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4061. Percutaneous therapy of a mediastinal lymphangioma with fibrin glue: case report with clinical success after 4 years. Full Text available with Trip Pro

completely. However, the patient's overall physical condition was very poor, and we thought she could not tolerate the bilateral surgery. Therefore, the patient was treated by percutaneous aspiration drainage followed by fibrin glue injection. Our method has never been reported in the treatment of such a large intrathoracic lesion thus far.Percutaneous puncture and aspiration drainage followed by fibrin glue injection may be a feasible treatment option for the therapy of intrathoracic lymphangioma (...) Percutaneous therapy of a mediastinal lymphangioma with fibrin glue: case report with clinical success after 4 years. Lymphangioma of the mediastinum is a rare benign tumor, and most of the cases are treated by a surgical approach.This work reports the case of a 62-year-old female with a large lymphangioma extending from her neck to her abdomen with dysphagia, dyspnea, and cough for 2 months. Because of the location of the mass, only bilateral excision could remove the multiloculated cyst

2018 BMC Surgery

4062. Trial of Local Consolidation Therapy (LCT) After Nivolumab and Ipilimumab (LONESTAR)

will be enrolled in this study. All will take part at MD Anderson. Condition or disease Intervention/treatment Phase Malignant Neoplasms of Respiratory and Intrathoracic Organs Non-small Cell Lung Cancer Drug: Ipilimumab Drug: Nivolumab Procedure: Local Consolidative Therapy (LCT) Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 270 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open (...) Label) Primary Purpose: Treatment Official Title: Randomized Phase III Trial of Local Consolidation Therapy (LCT) After Nivolumab and Ipilimumab for Immunotherapy-Naive Patients With Metastatic Non-Small Cell Lung Cancer (LONESTAR) -Strategic Alliance: BMS Actual Study Start Date : December 29, 2017 Estimated Primary Completion Date : December 2022 Estimated Study Completion Date : December 2022 Resource links provided by the National Library of Medicine related topics: available for: Arms

2018 Clinical Trials

4063. Training Therapy for the Prevention of Back Pain

for location information Austria University Department of Physical Medicine, Rehabilitation and Occupational Medicine Recruiting Vienna, Austria, 1090 Contact: Richard Crevenna, Prof. Dr. 004314040043330 Sponsors and Collaborators Medical University of Vienna Investigators Layout table for investigator information Principal Investigator: Gerold Ebenbichler, Prof. Dr. University Department of Physical Medicine, Rehabilitation and Occupational Medicine More Information Go to Layout table for additonal (...) musculature with appropriate equipment is considered as a useful preventive measure and thus commonly offered at large corporations, even during working hours of the staff. However, data clearly demonstrating the effectivity and cost-effectiveness of these interventions is largely missing. This pilot study serves several purposes: On one hand, the feasibility of a randomized, controlled study is to be examined, which is to prove the effectiveness of the medical training therapy in comparison to a general

2018 Clinical Trials

4064. Brodalumab in Subjects With Moderate to Severe Plaque Psoriasis Who Have Failed IL-17A Therapies

: Icahn School of Medicine at Mount Sinai Information provided by (Responsible Party): Mark Lebwohl, Icahn School of Medicine at Mount Sinai Study Details Study Description Go to Brief Summary: This study will evaluate the safety and efficacy of brodalumab in the treatment of moderate-to-severe psoriasis in patients who have previously failed treatment with interleukin (IL)-17A therapies. Forty patients will be enrolled in this 16-week open-label study. Patients will receive 210 mg of brodalumab (...) Primary Completion Date : August 18, 2018 Actual Study Completion Date : August 18, 2018 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Brodalumab Brodalumab (210 mg) via subcutaneous injection using prefilled syringes Drug: Brodalumab Weeks 0, 1, 2, and every 2 weeks thereafter through and including Week 16. Outcome Measures Go to Primary Outcome Measures : Change in Physician's Global

2018 Clinical Trials

4065. Microbiota Transfer Therapy for Adults With Autism Spectrum Disorder (ASD) Who Have Gastrointestinal Disorders

in medications, supplements, diet, therapies, or education in last 3 months, and no intention to change them during the clinical trial. General good physical health aside from gastrointestinal problems Neurotypical adult observer (such as parent, guardian, or sibling) who observes adult for at least 4 hours/week who can serve as an Evaluator to complete questionnaires on their symptoms with the assistance of the Participant as much as they are able. Ability to swallow pills (without chewing) Exclusion (...) Disorders Actual Study Start Date : January 4, 2018 Estimated Primary Completion Date : October 4, 2020 Estimated Study Completion Date : September 1, 2021 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Group A Group A receives treatment in Part 1 and Part 2 Drug: Vancomycin Oral vancomycin is administered to reduce pathogenic bacteria. Drug: MoviPrep MoviPrep is given

