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Peripheral Nerve Injury

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161. Autophagy Promotes Peripheral Nerve Regeneration and Motor Recovery Following Sciatic Nerve Crush Injury in Rats Full Text available with Trip Pro

Autophagy Promotes Peripheral Nerve Regeneration and Motor Recovery Following Sciatic Nerve Crush Injury in Rats Autophagy maintains cellular homeostasis by stimulating the lysosomal degradation of cytoplasmic structures, including damaged organelles and dysfunctional proteins. The role of autophagy in the renewal and regeneration of injured peripheral nerves remains poorly understood. The current study investigated the role of autophagy in peripheral nerve regeneration and motor function (...) inhibitor 3-methyladenine. These data indicate that the modulation of autophagy in peripheral nerve injury could be an effective pharmacological approach to promote nerve regeneration and reestablish motor function.

2016 Journal of Molecular Neuroscience

162. MRI Diffusion Tensor Tractography to Track and Monitor Peripheral Nerve Recovery After Severe Crush or Cut/Repair Nerve Injury

MRI Diffusion Tensor Tractography to Track and Monitor Peripheral Nerve Recovery After Severe Crush or Cut/Repair Nerve Injury MRI Diffusion Tensor Tractography to Track and Monitor Peripheral Nerve Recovery After Severe Crush or Cut/Repair Nerve Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. MRI Diffusion Tensor Tractography to Track and Monitor Peripheral Nerve Recovery After Severe Crush or Cut/Repair Nerve Injury The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our

2016 Clinical Trials

163. Surgery for nerve injury: current and future perspectives. Full Text available with Trip Pro

been a paradigm shift in surgical nerve repair, wherein surgeons are not only directing the repair at the injury zone, but also are deliberately performing distal-targeted nerve transfers as a preferred alternative in an attempt to restore function. The peripheral rewiring approach allows the surgeon to convert a very proximal injury with long regeneration distances and (often) uncertain outcomes to a distal injury and repair with a greater potential of regenerative success and functional recovery (...) Surgery for nerve injury: current and future perspectives. In this review article, the authors offer their perspective on nerve surgery for nerve injury, with a focus on recent evolution of management and the current surgical management. The authors provide a brief historical perspective to lay the foundations of the modern understanding of clinical nerve injury and its evolving management, especially over the last century. The shift from evaluation of the nerve injury using macroscopic

2019 Journal of Neurosurgery

164. Dexmedetomidine enhances ropivacaine-induced sciatic nerve injury in diabetic rats. Full Text available with Trip Pro

nerve injury in diabetic rats that is greatly potentiated by high-dose dexmedetomidine. Although the dose of dexmedetomidine used in this study is considerably higher than that used in clinical practice, our data suggest that further studies to assess ropivacaine (alone and in combination with dexmedetomidine) use for peripheral nerve blockade in diabetic patients are warranted.Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved. (...) Dexmedetomidine enhances ropivacaine-induced sciatic nerve injury in diabetic rats. Previous studies suggest that dexmedetomidine has a protective effect against local anaesthetic-induced nerve injury in regional nerve blocks. Whether this potentially protective effect exists in the context of diabetes mellitus is unknown.A diabetic state was established in adult male Sprague-Dawley rats with intraperitoneal injection of streptozotocin. Injections of ropivacaine 0.5%, dexmedetomidine 20 μg kg-1

2019 British Journal of Anaesthesia

165. Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice. Full Text available with Trip Pro

neuropathy throughout anti-inflammatory and metabolic mechanisms both in Ambra1 and in WT animals subjected to nerve injury. Moreover, we discovered that nerve lesion represents, per se, a metabolic stressor and CR reinstates glucose homeostasis, insulin resistance, incomplete fatty acid oxidation and energy metabolism. As autophagy inducer, CR promotes and anticipates Schwann cell autophagy via AMP-activated protein kinase (AMPK) that facilitates remyelination in peripheral nerve. In summary, we provide (...) Effects of caloric restriction on neuropathic pain, peripheral nerve degeneration and inflammation in normometabolic and autophagy defective prediabetic Ambra1 mice. There is a growing interest on the role of autophagy in diabetes pathophysiology, where development of neuropathy is one of the most frequent comorbidities. We have previously demonstrated that neuropathic pain after nerve damage is exacerbated in autophagy-defective heterozygous Ambra1 mice. Here, we show the existence

2018 PLoS ONE

166. Dental pulp-derived stem cell conditioned medium to regenerate peripheral nerves in a novel animal model of dysphagia. Full Text available with Trip Pro

