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181. Meeting Report: FDA Public Meeting on Patient-Focused Drug Development and Medication Adherence in Solid Organ Transplant Patients. Full Text available with Trip Pro

grafts. Participants described the physical, emotional, and social impacts of their transplant on daily life. They also discussed their posttransplant treatment regimens, including the most burdensome side effects and their hopes for future treatment. The afternoon scientific session consisted of presentations on prevalence and risk factors for medication nonadherence after transplantation in adults and children, and interventions to manage it. As new modalities of Immunosuppressive Drug Therapy (...) Meeting Report: FDA Public Meeting on Patient-Focused Drug Development and Medication Adherence in Solid Organ Transplant Patients. The Food and Drug Administration (FDA) held a public meeting and scientific workshop in September 2016 to obtain perspectives from solid organ transplant recipients, family caregivers, and other patient representatives. The morning sessions focused on the impact of organ transplantation on patients' daily lives and the spectrum of activities undertaken to maintain

2017 American Journal of Transplantation

182. Medical and Behavioral Approaches to Engage People Who Inject Drugs Into Care for Hepatitis C Virus Infection Full Text available with Trip Pro

reinfection among persons with substance use disorders. Widespread prescription of therapy for hepatitis C virus infection to substance users will be required to achieve the ultimate goal of global virus elimination. Combinations of medical and behavioral interventions should be used to promote persons with substance use disorders engagement into and adherence with direct-acting antiviral-based treatment approaches. Ultimately, either physical or virtual colocation of hepatitis C virus and substance use (...) Medical and Behavioral Approaches to Engage People Who Inject Drugs Into Care for Hepatitis C Virus Infection Direct-acting antivirals for hepatitis C virus infection may revolutionize treatment among persons with substance use disorders. Despite persons with substance use disorders having the highest hepatitis C virus prevalence and incidence, the vast majority have not engaged into care for the infection. Previously, interferon-based treatments, with substantial side effects

2017 Addictive disorders & their treatment

183. Australian Institute of Sport and Australian Medical Association position statement on concussion in sport

is suspected, the athlete must be immediately removed from sport and not be allowed to return to activity until they have been assessed by a medical practitioner. “If in doubt, sit them out.” A diagnosis of concussion requires immediate physical and cognitive rest, followed by a structured, graduated return to physical activity. Children require a longer period of recovery from concussion. Algorithms are provided for use by medical and non-medically trained stakeholders in the recognition and management (...) Australian Institute of Sport and Australian Medical Association position statement on concussion in sport Australian Institute of Sport and Australian Medical Association position statement on concussion in sport | The Medical Journal of Australia mja-search search Use the for more specific terms. Title contains Body contains Date range from Date range to Article type Author's surname Volume First page doi: 10.5694/mja__.______ Search Reset  close Individual Login Purchase options Connect

2017 MJA Clinical Guidelines

184. Interventional Spine and Pain Procedures in Patients on Antiplatelet and Anticoagulant Medications

guidelines for regional anesthesia in patients on antiplatelet and anticoagulant medications and/or if respondents incorporated different protocols for different pain procedures. One hundred twenty-four active participants attended the forum. Responses were collected using an audience response system. Eighty-four percent of respondents were anesthesiologists, and the remainders were physical medicine and rehabilitation physicians, neurologists, orthopedic surgeons, and neurological surgeons. Most (...) Interventional Spine and Pain Procedures in Patients on Antiplatelet and Anticoagulant Medications Interventional Spine and Pain Procedures in Patients on Anti... : Regional Anesthesia and Pain Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me on this computer Register for a free account

2018 American Society of Regional Anesthesia and Pain Medicine

185. Non-medical Prescription Stimulant Use among Post-secondary Students

to the greater negative impacts of street drugs, a finding consistent with other qualitative studies (Judson & Langdon, 2009; Kerley, Copes, & Giffin, 2015). Moreover, none of the 175 participants recognized that using prescription stimulants non-medically posed a significant health risk, and felt that because a pharmaceutical company manufactured them they were relatively safe. Other justifications for use included students’ beliefs that they were doing it for the right reasons (i.e., academic enhancement (...) of Use According to the 2015 Canadian Tobacco, Alcohol and Drug Survey (CTADS), 0.2% of the general population report the non-medical use of prescription stimulants (Statistics Canada, 2015). This statistic was not reportable among emerging adults, aged 18–25, in the 2015 CTADS due to high sampling variability, but other survey results suggest rates are highest among this subgroup. For example, the 2015 National Survey on Drug Use and Health in the United States showed that 2.2% of emerging adults

