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181. Gingivitis and plaque prevention using three commercially available dentifrices: A comparative clinical and microbiological randomized control parallel study. Full Text available with Trip Pro

Gingivitis and plaque prevention using three commercially available dentifrices: A comparative clinical and microbiological randomized control parallel study. The aim of the study was to compare the clinical and microbiological efficacy of Group I-delmopinol dentifrice, Group II-chlorhexidine, and Group III-triclosan-containing regularly used control dentifrice on plaque formation and gingivitis.A total of 45 healthy volunteer students fulfilling the inclusion criteria are recruited (...) for this randomized control parallel study. All the individuals were randomly assigned into 3 groups depending on the dentifrice prescribed. After the selection of individuals, thorough scaling and polishing were performed for all the individuals, and in a 4 days' washout period, they were refrained from regular oral hygiene maintenance and 0.9% NaCl (normal saline) rinse was prescribed to obtain plaque regrowth. Microbiological morphotypes were assessed using darkfield microscope.The data were analyzed using

2019 International journal of pharmaceutical investigation Controlled trial quality: uncertain

182. Effectiveness of erythrosine-mediated photodynamic antimicrobial chemotherapy on dental plaque aerobic microorganisms: A randomized controlled trial. Full Text available with Trip Pro

Effectiveness of erythrosine-mediated photodynamic antimicrobial chemotherapy on dental plaque aerobic microorganisms: A randomized controlled trial. Dental plaque is one of the predominant causes of major oral diseases. Although mechanical and chemical methods are extensively followed to control the development of plaque, plaque-related diseases still persist. Therefore, this necessitates for alternative measures of plaque control, one such alternative is photodynamic antimicrobial (...) chemotherapy (PACT).Split mouth randomized clinical trial (CTRI/2017/03/008239) was conducted on 30 participants who reported to the hospital. Participants were asked to rinse their mouth for 1 min using 10 ml of 25 μM erythrosine solutions. Same tooth on both quadrants of the same jaw are selected as the test and control. Intervention used was halogen-based composite curing light with wavelength of 500-590 nm. Plaque sample from the control tooth and test tooth was collected before and after exposure

2019 Journal of Indian Society of Periodontology Controlled trial quality: uncertain

183. Assessing the Synergistic Effect of a Fixed Combination Halobetasol Propionate 0.01% and Tazarotene 0.045% Lotion in Moderate-to-Severe Plaque Psoriasis (Abstract)

Assessing the Synergistic Effect of a Fixed Combination Halobetasol Propionate 0.01% and Tazarotene 0.045% Lotion in Moderate-to-Severe Plaque Psoriasis Background: Fixed combinations are commonplace in dermatology, providing significant efficacy and tolerability benefits. In some cases, two active ingredients complement each other providing a cumulative or additive effect. In rarer cases, a synergistic effect may be seen where the sum of the two active ingredients combined action is greater (...) than the sum of the efficacy of the constituent parts. Objective: To determine whether a novel halobetasol propionate 0.01% and tazarotene 0.045% (HP/TAZ) fixed combination lotion provides a synergistic effect in the treatment of moderate-to-severe plaque psoriasis. Methods: Post hoc analysis of 212 patients with moderate-to-severe plaque psoriasis randomized (2:2:2:1) to HP/TAZ lotion, HP, TAZ or vehicle once-daily for 8 weeks, with a 4-week posttreatment follow-up. Treatment success

2019 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

184. Effect of sugar-free chewing gum on plaque and gingivitis among 14-15-year-old school children: A randomized controlled trial. (Abstract)

Effect of sugar-free chewing gum on plaque and gingivitis among 14-15-year-old school children: A randomized controlled trial. The aim of the study was to find out the effect of sugar-free chewing gums (xylitol and sorbitol) on plaque and gingivitis among 14-15-year-old school children.A single center, double-blind, randomized controlled trial was conducted on 14-15-year-old children. Sample size was determined to be 48. Participants were randomly allocated to test group (xylitol [n = 12 (...) ], sorbitol [n = 12]) and control group (no gum, n = 24). Duration of the study was 14 days. Baseline assessment of plaque, gingival, and bleeding score, followed by oral prophylaxis. Selected children received daily two chewing gum (1.1 g each) to chew for 20 min postbreakfast and postlunch. Follow-up was done on 15th day. Analysis was done using independent t-test, ANOVA, and post hoc test. Significance level was kept at P < 0.05.There was a significant reduction in plaque, gingival, and bleeding score

