), a humanized IgG1 monoclonal antibody that inhibits interleukin-23 by specifically targeting the p19 subunit and thus prevents interleukin-23 signaling, and ustekinumab, an interleukin-12 and interleukin-23 inhibitor, in patients with moderate-to-severe plaque psoriasis.We randomly assigned a total of 166

2017 NEJM Controlled trial quality: uncertain

167. Methotrexate efficacy and tolerance in plaque psoriasis. A prospective real-life multicentre study in France. (Abstract)

Methotrexate efficacy and tolerance in plaque psoriasis. A prospective real-life multicentre study in France. Methotrexate (MTX) is a major systemic treatment for moderate to severe plaque psoriasis. A randomized trial has recently been published evaluating a single weekly dosage (17.5mg), but few prospective real-life data are available. The main objective of this study was to prospectively evaluate the efficacy of MTX in real-life. The secondary objectives were to evaluate predictive (...) parameters for treatment efficacy and the frequency of adverse events.A prospective cohort involving consecutive at in 25 centres belonging to GEM RESOPSO included all adults with plaque psoriasis in whom MTX treatment was initiated. The efficacy criterion was achievement of PASI 75 at week (W) 12/16. The impact of demographic data, psoriasis characteristics (duration, topography, rheumatism), dosage (W12/16 dosage, cumulative dose after 4 weeks), and mode of administration (subcutaneous vs. oral

2019 Annales de dermatologie et de venereologie Controlled trial quality: uncertain

168. Comparison of Plaque Removal and Wear between Charcoal Infused Bristle and Nylon Bristle Toothbrushes: A Randomized Clinical Crossover Study. (Abstract)

Comparison of Plaque Removal and Wear between Charcoal Infused Bristle and Nylon Bristle Toothbrushes: A Randomized Clinical Crossover Study. To compare plaque removal and wear between charcoal infused bristle toothbrushes (T1) and nylon bristle toothbrushes (T2) in a randomized clinical crossover study.A cross-over study was conducted in 2 phases of 6 weeks duration each with an intervening 2-week washout. Twenty-five participants meeting inclusion criteria were randomly allocated into groups (...) A (13) and B (12). In phase 1: group A was assigned T1 and group B was assigned T2. Toothbrushing was advised twice daily for 2 minutes by modified bass technique after meals. At baseline, 3 weeks and 6 weeks the wear index (WI), plaque index (PI) and gingival index (GI) were recorded. Following washout in phase 2 group A was assigned T2 and group B was assigned T1 and the same study protocol was followed.Intra-group comparison between baseline, 3 and 6 weeks by the paired t-test resulted

2019 The journal of contemporary dental practice Controlled trial quality: uncertain

169. Efficacy and safety of risankizumab in Japanese patients with moderate to severe plaque psoriasis: Results from the SustaIMM phase 2/3 trial. Full Text available with Trip Pro

Efficacy and safety of risankizumab in Japanese patients with moderate to severe plaque psoriasis: Results from the SustaIMM phase 2/3 trial. Risankizumab, a humanized immunoglobulin G1 monoclonal antibody, selectively inhibits interleukin-23, a key cytokine in the pathogenesis of psoriasis, by binding to its p19 subunit. In SustaIMM (ClinicalTrials.gov/NCT03000075), a phase 2/3, double-blinded, placebo-controlled study, Japanese patients with moderate to severe plaque psoriasis (n = 171) were (...) versus placebo. Through week 52, PASI and sPGA responses increased or were maintained and treatment-emergent adverse events were comparable across treatment groups. Both doses of risankizumab were superior to placebo in treating patients with moderate to severe plaque psoriasis. The safety profile was consistent with previous risankizumab trials, with no new or unexpected safety findings.© 2019 AbbVie. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese

2019 The Journal of dermatology Controlled trial quality: predicted high

170. Effect of Propolis mouthwash on plaque and gingival indices over fixed orthodontic patients. Full Text available with Trip Pro

Effect of Propolis mouthwash on plaque and gingival indices over fixed orthodontic patients. In patients with fixed orthodontics, the presence of orthodontic appliances causes dental plaque accumulation and hygiene problems. The purpose of this study was to evaluate the effect of Propolis and chlorhexidine mouthwashes on plaque and gingival indices in patients who are undergoing orthodontic treatment.In this triple blind study, in total, 37 patients aged from 15 to 35 years those who have been (...) undergoing fixed orthodontic treatment were studied. After that, one of the mouthwashes that containing either Propolis or Chlorhexidine was randomly prescribed to patients. The patients were asked to use mouthwashes twice a day after brushing their teeth for three weeks consecutively. Indicators of plaque, gingival and periodontal status (PI, GI, CPI) were determined on Ramford teeth at the beginning and at the end of three weeks for each patient. Then the results were analyzed statistically.The

2019 Journal of clinical and experimental dentistry Controlled trial quality: uncertain

171. Efficacy of Three Types of Plaque Control Methods During Fixed Orthodontic Treatment: A Randomized Controlled Trial. Full Text available with Trip Pro