2018 Canadian Centre on Substance Abuse

186. Medical Nutrition Education, Training, and Competencies to Advance Guideline-Based Diet Counseling by Physicians: A Science Advisory From the American Heart Association

medicine (LM) thread or track, an approach aligned with calls for more individualization in medical education. Rather than offering a distinct course or integration into standard UME curricula, some medical schools, such as Northwestern University Feinberg School of Medicine and the University of South Carolina–Greenville School of Medicine, have introduced separate LM tracks that provide in-depth UME in nutrition alongside other lifestyle factors, including physical activity, substance and tobacco use (...) are especially important for those planning careers in primary care, cardiology, neurology, endocrinology, obesity treatment, gastroenterology, oncology, intensive care medicine, and some surgical subspecialties. Although expanded nutrition competencies are needed across all health professions, those presented herein are limited to medical students and trainees and form the basis of the entrustable professional activities (EPAs) related to nutrition that are also presented. Educational resources for building

2018 American Heart Association

187. Interventional Spine and Pain Procedures in Patients on Antiplatelet and Anticoagulant Medications

Interventional Spine and Pain Procedures in Patients on Antiplatelet and Anticoagulant Medications Interventional Spine and Pain Procedures in Patients on Anti... : Regional Anesthesia and Pain Medicine You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page. Login No user account? Lippincott Journals Subscribers , use your username or email along with your password to log in. Remember me on this computer Register for a free account (...) and the evidentiary basis for such recommendations. This publication is intended as a living document to be updated periodically with consideration of new evidence. From the *Western Reserve Hospital, Cuyahoga Falls, OH; †Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL; ‡Pain Diagnostics and Interventional Care, Pittsburgh, PA; §Department of Anesthesiology, Rush University Medical Center, Chicago, IL; ∥Valencia University Medical School and Department

2018 American Society of Regional Anesthesia and Pain Medicine

188. CRACKCast E178 – Co-Morbird Medical Emergencies During Pregnancy

. Certain medical conditions in the mother result in neonatal complications that require special resuscitative measures. This is particularly true of many chemical dependency states, and anticipatory management of these patients is essential. Rosen’s in Perspective The enormous breadth of physical and physiologic changes that occur in pregnancy may overwhelm a woman’s compensatory mechanisms and lead to deterioration of pre-existing disease. This has implications for the mother, the fetus (...) and the first dose of vaccine within 12 hours of birth. Two additional doses of vaccine are administered at a later date. This post was copy-edited and uploaded by Andrew Guy. (Visited 665 times, 1 visits today) Chris Lipp is one of the founding Fathers for CrackCast. He currently divides his time as an EM Physician in Calgary (SHC/FMC) and in Sports Medicine. His interests are in endurance sports, exercise as medicine, and wilderness medical education. When he isn’t outdoors with his family, he's brewing

2018 CandiEM

189. Evidence Bite: Medical Education and caring for transgender patients Full Text available with Trip Pro

Evidence Bite: Medical Education and caring for transgender patients Evidence Bite: Medical Education and caring for transgender patients - CanadiEM Evidence Bite: Medical Education and caring for transgender patients In by Alexandre Coutin November 1, 2018 Transgender (trans) people make up 0.6% of the population 1 , yet are among the most underserved in health care. 2–5 Barriers to accessing care have been linked to unsafe surgical practices, self-prescribed hormone therapy, and even (...) specialties. Within this post we aim to translate the findings of the following article 20 : Coutin, A., Wright, S., Li, C., & Fung, R. (2018). Missed opportunities: are residents prepared to care for transgender patients? A study of family medicine, psychiatry, endocrinology, and urology residents. Canadian Medical Education Journal , 9 (3), 41-55. Central Questions: What is the nature of education gaps for residents? How might these gaps influence residents’ perceptions of their responsibilities

2018 CandiEM

190. CRACKCast E189 – Air Medical Transport

CRACKCast E189 – Air Medical Transport CRACKCast E189 – Air Medical Transport - CanadiEM CRACKCast E189 – Air Medical Transport In , by Adam Thomas June 25, 2018 This episode of CRACKCast covers Chapter 191 in Rosen’s Emergency Medicine (9th Ed.) – Air Medical Transport. Including a review of clinically relevant physics! Fun stuff! Shownotes – Key concepts Boyle’s law and Dalton’s law have the greatest impact and explain the development of hypoxia and most common altitude-related symptoms (...) the University of British Columbia. Currently spending his days between a fellowship in critical care and making sure his toddler survives past age 5. - 3 hours ago Latest posts by Adam Thomas ( ) - July 2, 2018 - June 25, 2018 - June 21, 2018 Chris Lipp is one of the founding Fathers for CrackCast. He currently divides his time as an EM Physician in Calgary (SHC/FMC) and in Sports Medicine. His interests are in endurance sports, exercise as medicine, and wilderness medical education. When he isn’t outdoors

2018 CandiEM

191. Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial. Full Text available with Trip Pro

Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial. Graded exercise therapy is an effective and safe treatment for chronic fatigue syndrome, but it is therapist intensive and availability is limited. We aimed to test the efficacy and safety of graded exercise delivered as guided self-help.In this pragmatic randomised controlled trial, we recruited adult patients (18 (...) years and older) who met the UK National Institute for Health and Care Excellence criteria for chronic fatigue syndrome from two secondary-care clinics in the UK. Patients were randomly assigned to receive specialist medical care (SMC) alone (control group) or SMC with additional guided graded exercise self-help (GES). Block randomisation (randomly varying block sizes) was done at the level of the individual with a computer-generated sequence and was stratified by centre, depression score

2017 Lancet Controlled trial quality: predicted high

192. Non-drug therapies in Alzheimer's disease

directly relevant to patients. The benefit assessment only considered randomized controlled trials (RCTs). When drugs for dementia therapy are administered for the first time, the Drug Commission of the German Medical Profession recommends a check-up after 12 weeks in order to assess treatment success [1]. EMEA recommends a minimum study duration of 6 months for the evaluation of the short-term effects of antidementia drugs [2,3]. In order to meet both recommendations, a minimum observation period (...) , Alzheimer’s disease, dementia, benefit assessment, systematic review References 1. Arzneimittelkommission der deutschen Ärzteschaft. Demenz: Therapieempfehlungen. [Commission of the German Medical Profession. Dementia. Therapy recommendations]. Köln: AkdÄ; 2004. 2. The European Agency for the Evaluation of Medicinal Products. Note for guidance in medicinal products in the treatment of Alzheimer’s disease [Online]. 12.04.1997 [Accessed on 04.08.2008]. URL: http://www.emea.europa.eu/pdfs/human/ewp

2009 Institute for Quality and Efficiency in Healthcare (IQWiG)

193. Appropriate Use of Drug Testing in Clinical Addiction Medicine

Special External Reviewer Michael Miller, MD, DFASAM, FAPA IRETATeam Members (in alphabetical order) Peter Cohen, MD, Medical Advisor Leila Giles, BS Matthew Hurford, MD, Expert Panel Moderator Piper Lincoln, MS Dawn Lindsay, PhD Peter Luongo, PhD Jessica Williams, MPH Disclosure information for the ASAM Expert Panel Mem- bers and Quality Improvement Council is available in Appendix 6. INTRODUCTION Purpose The purpose of the Appropriate Use of Drug Testing in Clinical Addiction Medicine (...) should be utilized effectively in treatment. ASAM has produced 2 key documents related to drug testing: ‘‘Public Policy Statement on Drug Testing as a Endorsed by the American College of Medical Toxicology. Adopted by the ASAM Board of Directors April 5, 2017 1 CONSENSUS STATEMENTCopyright © 2017 American Society of Addiction Medicine. Unauthorized reproduction of this article is prohibited. Component of Addiction Treatment and Monitoring Pro- grams and in other Clinical Settings’’ and ‘‘Drug

2017 American Society of Addiction Medicine

194. Short- and mid-term effects of adding upper cervical manual therapy to a conventional physical therapy program in patients with chronic mechanical neck pain. Randomized controlled clinical trial.

Short- and mid-term effects of adding upper cervical manual therapy to a conventional physical therapy program in patients with chronic mechanical neck pain. Randomized controlled clinical trial. "Short- and mid-term effects of adding upper cervical manual therapy to a conventional physical therapy program in patients with chronic mechanical neck pain. Randomized controlled clinical trial." - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete (...) Display options Format Share Permalink Copy Page navigation Clin Rehabil Actions . 2020 Oct 19;269215520965054. doi: 10.1177/0269215520965054. Online ahead of print. "Short- and mid-term effects of adding upper cervical manual therapy to a conventional physical therapy program in patients with chronic mechanical neck pain. Randomized controlled clinical trial." , , , , , , Affiliations Expand Affiliations 1 Facultat de Medicina i Ciències de la Salut, Universitat Intenacional de Catalunya, Barcelona

2020 EvidenceUpdates

195. Pharmaceuticals Requiring Companion Diagnostics

Pharmaceuticals Requiring Companion Diagnostics Pharmaceuticals Requiring Companion Diagnostics | CADTH.ca CADTH Document Viewer Pharmaceuticals Requiring Companion Diagnostics Table of Contents Search this document Pharmaceuticals Requiring Companion Diagnostics June 2016 Background and Context The purpose of this Environmental Scan is to provide an overview of the current and projected use of companion diagnostic tests required for the prescription of targeted drug therapies, as well (...) treatment, depending on the intervention and medical condition). Different definitions have been proposed for personalized medicine, including, but not limited to, the following: In the US, the Personalized Medicine Coalition defines personalized medicine as the “tailoring of medical treatment to the individual characteristics of each patient. It does not mean that drugs (or medical devices) are developed to be unique to a patient but rather the ability to classify individuals into subpopulations

