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81. Dopamine Augmented Rehabilitation in Stroke (DARS): a multicentre double-blind, randomised controlled trial of co-careldopa compared with placebo, in addition to routine NHS occupational and physical therapy, delivered early after stroke on functional rec Full Text available with Trip Pro

Dopamine Augmented Rehabilitation in Stroke (DARS): a multicentre double-blind, randomised controlled trial of co-careldopa compared with placebo, in addition to routine NHS occupational and physical therapy, delivered early after stroke on functional rec Dopamine Augmented Rehabilitation in Stroke (DARS): a multicentre double-blind, randomised controlled trial of co-careldopa compared with placebo, in addition to routine NHS occupational and physical therapy, delivered early after stroke (...) on functional recovery Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} Co-careldopa in addition to routine occupational and physical therapy did not improve walking

2019 NIHR HTA programme

82. Adaptive pacing, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome: a cost-effectiveness analysis Full Text available with Trip Pro

Adaptive pacing, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome: a cost-effectiveness analysis Adaptive pacing, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome: a cost-effectiveness analysis Adaptive pacing, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome: a cost-effectiveness analysis McCrone P, Sharpe M, Chalder T, Knapp M (...) -pacing therapy, cognitive behavioural therapy (CBT), or graded-exercise therapy to specialist medical care for adult patients with chronic fatigue syndrome in the UK from two alternative perspectives (health care and societal). Interventions Four alternatives were compared: specialist medical care (at least three sessions) plus CBT (at least 15 individual therapy sessions); 2) specialist medical care (at least three sessions) plus graded-exercise therapy (up to 15 sessions); specialist medical care

2013 NHS Economic Evaluation Database.

83. Physical health and drug safety in individuals with schizophrenia Full Text available with Trip Pro

Physical health and drug safety in individuals with schizophrenia While antipsychotic medications are the mainstay of therapy for individuals with schizophrenia and psychotic disorders, their use is associated with adverse effects on physical health that require the attention and care of prescribers.We used the ADAPTE process to adapt existing guideline recommendations from the National Institute for Health and Care Excellence (NICE) and Scottish Intercollegiate Guidelines Network (SIGN (...) interventions are recommended to mitigate antipsychotic-induced weight gain. Prescribers should follow Canadian guidelines on the treatment of obesity, dyslipidemia, and diabetes. Recommendations on antipsychotic drug choice are made for users particularly concerned about extrapyramidal symptoms.Careful monitoring and attention by prescribers may mitigate adverse effects associated with antipsychotic medications.

2017 CPG Infobase

84. Open letter from academics, practitioners, students and members of the public to the British Medical Association, the British Medical Journal publishing group, and the British Association of Sports and Exercise Medicine regarding editorial governance of t

-media portal that provides original research, reviews and debate relating to clinically-relevant aspects of sport and exercise medicine, including physiotherapy, physical therapy and rehabilitation. We contribute to innovation (research), education (teaching and learning) and knowledge translation (implementing research into practice and policy). Our web, print, video and audio material, combined with active social media, serves the international community of clinicians who treat active people (...) Open letter from academics, practitioners, students and members of the public to the British Medical Association, the British Medical Journal publishing group, and the British Association of Sports and Exercise Medicine regarding editorial governance of t Open letter from academics, practitioners, students and members of the public to the British Medical Association, the British Medical Journal publishing group, and the British Association of Sports and Exercise Medicine regarding editorial

2018 British Journal of Sports Medicine Blog

85. Policy on Medically-Necessary Care

and pro-vision of individual and community-based health care programs to achieve comprehensive health care. 2. Establishment of a dental home for all children by 12 months of age in order to institute an individualized preventive oral health program based upon each patient’s unique caries risk assessment. 3. Healthcare providers who diagnose oral disease to either provide therapy or refer the patient to a primary care dentist or dental/medical specialist as dictated by the nature and complexity (...) 2000;22(1):27-32. 67. Prabhu NT, Nunn JH, Evans DJ. A comparison of costs in providing dental care for special needs patients under sedation or general anesthesia in the North East of England. Prim Dent Care 2006;13(4):125-8. 68. Institute of Medicine Committee on Medicare Coverage Extensions. Medically necessary dental services. In; Field MJ, Lawrence RL, Zwanziger L, eds. Extending Medicare Coverage for Preventive and Other Services. Washington (DC): National Academies Press (US); 2000. Available

