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141. Efficacy and safety of Tildrakizumab for treatment of moderate to severe plaque psoriasis: a systematic review and meta-analysis

Efficacy and safety of Tildrakizumab for treatment of moderate to severe plaque psoriasis: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

142. Does indirect bonding influence higher plaque accumulation and the presence of white spot lesions when compared to direct bonding?

Does indirect bonding influence higher plaque accumulation and the presence of white spot lesions when compared to direct bonding? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record

2019 PROSPERO

143. Ablation of Interferon Regulatory Factor 3 (IRF3) promotes the stability of atherosclerotic plaques Full Text available with Trip Pro

Ablation of Interferon Regulatory Factor 3 (IRF3) promotes the stability of atherosclerotic plaques 28115512 2018 01 16 2018 12 02 1524-4563 69 3 2017 03 Hypertension (Dallas, Tex. : 1979) Hypertension Ablation of Interferon Regulatory Factor 3 Promotes the Stability of Atherosclerotic Plaques. 407-408 10.1161/HYPERTENSIONAHA.116.08486 Okon Imoh I From the Center for Molecular and Translational Medicine, Georgia State University, Atlanta, GA. Ding Ye Y From the Center for Molecular (...) HL NHLBI NIH HHS United States R01 HL080499 HL NHLBI NIH HHS United States R01 HL096032 HL NHLBI NIH HHS United States R01 HL132500 HL NHLBI NIH HHS United States Editorial Research Support, N.I.H., Extramural Comment 2017 01 23 United States Hypertension 7906255 0194-911X 0 Apolipoproteins E 0 Interferon Regulatory Factor-3 IM Hypertension. 2017 Mar;69(3):510-520 28115514 Apolipoproteins E Atherosclerosis Humans Interferon Regulatory Factor-3 Plaque, Atherosclerotic 2017 1 25 6 0 2018 1 18 6 0

2017 Hypertension (Dallas, Tex. : 1979)

144. Clinical utility of ixekizumab in the treatment of moderate-to-severe plaque psoriasis Full Text available with Trip Pro

Clinical utility of ixekizumab in the treatment of moderate-to-severe plaque psoriasis Psoriasis vulgaris is a chronic, immune-mediated systemic disease that affectŝ7.5 million people in the US. It can be treated with many therapies, often in combination, which include topicals, phototherapy, oral systemics, and biologics. Biologic agents target specific components of the immune system involved in the pathogenesis of psoriasis including TNF-alpha, IL-12, IL-17, and IL-23. The biologic (...) ixekizumab, approved for the treatment of moderate-severe plaque psoriasis in the US, targets IL-17. This review describes the role of IL-17 in psoriasis, the mechanism by which ixekizumab targets this cytokine, and the clinical utility of ixekizumab.

2017 Psoriasis (Auckland, N.Z.)

145. Blue plaque on the chest: A sign of systemic disease Full Text available with Trip Pro

Blue plaque on the chest: A sign of systemic disease 28831425 2019 02 26 2352-6475 3 3 2017 Sep International journal of women's dermatology Int J Womens Dermatol Blue plaque on the chest: A sign of systemic disease. 151-153 10.1016/j.ijwd.2017.06.006 Kelsey A A University of Connecticut, Health Center Dermatology Department, Farmington, CT. Bordelon J J University of Connecticut, Health Center Dermatology Department, Farmington, CT. Tendler B R BR University of Connecticut, Health Center (...) Dermatology Department, Farmington, CT. Rothe M M University of Connecticut, Health Center Dermatology Department, Farmington, CT. eng Case Reports 2017 07 24 Netherlands Int J Womens Dermatol 101654170 2352-6475 blue carcinoma malignancy papillary plaque thyroid 2017 05 22 2017 06 19 2017 06 20 2017 8 24 6 0 2017 8 24 6 0 2017 8 24 6 1 epublish 28831425 10.1016/j.ijwd.2017.06.006 S2352-6475(17)30055-2 PMC5555284 Am J Med. 1994 Nov;97(5):418-28 7977430 Am J Surg Pathol. 2010 Jan;34(1):44-52 19956062 World

2017 International journal of women's dermatology

146. Bone mineral density is lower in male than female patients with plaque-type psoriasis in Iran Full Text available with Trip Pro

