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2. 2018 Canadian Urological Association guideline for Peyronie's disease and congenital penile curvature

2018 Canadian Urological Association guideline for Peyronie's disease and congenital penile curvature CUAJ • May 2018 • Volume 12, Issue 5 © 2018 Canadian Urological Association E197 Cite as: Can Urol Assoc J 2018;12(5):E197-209. http://dx.doi.org/10.5489/cuaj.5255 Published online February 22, 2018 Introduction Peyronie’s disease (PD) is a highly prevalent condition that affects the physical and psychosocial well-being and quality of life (QoL) for thousands of Canadian men. The specific (...) improvement of penile deformity is rare, and pre - dictors of disease progression/resolution are inconsistent or absent. 6,7 As such, patients with penile deformities that result in sexual dysfunction or distress should be counselled regarding treatment options that may influence the natural history of the condition and restore functionality. PD and QoL impact The relationship between PD and ED due to resultant physi- cal penile deformity is clear, as are most diagnoses of PD. In the clinical practice

2018 Canadian Urological Association

3. Factors Associated with Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients with Peyronie's Disease. Full Text available with Trip Pro

Factors Associated with Erectile Dysfunction and the Peyronie's Disease Questionnaire in Patients with Peyronie's Disease. To elucidate patient characteristics that impact symptom-related bother and erectile function in patients with Peyronie disease (PD).A post hoc analysis used data from patients with PD (ie, had PD symptoms ≥12 months and penile curvature deformity of 30-90 degrees) who received ≥1 injection of study medication in 2 phase 3 trials of collagenase clostridium histolyticum (...) domain.Pain during intercourse (P = .02) and PD bother (P <.0001) had a significant impact on International Index of Erectile Function, erectile function scores. The Peyronie's Disease Questionnaire bother domain score was significantly affected by penile curvature deformity, penile shortening, pain during intercourse, and the presence of plaques (P ≤.0005 for all), with pain during intercourse having the greatest impact (maximum likelihood estimation ± standard error = .496 ± .030; P <.0001). Erectile

2017 Urology Controlled trial quality: uncertain

4. Clinical Efficacy of Injection and Mechanical Therapy for Peyronie's Disease: A Systematic Review of the Literature Full Text available with Trip Pro

Clinical Efficacy of Injection and Mechanical Therapy for Peyronie's Disease: A Systematic Review of the Literature Conservative therapies for Peyronie's disease (PD) aim to treat early-stage disease by improving clinical outcomes such as penile curvature, penile length erectile dysfunction, and pain.To summarise the available evidence regarding injection and mechanical therapies for PD treatment.An extensive search of Medline, Embase, and Scopus databases retrieved English-language articles up (...) of injection therapies provides evidence for improvements in penile curvature for patients with Peyronie's disease. No robust evidence is available to support the use of other local treatments including calcium channel blockers, hyaluronic acid, or mechanical therapies.Copyright © 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved.

2018 EvidenceUpdates

5. Peyronie's Disease

, flu-like symptoms, and minor penile swelling. (Clinical Principle) 12. Clinicians may offer intralesional verapamil for the treatment of patients with Peyronie's disease. (Conditional Recommendation; Evidence Strength Grade C) 13. Clinicians should counsel patients with Peyronie's disease prior to beginning treatment with intralesional verapamil about potential adverse events, including penile bruising, dizziness, nausea, and pain at the injection site. (Clinical Principle) 14. Clinicians should (...) not use extracorporeal shock wave therapy (ESWT) for the reduction of penile curvature or plaque size. (Moderate Recommendation; Evidence Strength Grade B) 15. Clinicians may offer extracorporeal shock wave therapy (ESWT) to improve penile pain. (Conditional Recommendation; Evidence Strength Grade B) 16. Clinicians should not use radiotherapy (RT) to treat Peyronie's disease. (Moderate Recommendation; Evidence Strength Grade C) 17. Clinicians should assess patients as candidates for surgical

2015 American Urological Association

6. Efficacy of Combined Collagenase Clostridium histolyticum and RestoreX Penile Traction Therapy in Men with Peyronie's Disease. Full Text available with Trip Pro

Efficacy of Combined Collagenase Clostridium histolyticum and RestoreX Penile Traction Therapy in Men with Peyronie's Disease. Previous studies of penile traction therapy (PTT) devices have demonstrated limited/no efficacy when combined with intralesional therapies for Peyronie's disease (PD). Recently, randomized data have demonstrated the efficacy of a novel PTT device, RestoreX, developed in cooperation with the Mayo Clinic, in men with PD.To assess the safety and efficacy of treatment (...) A, et al. Efficacy of Combined Collagenase Clostridium histolyticum and RestoreX Penile Traction Therapy in Men with Peyronie's Disease. J Sex Med 2019;XX:XXX-XXX.Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