Efficacy of Three Types of Plaque Control Methods During Fixed Orthodontic Treatment: A Randomized Controlled Trial. The aim of this study was to evaluate and compare the efficacy of three types of plaque control methods among 13- to 35-year-old subjects receiving fixed orthodontic treatment in Coorg Institute of Dental Sciences, Virajpet, Coorg district, Karnataka, India.A total of 111 subjects who fulfilled the inclusion and exclusion criteria were randomly included in the study. The subjects (...) were recalled after 1 month of the commencement of fixed orthodontic treatment for the recording of baseline data including plaque index (PI), gingival index (GI), and modified papillary bleeding index (MPBI). After recording of the baseline data, the subjects were randomly allocated into each of the intervention groups, i.e., group A (manual tooth brush), group B (powered tooth brush), and group C (manual tooth brush combined with mouthwash) by lottery method. Further, all the subjects were

2019 Journal of pharmacy & bioallied sciences Controlled trial quality: uncertain

172. Statins' Withdrawal Induces Atherosclerotic Plaque Destabilization in Animal Model-A "Rebound" Stimulation of Inflammation. (Abstract)

Statins' Withdrawal Induces Atherosclerotic Plaque Destabilization in Animal Model-A "Rebound" Stimulation of Inflammation. To evaluate the impact of atorvastatin discontinuation on the progression and stability of atherosclerotic plaques in a valid animal model of atherosclerosis.Seventy ApoE-/- male mice fed with high-fat diet were randomly assigned into: (1) long-term intervention groups: (i) ATL, received atorvastatin for 12 weeks, (ii) CO-12W, control received vehicle for 12 weeks, (iii (...) atherosclerosis regression and stabilization compared to control ( P < .05). Atorvastatin's withdrawal was associated with acute (ATW-3D) reduction in connective tissue and collagen contents within plaques compared to ATS ( P < .05). Those changes were almost restored after a while (ATW-7D) and started appearing again after longer cessation (ATW-6W). Moreover, atorvastatin withdrawal induced shortly (ATW-3D) a peak in inflammatory markers (macrophages, MCP-1, tumor necrosis factor-α) and matrix

2019 Journal of cardiovascular pharmacology and therapeutics Controlled trial quality: uncertain

173. The effect of fluoride varnish and chlorhexidine gel on white spots and gingival and plaque indices in fixed orthodontic patients: A placebo-controlled study. (Abstract)

The effect of fluoride varnish and chlorhexidine gel on white spots and gingival and plaque indices in fixed orthodontic patients: A placebo-controlled study. Difficulties to maintain good oral hygiene during orthodontic treatment can cause prolonged accumulation of dental plaque, thereby increasing the risk of developing gingival inflammation and periodontal disease as well as enamel demineralization and caries. The purpose of this study was to determine the effect of chlorhexidine (CHX) gel (...) and fluoride varnish versus placebo and control groups on plaque and gingival indices as well as their influence on enamel demineralization prevention in orthodontic patients with fixed appliances.In this clinical trial, forty patients with fixed orthodontic appliances were participated and were divided into control, CHX gel (0.2%), fluoride varnish (5%), and placebo groups. The parameters evaluated in this research were dental plaque index (DPI), index of gingival inflammation, and white spot lesion (WSL

2019 Dental research journal Controlled trial quality: uncertain

174. In situ Effect of Arginine-Containing Dentifrice on Plaque Composition and on Enamel Demineralization under Distinct Cariogenic Conditions. (Abstract)

In situ Effect of Arginine-Containing Dentifrice on Plaque Composition and on Enamel Demineralization under Distinct Cariogenic Conditions. There is limited evidence that arginine-containing fluoridated dentifrices (AFD) have a better anticaries effect than regular fluoridated dentifrices (FD), especially in subjects at a higher risk for caries development. This study aimed to assess the effect of AFD on enamel demineralization and on the microbial and biochemical compositions of biofilm formed

2019 Caries research Controlled trial quality: uncertain

175. Fate of Nonculprit Plaques in Patients With STEMI Undergoing Primary PCI Followed by Statin Therapy: A Serial Optical Coherence Tomography Analysis From the OCTAVIA Study. Full Text available with Trip Pro

Fate of Nonculprit Plaques in Patients With STEMI Undergoing Primary PCI Followed by Statin Therapy: A Serial Optical Coherence Tomography Analysis From the OCTAVIA Study. 28017394 2019 02 04 2019 02 15 1876-7591 10 7 2017 07 JACC. Cardiovascular imaging JACC Cardiovasc Imaging Fate of Nonculprit Plaques in Patients With STEMI Undergoing Primary PCI Followed by Statin Therapy: A Serial Optical Coherence Tomography Analysis From the OCTAVIA Study. 827-829 S1936-878X(16)30796-3 10.1016/j.jcmg (...) diagnostic imaging pathology Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage adverse effects Male Percutaneous Coronary Intervention adverse effects Plaque, Atherosclerotic Predictive Value of Tests Prospective Studies ST Elevation Myocardial Infarction diagnostic imaging pathology therapy Time Factors Tomography, Optical Coherence Treatment Outcome 2016 06 16 2016 09 02 2016 09 08 2016 12 27 6 0 2019 2 5 6 0 2016 12 27 6 0 ppublish 28017394 S1936-878X(16)30796-3

