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121. For Patients Taking Nonbisphosphonate Medications such as Xgeva, Avastin, or Sutent, Medication Related Osteonecrosis of the Jaw (MRONJ) Following Dentoalveolar Surgery Occurs at a Rate Comparable to that of Patients Taking IV Bisphosphonates

at a rate comparable to that of patients taking IV bisphosphonates. These drugs, when used concurrently with bisphosphonates, have a synergistic effect, and the risk for MRONJ is even greater. Any patient receiving these medications and needing dentoalveolar surgery must be given special precautions. Best Evidence (you may view more info by clicking on the PubMed ID link) PubMed ID Author / Year Patient Group Study type (level of evidence) #1) Troeltzsch/2012 Patients taking denosumab, bevacizumab (...) , and sunitinib Narrative Review Key results Denosumab (Xgeva) therapy causes MRONJ at a rate similar to IV bisphosphonates. Bevacizumab (Avastin) and sutinib (Sutent) related ONJ cases have been reported, but evidence of a causal relationship is still anecdotal. #2) Ruggiero/2014 Patients taking medications that can cause ONJ Practice Guideline Key results Patients at risk of developing MRONJ can be treated conservatively for caries and periodontal disease and may benefit from pain medication and antibiotics

2015 UTHSCSA Dental School CAT Library

122. Hyperbaric Oxygen Compared to Pharmaceutical Therapies for Fibromyalgia Syndrome

HBOT to current standard of care of FMS (pharmacological and non - pharmacological). Condition or disease Intervention/treatment Phase Fibromyalgia Hyperbaric Oxygen Device: Hyperbaric oxygen therapy Drug: Cymbalta / lyrica Device: Crossover Hyperbaric oxygen therapy Not Applicable Detailed Description: The study will include 70 fibromyalgia patients in whom physical trauma, such mild traumatic brain injury (mTBI), could be considered as the trigger for FMS. Each participant will be examined (...) Hyperbaric Oxygen Compared to Pharmaceutical Therapies for Fibromyalgia Syndrome Hyperbaric Oxygen Compared to Pharmaceutical Therapies for Fibromyalgia Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2017 Clinical Trials

123. Cellular and Molecular Mechanisms Underlying Non-Pharmaceutical Ischemic Stroke Therapy in Aged Subjects Full Text available with Trip Pro

Cellular and Molecular Mechanisms Underlying Non-Pharmaceutical Ischemic Stroke Therapy in Aged Subjects The incidence of ischemic stroke in humans increases exponentially above 70 years both in men and women. Comorbidities like diabetes, arterial hypertension or co-morbidity factors such as hypercholesterolemia, obesity and body fat distribution as well as fat-rich diet and physical inactivity are common in elderly persons and are associated with higher risk of stroke, increased mortality (...) and disability. Obesity could represent a state of chronic inflammation that can be prevented to some extent by non-pharmaceutical interventions such as calorie restriction and hypothermia. Indeed, recent results suggest that H₂S-induced hypothermia in aged, overweight rats could have a higher probability of success in treating stroke as compared to other monotherapies, by reducing post-stroke brain inflammation. Likewise, it was recently reported that weight reduction prior to stroke, in aged, overweight

2017 International journal of molecular sciences

124. The Impact of Integrating Physical Health into a Brief CBT Approach for Medically Ill Veterans. (Abstract)

The Impact of Integrating Physical Health into a Brief CBT Approach for Medically Ill Veterans. The current study explored the use and preliminary outcomes of physical health treatment elements integrated into a traditional brief cognitive behavioral therapy (bCBT) approach for medically ill veterans with depression and/or anxiety. Data were collected as part of a pragmatic randomized trial examining patient outcomes of bCBT versus an enhanced usual care condition. bCBT was delivered (...) that incorporating physical health elements with a bCBT approach hold the potential to positively impact treatment engagement/completion and may result in improved outcomes for medically ill patient populations.