2019 American Academy of Pediatric Dentistry

86. Systematic Approaches to Rehabilitative Medical Treatment of Patients: A Review of Clinical Effectiveness and Guidelines

with standard exercises and (ii) undiagnosed patients in a waitlist condition.8 No evidence-based guidelines were identified regarding systematic approaches to physical rehabilitation treatment. Files Rapid Response Summary with Critical Appraisal Published : November 9, 2018 Follow us: © 2019 Canadian Agency for Drugs and Technologies in Health Get our newsletter: (...) Systematic Approaches to Rehabilitative Medical Treatment of Patients: A Review of Clinical Effectiveness and Guidelines Systematic Approaches to Rehabilitative Medical Treatment of Patients: A Review of Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Systematic Approaches to Rehabilitative Medical Treatment of Patients: A Review of Clinical Effectiveness and Guidelines Systematic Approaches to Rehabilitative Medical Treatment of Patients: A Review of Clinical

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

87. Pregnant women and poor sleep: medication is rarely the right solution

women and poor sleep: medication is rarely the right solution In the case of poor sleep during pregnancy, sedatives are rarely the right solution. Non-drug measures are preferable. When a pregnant woman is troubled by poor sleep, preference should be given to non-drug measures: avoid consumption of stimulants and heavy meals and follow the usual advice such as physical activity in the run-up to bedtime, going to bed only when sleepy, getting up at the same time every day. At present, given what (...) and third trimesters, provided that it is in the form of low-concentration aqueous or hydroalcoholic extract. In general, it is preferable to avoid taking concentrated plant extracts repeatedly for medicinal purposes during pregnancy, due to uncertainties about their effects. Some drugs with an adverse harm-benefit balance for pregnant women or the unborn child should be ruled out. These include alimemazine and promethazine; fast-acting benzodiazepines such as flunitrazepam and triazolam; melatonin

2018 Prescrire

88. The Patient Centred Medical Home: barriers and enablers to implementation

The Patient Centred Medical Home: barriers and enablers to implementation The Patient Centred Medical Home: barriers and enablers to implementation An Evidence Check rapid review brokered by the Sax Institute for COORDINARE. January 2018 An Evidence Check rapid review brokered by the Sax Institute for COORDINARE. January 2018. This report was prepared by: Jim Pearse and Deniza Mazevska – Health Policy Analysis Pty Ltd. January 2018 © Sax Institute 2018 This work is copyright. It may (...) : Pearse J, Mazevska D. The Patient Centered Medical Home: barriers and enablers: an Evidence Check rapid review brokered by the Sax Institute (www.saxinstitute.org.au) for COORDINARE, 2018. Disclaimer: This Evidence Check Review was produced using the Evidence Check methodology in response to specific questions from the commissioning agency. It is not necessarily a comprehensive review of all literature relating to the topic area. It was current at the time of production (but not necessarily

2018 Sax Institute Evidence Check

89. Medical decision-making in paediatrics: Infancy to adolescence

Medical decision-making in paediatrics: Infancy to adolescence Medical decision-making in the paediatric population is complicated by the wide variation in physical and psychological development that occurs as children progress from infancy to adolescence. Parents and legal guardians are the de facto decision-makers in early infancy, but thereafter, the roles of parents/legal guardians and paediatric patients become ever more complex. Health care providers (HCPs), while not decision-makers per (...) se, have a significant role in medical decision-making throughout childhood. This statement outlines the ethical principles of medical decision-making for HCPs involved in caring for paediatric patients. This revision focuses on individual decision-making in the context of the patient–provider relationship and provides increased guidance for dealing with disagreements. Keywords: Advanced directives; Best Interests; Emancipated minors; End-of-life; Informed consent; Mature minors; SDM

2018 Canadian Paediatric Society

90. Drug therapy during pregnancy: implications for dental practice. (Abstract)

Drug therapy during pregnancy: implications for dental practice. Pregnancy is accompanied by various physiological and physical changes, including those found in the cardiovascular, respiratory, gastrointestinal, renal and haematological systems. These alterations in the pregnant patient may potentially affect drug pharmacokinetics. Also, pharmacotherapy presents a unique matter due to the potential teratogenic effects of certain drugs. Although medications prescribed by dentists are generally (...) safe during pregnancy, some modifications may be needed. In this article we will discuss the changes in the physiology during pregnancy and its impact on drug therapy. Specific emphasis will be given to the drugs commonly given by dentists, namely, local anaesthetics, analgesics, antibiotics and sedatives.