2019 Indian journal of dental research : official publication of Indian Society for Dental Research Controlled trial quality: uncertain

185. Efficacy and safety of etanercept combined plus methotrexate and comparison of expression of pro-inflammatory factors expression for the treatment of moderate-to-severe plaque psoriasis. (Abstract)

Efficacy and safety of etanercept combined plus methotrexate and comparison of expression of pro-inflammatory factors expression for the treatment of moderate-to-severe plaque psoriasis. Etanercept has greatly improved management considerably. However, the efficacy and safety of combination therapy with methotrexate and the mechanism of action are not known. We aimed to describe the use of combined therapy of etanercept and methotrexate against moderate-to-severe plaque psoriasis in a Chinese (...) population. We also wished to study the changes in expression of pro-inflammatory factors in peripheral blood mononuclear cells (PBMCs) and serum after the treatment to ascertain the mechanism of action. Thirty patients with moderate-to-severe plaque psoriasis were assigned into a monotherapy group and combination group randomly and equally. All patients received etanercept (50 mg, s.c., weekly), whereas patients in the combination group also received oral methotrexate (7.5-15 mg, p.o., weekly). Serum

2019 International immunopharmacology Controlled trial quality: uncertain

186. The comparison of two professional prophylaxis systems in plaque removal and debonding of orthodontic brackets. Full Text available with Trip Pro

The comparison of two professional prophylaxis systems in plaque removal and debonding of orthodontic brackets. During orthodontic treatment, patients are expected to undergo consistent periodic prophylaxis as a result of complexities in oral hygiene. The aim of this study was to investigate, analyze, and compare the effectiveness of two professional prophylaxis systems of rubber cup polishing (RCP) and air-powder polishing (APP) in patients undergoing orthodontic treatment based on different (...) levels of plaque and pigment on teeth and the extent of attachment of brackets after prophylaxis.A total of 50 patients were selected for this clinical trial study. A couple of months after the orthodontic treatment, the patients were placed on professional prophylaxis in terms of the plaque index. Randomized cross-arch prophylaxis (right maxilla with left mandible), RCP (left maxilla with right mandible), and APP were carried out on the patients. The main indexes in the study (number of plaque

2019 Journal of Indian Society of Periodontology Controlled trial quality: uncertain

187. Whether Fire-needle Therapy Benefits Plaque Psoriasis: A Multicenter, Randomized, and Controlled Trial. (Abstract)

Whether Fire-needle Therapy Benefits Plaque Psoriasis: A Multicenter, Randomized, and Controlled Trial. To observe the clinical effectiveness and safety of fire-needle therapy, an external approach of Chinese medicine in treating plaque psoriasis.This study was a two-parallel-arm randomized controlled trial. A total of 151 participants with plaque psoriasis were randomly assigned to the fire-needle therapy group (treatment group, 76 cases) or the control group (75 cases) at a 1:1 allocation

2019 Chinese journal of integrative medicine Controlled trial quality: predicted high

188. A Comparison of the Effects of a Powered and Manual Toothbrush on Gingivitis and Plaque: A Randomized Parallel Clinical Trial. (Abstract)

A Comparison of the Effects of a Powered and Manual Toothbrush on Gingivitis and Plaque: A Randomized Parallel Clinical Trial. To compare the effect of a powered and a manual toothbrush on gingivitis and plaque following two and four weeks of home use.This was a randomized, parallel-design, single-blind clinical trial. Eligible participants were generally healthy non-smoking manual toothbrush users aged 18-65 years, with a plaque score of = 1.8 per Lobene and Soparkar Modified Plaque Index (MPI (...) ) following a 3-6 hour plaque accumulation period, and mild to moderate gingivitis defined as a Gingival Bleeding Index (GBI) = 1 on at least 20 sites. Subjects with advanced periodontal disease, xerostomia, excessive gingival recession, uncontrolled diabetes, and heavy deposits of calculus or rampant decay were excluded. Enrolled participants were randomly dispensed either a Philips Sonicare powered toothbrush used with the InterCare brush head (PTB) or an American Dental Association (ADA) reference