2019 Journal of clinical psychology in medical settings Controlled trial quality: uncertain

125. Identification of patients with moderate medically unexplained physical symptoms in primary care with a five years follow-up. Full Text available with Trip Pro

Identification of patients with moderate medically unexplained physical symptoms in primary care with a five years follow-up. Patients with medically unexplained physical symptoms (MUPS) are common in primary care, with a spectrum from mild to moderate and chronic MUPS. The burden of chronic MUPS is high, and early identification of moderate MUPS patients is important to prevent chronicity. The PRESUME screening method to identify moderate MUPS patients in primary care was developed (...) , but insight in prognostic accuracy is needed. Therefore, our objective is to determine the prognostic accuracy for identification of moderate MUPS patients using the screening method with 5 year follow-up.The PRESUME screening method consists of three subsequent steps based on consultation frequency, exclusion of medical/psychiatric diagnosis and identification of MUPS. In a random 10% sample of patients from the Julius General Practitioners Network (n = 114.185), patients were identified with mild

2019 BMC Family Practice

126. Developing a training programme in physical activity counselling for undergraduate medical curricula: a nationwide Delphi study. Full Text available with Trip Pro

Developing a training programme in physical activity counselling for undergraduate medical curricula: a nationwide Delphi study. To identify the essential content and approaches for developing a training programme in physical activity (PA) counselling for undergraduate medical curricula.A three-round Delphi survey was conducted to investigate four key topics: (1) contents of PA counselling in medical education; (2) teaching and learning methods; (3) medical school collaboration and (4 (...) ) educational policy implementation. Round 1 collected opinions from the participants. Round 2 focused on scoring the opinions. Round 3 summarised the expert opinions. A mean score of 4 or above identified as an important item.All 23 medical schools in Thailand.Academic staff who were experts or in charge of medical schools in the fields of PA, health promotion or medical education.A total of 20 representatives from 18 of the 23 Thai medical schools participated in the study (for a response rate of 78.2

2019 BMJ open

127. Effects of Student Physical Therapists on Clinical Instructor Productivity Across Settings in an Academic Medical Center. (Abstract)

Effects of Student Physical Therapists on Clinical Instructor Productivity Across Settings in an Academic Medical Center. Clinical education is an integral component of physical therapy education. Both benefits and barriers exist in clinical education, but 1 commonly stated barrier includes the perception that students have a negative impact on clinical instructor (CI) productivity.The purposes of this study were to evaluate the productivity of physical therapist CIs in an academic medical (...) in that setting during the same time frame.We studied only 1 academic medical center and could not account for CI factors such as years of experience or student factors such as year in their program.Our results indicate that having a student increases productivity of therapists in various settings. Future studies should examine the impact of CI experience, student characteristics, and should expand to other settings.© American Physical Therapy Association 2019. All rights reserved. For permissions, please e

2019 Physical therapy

128. Assessing the impact of physical exercise on cognitive function in older medical patients during acute hospitalization: Secondary analysis of a randomized trial. Full Text available with Trip Pro

Assessing the impact of physical exercise on cognitive function in older medical patients during acute hospitalization: Secondary analysis of a randomized trial. Acute illness requiring hospitalization frequently is a sentinel event leading to long-term disability in older people. Prolonged bed rest increases the risk of developing cognitive impairment and dementia in acutely hospitalized older adults. Exercise protocols applied during acute hospitalization can prevent functional decline (...) (aged ≥75 years) were randomly allocated to an exercise intervention (n = 185) or a control (n = 185) group (usual care). The intervention consisted of a multicomponent exercise training program performed during 5-7 consecutive days (2 sessions/day). The usual care group received habitual hospital care, which included physical rehabilitation when needed. The main outcomes were change in executive function from baseline to discharge, assessed with the dual-task (i.e., verbal and arithmetic) Gait