Bone mineral density is lower in male than female patients with plaque-type psoriasis in Iran There are many similarities with regard to contributing cytokines in patients with psoriasis and osteoporosis. A theory of probable relationship between these two entities has been proposed but there is no concordant consensus. The aim of this study was to evaluate bone mineral density (BMD) in patients with psoriasis.This cross-sectional study of BMD was conducted with 64 eligible patients

2017 International journal of women's dermatology

147. The clinical evaluation of Vi-one chlorhexidine mouthwash on plaque-induced gingivitis: A double-blind randomized clinical trial Full Text available with Trip Pro

The clinical evaluation of Vi-one chlorhexidine mouthwash on plaque-induced gingivitis: A double-blind randomized clinical trial Chlorhexidine (CHX) is the most effective antiseptic mouthwash to date. Essential oil such as thymol, have inhibitory and biocidal effects a range of bacteria.To determine the effect of mouthwash containing CHX and thymol on plaque induced gingivitis.This double-blind randomized clinical trial study was performed on 60 patients with plaque induced gingivitis who were (...) randomly divided into two groups: Group I (CHX/thymol mouthwash-Vi-one) and Group II (CHX mouthwash-Behsa). Patients in each group underwent scaling and root planning and polishing, then were educated about BASS-Method brushing, and were recommended Oral-B toothbrushes and Pooneh toothpaste. The two groups were asked to rinse their mouths for 60 seconds twice a day, once in the morning and once at night, after brushing their teeth. Plaque index, gingival index, bleeding index and stain index were

2017 Electronic physician Controlled trial quality: uncertain

148. The effect of tooth brushing and flossing sequence on dental plaque and gingival inflammation: a systematic review

The effect of tooth brushing and flossing sequence on dental plaque and gingival inflammation: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne") for correspondence

2019 PROSPERO

149. Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events—design and rationale Full Text available with Trip Pro

Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events—design and rationale Carotid atherosclerotic plaque is identified as one of the main sources of ischaemic stroke. However, the prevalence of carotid high-risk atherosclerotic plaque in Chinese patients with ischaemic cerebrovascular events has been inconsistently reported (...) and needs to be investigated in a large population.The primary objective of CARE II study was to determine the prevalence and characteristics of high-risk features of atherosclerotic plaques in the carotid arteries in Chinese patients with recent ischaemic stroke or transient ischaemia attack (TIA). The relationship between carotid plaque features and cerebral infarcts, the differences of carotid plaque patterns among different regions of China and the gender specific characteristics of carotid plaque

2017 Stroke and vascular neurology

150. Carotid plaque burden is associated with higher levels of total homocysteine Full Text available with Trip Pro

Carotid plaque burden is associated with higher levels of total homocysteine 28959489 2019 01 12 2059-8696 2 1 2017 Mar Stroke and vascular neurology Stroke Vasc Neurol Carotid plaque burden is associated with higher levels of total homocysteine. 40 10.1136/svn-2017-000076 Spence J David JD Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada. eng Journal Article 2017 02 24 England Stroke Vasc Neurol 101689996 2059-8696 (...) Carotid plaque burden total homocysteineeine Competing interests: JDS is an officer of Vascularis. 2017 02 06 2017 02 07 2017 9 30 6 0 2017 9 30 6 0 2017 9 30 6 1 epublish 28959489 10.1136/svn-2017-000076 svn-2017-000076 PMC5435215 Arterioscler Thromb Vasc Biol. 2000 Jul;20(7):1704-6 10894806 CMAJ. 2005 Jun 7;172(12):1569-73 15939916 Atherosclerosis. 2015 Jul;241(1):208-10 25980844 Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1910-3 26310810

2017 Stroke and vascular neurology

151. Carious status and supragingival plaque microbiota in hemodialysis patients. Full Text available with Trip Pro

Carious status and supragingival plaque microbiota in hemodialysis patients. The aim of this study was to evaluate the carious status and the microbial profiles of supragingival plaque in patients with chronic kidney disease undergoing hemodialysis.This study included 30 patients with chronic kidney disease undergoing hemodialysis as well as 30 control subjects. Dental examination was performed and the decayed-missing-filled-teeth was recorded. Supragingival plaque was taken and analyzed using (...) 16S rRNA gene amplicon by Illumina MiSeq sequencing to detect microbial composition and community diversity and structure.The level of decayed-missing-filled-teeth was higher in the hemodialysis group than that in the control group. Microbial analysis showed a decrease in α diversity and a increase in relative abundance and prevalence of many acidogenic and aciduric caries related species in the supragingival plaque samples of the hemodialysis patients, including Streptococcus mutans

