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Pharmaceutical Representative

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181. Prescription of potentially inappropriate medication to older patients presenting to the emergency department: a nationally representative population study Full Text available with Trip Pro

Prescription of potentially inappropriate medication to older patients presenting to the emergency department: a nationally representative population study Potentially inappropriate medication (PIM) was associated with adverse clinical outcomes and higher healthcare resource utilization among older patients. In order to investigate the prevalence of PIM use based on three different sets of criteria and their associated factors among older patients in the emergency department (ED) in Taiwan (...) criteria was only inferior to that of the Beers Criteria. The most important factor associated with PIM was the number of medications prescribed in the ED, and PIM use was associated with higher annual health resource utilization in the ED. PIM use was a significant issue and was associated with higher annual emergency care resource utilization in the ED.

2018 Scientific reports

182. Medical Oncologists' Beliefs, Practices, and Knowledge Regarding Marijuana Used Therapeutically: A Nationally Representative Survey Study. Full Text available with Trip Pro

Medical Oncologists' Beliefs, Practices, and Knowledge Regarding Marijuana Used Therapeutically: A Nationally Representative Survey Study. Background Although almost every state medical marijuana (MM) law identifies cancer as a qualifying condition, little research supports MM's use in oncology. We hypothesized that the discrepancy between these laws and the scientific evidence base poses clinical challenges for oncologists. Oncologists' beliefs, knowledge, and practices regarding MM were (...) examined in this study. Methods In November 2016, we mailed a survey on MM to a nationally-representative, random sample of 400 medical oncologists. Main outcome measures included whether oncologists reported discussing MM with patients, recommended MM clinically in the past year, or felt sufficiently informed to make such recommendations. The survey also queried oncologists' views on MM's comparative effectiveness for several conditions (including its use as an adjunct to standard pain management

2018 Journal of Clinical Oncology

183. Impact of the New Cooperative Medical Scheme on the trend of catastrophic health expenditure in Chinese rural households: results from nationally representative surveys from 2003 to 2013. Full Text available with Trip Pro

Impact of the New Cooperative Medical Scheme on the trend of catastrophic health expenditure in Chinese rural households: results from nationally representative surveys from 2003 to 2013. To evaluate the trend of catastrophic health expenses (CHE) for inpatient care in relation to the commencement of the New Cooperative Medical Scheme (NCMS) in rural China from 2003 to 2013, and the roles of NCMS in protecting affected households from CHE.We assessed the 10-year trend of the incidence

2018 BMJ open

184. Are efforts to attract graduate applicants to UK medical schools effective in increasing the participation of under-represented socioeconomic groups? A national cohort study. Full Text available with Trip Pro

Are efforts to attract graduate applicants to UK medical schools effective in increasing the participation of under-represented socioeconomic groups? A national cohort study. Attracting graduates was recommended as a means of diversifying the UK medical student population. Graduates now make up nearly a quarter of the total medical student population. Research to date has focused on comparing the sociodemographic characteristics of applicants to and/or students on traditional and graduate entry (...) programmes (GEMs), yet GEMs account for only 40% of the graduate medical student population. Thus, we aimed to compare the sociodemographic characteristic and outcomes of graduates and non-graduate applicants across a range of programmes.This was an observational study of 117 214 applicants to medicine who took the UK Clinical Aptitude Test (UKCAT) from 2006 to 2014 and who applied to medical school through Universities and Colleges Admissions Service (UCAS). We included applicant demographics, UKCAT

2018 BMJ open

185. Sources of Opioid Medication for Misuse in Older Adults: Results from A Nationally Representative Survey. Full Text available with Trip Pro

Sources of Opioid Medication for Misuse in Older Adults: Results from A Nationally Representative Survey. Despite increasing rates of prescription opioid (PO) misuse in adults 50 years of age and older, little research has investigated such misuse in this population. This work aimed to examine sources of misused opioid medication in adults 50 years and older, with comparisons to younger groups. Data were from the 2009 to 2014 National Survey on Drug Use and Health surveys. Prevalence rates

2018 Pain

186. Attitudes Concerning Antipsychotic Depot Medication in the German General Population: A Representative Telephone Survey. (Abstract)

Attitudes Concerning Antipsychotic Depot Medication in the German General Population: A Representative Telephone Survey. Treatment of schizophrenia with depot medication has advantages compared with oral medication, and among these include an improved compliance. Despite such advantages, prescription rates in many European countries are lower than 20%. The aim of this survey was to study the attitudes toward depot medication among the German general population. To the best of our knowledge (...) , only selective samples have been investigated up until now.A representative sample of 754 people were interviewed via telephone by a professional market research and polling organization. The questionnaire queried demographic characteristics, experience with medication, and the treatment of mental disorders. Subjects' attitudes toward medication in general, long-term medication, and depot medication were surveyed.Most (66.7%) of the subjects stated that they would be willing to receive depot