2016 Canadian Agency for Drugs and Technologies in Health - Environmental Scanning

196. Shared Medical Appointments for Chronic Medical Conditions: A Systematic Review

offer ready access to high-quality primary care—an approach that is embedded in the fundamental design of Veterans Affairs (V A) health care and which is consistent with the Institute of Medicine’s definition of high-quality care. This definition emphasizes safe, effective, patient-centered, timely, efficient, and equitable health care. Group medical visits are a method to deliver health care that offers the promise of improving these aspects for patients with chronic conditions. Group visits (...) searched MEDLINE ® (via PubMed ® ), Embase ® , CINAHL ® , PsycINFO ® , and Web of Science for peer-reviewed publications comparing shared medical appointments or group visits with usual care from January 1996 through April 2012. Our search strategy used the National Library of Medicine’s medical subject headings (MeSH) keyword nomenclature and text words for group visits, and validated search terms for both randomized controlled trials and relevant observational studies. We limited the search

2012 Veterans Affairs Evidence-based Synthesis Program Reports

197. Monitoring of physical health and metabolic side effects in children and adolescents taking antipsychotic medication: a systematic review

Monitoring of physical health and metabolic side effects in children and adolescents taking antipsychotic medication: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration (...) . Not an in vivo animal study 3. No metastases/ only primary tumor 4. No control group 5. Combination therapy or contamination 6. Not about analgesics used in the clinic Full text-screening: As above, with the addition of: 7. No relevant outcome measure reported ">Prioritise the exclusion criteria Example: Two reviewers will independently extract data from each article. We first try to extract numerical data from tables, text or figures. If these are not reported, we will extract data from graphs using digital

2020 PROSPERO

198. Ondansetron does not prevent physical dependence in patients taking opioid medications chronically for pain control. Full Text available with Trip Pro

Ondansetron does not prevent physical dependence in patients taking opioid medications chronically for pain control. In this study, we investigated the co-administration of ondansetron with morphine, and whether it could prevent the development of physical dependence in patients taking opioids for the treatment of chronic pain.A total of 48 chronic back pain patients (N = 48) participated in this double-blinded, placebo-controlled, randomized study. Patients were titrated onto sustained-release (...) in all participants (ΔOOWS = 4.3 ± 2.4, p < 0.0001; ΔSOWS = 14.1 ± 11.7, p < 0.0001), however no significant differences in withdrawal scores were detected between treatment groups.We hypothesized that ondansetron would prevent the development of physical dependence in human subjects when co-administered with opioids, but found no difference in naloxone-precipitated opioid withdrawal scores between ondansetron and placebo treatment groups. These results suggest that further studies are needed

2018 Drug and alcohol dependence Controlled trial quality: uncertain

199. Educating Medical Students in Counselling Older Adults about Exercise: The Impact of a Physical Activity Module. (Abstract)

physical activity module including a one-hour exercise tutorial combined with a 30-minute practical counselling session on senior medical students' perceptions of the importance of exercise and their perceived competence in advising older people about exercise.Pre-post survey.University campus.161 senior medical students taking part in the Queen Elizabeth Hospital Geriatric Medicine course in 2015 (control group) and 2016 (intervention group).The modified Exercise and Physical Activity Competence (...) Educating Medical Students in Counselling Older Adults about Exercise: The Impact of a Physical Activity Module. Exercise courses during medical school contribute to medical students' confidence in promoting physical activity to their patients. However, there is still a lack of uniform physical activity education across medical school curricula to equip medical students with the necessary skills and knowledge to counsel their patients about exercise.To determine the effects of a 1.5-hour

2018 The Journal of frailty & aging

200. The effectiveness of an incentivized physical activity programme (Active Student) among female medical students in Pakistan: A Randomized Controlled Trial. (Abstract)

The effectiveness of an incentivized physical activity programme (Active Student) among female medical students in Pakistan: A Randomized Controlled Trial. To determine the efficacy of an incentive-based approach combined with a smartphone application in promoting physical activity and weight-loss among female medical students, and to explore among them psychological effects pertaining to self-esteem, guilt, body-shaming, and perception of physical beauty.The pilot, randomised controlled trial (...) was conducted at the Peoples University of Medical and Health Sciences for Women, Nawabshah, Pakistan, from March to May 2017, and comprised female students who were randomly allocated to either the incentivized or the non-incentivized group. The incentivized group was given a weekly financial incentive based on the required level of physical activity, measured each week for five weeks using Moves application. All subjects completed several questionnaires covering secondary outcomes at the end of the trial

2018 JPMA. The Journal of the Pakistan Medical Association Controlled trial quality: uncertain

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