2018 Clinical Trials

4066. Training to Reconnect With Emotional Awareness Therapy

information Principal Investigator: Dawn Neumann, PhD Indiana Universtiy More Information Go to Layout table for additonal information Responsible Party: Dawn Neumann, Research Director of Physical Medicine and Rehabilitation, Indiana University ClinicalTrials.gov Identifier: Other Study ID Numbers: 1711946589 First Posted: January 30, 2018 Last Update Posted: May 14, 2018 Last Verified: May 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA (...) impairments that would impede participation unable to communicate verbally unstable or anticipated medication changes during study participation active psychological treatment; or actively participating in the Traumatic Brain Injury Model System (TBIMS) alexithymia outcome module Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please

2018 Clinical Trials

4067. The Effects of Vestibular Rehabilitation Therapy Supported With Virtual Reality in the Elderly Patients With Dizziness

) Masking Description: Single blind Primary Purpose: Treatment Official Title: The Effects of Vestibular Rehabilitation Therapy Supported With Virtual Reality on Dizziness and Balance in the Elderly Patients With Dizziness Actual Study Start Date : May 23, 2017 Estimated Primary Completion Date : November 2018 Estimated Study Completion Date : December 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Active (...) Pamukkale University Faculty of Medicine Denizli, Turkey Sponsors and Collaborators Pamukkale University More Information Go to Publications: Ellialtıoğlu A, Karan A, İşsever H, Aksoy C. Validity and reliability of Turkish version of Dizziness Handicap Inventory (DHI). XVIII National Physical Medicine and Rehabilitation Congress, May 12-17, 2001, Antalya, Program and Abstract Book; 2001. p. 131 Baldwin, S.L., T.W. VanArnam,L.L. Ploutz-Snyder. Reliability of dynamic bilateral postural stability

2018 Clinical Trials

4068. A Prospective Observational Program Using Digital Technology Tools to Enhance Patient Adherence to Omacor Therapy

(Omega-3-acid ethyl esters) Adult patients with history of myocardial infarction not earlier than 6 months ago and/or with diagnosis of hypertriglyceridemia who having been prescribed Omacor for at least 6 months. Drug: Omacor (Omega-3-acid ethyl esters) Observational study without intervention, Omacor is prescribed in routine manner in accordance with clinical practice and the valid Instruction for Medical Use regarding the dose, duration of therapy, patient population, and therapeutic indication (...) Posted : January 30, 2018 Last Update Posted : March 4, 2019 Sponsor: Abbott Information provided by (Responsible Party): Abbott Study Details Study Description Go to Brief Summary: A prospective observational program using digital technology tools to enhance patient adherence to Omacor therapy Condition or disease Intervention/treatment History of Myocardial Infarction Hypertriglyceridemia Drug: Omacor (Omega-3-acid ethyl esters) Detailed Description: It is known that only 50% of patients

2018 Clinical Trials

4069. Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis

antibiotic prophylaxis before the treatment smoking pregnancy and lactation ingestion of antibiotics, anti-inflammatory drugs or any other medication during study period any physical limitations or restrictions that might preclude normal oral hygiene procedures Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer (...) for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: systemically healthy, non-smoker not received any periodontal treatment within the last 6 months no antibiotics, anti-inflammatory drugs or any other medication taken within the last 6 months consent to participate in the study Exclusion Criteria: any systemic disease (i.e. diabetes mellitus, HIV infection) that might influence the prognosis of periodontal disease and outcome of the treatment any medical condition that required

2018 Clinical Trials

4070. Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer

Estimated Primary Completion Date : October 2021 Estimated Study Completion Date : August 2035 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Group I (radiation therapy) Patients undergo radiation therapy daily on Monday-Friday for 5-6 weeks. Radiation: Radiation Therapy Undergo RT Other: Questionnaire Administration Ancillary studies Other: Quality-of-Life Assessment Ancillary studies (...) is a sexually mature female who has not undergone a hysterectomy or bilateral oophorectomy and has not been naturally postmenopausal for at least 12 consecutive months Women of child-bearing potential must agree to utilize a form of birth control or agree to undergo sexual abstinence during radiation therapy Eastern Cooperative Oncology Group (ECOG) (Zubrod) performance status 0-1 Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your