2018 Journal of Clinical Psychopharmacology

187. Patent foramen ovale closure, antiplatelet therapy or anticoagulation therapy alone for management of cryptogenic stroke

or anticoagulation therapy alone for management of cryptogenic stroke Order Download: Key message We are constantly trying to make our products better. On this publication we have tried out a new presentation: Patent foramen ovale (PFO) represents an opening in the heart placing people at risk of ischemic stroke. This report evaluates catheter-based PFO closure as an alternative treatment to antiplatelet therapy or anticoagulation for patients with a PFO having suffered a stroke. Our findings: PFO closure plus (...) be a treatment option to prevent new embolic strokes. Today's treatment is drug prevention with platelet inhibitor or anticoagulation. Objective The purpose of this report is to investigate whether PFO closure is an effective and cost-effective alternative to medical treatment. Method The commission of this report contained a new systematic overview of the efficacy and safety of PFO closure compared to treatment with platelet inhibitors and anticoagulation. In line with our methods, we conducted a systematic

2019 Norwegian Institute of Public Health

188. Does directly administered antiretroviral therapy represent good value for money in sub-Saharan Africa? A cost-utility and value of information analysis. Full Text available with Trip Pro

Does directly administered antiretroviral therapy represent good value for money in sub-Saharan Africa? A cost-utility and value of information analysis. Successful antiretroviral therapy (ART) relies on the optimal level of ART adherence to achieve reliable viral suppression, avert HIV drug resistance, and prevent avoidable deaths. It has been shown that there are various groups of people living with HIV at high-risk of non-adherence to ART in sub-Saharan Africa. The objective of this study (...) was to examine the cost effectiveness and value-of-information of directly administered antiretroviral therapy (DAART) versus self-administered ART among people living with HIV, at high risk of non-adherence to ART in sub-Saharan Africa.A Markov model was developed that describes the transition between HIV stages based on the CD4 count, along with direct costs, quality of life and the mortality rate associated with DAART in comparison with self-administered ART. Data used in the model were derived from

2018 PLoS ONE

189. Emergency and acute medical care in over 16s: service delivery and organisation

explains how we use words to show the strength (or certainty) of our recommendations, and has information about prescribing medicines (including off-label use), professional guidelines, standards and laws (including on consent and mental capacity), and safeguarding. 1.1 Emergency and acute medical care in the community Recommendations for commissioners and pro Recommendations for commissioners and providers of health and social care in the viders of health and social care in the community community (...) to hospital with a medical emergency [3] . [See the evidence review on pharmacist support.] 1.2.8 Provide access to physiotherapy and occupational therapy 7 days a week for people admitted to hospital with a medical emergency. [See the evidence review on enhanced inpatient access to physiotherapy and occupational therapy.] 1.2.9 Consider providing access to critical care outreach teams (CCOTs) for people in hospital who have, or are at risk of, acute deterioration, accompanied by local evaluation

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

190. Turkish Final Year Medical Students' Exposure to and Attitudes Concerning Drug Company Interactions: A Perspective from a Minimally Regulated Environment for Medical Students. Full Text available with Trip Pro

, in April and May 2015 attracted a response rate of 92.2% (n/N, 154/164). Exposure to interaction with a pharmaceutical representative was reported by 90.3% (139/154) of students, and 68.8% (106/154) reported experiencing such interaction alongside a resident. In addition, 83.7% (128/153) of students reported an interaction during internship. Furthermore, 69.9% (107/153) of students agreed that interactions influence physicians' prescription preferences, while 33.1% (51/154) thought that a medical (...) Turkish Final Year Medical Students' Exposure to and Attitudes Concerning Drug Company Interactions: A Perspective from a Minimally Regulated Environment for Medical Students. Interactions between drug companies and medical students may affect evidence-based medical practice and patient safety. The aim of this study was to assess drug company-medical student interactions in a medical faculty where limited specific national or institutional regulations apply between drug companies and medical

2016 PLoS ONE

191. What is the current evidence for the efficacy of drug consumption rooms?

Supervised Injection Site in the U.S. American Journal of Preventive Medicine. 2017;53(6):919-22. 28. Fast D, Small W, Wood E, Kerr T. The perspectives of injection drug users regarding safer injecting education delivered through a supervised injecting facility. Harm Reduction Journal. 2008;5:32. 29. Wood E, Tyndall MW, Montaner JS, Kerr T. Summary of findings from the evaluation of a pilot medically supervised safer injecting facility. CMAJ. 2006;175(11):1399-404. 30. Hunt N, Lloyd C, Kimber J, Tompkins (...) , or without a fixed address. • DCRs have been used to provide people who use drugs with education on safer drug use, access to medical services and referrals to other health and social care services. Staff build harm reduction principles into their conversations with clients. • Some studies have shown that DCRs have decreased incidences of syringe and pipe sharing, though this is not consistent across all research. • Ambulance call-outs for overdoses in the vicinity of a DCR in Sydney, Australia were