2019 The Journal of clinical dentistry Controlled trial quality: uncertain

189. Effect of toothpaste containing amine fluoride and stannous chloride on the reduction of dental plaque and gingival inflammation. A randomized controlled 12-week home-use study. (Abstract)

Effect of toothpaste containing amine fluoride and stannous chloride on the reduction of dental plaque and gingival inflammation. A randomized controlled 12-week home-use study. This single-centre, controlled, randomized, double-blinded clinical study in parallel groups was performed to assess the efficacy of an experimental toothpaste on plaque and gingivitis.In adult subjects with gingivitis, amine fluoride/stannous chloride toothpaste (test) and monofluorophosphate toothpaste (control) were (...) applied twice daily by regular toothbrushing at home. Evaluations of plaque index (PI), gingival index (GI), modified sulcus bleeding index (mSBI) and safety took place at baseline and after 3 and 12 weeks of study product use. After study completion, all subjects received a dental prophylaxis. A descriptive statistical analysis included means and standard deviations. Unpaired t tests compared index reductions between groups at a significance level of 0.05.Intention-to-treat analysis included 240 out

2019 International journal of dental hygiene Controlled trial quality: uncertain

190. Safety and efficacy of halobetasol propionate lotion 0.01% in the treatment of moderate to severe plaque psoriasis: a pooled analysis of 2 phase 3 studies. (Abstract)

Safety and efficacy of halobetasol propionate lotion 0.01% in the treatment of moderate to severe plaque psoriasis: a pooled analysis of 2 phase 3 studies. Potent topical corticosteroids (TCSs) are the mainstay of psoriasis treatment. Safety concerns have limited use to 2 to 4 weeks. The objective of our study was to investigate the safety and efficacy of once-daily halobetasol propionate (HP) lotion 0.01% in moderate to severe plaque psoriasis through 2 multicenter, randomized, double-blind

2019 Cutis Controlled trial quality: predicted high

191. The Effects of Use of a Powered and a Manual Home Oral Hygiene Regimen on Plaque and Gum Health in an Orthodontic Population. (Abstract)

The Effects of Use of a Powered and a Manual Home Oral Hygiene Regimen on Plaque and Gum Health in an Orthodontic Population. The objective of this study was to compare the effect of two home use oral hygiene regimens on plaque, gingivitis, and gingival bleeding on subjects undergoing orthodontic treatment with fixed appliances.This was a randomized, parallel, single-center clinical trial. Eligible study subjects fit the following profile: age 12-65 years; nonsmoker; plaque score of = 2.0 per (...) , and included assessments of BBI, GBI, Modified Gingival Index (MGI), and Modified Plaque Index (MPI).Of 228 enrolled subjects, 223 were included in the primary analysis. For the primary endpoint, reduction in BBI score following three weeks of product use, the overall least squares (LS) mean (95% CI) reduction was 0.89 (0.84, 0.95) for SOR and 0.06 (0.01, 0.12) for MTF. Expressed as percent reduction (95% CI) from Baseline, this was 33.1% (31.1%, 35.2%) for SOR and 2.01% (-0.06%, 4.07%) for MTF

2019 The Journal of clinical dentistry Controlled trial quality: uncertain

192. "Is powered toothbrush better than manual toothbrush in removing dental plaque?" - A crossover randomized double-blind study among differently abled, India. Full Text available with Trip Pro

