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Peyronies Disease

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2. Factors Associated with Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients with Peyronie's Disease. (PubMed)

Factors Associated with Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients with Peyronie's Disease. To elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie disease (PD).A post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in 2 phase 3 trials of collagenase clostridium histolyticum (...) (Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study I [n = 417] and Investigation for Maximal Peyronie's Reduction Efficacy and Safety Study II [n = 415]). The Covariance Analysis of Linear Structural Equations procedure was used to estimate the potential relationship of specified variables on the level of distress and erectile dysfunction associated with PD as measured by the Peyronie's Disease Questionnaire and the International Index of Erectile Function, erectile function

2017 Urology Controlled trial quality: uncertain

3. Clinical Efficacy of Injection and Mechanical Therapy for Peyronie's Disease: A Systematic Review of the Literature

Clinical Efficacy of Injection and Mechanical Therapy for Peyronie's Disease: A Systematic Review of the Literature Conservative therapies for Peyronie's disease (PD) aim to treat early-stage disease by improving clinical outcomes such as penile curvature, penile length erectile dysfunction, and pain.To summarise the available evidence regarding injection and mechanical therapies for PD treatment.An extensive search of Medline, Embase, and Scopus databases retrieved English-language articles up (...) of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie's disease. No robust evidence is available to support the use of other local treatments including calcium channel blockers, hyaluronic acid, or mechanical therapies.Copyright © 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved.

2018 EvidenceUpdates

4. The clinical efficacy of surgical techniques in patients with Peyronie's disease: a systematic review and meta-analysis

The clinical efficacy of surgical techniques in patients with Peyronie's disease: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) cell dose (linear); blinding of outcome assessment reported (stratified yes vs no). For stratified analyses, a minimum number of 8 studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome

2019 PROSPERO

5. Re: Self-Report and Clinical Response to Peyronie's Disease Treatment: Peyronie's Disease Questionnaire Results from 2 Large Double-Blind, Randomized, Placebo-Controlled Phase 3 Studies. (PubMed)

Re: Self-Report and Clinical Response to Peyronie's Disease Treatment: Peyronie's Disease Questionnaire Results from 2 Large Double-Blind, Randomized, Placebo-Controlled Phase 3 Studies. 27302808 2016 12 14 2018 12 02 1527-3792 195 4 Pt 1 2016 04 The Journal of urology J. Urol. Re: Self-Report and Clinical Response to Peyronie's Disease Treatment: Peyronie's Disease Questionnaire Results from 2 Large Double-Blind, Randomized, Placebo-Controlled Phase 3 Studies. 1075 10.1016/j.juro.2016.01.051

2016 The Journal of urology Controlled trial quality: predicted high

6. Comparative Effectiveness of Intralesional Therapy for Peyronie's Disease in Controlled Clinical Studies: A Systematic Review and Network Meta-Analysis. (PubMed)

Comparative Effectiveness of Intralesional Therapy for Peyronie's Disease in Controlled Clinical Studies: A Systematic Review and Network Meta-Analysis. Medical treatment of Peyronie's disease (PD) in terms of intralesional therapy is still a matter of debate.To compare the efficacy of different classes of intralesional therapy with a network meta-analysis (NMA) method.The search was conducted using documents published in PubMed, Scopus, and Web of Science databases until September 30, 2017. We (...) studies. Moreover, because of the few included studies, a meta-regression analysis of predictive factors of treatment response was not calculated.This is the first meta-analysis comparing all available intralesional treatments for PD. CCH and interferon α-2b showed the best outcome in terms of PC, whereas hyaluronic acid was most efficient in relation to EF. Russo GI, Cacciamani G, Cocci A, et al. Comparative Effectiveness of Intralesional Therapy for Peyronie's Disease in Controlled Clinical Studies

2019 Journal Of Sexual Medicine

7. Surgical Technique for Complex Cases of Peyronie's Disease With Implantation of Penile Prosthesis, Multiple Corporeal Incisions, and Grafting With Collagen Fleece. (PubMed)