2020 Public Health England - Evidence Briefings

192. Covid-19 drug vignettes: Azithromycin

Covid-19 drug vignettes: Azithromycin Drug vignettes: Azithromycin - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Drug vignettes: Azithromycin May 13, 2020 Robin E Ferner*, Jeffrey K Aronson On behalf of the Oxford COVID-19 Evidence Service Team Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences University of Oxford *University of Birmingham Correspondence (...) ); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000). QTc interval prolongation Azithromycin prolongs the QT c interval and therefore increases the risk of the ventricular arrhythmia known as torsade de pointes; this can be fatal . See also Drugdrug interactions below. Drugdrug interactions Azithromycin inhibits the enzyme CYP3A4, although less so than some other macrolides. This can lead to interactions with medicines that are metabolized by CYP3A4. Macrolides

2020 Oxford COVID-19 Evidence Service

193. Standardisation of immunosuppressive and anti-infective drug regimens in UK Paediatric Renal transplantation: The Harmonisation programme

transplant if either donor or recipient are CMV positive (CMV D+R- / CMV D-R+ / CMV D+R+). (1D) Summary of audit measures for immunosuppressive and anti-infective drug prescribing and monitoring in children and young people receiving routine, initial therapy for kidney-only transplantation 1. Proportion of parents or carers of CYP undergoing renal transplantation offered information on steroid maintenance and early steroid withdrawal ISD regimens by health professionals with specialist knowledge (...) : The Harmonisation Programme 10 Summary of research recommendations for immunosuppressive and anti-infective drug prescribing and monitoring in children and young people receiving routine, initial therapy for kidney-only transplantation 1. In children and young people receiving initial therapy for routine, kidney only transplantation, is early steroid withdrawal associated with improved outcomes compared with steroid maintenance therapy? Rationale for clinical practice recommendations for immunosuppressive

2020 Renal Association

194. Are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) safe in the context of the COVID-19 pandemic?

Are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) safe in the context of the COVID-19 pandemic? COVID-19 Scientific Advisory Group Rapid Response Report April 22, 2020 © 2020, Alberta Health Services, COVID-19 Scientific Advisory Group Key Research Topic: Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in COVID-19 Patients 1. Should patients who are on prescribed NSAIDS as chronic therapy stop taking these drugs if they develop COVID-19? 2. Should NSAIDs be used for anti-pyretic therapy (...) or other indications in patients with COVID-19? Key Messages from the Evidence Summary • The evidence for this topic is gathered entirely from existing guidance and literature reviews. No primary studies were identified that support or refute the safety of NSAIDs in COVID-19 treatment. • Guidance from Canadian sources and the European Medicines Agency state that patients who take prescribed NSAIDs prior to developing COVID-19 should continue to take their medication. • Canadian, British, and American

2020 Covid-19 Ad hoc papers

195. Emergency Use Authorization of remdesivir by the US Food and Drug Administration

Emergency Use Authorization of remdesivir by the US Food and Drug Administration Emergency Use Authorization of remdesivir by the US Food and Drug Administration - CEBM CEBM The Centre for Evidence-Based Medicine develops, promotes and disseminates better evidence for healthcare. Navigate this website Emergency Use Authorization of remdesivir by the US Food and Drug Administration May 6, 2020 Jeffrey K Aronson, Robin E Ferner*, David Nunan On behalf of the Oxford COVID-19 Evidence Service Team (...) Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences University of Oxford *University of Birmingham Correspondence to On 1 May the US Food and Drug Administration (FDA) announced that it had issued Emergency Use Authorization (EUA) for the use of remdesivir in treating COVID-19. Here is the announcement, as posted on the FDA’s : “On May 1, 2020, FDA issued an EUA to allow remdesivir to be distributed and used by licensed health care providers to treat adults

2020 Oxford COVID-19 Evidence Service

196. Drug-induced heart valve disease: a blind spot for cardiologists

with a drug when they detected heart valve disease. Furthermore, few cardiologists spontaneously mentioned medication as a possible cause of heart valve disease (2). Often diagnosed as rheumatic heart disease by cardiologists When the cardiologists who responded to this survey detected heart valve disease before 2009-2010, they diagnosed rheumatic heart disease (valve damage subsequent to acute rheumatic fever) three times more often than drug-induced heart valve disease (2). According to an article (...) antimigraine drug methysergide, was published in the 1960s (6). The first article indicating a link between heart valve disease and fenfluramines was published in 1997 in the New England Journal of Medicine, and involved patients taking fenfluramine combined with phentermine (2,6). That same year, marketing authorisation for dexfenfluramine and fenfluramine, both marketed by Servier and both suspected of damaging heart valves, was suspended in France and revoked in the United States (2,11). Benfluorex