2019 JACC. Cardiovascular imaging Controlled trial quality: uncertain

176. Efficacy of a Topical Formulation of Sodium Bicarbonate in Mild to Moderate Stable Plaque Psoriasis: a Randomized, Blinded, Intrapatient, Controlled Study. Full Text available with Trip Pro

Efficacy of a Topical Formulation of Sodium Bicarbonate in Mild to Moderate Stable Plaque Psoriasis: a Randomized, Blinded, Intrapatient, Controlled Study. Psoriasis is a chronic inflammatory disease characterized by the presence of erythematosquamous lesions. A wide variety of topical treatments for therapy of this pathology are available, including sodium bicarbonate (SB). A few papers reported in literature focus on use of SB baths for treatment of psoriasis, but none assess evidence (...) concerning the efficacy of SB topical preparations. This study aimed to determine the effectiveness of a galenic SB in lanette vax formulation compared with lanette vax base in mild to moderate stable plaque psoriasis.A randomized, double-blind, intrapatient, controlled study was performed in 28 days. Thirty patients of both genders were selected for testing. A blinded investigator evaluated the patients' psoriasis using a modified Psoriasis Area and Severity Index (PASI), body surface area (BSA

2019 Dermatology and therapy Controlled trial quality: uncertain

177. Comparative Evaluation of Plaque Inhibitory and Antimicrobial Efficacy of Probiotic and Chlorhexidine Oral Rinses in Orthodontic Patients: A Randomized Clinical Trial. Full Text available with Trip Pro

Comparative Evaluation of Plaque Inhibitory and Antimicrobial Efficacy of Probiotic and Chlorhexidine Oral Rinses in Orthodontic Patients: A Randomized Clinical Trial. Antimicrobial agents serve as an effective adjunct in plaque control, and chlorhexidine has been the gold standard. However, the philosophy that natural agents are better for children's oral health is on the rise. Probiotic technology represents a breakthrough approach to maintain oral health by utilizing natural beneficial (...) bacteria commonly found in healthy mouths.To compare efficacy of probiotic and chlorhexidine oral rinses in orthodontic patients.30 healthy patients undergoing fixed orthodontic treatment were randomly selected for the study by block randomization and allocation concealment and were divided into three groups: group a, 0.2% chlorhexidine mouthwash; group b, probiotic mouthwash; and group c, a control group.Probiotic and chlorhexidine groups had significantly decreased plaque indices as compared

2019 International journal of dentistry Controlled trial quality: uncertain

178. Effect of supragingival oral irrigation as an adjunct to toothbrushing on plaque accumulation in chronic generalized gingivitis patients. Full Text available with Trip Pro

Effect of supragingival oral irrigation as an adjunct to toothbrushing on plaque accumulation in chronic generalized gingivitis patients. The aim of this study was to evaluate the efficacy of supragingival oral irrigation either with water or different concentrations of chlorhexidine (CHX) digluconate as an adjunct to toothbrushing on plaque accumulation in chronic generalized gingivitis patients.Fifty patients were randomly allocated into five groups. Group 1: toothbrushing alone, Group 2

2019 Journal of Indian Society of Periodontology Controlled trial quality: uncertain

179. Cost per response for guselkumab versus adalimumab in the United States using data from a head-to-head trial in moderate-to-severe plaque psoriasis. Full Text available with Trip Pro

Cost per response for guselkumab versus adalimumab in the United States using data from a head-to-head trial in moderate-to-severe plaque psoriasis. Aims: To estimate annual cost per response (CPR) in the US and number needed to treat (NNT) among patients receiving guselkumab or adalimumab treatment for moderate-to-severe plaque psoriasis (PsO).Materials and methods: Results from VOYAGE 1, a double-blind, placebo-controlled, head-to-head, 48-week study of guselkumab compared with adalimumab

2019 Journal of medical economics Controlled trial quality: uncertain

180. A Randomized Parallel Study to Compare the Effects of Powered and Manual Tooth Brushing on Gingival Health and Plaque. (Abstract)

A Randomized Parallel Study to Compare the Effects of Powered and Manual Tooth Brushing on Gingival Health and Plaque. To compare the effect of powered and manual tooth brushing on plaque and gingivitis following two and six weeks of home use.This was a randomized, three-arm, parallel-design clinical trial. Eligible participants were manual toothbrush users who were generally healthy non-smokers, aged 18-65 years, with a plaque score of = 1.8 per Lobene and Soparkar Modified Plaque Index (MPI (...) toothbrush group and the manual toothbrush was statistically significant (p < 0.0001). Statistically significant differences were also observed between DC-GH, DC-C, and manual tooth brushing for MGI at Week 6, as well as for MPI and GBI at Weeks 2 and 6.The powered toothbrush, used in either Gum Health or Clean mode, was statistically significantly superior to a manual tooth brush in reducing gingival inflammation, gingival bleeding, and plaque following two and six weeks of home use.Copyright©

2019 The Journal of clinical dentistry Controlled trial quality: uncertain

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