2019 PLoS medicine Controlled trial quality: predicted high

129. Demographic differences in Canadian medical students' motivation and confidence to promote physical activity. (Abstract)

Demographic differences in Canadian medical students' motivation and confidence to promote physical activity. Physical activity (PA) remains under prescribed by physicians. Motivation and confidence are clear drivers of frequency of promoting PA. Research shows demographic differences in physicians' preventive practices, yet none have included medical students who form habits during training.Study objectives were to (i) examine how Canadian medical students' motivation to recommend PA to future (...) and refer to an exercise specialist compared to males (P < 0.01). Second year students were more motivated to assess a patients' level of PA compared to third and fourth year students (P < 0.01). Students pursuing family medicine were more confident to assess and counsel compared to students pursuing paediatrics (P < 0.01).Given that motivation and confidence have a positive influence on frequency-promoting PA, these results suggest where future efforts should focus, to improve PA promotion in medical

2019 Family Practice

130. Effectiveness of a motivational-volitional group intervention to increase physical activity among breast cancer survivors compared to standard medical rehabilitation-Study protocol of a prospective controlled bi-centred interventional trial. (Abstract)

Effectiveness of a motivational-volitional group intervention to increase physical activity among breast cancer survivors compared to standard medical rehabilitation-Study protocol of a prospective controlled bi-centred interventional trial. Despite proven benefits of regular physical activity, the majority of breast cancer survivors do not meet recommended physical activity guidelines. The Motivation-Volition (MoVo) Concept was designed to help people to set up and maintain a health-enhancing (...) rehabilitation. Our target groups are inactive women after breast cancer. Primary outcome is the amount of physical activity per week. Secondary outcomes include physical functioning, fatigue and depression. 800 patients diagnosed with breast cancer on medical rehabilitation will be included, 400 participants per clinic and group. Participants will be assessed by questionnaires upon clinic arrival, before discharge and six and twelve months after discharge. The study will provide evidence on the effect

2019 European journal of cancer care Controlled trial quality: uncertain

131. Does Cardiac Physical Exam Teaching Using a Cardiac Simulator Improve Medical Students' Diagnostic Skills? Full Text available with Trip Pro

Does Cardiac Physical Exam Teaching Using a Cardiac Simulator Improve Medical Students' Diagnostic Skills? Background Challenges in bedside teaching may be overcome by the use of high-fidelity simulators for teaching the cardiac physical exam. The purpose of this study is to compare the ability of first-year medical students (MS1) to perform a cardiac physical exam and make the correct diagnosis after instruction using standardized patients (SPs) as compared to a cardiac simulator (Harvey (...) , Laerdal Medical Corporation, NY, US). Methods Thirty-two MS1 were randomized to a teaching module on either SPs or Harvey. Their performance and ability to make the correct diagnosis were evaluated during a posttest objective structured clinical examination (OSCE) on real patients. Results No difference in the mean OSCE score was observed (SP: M=62.2% vs. Harvey: M=57.2%, p=0.32). The SP group obtained a higher frequency of correct diagnoses (M=61.5% SP vs. M=21.0% Harvey, p=0.03). Student feedback

2019 Cureus Controlled trial quality: uncertain

132. Physical activity in COPD: Minimal clinically important difference for medical events. Full Text available with Trip Pro

Physical activity in COPD: Minimal clinically important difference for medical events. Estimates of the minimal clinically important difference (MCID) for physical activity (PA) in chronic obstructive pulmonary disease (COPD) are needed. The objective is to provide an anchor-based estimate of the MCID for daily step count. PA was promoted in persons with COPD using a pedometer (Omron HJ-720ITC) alone or a pedometer plus interactive website for 3 months. Participants wore the pedometer daily (...) and received phone calls monthly to ascertain medical events. Medical events were counted when a participant self-reported that he/she had (1) worsening of breathing, (2) change to breathing medications, (3) medical care from an emergency room for any reason, or (4) hospitalization for any reason. Generalized linear regression models assessed daily step count as change at the end of study and averaged over the 15, 31, or 61 days centered on the event, in those with an event compared to those without one