"Is powered toothbrush better than manual toothbrush in removing dental plaque?" - A crossover randomized double-blind study among differently abled, India. Although mechanical plaque removal is an effective method, powered toothbrushes are specially designed to benefit differently abled. Literature comparing plaque removal efficacy between manual and powered toothbrushes among differently abled is sparse.A cross-over, randomized, double-blind study was conducted in differently abled (...) institution.Twenty differently abled participants were randomly assigned to two groups of ten participants. Plaque removal efficacy of battery-operated powered toothbrush was compared with manual toothbrush in a single brushing on the 8th day. After a washout of 1 week, groups were switched. Assessment of plaque scores was done using Turesky's modification of Quigley-Hein plaque index.Difference in plaque score between pre- and post-brushing in each group was compared using paired sample t-test.In the pooled

2019 Journal of Indian Society of Periodontology Controlled trial quality: uncertain

193. Efficacy of a Calcium Sucrose Phosphate Based Toothpaste in Elevating the Level of Calcium, Phosphate Ions in Saliva and Reducing Plaque: A Clinical Trial. Full Text available with Trip Pro

Efficacy of a Calcium Sucrose Phosphate Based Toothpaste in Elevating the Level of Calcium, Phosphate Ions in Saliva and Reducing Plaque: A Clinical Trial. To evaluate and compare the efficacy of "calcium sucrose phosphate" (CaSP) toothpaste (Enafix 5%) with ordinarily used calcium, phosphate-containing toothpaste in elevating the level of calcium, phosphate ions in saliva. Secondary aims were to evaluate substantivity and plaque-reducing ability of CaSP toothpaste.Thirty study participants (...) of age group 6-13 years were divided into two groups: Group X (Control group) was made to continue brushing with their regularly used calcium, phosphate-containing toothpaste and Group Y (Test group) was allotted CaSP toothpaste. 1 ml of unstimulated saliva was periodically collected from both groups to determine any alteration in the salivary calcium, phosphate level. Parameters such as substantivity and plaque-reducing ability of CaSP toothpaste were also evaluated. Salivary mineral's intergroup

2019 Contemporary clinical dentistry Controlled trial quality: uncertain

194. Efficacy of the lift-the-lip technique for dental plaque removal in preschool children. Full Text available with Trip Pro

Efficacy of the lift-the-lip technique for dental plaque removal in preschool children. The objective of this study was to compare the efficacy of two dental brushing techniques in relation to the lift lip method to control oral hygiene.This controlled and randomized field trial included 40 preschool children aged 24-59 months, divided into four groups: Group A (modified bass without lift the lip), Group B (modified bass with lift the lip), Group C (horizontal technique with lift the lip (...) ), and Group D (horizontal technique without lift the lip). The dental plaque accumulation was recorded through the O'Leary index. In addition, to perform hygiene control, the plaque index was performed in the initial evaluation at 7 and 14 days.ANOVA and Friedman test were applied to compare oral hygiene in each group. Finally, Kruskal-Wallis test was applied to compare groups at 7 and 14 days. The children with the modified Bass associated to the lift the lip had significantly more plaque removed at 7 (P

2019 Journal of the Indian Society of Pedodontics and Preventive Dentistry Controlled trial quality: uncertain

195. Carotid plaques and detection of atrial fibrillation in embolic stroke of undetermined source. (Abstract)

Carotid plaques and detection of atrial fibrillation in embolic stroke of undetermined source. To investigate the association between the presence of ipsilateral nonstenotic carotid plaques and the rate of detection of atrial fibrillation (AF) during follow-up in patients with embolic strokes of undetermined source (ESUS).We pooled data of all consecutive ESUS patients from 3 prospective stroke registries. Multivariate stepwise regression assessed the association between the presence (...) of nonstenotic carotid plaques and AF detection. The 10-year cumulative probabilities of AF detection were estimated by the Kaplan-Meier product limit method.Among 777 patients followed for 2,642 patient-years, 341 (38.6%) patients had an ipsilateral nonstenotic carotid plaque. AF was detected in 112 (14.4%) patients in the overall population during follow-up. The overall rate of AF detection was 8.5% in patients with nonstenotic carotid plaques (2.9% per 100 patient-years) and 19.0% in patients without (5.0