2018 Clinical Trials

4071. Lentiviral Gene Therapy for CGD

) Estimated Enrollment : 10 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: Lentiviral Gene Therapy for Chronic Granulomatous Disease (CGD) Actual Study Start Date : July 1, 2018 Estimated Primary Completion Date : June 30, 2021 Estimated Study Completion Date : December 31, 2021 Resource links provided by the National Library of Medicine related topics: related topics: resources: Arms and Interventions Go to Arm Intervention (...) , cardiovascular instability, severe coagulopathy) or for administration of conditioning medication Female patients who are pregnant or lactating as determined by history and/or positive pregnancy test Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03645486

2018 Clinical Trials

4072. Root Canal Treatment in Primary Molars With Necrotic Pulp Using Two Different Pulp Therapies

of physically isolating the CTZ paste from the restorative material. Drug: Pulp Therapy CTZ Paste CTZ paste is composed of 62.5 mg of chloramphenicol, 62.5 mg of tetracycline and 125 mg of zinc oxide and manipulated with 0.1ml of eugenol in a sterile glass plate with flexible metal spatula at the time of use. Other Name: Endodontic Treatment Experimental: Group 2 In Group 2, Pulp Therapy will be done with ZOE paste. The mechanical preparation of the root canals with 2% chlorhexidine solution and first (...) of the study is that both pastes present similar clinical and radiographic results. Condition or disease Intervention/treatment Phase Dental Pulp Necrosis Drug: Pulp Therapy CTZ Paste Drug: Pulp Therapy ZOE Paste Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 86 participants Allocation: Randomized Intervention Model: Parallel Assignment Intervention Model Description: The patients will be allocated into two groups

2018 Clinical Trials

4073. Effects of Green Light Therapy on Body Contouring and Cellulite

of treatment. Known cardiovascular disease such as cardiac arrhythmias, congestive heart failure. Cardiac surgeries such as cardiac bypass, heart transplant surgery, pacemakers. Prior surgical intervention for body sculpting/weight loss, such as liposuction, abdominoplasty, stomach stapling, lap band surgery, etc. Medical, physical, or other contraindications for body sculpting/weight loss. Current use of medication(s) known to affect weight levels/cause bloating or swelling and for which abstinence during (...) Effects of Green Light Therapy on Body Contouring and Cellulite Effects of Green Light Therapy on Body Contouring and Cellulite - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Green Light Therapy

2018 Clinical Trials

4074. The Effects of Soft Tissue Therapy and Exercise on Hamstring Tightness

The Effects of Soft Tissue Therapy and Exercise on Hamstring Tightness The Effects of Soft Tissue Therapy and Exercise on Hamstring Tightness - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Effects (...) of Soft Tissue Therapy and Exercise on Hamstring Tightness The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03651141 Recruitment Status : Completed First Posted : August 29, 2018 Last Update Posted : August 29, 2018 Sponsor: Oklahoma State University Information provided by (Responsible Party): Samantha

2018 Clinical Trials

4075. This Study Was a Prospective, One-arm Open Phase II Clinical Trial. A Systematic Review of the pCR of Apatinib in Combination With the Albumin Paclitaxel and Carboplatin Regimens for the Neoadjuvant Therapy of Triple-negative Breast Cancer, as Well as the

for the neoadjuvant therapy of triple-negative breast cancer, as well as the safety of treatment, at the same time, relevant exploratory biomarker research is conducted. Condition or disease Intervention/treatment Phase Systematic Review of the pCR Rate of Apatinib Combined With Albumin Paclitaxel and Carboplatin Regimen for Neoadjuvant Therapy of Triple-negative Breast Cancer Drug: Apatinib Phase 2 Detailed Description: Neoadjuvant program: apatinib 250mg oral d1-21; albumin paclitaxel 260mg/m2 intravenous drip (...) of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Study group apatinib 250mg oral d1-21; albumin paclitaxel 260mg/m2 intravenous drip d1; carboplatin AUC=5-6 intravenous drip d1; 21 days for 1 cycle. The treatment regimen was used for a total of 6 cycles, or to PD, or the toxicity was not tolerated. Drug: Apatinib Neoadjuvant program: apatinib 250mg oral d1-21; albumin paclitaxel 260mg/m2 intravenous drip d1; carboplatin AUC=5