2016 British Dental Journal

91. Slowing down glioblastoma progression in mice by running or the anti-malarial drug dihydroartemisinin? Induction of oxidative stress in murine glioblastoma therapy Full Text available with Trip Pro

Slowing down glioblastoma progression in mice by running or the anti-malarial drug dihydroartemisinin? Induction of oxidative stress in murine glioblastoma therapy Influencing cancer metabolism by lifestyle changes is an attractive strategy as - if effective - exercise-induced problems may be less severe than those induced by classical anti-cancer therapies. Pursuing this idea, clinical trials evaluated the benefit of e.g. different diets such as the ketogenic diet, intermittent caloric (...) restriction and physical exercise (PE) in the primary and secondary prevention of different cancer types. PE proved to be beneficial in the context of breast and colon cancer.Glioblastoma has a dismal prognosis, with an average overall survival of about one year despite maximal safe resection, concomitant radiochemotherapy with temozolomide followed by adjuvant temozolomide therapy. Here, we focused on the influence of PE as an isolated and adjuvant treatment in murine GB therapy.PE did not reduce toxic

2016 Oncotarget

92. Incidence of Malignancies in a Cohort of Psoriatic Arthritis Patients Taking Traditional Disease Modifying Antirheumatic Drug and Tumor Necrosis Factor Inhibitor Therapy: An Observational Study. (Abstract)

Incidence of Malignancies in a Cohort of Psoriatic Arthritis Patients Taking Traditional Disease Modifying Antirheumatic Drug and Tumor Necrosis Factor Inhibitor Therapy: An Observational Study. Psoriatic arthritis (PsA) is an inflammatory arthropathy, associated with skin and/or nail psoriasis. As suggested in 2012 by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), studies devoted to assess cancer in the PsA population are still limited and need (...) to be increased. Therefore, the aim of this study was to determine the incidence of malignancies in patients with PsA who are taking conventional and biologic therapies.A cohort of patients with PsA was followed prospectively. At first visit, as well as at each 3-4 month followup visit, according to standardized clinical practice, medical history, and physical and laboratory findings were recorded. Information on the presence of comorbidities, as well as malignancies, was collected. At each visit, data were

2016 Journal of Rheumatology

93. Balneological outpatient treatment for patients with knee osteoarthritis; an effective non-drug therapy option in daily routine? (Abstract)

Balneological outpatient treatment for patients with knee osteoarthritis; an effective non-drug therapy option in daily routine? This study aims to compare the effects of balneological treatments applied at consecutive and intermittent sessions without interfering with their daily routine in patients with knee osteoarthritis. This is a randomized, controlled, single-blind clinical trial. Fifty patients diagnosed with knee osteoarthritis were included. The patients were divided into two groups (...) to be maintained in terms of role-physical (SF-36) parameter, while the well-being of group 1 was unable to be maintained in terms of pain, WOMAC (pain, physical functions, total), and SF-36 (physical functioning, role-physical, pain, role-emotional, and mental health) variables, compared to data obtained immediately after treatment. Our study suggests that traditional and intermittent balneological therapies have similar efficacy in patients with knee osteoarthritis.

2016 International journal of biometeorology Controlled trial quality: uncertain

94. Integration of Dermatology-Focused Physical Diagnosis Rounds and Case-Based Learning within the Internal Medicine Medical Student Clerkship Full Text available with Trip Pro

Integration of Dermatology-Focused Physical Diagnosis Rounds and Case-Based Learning within the Internal Medicine Medical Student Clerkship Over half of dermatologic conditions are seen by nondermatologists, yet medical students receive little dermatology education. Medical students in the clinical years of training at our institution felt insecure in their physical diagnosis skills for dermatologic conditions.The objective of this study was to implement dermatology-focused curricula within (...) the Internal Medicine (IM) Core Clerkship to increase student confidence in diagnosing skin diseases.Two dermatology-focused sessions were integrated into the IM Clerkship. A faculty dermatologist leads students on a dermatology-focused physical diagnosis "Skin Rounds", where patients are seen at the bedside and students practice describing skin lesions and forming a differential diagnosis. Students also participate in a case-based active learning session. A dermatologist selects images of common skin

2016 Journal of medical education and curricular development

95. Appropriate prescribing of psychotropic medication for non-cognitive symptoms in people with dementia

Grading of Recommendations Assessment, Development and Evaluation GDG Guideline Development Group GDP Global Domestic Product MCI Mild Cognitive Impairment MHBC Ministry of Health British Columbia MHRA Medicines and Healthcare products Regulatory Agency NCEC National Clinical Effectiveness Committee NHMRC National Health and Medical Research Council NHS National Health Service NICE National Institute for Health and Care Excellence NPI Neuropsychiatric Inventory PBS Pharmaceutical Benefit Scheme PDD (...) . However, most evidence is based on common dementia types, particularly Alzheimer’s dementia; this needs to be borne in mind by the user when applying the evidence to other dementia types. Clinicians’ attention is also drawn to the fact that many psychotropic medications are used “off label” for people with dementia, particularly antipsychotic medication. While this is not prohibited by medicine regulations, it does require particular caution by the prescriber. This National Clinical Guideline