2019 Journal Of Sexual Medicine

7. Safety and Efficacy of Collagenase Clostridium Histolyticum in Peyronie's Disease Men With Ventral Curvatures. (Abstract)

Safety and Efficacy of Collagenase Clostridium Histolyticum in Peyronie's Disease Men With Ventral Curvatures. To evaluate the safety and efficacy of collagenase clostridium histolyticum (CCH) in men with ventral penile curvatures secondary to Peyronie's Disease (PD).A prospective registry has been maintained of PD men undergoing CCH at our institution. Curvature assessments and subjective questioning were obtained at baseline and following 2 and 4 injection series. Clinicopathologic data were

2019 Urology

8. A Comparison of Hemostatic Patches Versus Pericardium Allograft for the Treatment of Complex Peyronie's Disease With Penile Prosthesis and Plaque Incision. (Abstract)

A Comparison of Hemostatic Patches Versus Pericardium Allograft for the Treatment of Complex Peyronie's Disease With Penile Prosthesis and Plaque Incision. To compare outcomes between hemostatic patches (HP) versus pericardium allografts (PA) for complex Peyronie's disease with erectile dysfunction managed with inflatable penile prosthesis (IPP) and plaque incision and grafting (PIG).We reviewed all men who underwent IPP with PIG for PD at our institution (4/2010-9/2018). PIG was performed via

2019 Urology

9. Outcomes Of A Novel Penile Traction Device (Restorex) In Men With Peyronie's Disease: A Randomized, Single-Blinded, Controlled Trial. (Abstract)

Outcomes Of A Novel Penile Traction Device (Restorex) In Men With Peyronie's Disease: A Randomized, Single-Blinded, Controlled Trial. Current penile traction therapy (PTT) devices have significant limitations, including a need to utilize 3-8 hours/day. Given these issues, a novel PTT device (RestoreX) was developed in cooperation with Mayo Clinic.A randomized, controlled, single-blinded, intent-to-treat trial (NCT03389854) was conducted with Peyronie's Disease (PD) men assigned to RestoreX 30 (...) -90 min/day or no therapy for 3 months. Inclusion criteria was ≥30° curvature, with no exclusions for complex curvatures, hourglass, prior PD therapy/surgery, or calcification. The primary outcome was safety, and secondary outcomes were penile length, curvature, and questionnaire responses.110 men were randomized 3:1 to PTT or control. Cohorts were well-matched: mean age 58.4 years, PD duration 49.7 months, and curvature 59.3°. Overall, PTT was well tolerated, with only transient and mild adverse

2019 Journal of Urology Controlled trial quality: predicted high

10. Current Strategies in the Management of Peyronie's Disease (PD)-Results of a Survey of 401 Sexual Medicine Experts Across Europe. (Abstract)

Current Strategies in the Management of Peyronie's Disease (PD)-Results of a Survey of 401 Sexual Medicine Experts Across Europe. Peyronie's disease (PD) is a progressive and devastating penile disorder that often results in severe penile curvature with penile shrinking, making vaginal insertion difficult or even impossible. Until now, in contrast to other penile disorders such as erectile dysfunction, PD is characterized by a paucity of conservative treatment options.To investigate the current (...) with specialization in sexual medicine and may therefore not be generalizable to regions outside Europe or to other physicians treating PD.Around one-third of experts and, from their perspective, around two-thirds of patients are dissatisfied with the currently available PD treatment options. Porst H, Burri A, the European Society for Sexual Medicine (ESSM) Educational Committee. Current Strategies in the Management of Peyronie's Disease (PD)-Results of a Survey of 401 Sexual Medicine Experts Across Europe. J Sex

2019 Journal Of Sexual Medicine

11. A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie's disease. (Abstract)

A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie's disease. Peyronie's disease (PD) is a superficial fibrosing disorder that causes penile deformity and can interfere with sexual intercourse and reproduction, as well as diminish quality of life. While the exact mechanism of PD is still being investigated, there is likely a genetic component to the predisposition to penile plaque formation. Ultimately, however, perturbations in normal wound healing (...) and aberrant deposition of extracellular matrix components lead to fibrotic tissue deposition. Fibrosis in PD is regulated by a complex pathway of inflammatory and fibrotic mediators. Currently there are no treatments for PD that address an underlying cause or disease progression. In this review, we provide an overview of the known inflammatory and fibrotic mediators of PD and explore the pathophysiology of other human superficial fibrosing disorders to develop further insights into PD.