2019 Neurology

196. Adiponectin levels in a large pooled plaque psoriasis study population. Full Text available with Trip Pro

Adiponectin levels in a large pooled plaque psoriasis study population. Background: Adiponectin is an adipocyte-secreted protein potentially relevant in the context of cardiometabolic comorbidity of psoriasis patients. Objective: This post-hoc analysis aimed to assess the impact of obesity, metabolic syndrome, psoriasis severity and treatment with secukinumab/etanercept on adiponectin. Methods: Three phase III trials in moderate to severe plaque psoriasis were included. Correlations

2019 Journal of Dermatological Treatment

197. Management of Pediatric Plaque Psoriasis using Biologics. (Abstract)

Management of Pediatric Plaque Psoriasis using Biologics. Psoriasis is a chronic inflammatory disease with clinical manifestations of the skin that affect both adults and children. In adults, biologics have revolutionized the treatment of moderate to severe plaque psoriasis where clear or almost clear is a tangible goal. Recently, research on biologics has been extended to children. The introduction of these new therapeutic options has outpaced the limited guidelines in this population.To (...) provide a review of current data on biologics, with a proposal for a clinically relevant treatment algorithm on the management of moderate to severe plaque psoriasis in the pediatric population.A Canadian panel with expertise in psoriasis, pediatric dermatology and/or experience with consensus recommendation processes was selected to review the current landscape of pediatric psoriasis and clinical data on biologics plus identify special considerations for baseline work-up and monitoring

2019 Journal of American Academy of Dermatology

198. Comment on "Progressive erythematous papules and plaques in an infant": Sweet that is not so sweet! (Abstract)

Comment on "Progressive erythematous papules and plaques in an infant": Sweet that is not so sweet! 31215671 2019 07 15 1365-2230 2019 Jun 19 Clinical and experimental dermatology Clin. Exp. Dermatol. Comment on 'Progressive erythematous papules and plaques in an infant': Sweet that is not so sweet! 10.1111/ced.14024 Abdelmaksoud A A https://orcid.org/0000-0003-4848-959X Mansoura Dermatology, Venerology and Leprology Hospital, Mansoura, Egypt. eng Letter 2019 06 19 England Clin Exp Dermatol

2019 Clinical & Experimental Dermatology

199. Efficacy and safety of Pioglitazone for treatment of plaque psoriasis: a systematic review and meta-analysis of randomized controlled trials. (Abstract)

Efficacy and safety of Pioglitazone for treatment of plaque psoriasis: a systematic review and meta-analysis of randomized controlled trials. Background A growing number of studies have shown that thiazolidinedoniones(TZD) can be antipsoriatic. Pioglitazone is a representative of the class of antidiabetic drugs known as TZD. TZD can activate nuclear peroxisome proliferator-activated receptors (PPAR)-c. PPARs are expressed on epidermal keratinocytes and exert their effects by promoting (...) , and nausea. Study selection Randomized, single blind, or double blind, published studies of Pioglitazone compared with placebo, given to patients with plaque psoriasis for 10 weeks or 12 weeks were considered for inclusion in this review. The primary outcomes were 75% or greater improvement in the Psoriasis Area and Severity Index score from baseline (PASI 75) with pioglitazone. Data collection and analysis The systematic literature search was conducted in the PubMed, Embase, Google Scholar, and Cochrane

2019 Journal of Dermatological Treatment

200. Frontiers in PET imaging of the vulnerable atherosclerotic plaque. Full Text available with Trip Pro

Frontiers in PET imaging of the vulnerable atherosclerotic plaque. Rupture of vulnerable atherosclerotic plaques leading to an atherothrombotic event is the primary driver of myocardial infarction and stroke. The ability to detect non-invasively the presence and evolution of vulnerable plaques could have a huge impact on the future identification and management of atherosclerotic cardiovascular disease. Positron imaging tomography (PET) imaging with an appropriate radiotracer has the potential (...) to achieve this goal. This review will discuss the biological hallmarks of plaque vulnerability before going on to evaluate and to present PET imaging approaches which target these processes. The focus of this review will be on techniques beyond [18F]FDG imaging, some of which are clinically advanced, and others which are on the horizon. As inflammation is the primary driving force behind atherosclerotic plaque development, we will predominantly focus on approaches which either directly, or in directly

2019 Cardiovascular Research

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