2018 PLoS ONE

152. Molecular imaging of MMP activity discriminates unstable from stable plaque phenotypes in shear-stress induced murine atherosclerosis. Full Text available with Trip Pro

Molecular imaging of MMP activity discriminates unstable from stable plaque phenotypes in shear-stress induced murine atherosclerosis. As atherosclerotic plaque ruptures are the primary cause of ischaemic events, their preventive identification by imaging remains a clinical challenge. Matrix metalloproteinases (MMP) are involved in plaque progression and destabilisation and are therefore promising targets to characterize rupture-prone unstable plaques. This study aims at evaluating MMP imaging (...) to discriminate unstable from stable plaque phenotypes.ApoE deficient mice (ApoE-/-) on a high cholesterol diet underwent implantation of a tapered cuff around the right common carotid artery (CCA) inducing a highly inflamed atherosclerotic plaque upstream (US) and a more stable plaque phenotype downstream (DS) of the cuff. 8 weeks after surgery, the MMP inhibitor-based photoprobe Cy5.5-AF443 was administered i.v. 3h prior to in situ and ex vivo fluorescence reflectance imaging of the CCAs. Thereafter, CCAs

2018 PLoS ONE

153. The occurrence of Treponema spp. in gingival plaque from dogs with varying degree of periodontal disease. Full Text available with Trip Pro

The occurrence of Treponema spp. in gingival plaque from dogs with varying degree of periodontal disease. Periodontal disease is common in dogs and is initiated by gingival plaque composed of several hundred bacterial species. Some of these species have specifically been pointed out as potential periodontal pathogens, such as Treponema spp. Treponema spp. are difficult to culture and therefore the majority have been detected by culture-independent methods, such as PCR (Polymerase Chain Reaction (...) ). This leaves many Treponema spp. uncharacterized and unnamed. In this study, treponemes were investigated in gingival plaque from dogs with varying degree of periodontal disease with the aim to describe their occurrence and diversity in dogs. The methods used were culture, phase-contrast microscopy, PCR targeting the 16SrRNA-tRNAIle intergenic spacer region (ISR2), sequencing of the ISR2 and phylogenetic analysis. Treponema spp. were detected in samples from 10 out of 11 dogs and isolates were obtained

2018 PLoS ONE

154. Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease. Full Text available with Trip Pro

Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease. Transgenic rat models of Alzheimer's disease were used to examine differences in memory and brain histology. Double transgenic female rats (APP+PS1) over-expressing human amyloid precursor protein (APP) and presenilin 1 (PS1) and single transgenic rats (APP21) over-expressing human APP were compared with wild type Fischer rats (WT). The Barnes maze assessed (...) learning and memory and showed that both APP21 and APP+PS1 rats made significantly more errors than the WT rats during the acquisition phase, signifying slower learning. Additionally, the APP+PS1 rats made significantly more errors following a retention interval, indicating impaired memory compared to both the APP21 and WT rats. Immunohistochemistry using an antibody against amyloid-β (Aβ) showed extensive and mostly diffuse Aβ plaques in the hippocampus and dense plaques that contained tau

2018 PLoS ONE

155. Macrophage polarization and acceleration of atherosclerotic plaques in a swine model. Full Text available with Trip Pro

Macrophage polarization and acceleration of atherosclerotic plaques in a swine model. Atherosclerosis is a well-known cause of cardiovascular disease and is associated with a variety of inflammatory reactions. However, an adequate large-animal model of advanced plaques to investigate the pathophysiology of atherosclerosis is lacking. Therefore, we developed and assessed a swine model of advanced atherosclerotic plaques with macrophage polarization.Mini-pigs were fed a 2% high-cholesterol diet (...) for 7 weeks followed by withdrawal periods of 4 weeks. Endothelial denudation was performed using a balloon catheter on 32 coronary and femoral arteries of 8 mini-pigs. Inflammatory proteins (high-mobility group box 1 [HMGB1] or tumor necrosis factor alpha (TNF-α) were injected via a micro-infusion catheter into the vessel wall. All lesions were assessed with angiography and optical coherence tomography and all tissues were harvested for histological evaluation.Intima/plaque area was significantly

2018 PLoS ONE

156. Effect of chewing an apple on dental plaque removal and on salivary bacterial viability. Full Text available with Trip Pro