2019 Chronic respiratory disease

133. Moderation of the association between chronic medical conditions and functional limitations over time by physical activity: Effects of age. Full Text available with Trip Pro

Moderation of the association between chronic medical conditions and functional limitations over time by physical activity: Effects of age. Age-related accumulation of chronic medical conditions increases disability in older adults. Physical activity potently combats chronic conditions and disability. However, it is unclear whether activity maintenance alleviates the effects of chronic conditions on disability and if this buffering effect differs with age. This study examined whether long-term (...) physical activity can forestall functional limitations in the face of accumulating chronic conditions among middle-aged and older adults.Participants (n = 2,119; 54.7% female) were from the Survey of Midlife Development in the United States. Self-reported physical activity, number of chronic conditions, and functional limitations were obtained across 18-20 years. Functional limitations were regressed against the change in chronic conditions, physical activity, and their interaction over time in a multi

2019 Biological Sciences and Medical Sciences

134. Helpful ways providers can communicate about persistent medically unexplained physical symptoms. Full Text available with Trip Pro

Helpful ways providers can communicate about persistent medically unexplained physical symptoms. Communication between patients and providers about persistent "medically unexplained" physical symptoms (MUS) is characterized by discordance. While the difficulties are well documented, few studies have examined effective communication. We sought to determine what veterans with Gulf War Illness (GWI) perceive as the most helpful communication from their providers. Veterans with GWI, a type of MUS (...) , have historically had complex relationships with medical providers. Determining effective communication for patients with particularly complex relationships may help identify the most critical communication elements for all patients with MUS.Two hundred and-ten veterans with GWI were asked, in a written questionnaire, what was the most useful thing a medical provider had told them about their GWI. Responses were coded into three categories with 10 codes.The most prevalent helpful communication

2019 BMC Family Practice

135. Long-term exposure to anticholinergic and sedative medications and cognitive and physical function in later life. Full Text available with Trip Pro

Long-term exposure to anticholinergic and sedative medications and cognitive and physical function in later life. Anticholinergic and sedative medications are frequently prescribed to older individuals. These medications are associated with short-term cognitive and physical impairment, but less is known about long-term associations. We therefore examined over twenty years whether cumulative exposure to these medications was related to poorer cognitive and physical functioning.Older adult (...) participants of the Longitudinal Aging Study Amsterdam (LASA) were followed from 1992-2012. On 7 measurement occasions, cumulative exposure to anticholinergic and sedative medications was quantified with the Drug Burden Index (DBI), a linear additive pharmacological dose-response model. Cognitive functioning was assessed with the Mini Mental State Examination (MMSE), Alphabet Coding Task (ACT, 3 trials), Auditory Verbal Learning Test (AVLT, learning and retention condition), and Raven Colored Progressive

2019 Biological Sciences and Medical Sciences

136. Prevalence and Correlates of Receiving Medical Advice to Increase Physical Activity in U.S. Adults: National Health and Nutrition Examination Survey 2013-2016. (Abstract)

Prevalence and Correlates of Receiving Medical Advice to Increase Physical Activity in U.S. Adults: National Health and Nutrition Examination Survey 2013-2016. National objectives recommend healthcare professionals provide physical activity advice. This study examined health and demographic characteristics associated with receipt of medical advice to increase physical activity among U.S. health care-utilizing adults and differences in associations by age group.Analyses included 8,410 health (...) care-utilizing adults aged ≥20 years from the 2013-2016 National Health and Nutrition Examination Surveys (analyzed in 2018). Logistic regression was used to examine associations between receipt of medical advice to increase physical activity in the past year and measured health conditions, reported health behaviors, and demographic characteristics. Models were stratified by age group (20-39, 40-59, and ≥60 years).Physical activity medical advice was received by 42.9% (95% CI=40.8, 44.9) of adults