2019 World journal of urology

12. Characteristics predictive of response to collagenase clostridium histolyticum for Peyronie's disease: a review of the literature. (Abstract)

Characteristics predictive of response to collagenase clostridium histolyticum for Peyronie's disease: a review of the literature. To evaluate characteristics predictive of successful treatment outcomes of Peyronie's disease (PD) with collagenase clostridium histolyticum (CCH) METHODS: CCH is the only FDA-approved medication for treating PD. We reviewed the literature that addresses pre-treatment clinical characteristics that may predict favorable response to CCH therapy.Despite significant (...) heterogeneity in reporting treatment success, we identified four well-studied characteristics that may be predictive of favorable response to CCH therapy: baseline penile curvature, baseline IIEF, duration of PD, and presence of calcification. CCH demonstrated a favorable response in those with pre-treatment curvature 30°-60°, longer duration of disease, mild to moderate baseline sexual function, and low calcification within plaques. Of all factors, calcification is emerging as the most significant factor

2019 World journal of urology

13. A modified technique for intralesional injection of collagenase Clostridium histolyticum for Peyronie's disease results in reduced procedural morbidity using a standardized hematoma classification rubric. (Abstract)

A modified technique for intralesional injection of collagenase Clostridium histolyticum for Peyronie's disease results in reduced procedural morbidity using a standardized hematoma classification rubric. Early clinical trials of injectable collagenase Clostridium histolyticum (CCh) for Peyronie's disease (PD) demonstrated safety and efficacy. Since then, modified injection protocols have been proposed. Adverse events-such as bruising, swelling, hematoma, and corporal rupture-exceed 50% in many

2019 World journal of urology

14. Management of Peyronie's disease with collagenase Clostridium histolyticum in the acute phase. (Abstract)

Management of Peyronie's disease with collagenase Clostridium histolyticum in the acute phase. Peyronie's disease (PD) can affect men of all ages and is associated with penile pain as well as curvature and erectile dysfunction. Treatment modalities for PD include conservative, less invasive and surgical treatments. Choice of treatment depends on the disease's phase. Injection of collagenase Clostridium histolyticum (CCH) is only the Food and Drug Administration approved treatment (...) for the management of the chronic phase of the disease. Only a few limited studies have evaluated its potential benefits during the acute phase.To evaluate the current evidence on the use of injectable CCH during the acute or active phase of PD.We performed a PubMed database search for articles published between 2015 and 2018 that investigated the use of CCH for the management of the acute phase of PD. Search keywords included "Peyronie's disease", "collagenase Clostridium histolyticum", and "acute phase

2019 World journal of urology

15. Peyronie's disease and testosterone deficiency: Is there a link? (Abstract)

Peyronie's disease and testosterone deficiency: Is there a link? Peyronie's disease (PD) and testosterone deficiency (TD) impact men at the same stage of life and can ultimately contribute to erectile dysfunction. There is speculation that low levels of testosterone (T) may predispose men to penile fibrosis; however, there is no published, up-to-date review summarizing the current evidence. Therefore, we conducted a narrative review of the literature exploring the relationship between PD (...) , bioavailable T, greater penile curvature, and plaque development. However, one study demonstrated no connection between the conditions. The literature is restricted by small studies with methodological flaws.There are a number of mechanisms to support the link between TD and PD. The literature on the topic is limited by small studies which are overall conflicting. The findings of this work suggest the need for larger, prospective studies to clarify the role of TD in the development, evaluation

2019 World journal of urology

16. Diagnostic utility of penile ultrasound in Peyronie's disease. (Abstract)

Diagnostic utility of penile ultrasound in Peyronie's disease. To review the literature regarding the use of penile ultrasound in the evaluation and management of Peyronie's disease.A literature review was performed using PubMed from 1980 to 2018 using the keywords: Peyronie's disease, ultrasound, sonography, calcification, penile fracture, and penile hematoma. Articles were reviewed for study size, image protocols, and findings. In addition, we reviewed images from 227 penile ultrasounds (...) performed on Peyronie's disease patients at the Walter Reed National Military Medical Center between 2014 and 2018.Through extensive urological and radiographic literature review over the last four decades, common patterns and characteristic of Peyronie's plaques were identified. These characteristics are not always delineated by physical examination alone. The ultrasound images often added objective information including etiology of erectile dysfunction and location or plaques, and presence