Effect of chewing an apple on dental plaque removal and on salivary bacterial viability. Studies on dental plaque removal by chewing an apple are scarce and dated, with conflicting findings. This study aimed to determine whether chewing an apple produced mechanical removal of dental plaque or had any effect on salivary bacterial viability.The study group consisted of 20 healthy adults with good oral health status who were randomly assigned to brush their teeth or eat an apple. After 2 weeks (...) , the experiment was repeated with the order reversed. Plaque index (PI) and the bacterial viability (BV) in a sample of whole saliva (spit) were determined before brushing or apple eating (baseline, B), immediately afterward (A) and 24 hours afterward (24).After chewing an apple, PI-A was significantly higher than both PI-B (P < .001) and PI-24 (P < .001). BV-A was significantly lower than BV-B (P < .001), with a return to baseline values at the BV-24 measurement.Chewing an apple does not remove dental plaque

2018 PLoS ONE Controlled trial quality: uncertain

157. Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls. Full Text available with Trip Pro

Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls. An unanswered question regarding Alzheimer disease dementia (ADD) is whether amyloid-beta (Aβ) plaques sequester toxic soluble Aβ species early during pathological progression. We previously reported that the concentration of soluble Aβ aggregates from patients with mild dementia was higher than soluble Aβ aggregates from patients with modest Aβ plaque burden but no dementia. The ratio (...) of soluble Aβ aggregate concentration to Aβ plaque area fully distinguished these groups of patients. We hypothesized that initially plaques may serve as a reservoir or sink for toxic soluble Aβ aggregates, sequestering them from other targets in the extracellular space and thereby preventing their toxicity. To initially test a generalized version of this hypothesis, we have performed binding assessments using biotinylated synthetic Aβ1-42 peptide. Aβ1-42-biotin peptide was incubated on unfixed frozen

2018 PLoS ONE

158. Distinctions and associations between the microbiota of saliva and supragingival plaque of permanent and deciduous teeth. Full Text available with Trip Pro

Distinctions and associations between the microbiota of saliva and supragingival plaque of permanent and deciduous teeth. Using salivary microbiota as an accurate proxy for monitoring supragingival microbiota remains controversial because their relationship remains unclear. The eruption of permanent teeth and the exfoliation of primary teeth in mixed dentition greatly alter microbial habitats, which may cause compositional shifts of oral microbiota from childhood to adults.This study's purpose (...) was to assess whether saliva represents a suitable sample for monitoring supragingival microbiota in healthy people, and to explore how the replacement process of deciduous teeth with permanent teeth in mixed dentition influences microbiota within the oral cavity.Samples of saliva and of supragingival plaque from permanent and deciduous teeth were collected separately from 20 healthy children with mixed dentition. To characterize their microbial communities, we used the V3-V4 hypervariable region

2018 PLoS ONE

159. Targeted metabolomic approach in men with carotid plaque. Full Text available with Trip Pro

Targeted metabolomic approach in men with carotid plaque. The aim of the study was to analyse the presence of several metabolites related to atherosclerosis in the plasma of patients with unstable carotid plaque and in the plasma of healthy subjects.We included 20 patients who had undergone carotid endarterectomy and 20 healthy subjects as a control group. All the subjects recruited were male. We used a metabolomic approach with liquid chromatography coupled to mass spectrometry to evaluate (...) plasma metabolite levels in the metabolic pathway involved in the progression of atherosclerotic plaque.We observed that circulating levels of 20-HETE were significantly higher in patients with atheroma plaque than in healthy subjects (p = 0.018). No differences were found with regard to the other metabolites analysed. We also conducted a random forest analysis and found that 20-HETE was the main differentiator in the list of selected metabolites. In addition, plasma levels of 20-HETE correlated

2018 PLoS ONE

160. Neem Powder is a Better Alternative to a Chemically Derived Mouthwash Against Dental Plaque

Neem Powder is a Better Alternative to a Chemically Derived Mouthwash Against Dental Plaque UTCAT2835, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Neem Powder is a Better Alternative to a Chemically Derived Mouthwash Against Dental Plaque Clinical Question Is there an effect on dental plaque using a neem powder mouthwash vs. a chemically derived mouthwash? Clinical Bottom Line Neem showed effectiveness on gingiva (...) better than chlorhexidine. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Balappanavar/2013 30 healthy human volunteers of age group 18-25 years were carried out. Randomized Controlled Trial Key results Mean plaque and gingival scores were reduced over the 3 week trial period for experimental and control groups. Anti-plaque effectiveness was observed in all groups and the highest being in group C (tea

2015 UTHSCSA Dental School CAT Library

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