2019 American journal of preventive medicine

137. Utilizing mobile technologies to improve physical activity and medication adherence in patients with heart failure and diabetes mellitus: Rationale and design of the TARGET-HF-DM Trial. (Abstract)

Utilizing mobile technologies to improve physical activity and medication adherence in patients with heart failure and diabetes mellitus: Rationale and design of the TARGET-HF-DM Trial. Heart failure (HF) and diabetes mellitus (DM) are major public health issues that place significant burden on patients and health care systems. Patients with both HF and DM are at higher risk of adverse cardiovascular and HF outcomes than those with either disease in isolation. Different antihyperglycemic (...) medications (even within the same medication class) have conflicting results of benefit or harm in patients with established and incident HF. Recent data highlight the importance of a renewed focus on optimal pharmacotherapy for this population with DM and HF (or at risk for HF). Both HF and DM require major lifestyle modification for optimal management, in terms of both optimizing health behaviors (eg, physical activity, diet) and adherence to complex medical and self-care regimens. Mobile health

2019 American Heart Journal

138. Association of physical activity and medication with enthesitis on ultrasound in psoriatic arthritis. (Abstract)

Association of physical activity and medication with enthesitis on ultrasound in psoriatic arthritis. Enthesitis is a manifestation of psoriatic arthritis (PsA), but its symptoms are difficult to interpret clinically. We investigated the associations of ultrasonographic changes in entheses with clinical characteristics in PsA patients, and compared enthesis changes of PsA patients aged 35 to 60 with healthy volunteers of that age.Consecutive PsA patients participated in this cross-sectional (...) study, irrespective of enthesitis complaints and age. We collected data about complaints, physical activity and activity avoidance, medication and clinical enthesitis. Inflammatory and structural enthesis changes were scored with the modified MAdrid Sonographic Enthesitis Index (MASEI). Among all PsA patients, associations between ultrasound scores and clinical characteristics were investigated using linear regression. We compared ultrasound scores of healthy volunteers and PsA patients aged 35-60

2019 Journal of Rheumatology

139. Development and evaluation of the medication-based index of physical function (MedIP) Full Text available with Trip Pro

Development and evaluation of the medication-based index of physical function (MedIP) the development of an objective and comprehensive drug-based index of physical function for older adults has the potential to more accurately predict fall risk.the index was developed using 862 adults (ages 57-85) from the National Social Life, Health, and Aging Project (NSHAP) Wave 1 study. The index was evaluated in 70 adults (ages 51-88) from a rehabilitation study of dizziness and balance.the prevalence (...) among 601 drugs for 1,694 side effects was used with fall history to determine the magnitude of each side effect's contribution towards physical function. This information was used to calculate a Medication-based Index of Physical function (MedIP) score for each individual based on his or her medication profile. The MedIP was compared to the timed up and go (TUG) test as well as drug counts using receiver operating characteristic (ROC) analysis. The associations between various indices of physical

2017 EvidenceUpdates

140. Australian Institute of Sport and Australian Medical Association position statement on concussion in sport

is suspected, the athlete must be immediately removed from sport and not be allowed to return to activity until they have been assessed by a medical practitioner. “If in doubt, sit them out.” A diagnosis of concussion requires immediate physical and cognitive rest, followed by a structured, graduated return to physical activity. Children require a longer period of recovery from concussion. Algorithms are provided for use by medical and non-medically trained stakeholders in the recognition and management (...) Australian Institute of Sport and Australian Medical Association position statement on concussion in sport Australian Institute of Sport and Australian Medical Association position statement on concussion in sport | The Medical Journal of Australia mja-search search Use the for more specific terms. Title contains Body contains Date range from Date range to Article type Author's surname Volume First page doi: 10.5694/mja__.______ Search Reset  close Individual Login Purchase options Connect

2017 MJA Clinical Guidelines

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