2020 Prescrire

197. Effectiveness of mental health electronic medical records

level Hierarchy of Evidence based on a combination of recommendations from the National Health and Medical Research Council (NHMRC), the Oxford Centre for Evidence-based Medicine Levels of Evidence and a publication by Melynyk and Fineout-Overholt (2011). Most of the papers included in our review were graded as low quality, with only two randomised controlled trials identified. Key findings A total of 14 primary research studies focussed on EMRs in mental health settings and eight literature reviews (...) for accuracy of interpretation based on original sources. The terminology used throughout this report is aligned with the Glossary of Usability Terms published by Human Factors International https://humanfactors.com/downloads/Glossary_of_Usability_Terms.pdf Assessment of evidence quality We used The Hierarchy of evidence (Table 3) which includes seven levels based on publications by the National Health and Medical Research Council (NHMRC) (28) the Oxford Centre for Evidence-based Medicine Levels

2020 Sax Institute Evidence Check

198. Cardiovascular Disease: Tailored Pharmacy-based Interventions to Improve Medication Adherence

, Rompelberg CJ, Garssen J, et al. A pharmaceutical care program to improve adherence to statin therapy: a randomized controlled trial. Annals of Pharmacotherapy 2010;44(12):1905-13. Fikri-Benbrahim N, Faus MJ, Martínez-Martínez F, Sabater-Hernández D. Impact of a community pharmacists' hypertension-care service on medication adherence. The AFenPA study. Research in Social and Administrative Pharmacy 2013 ;9(6):797-805. Hedegaard U, Kjeldsen LJ, Pottegård A, Bak S, Hallas J. Multifaceted intervention (...) in Pharmacology 2016;7:269. Lee VW, Pang KK, Hui KC, Kwok JC, Leung SL, et al. Medication adherence: Is it a hidden drug-related problem in hidden elderly? Geriatrics & Gerontology International 2013;13(4):978-85. Lee VW, Choi LM, Wong WJ, Chung HW, Ng CK, et al. Pharmacist intervention in the prevention of heart failure for high-risk elderly patients in the community. BMC Cardiovascular Disorders 2015;15(1):178. L Lyons I, Barber N, Raynor DK, Wei L. The Medicines Advice Service Evaluation (MASE

2020 Community Preventive Services Task Force

199. Recommendations: Prehospital Emergency Medical Services (EMS) COVID-19

into six sections, representing the functions of pre-hospital EMS and includes: 1. Dispatch/Call Management 2. Pre-Transport/EMS on Scene 3. Transport 4. Post-Transport 5. Administration (911/EMS) 6. Special Considerations Prehospital Emergency Medical Services (EMS) COVID-19 Recommendations | 3 Section 1: DISPATCH / CALL MANAGEMENT Dispatch screening is designed to preliminarily identify COVID-19 Patients Under Investigation (PUI) based on the latest guidelines, assess illness severity and recommend (...) Recommendations: Prehospital Emergency Medical Services (EMS) COVID-19 Prehospital Emergency Medical Services (EMS) C O V I D - 19 R e c o m m e n d a t i o n s Draft document, Version 4.4. March 27, 2020 PAN AMERICAN HEALTH ORGANIZATION (PAHO/WHO) | www.paho.org Prehospital Emergency Medical Services Prehospital Emergency Medical Services (EMS) COVID-19 Recommendations | 1 Contents Introduction 2 Section 1: DISPATCH / CALL MANAGEMENT 3 Section 2: PRE-TRANSPORT / EMS ON SCENE 4 Section 3: EMS

2020 WHO Coronavirus disease (COVID-19) Pandemic

200. The Geriatricians’ Perspective on Medical Services to Residential Aged Care Facilities (RCFs) in Australia.

The Geriatricians’ Perspective on Medical Services to Residential Aged Care Facilities (RCFs) in Australia. Australian and New Zealand Society for Geriatric Medicine Position Statement No’s 9 and 10 The Geriatricians’ Perspective on Medical Services to Residential Aged Care Facilities (RCFs) in Australia. Revised August 2011 Companion paper regarding the NZ perspective to follow. 1. The demand for residential aged care in Australia continues to grow as the population ages. 2. Dementia, chronic (...) in multidisciplinary policy and procedure development. 9. There is a need for the establishment of a medical special interest group, dedicated to promoting high quality research and medical care for the residential care population, in which the Australian and New Zealand Society for Geriatric Medicine should have a major role. This body could progressively establish education and training requirements for recognition of competency in residential care medicine. This recognition could become an entitlement

2020 Australian and New Zealand Society for Geriatric Medicine

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