Surgical Technique for Complex Cases of Peyronie's Disease With Implantation of Penile Prosthesis, Multiple Corporeal Incisions, and Grafting With Collagen Fleece. Patients with Peyronie's disease (PD) and erectile dysfunction (ED) concomitant with shortening or other malformations benefit from prosthesis implantation and penile lengthening procedures.To evaluate the safety and efficacy of a multi-incisional technique with penile prosthesis implantation with multiple corporeal incisions (...) of the technique by a single high-volume implanter.The implantation of a penile prosthesis (malleable or inflatable) together with multiple incisions of the plaque/tunica albuginea and grafting with a collagen fleece is a safe and efficient treatment for patients with complex PD in addition to ED and significant shortening. Fernández-Pascual E, Gonzalez-García FJ, Rodríguez-Monsalve M, et al. Surgical Technique for Complex Cases of Peyronie's Disease With Implantation of Penile Prosthesis, Multiple Corporeal

2019 Journal Of Sexual Medicine

8. Peyronie's disease and testosterone deficiency: Is there a link? (PubMed)

Peyronie's disease and testosterone deficiency: Is there a link? Peyronie's disease (PD) and testosterone deficiency (TD) impact men at the same stage of life and can ultimately contribute to erectile dysfunction. There is speculation that low levels of testosterone (T) may predispose men to penile fibrosis; however, there is no published, up-to-date review summarizing the current evidence. Therefore, we conducted a narrative review of the literature exploring the relationship between PD

2019 World journal of urology

9. Intralesional Collagenase Clostridium Histolyticum Causes Meaningful Improvement in Men with Peyronie's Disease: Results of a Multi-Institutional Analysis. (PubMed)

Intralesional Collagenase Clostridium Histolyticum Causes Meaningful Improvement in Men with Peyronie's Disease: Results of a Multi-Institutional Analysis. In a multi-institutional setting we studied the efficacy and safety outcomes at multiple high volume centers where collagenase Clostridium histolyticum is used to treat Peyronie's disease.We collected retrospective data on consecutive patients with Peyronie's disease who underwent treatment with collagenase C. histolyticum between April 2014 (...) of treatment developed in 9% of patients. The number of cycles of collagenase C. histolyticum received was predictive of curvature improvement (p <0.0001).This large multi-institutional analysis confirms the safety and efficacy of collagenase C. histolyticum therapy in men with Peyronie's disease. Intralesional collagenase C. histolyticum for Peyronie's disease according to the IMPRESS (Investigation of Maximal Peyronie's Reduction Efficacy and Safety Studies) trial protocol produced an improvement

2019 Journal of Urology

10. Safety and Efficacy of Collagenase Clostridium Histolyticum in Peyronie's Disease Men With Ventral Curvatures. (PubMed)

Safety and Efficacy of Collagenase Clostridium Histolyticum in Peyronie's Disease Men With Ventral Curvatures. To evaluate the safety and efficacy of collagenase clostridium histolyticum (CCH) in men with ventral penile curvatures secondary to Peyronie's Disease (PD).A prospective registry has been maintained of PD men undergoing CCH at our institution. Curvature assessments and subjective questioning were obtained at baseline and following 2 and 4 injection series. Clinicopathologic data were

2019 Urology

11. A Comparison of Hemostatic Patches Versus Pericardium Allograft for the Treatment of Complex Peyronie's Disease With Penile Prosthesis and Plaque Incision. (PubMed)

A Comparison of Hemostatic Patches Versus Pericardium Allograft for the Treatment of Complex Peyronie's Disease With Penile Prosthesis and Plaque Incision. To compare outcomes between hemostatic patches (HP) versus pericardium allografts (PA) for complex Peyronie's disease with erectile dysfunction managed with inflatable penile prosthesis (IPP) and plaque incision and grafting (PIG).We reviewed all men who underwent IPP with PIG for PD at our institution (4/2010-9/2018). PIG was performed via

2019 Urology

12. Optimizing Collagenase Clostridium Histolyticum Therapy for Peyronie's Disease by a Novel Approach with Percutaneous Needle Tunnelling. (PubMed)