2019 World journal of urology

17. Testosterone Levels Are Not Associated With Magnitude of Deformity in Men With Peyronie's Disease. (Abstract)

Testosterone Levels Are Not Associated With Magnitude of Deformity in Men With Peyronie's Disease. There are some data suggesting that there is a relationship between the magnitude of Peyronie's disease (PD)-associated penile curvature and low serum testosterone.To evaluate the relationship between PD associated penile deformity and total testosterone (TT) and free testosterone (FT) levels.We identified patients diagnosed with PD who had early morning TT measurements. Because laboratories have (...) does not appear to be any association between testosterone levels and the magnitude of PD-associated penile deformity. Mulhall JP, Matsushita K, Nelson CJ. Testosterone Levels Are Not Associated With Magnitude of Deformity in Men With Peyronie's Disease. J Sex Med 2019;16:1283-1289.Copyright © 2019 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

2019 Journal Of Sexual Medicine

18. Comparative Cost-effectiveness of Surgery, Collagenase Clostridium Histolyticum, and Penile Traction Therapy in Men with Peyronie's Disease in an Era of Effective Clinical Treatment. Full Text available with Trip Pro

Comparative Cost-effectiveness of Surgery, Collagenase Clostridium Histolyticum, and Penile Traction Therapy in Men with Peyronie's Disease in an Era of Effective Clinical Treatment. Traditionally, surgery has been considered the gold standard treatment for Peyronie's disease (PD). Less-invasive alternatives, such as collagenase Clostridium histolyticum (CCH) and traction therapy, have been proposed and proven effective.To compare cost-effectiveness of management options for PD.A Markov (...) by assumptions and may not apply to all scenarios.RXPTT represents a more cost-effective method for achieving ≥20% curvature improvement compared with surgery or CCH. Depending on treatment goals, rate of surgical complications, and willingness to pay threshold, surgery and CCH may become more cost-effective in select scenarios. Wymer K, Kohler T, Trost L. Comparative Cost-effectiveness of Surgery, Collagenase Clostridium Histolyticum, and Penile Traction Therapy in Men with Peyronie's Disease in an Era

2019 Journal Of Sexual Medicine

19. The Surgical Treatment of Peyronie's Disease in the Older Man: Patient Characteristics and Surgical Outcomes in Men 65 and Older. (Abstract)

The Surgical Treatment of Peyronie's Disease in the Older Man: Patient Characteristics and Surgical Outcomes in Men 65 and Older. Surgery remains the gold standard for the correction of penile deformities secondary to Peyronie's disease (PD). Nevertheless, there is no published data on the surgical treatment of PD in older men.Considering the aging national and international population, we sought to evaluate the pre-operative characteristics and surgical outcomes of men aged 65 or older who (...) and reliable option for the properly selected and counseled older men with PD. Abdelsayed GA, Setia SA, Levine LA. The Surgical Treatment of Peyronie's Disease in the Older Man: Patient Characteristics and Surgical Outcomes in Men 65 and Older. J Sex Med 2019;XX:XXX-XXX.Copyright © 2019. Published by Elsevier Inc.

2019 Journal Of Sexual Medicine

20. Surgical Technique for Complex Cases of Peyronie's Disease With Implantation of Penile Prosthesis, Multiple Corporeal Incisions, and Grafting With Collagen Fleece. (Abstract)

Surgical Technique for Complex Cases of Peyronie's Disease With Implantation of Penile Prosthesis, Multiple Corporeal Incisions, and Grafting With Collagen Fleece. Patients with Peyronie's disease (PD) and erectile dysfunction (ED) concomitant with shortening or other malformations benefit from prosthesis implantation and penile lengthening procedures.To evaluate the safety and efficacy of a multi-incisional technique with penile prosthesis implantation with multiple corporeal incisions (...) of the technique by a single high-volume implanter.The implantation of a penile prosthesis (malleable or inflatable) together with multiple incisions of the plaque/tunica albuginea and grafting with a collagen fleece is a safe and efficient treatment for patients with complex PD in addition to ED and significant shortening. Fernández-Pascual E, Gonzalez-García FJ, Rodríguez-Monsalve M, et al. Surgical Technique for Complex Cases of Peyronie's Disease With Implantation of Penile Prosthesis, Multiple Corporeal

2019 Journal Of Sexual Medicine

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