2019 National Clinical Guidelines (Ireland)

96. Medical management of abortion

of abortion (medical abortion): Use of pharmacological drugs to terminate pregnancy. Sometimes the terms “non-surgical abortion” or “medication abortion” are also used. Routes of misoprostol administration: oral pills are swallowed; buccal pills are placed between the cheek and gums and swallowed after 30 minutes; sublingual pills are placed under the tongue and swallowed after 30 minutes; vaginal pills are placed in the vaginal fornices (deepest portions of the vagina) and the individual is instructed (...) , auxiliary nurse midwives, nurses, midwives, associate/advanced associate clinicians, and non-specialist and specialist doctors. Doctors of complementary systems of medicine can be providers of this service in health system contexts with an established mechanism for the participation of such doctors in other tasks related to maternal and reproductive health (10). Alongside non-specialist and specialist doctors, the following cadres can provide medical abortion for pregnancies = 12 weeks in contexts where

2019 World Health Organisation Guidelines

97. American Gastroenterological Association Institute Guideline on the Medical Management of Opioid-Induced Constipation Full Text available with Trip Pro

., Dorn, S.D. et al. American Gastroenterological Association medical position statement on constipation. Gastroenterology . 2013 ; 144 : 211–217 | | | | | Once a diagnosis of OIC has been confirmed and other potential causes of constipation are excluded, the recommendations here can help guide appropriate evidence-based management. This guideline focuses on the medical management of OIC. Therefore, it does not address the role of psychological therapy, alternative medicine approaches, surgery (...) control, the AGA recommends escalation of therapy to PAMORA drugs with high- or moderate-quality evidence of efficacy, namely naldemedine and naloxegol. The AGA also conditionally recommends use of methylnatrexone. Due to insufficient evidence, the AGA did not issue a recommendation regarding use of either lubiprostone or prucalopride in OIC. The recommendations are similar to those proposed by recent clinical guidelines related to OIC published by the American Academy of Pain Medicine x 25 Muller

2019 American Gastroenterological Association Institute

98. Principles of Pediatric Patient Safety: Reducing Harm Due to Medical Care

the standardization of concentrations in compounded medications; developing, spreading, and advocating for pediatric-specific health care information technology for drug delivery; educating providers on methods to reduce medication errors, including medication reconciliation; ensuring that providers maintain access to and proficiency in the use of a comprehensive and current pharmaceutical knowledge base; and creating policies that advocate for safe medication delivery to children in all health care settings (...) . Principles of Pediatric Patient Safety: Reducing Harm Due to Medical Care Brigitta U. Mueller , Daniel Robert Neuspiel , Erin R. Stucky Fisher , COUNCIL ON QUALITY IMPROVEMENT AND PATIENT SAFETY, COMMITTEE ON HOSPITAL CARE Abstract Pediatricians render care in an increasingly complex environment, which results in multiple opportunities to cause unintended harm. National awareness of patient safety risks has grown since the National Academy of Medicine (formerly the Institute of Medicine) published its

2019 American Academy of Pediatrics

99. Breast Cancer: Medication Use to Reduce Risk

-sensitive epithelial cells where breast cancer can develop. These medications have been approved by the US Food and Drug Administration for risk reduction of breast cancer. Aromatase inhibitors inhibit conversion of androgen to estrogen and can reduce risk of ER-positive breast cancer by decreasing the amount of estrogen available to bind to estrogen-sensitive epithelial cells. Aromatase inhibitors have been evaluated for risk reduction of breast cancer in clinical trials, although they are primarily (...) used for treatment rather than risk reduction of primary cancer. Aromatase inhibitors are not currently approved by the US Food and Drug Administration for risk reduction of primary breast cancer. This recommendations is consistent with the 2013 USPSTF recommendation. As before, the USPSTF recommends offering risk-reducing medications to women at increased risk for breast cancer and at low risk for adverse medication effects (B recommendation) and recommends against routine use of risk-reducing

2019 U.S. Preventive Services Task Force

100. Declining racial and ethnic representation in clinical academic medicine: A longitudinal study of 16 US medical specialties. Full Text available with Trip Pro

Declining racial and ethnic representation in clinical academic medicine: A longitudinal study of 16 US medical specialties. To evaluate trends in racial, ethnic, and sex representation at US medical schools across 16 specialties: internal medicine, pediatrics, surgery, psychiatry, radiology, anesthesiology, obstetrics and gynecology, neurology, family practice, pathology, emergency medicine, orthopedic surgery, ophthalmology, otolaryngology, physical medicine and rehabilitation (...) , and dermatology. Using a novel, Census-derived statistical measure of diversity, the S-score, we quantified the degree of underrepresentation for racial minority groups and female faculty by rank for assistant, associate, and full professors from 1990-2016.This longitudinal study of faculty diversity uses data obtained from the American Association of Medical Colleges (AAMC) Faculty Roster from US allopathic medical schools. The proportion of professors of racial minority groups and female faculty by rank

2018 PLoS ONE

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