Optimizing Collagenase Clostridium Histolyticum Therapy for Peyronie's Disease by a Novel Approach with Percutaneous Needle Tunnelling. To compare the efficacy and safety of a combined treatment of percutaneous needle tunnelling and a modified collagenase C. histolyticum protocol (PNT/CCH), with the modified protocol alone (CCH) in the treatment of Peyronie's disease.A prospective registry of patients treated with a modified CCH protocol was maintained between June 2014 and February 2018 (...) was improvement of curvature. Secondary outcomes were improvement in erectile function, Peyronie's disease symptoms, stretched penile length and satisfaction.Improvement in curvature was greater in patients in the PNT/CCH group than in the CCH group (19.2±6.1º [36.2±12.5%] versus 12.7±5.0º, p<0.001 [28.1±14.5%], p=0.001]). Compared with baseline, both interventions were associated with significant improvement in secondary outcomes. Main complications were ecchymosis, bruising and penile pain

2019 BJU international

13. Evolution of the surgical sealing patch TachoSil<sup>®</sup> in Peyronie's disease reconstructive surgery: technique and contemporary literature review. (PubMed)

Evolution of the surgical sealing patch TachoSil® in Peyronie's disease reconstructive surgery: technique and contemporary literature review. The aim of this study is to review the current literature that reports outcomes of Peyronie's disease (PD) reconstructive surgery using the collagen fleece TachoSil® (Baxter, CA, USA), a novel graft that has self-adhesive properties and gained popularity in recent years.A literature review was performed through PubMed between 2013 and 2018 (...) regarding the use of TachoSil® in PD penile reconstructive surgery. Keywords used for the search were: Peyronie's disease, surgical therapy, surgical outcomes, grafting techniques, graft materials, collagen fleece, surgical patch, and TachoSil.Grafting procedures are indicated for men with PD and preserved erectile function. TachoSil® is a novel graft used for defect closure after tunical incision or partial plaque excision. Long-term results of this technique are encouraging and reliable. One major

2019 World journal of urology

14. Efficacy of Combined Collagenase Clostridium histolyticum and RestoreX Penile Traction Therapy in Men with Peyronie's Disease. (PubMed)

Efficacy of Combined Collagenase Clostridium histolyticum and RestoreX Penile Traction Therapy in Men with Peyronie's Disease. Previous studies of penile traction therapy (PTT) devices have demonstrated limited/no efficacy when combined with intralesional therapies for Peyronie's disease (PD). Recently, randomized data have demonstrated the efficacy of a novel PTT device, RestoreX, developed in cooperation with the Mayo Clinic, in men with PD.To assess the safety and efficacy of treatment (...) A, et al. Efficacy of Combined Collagenase Clostridium histolyticum and RestoreX Penile Traction Therapy in Men with Peyronie's Disease. J Sex Med 2019;XX:XXX-XXX.Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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2019 Journal Of Sexual Medicine

15. Characteristics predictive of response to collagenase clostridium histolyticum for Peyronie's disease: a review of the literature. (PubMed)

Characteristics predictive of response to collagenase clostridium histolyticum for Peyronie's disease: a review of the literature. To evaluate characteristics predictive of successful treatment outcomes of Peyronie's disease (PD) with collagenase clostridium histolyticum (CCH) METHODS: CCH is the only FDA-approved medication for treating PD. We reviewed the literature that addresses pre-treatment clinical characteristics that may predict favorable response to CCH therapy.Despite significant (...) heterogeneity in reporting treatment success, we identified four well-studied characteristics that may be predictive of favorable response to CCH therapy: baseline penile curvature, baseline IIEF, duration of PD, and presence of calcification. CCH demonstrated a favorable response in those with pre-treatment curvature 30°-60°, longer duration of disease, mild to moderate baseline sexual function, and low calcification within plaques. Of all factors, calcification is emerging as the most significant factor