2018 Clinical Trials

4076. Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease

University Study Details Study Description Go to Brief Summary: NTM therapy consists of a multi-drug macrolide based regimen for 18-24 months. Treated patients frequently experience debilitating side effects, and many patients delay the start of antibiotic treatment due to these risks. Common side effects include nausea, diarrhea, and fatigue, and rare but serious toxicities include ocular toxicity, hearing loss, and hematologic toxicity. To date, most of the evidence underlying the current treatment (...) are sufficient. The study is a multicenter randomized pragmatic clinical trial to compare azithromycin + ethambutol (2-drug therapy) vs. azithromycin + ethambutol + rifampin (3-drug therapy) for non-cavitary pulmonary MAC disease. All clinical outcomes will be considered standard of care and abstracted from clinical records. Therapy changes and adverse events will be recorded at routine visits. Health-related quality of life (HRQoL) and self-reported toxicity will be captured centrally in a web-based

2018 Clinical Trials

4077. Cognitive Behavioural Therapy to Optimize Post-Operative Recovery

of the lower extremity or pelvis. Our secondary objectives are to determine if CBT, versus usual care: 1) increases physical functioning, 2) improves mental functioning, 3) accelerates return to function, 4) reduces pain severity, and 5) reduces pain interference over 12 months post-fracture, and 6) reduces the proportion of participants prescribed opioid class medications (and average dose) at 6 and 12 months post-fracture in patients with an open fracture of the appendicular skeleton or closed fracture (...) Recovery: A Randomized Controlled Trial Actual Study Start Date : January 9, 2019 Estimated Primary Completion Date : October 2022 Estimated Study Completion Date : October 2022 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Intervention - CBT Participants in this arm will receive cognitive behavioural therapy. Participants will have the choice of completing six real-time telephone or video-delivered CBT

2018 Clinical Trials

4078. Neoadjuvant Therapy Followed by Stereotactic Body Radiotherapy (SBRT) for Locally Advanced Pancreatic Cancer

Pancreas Cancer Drug: FOLFIRINOX Drugs Drug: Gemcitabine-nab Paclitaxel Phase 1 Phase 2 Detailed Description: We want to find out what effects, good and bad, using chemotherapy combinations modified FOLFIRINOX (Oxaliplatin, Irinotecan, and fluorouracil) OR gemcitabine plus nab-paclitaxel (Gem-ABRAXANE) and radiation using Stereotactic Body Radiation Therapy (SBRT) have on the cancer and to increase the percentage of patients who can have surgery to remove their disease. SBRT is a short course of high (...) dose precisely delivered radiation. The two combination chemotherapy routines (mFOLFIRINOX or GEM-ABRAXANE) have been shown in previous clinical trials to be the most effective FDA approved chemotherapy in wide spread pancreatic cancers. These chemotherapy drugs will be given before the surgery. Radiation Therapy, using the 5 ½ week method as well as SBRT has been used as standard of care and found to be effective to reduce the size of pancreatic cancer, so patients can have surgery. SBRT uses

2018 Clinical Trials

4079. Systemic Light Exposure in Preventing Frailty in Older Participants With Prostate Cancer on Hormonal Therapy

: NCT03661437 Recruitment Status : Recruiting First Posted : September 7, 2018 Last Update Posted : October 8, 2018 See Sponsor: City of Hope Medical Center Collaborator: National Cancer Institute (NCI) Information provided by (Responsible Party): City of Hope Medical Center Study Details Study Description Go to Brief Summary: This pilot trial studies how well systemic light exposure works in preventing frailty in older participants with prostate cancer on hormonal therapy. Hormone therapy causes many (...) white light (BWL), compared to dim white light (DWL), significantly prevents frailty development in older prostate cancer (PC) patients following prostate anti-androgen therapy initiation. II. Determine if BWL, compared to DWL, significantly increases functional performance and physical activity levels, yields significant reductions in fatigue, lowers body mass index (BMI), and reduces weakness in older PC patients following prostate anti-androgen therapy initiation. III. Examine the feasibility

2018 Clinical Trials

4080. Dissemination and Implementation Field Trial of Dialectical Behavior Therapy for Adolescents With Bipolar Disorder

of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Adolescents with bipolar disorder 40 adolescents aged 13 to 19 with bipolar disorder (type I, type II, not otherwise specified/nos) will be enrolled in the dialectical behavioral therapy intervention. Behavioral: Dialectical behavioral therapy DBT will be conducted over 1 year, and divided into two modalities: skills training, conducted in 60 minute biweekly family meetings and individual (...) of sexual or physical abuse. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03661333 Contacts Layout table for location contacts Contact: Jessica L Roane, MSW 416-480-6067 Contact: Vanessa H Timmins, MSW 416-480-6063 Locations Layout table for location

2018 Clinical Trials

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