2019 World journal of urology

16. Management of Peyronie's disease with collagenase Clostridium histolyticum in the acute phase. (PubMed)

Management of Peyronie's disease with collagenase Clostridium histolyticum in the acute phase. Peyronie's disease (PD) can affect men of all ages and is associated with penile pain as well as curvature and erectile dysfunction. Treatment modalities for PD include conservative, less invasive and surgical treatments. Choice of treatment depends on the disease's phase. Injection of collagenase Clostridium histolyticum (CCH) is only the Food and Drug Administration approved treatment (...) for the management of the chronic phase of the disease. Only a few limited studies have evaluated its potential benefits during the acute phase.To evaluate the current evidence on the use of injectable CCH during the acute or active phase of PD.We performed a PubMed database search for articles published between 2015 and 2018 that investigated the use of CCH for the management of the acute phase of PD. Search keywords included "Peyronie's disease", "collagenase Clostridium histolyticum", and "acute phase

2019 World journal of urology

17. A modified technique for intralesional injection of collagenase Clostridium histolyticum for Peyronie's disease results in reduced procedural morbidity using a standardized hematoma classification rubric. (PubMed)

A modified technique for intralesional injection of collagenase Clostridium histolyticum for Peyronie's disease results in reduced procedural morbidity using a standardized hematoma classification rubric. Early clinical trials of injectable collagenase Clostridium histolyticum (CCh) for Peyronie's disease (PD) demonstrated safety and efficacy. Since then, modified injection protocols have been proposed. Adverse events-such as bruising, swelling, hematoma, and corporal rupture-exceed 50% in many

2019 World journal of urology

18. Current Strategies in the Management of Peyronie's Disease (PD)-Results of a Survey of 401 Sexual Medicine Experts Across Europe. (PubMed)

Current Strategies in the Management of Peyronie's Disease (PD)-Results of a Survey of 401 Sexual Medicine Experts Across Europe. Peyronie's disease (PD) is a progressive and devastating penile disorder that often results in severe penile curvature with penile shrinking, making vaginal insertion difficult or even impossible. Until now, in contrast to other penile disorders such as erectile dysfunction, PD is characterized by a paucity of conservative treatment options.To investigate the current (...) with specialization in sexual medicine and may therefore not be generalizable to regions outside Europe or to other physicians treating PD.Around one-third of experts and, from their perspective, around two-thirds of patients are dissatisfied with the currently available PD treatment options. Porst H, Burri A, the European Society for Sexual Medicine (ESSM) Educational Committee. Current Strategies in the Management of Peyronie's Disease (PD)-Results of a Survey of 401 Sexual Medicine Experts Across Europe. J Sex

2019 Journal Of Sexual Medicine

19. A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie's disease. (PubMed)

A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie's disease. Peyronie's disease (PD) is a superficial fibrosing disorder that causes penile deformity and can interfere with sexual intercourse and reproduction, as well as diminish quality of life. While the exact mechanism of PD is still being investigated, there is likely a genetic component to the predisposition to penile plaque formation. Ultimately, however, perturbations in normal wound healing (...) and aberrant deposition of extracellular matrix components lead to fibrotic tissue deposition. Fibrosis in PD is regulated by a complex pathway of inflammatory and fibrotic mediators. Currently there are no treatments for PD that address an underlying cause or disease progression. In this review, we provide an overview of the known inflammatory and fibrotic mediators of PD and explore the pathophysiology of other human superficial fibrosing disorders to develop further insights into PD.

2019 World journal of urology

20. Outcomes Of A Novel Penile Traction Device (Restorex) In Men With Peyronie's Disease: A Randomized, Single-Blinded, Controlled Trial. (PubMed)

Outcomes Of A Novel Penile Traction Device (Restorex) In Men With Peyronie's Disease: A Randomized, Single-Blinded, Controlled Trial. Current penile traction therapy (PTT) devices have significant limitations, including a need to utilize 3-8 hours/day. Given these issues, a novel PTT device (RestoreX) was developed in cooperation with Mayo Clinic.A randomized, controlled, single-blinded, intent-to-treat trial (NCT03389854) was conducted with Peyronie's Disease (PD) men assigned to RestoreX 30

2019 Journal of Urology Controlled trial quality: predicted high

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