Dental pulp-derived stem cell conditioned medium to regenerate peripheral nerves in a novel animal model of dysphagia. In nerve regeneration studies, various animal models are used to assess nerve regeneration. However, because of the difficulties in functional nerve assessment, a visceral nerve injury model is yet to be established. The superior laryngeal nerve (SLN) plays an essential role in swallowing. Although a treatment for SLN injury following trauma and surgery is desirable (...) , no such treatment is reported in the literature. We recently reported that stem cells derived from human exfoliated deciduous teeth (SHED) have a therapeutic effect on various tissues via macrophage polarization. Here, we established a novel animal model of SLN injury. Our model was characterized as having weight loss and drinking behavior changes. In addition, the SLN lesion caused a delay in the onset of the swallowing reflex and gain of laryngeal residue in the pharynx. Systemic administration of SHED

2018 PLoS ONE

167. NeuraGen nerve guide (Integra LifeSciences Corp.) for repair of severed peripheral nerves of the upper extremity

for the HTA database. Citation NeuraGen nerve guide (Integra LifeSciences Corp.) for repair of severed peripheral nerves of the upper extremity. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2012 Authors' conclusions Peripheral nerve injury affects more than 1 million people worldwide and leads to loss or disturbance of sensory and/or motor function mediated by the injured nerve. It is usually caused by traumatic injury (~90%) but may also be caused by surgical procedures (~10 (...) %). Approximately 80% of nerve injuries occur in the upper extremities and 10% in the lower extremities. Delays in reinnervation of the associated muscle can lead to a permanent loss of muscle function. Although the distal stump of a damaged nerve degenerates, the proximal segment has the ability to regenerate, restoring nerve function. Therefore, severed peripheral nerves demand prompt surgical exploration and repair. More than 200,000 peripheral nerve repair procedures are performed annually in the United

2012 Health Technology Assessment (HTA) Database.

168. Peripheral Nerve Blocks for Post-Operative Pain Relief After Arthroscopic Knee Ligament Reconstruction

Peripheral Nerve Blocks for Post-Operative Pain Relief After Arthroscopic Knee Ligament Reconstruction Peripheral Nerve Blocks for Post-Operative Pain Relief After Arthroscopic Knee Ligament Reconstruction: A Rapid Review. August 2014; pp. 1–23 Peripheral Nerve Blocks for Post-Operative Pain Relief After Arthroscopic Knee Ligament Reconstruction: A Rapid Review SE McDowell August 2014 Evidence Development and Standards Branch at Health Quality Ontario Peripheral Nerve Blocks for Post-Operative (...) Pain Relief After Arthroscopic Knee Ligament Reconstruction: A Rapid Review. August 2014; pp. 1–23 2 Suggested Citation This report should be cited as follows: McDowell SE. Peripheral nerve blocks for post-operative pain relief after arthroscopic knee ligament reconstruction: a rapid review. Toronto: Health Quality Ontario; 2014 August. 23 p. Available from: http://www.hqontario.ca/evidence/evidence-process/episodes-of-care#knee-arthroscopy. Permission Requests All inquiries regarding permission

2014 Health Quality Ontario

169. ERK/MAPK and PI3K/AKT signal channels simultaneously activated in nerve cell and axon after facial nerve injury Full Text available with Trip Pro

ERK/MAPK and PI3K/AKT signal channels simultaneously activated in nerve cell and axon after facial nerve injury The in-vitro study indicated that ERK/MAPK and PI3K/AKT signal channels may play an important role in reparative regeneration process after peripheral nerve injury. But, relevant in-vivo study was infrequent. In particular, there has been no report on simultaneous activation of ERK/MAPK and PI3K/AKT signal channels in facial nerve cell and axon after facial nerve injury.The expression (...) , but the expression levels of P-ERK and P-AKT varied as the function of the time. In particular, they were quite different in axon of the far section. It has been speculated that two signal channels might have different functions after nerve injury. However, their specific regulating effects should still be testified by further studies in regenerative process of peripheral nerve injury.

2017 Saudi journal of biological sciences

170. Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model Full Text available with Trip Pro

Dexmedetomidine to Help Nerve Regeneration in a Rat Sciatic Nerve Injury Model Several studies have shown that dexmedetomidine (DXM), a selective α2-adrenoceptor agonist, also has neuroprotective effects. However, its effect on impaired peripheral nerve regeneration has not been studied.Forty-five Sprague-Dawley rats were randomly assigned to three groups: group 1 (control SHAM), group 2 (sciatic nerve injury + normal saline), and group 3 (sciatic nerve injury + DXM). The rats of group 3 were (...) subdivided into the following three groups: DXM 0.5, 6, and 20 μg·kg-1 (groups 3A, 3B, and 3C, resp.). The sciatic nerve injury was assessed for nerve regeneration at 2 and 6 weeks.There were no differences between groups 2 and 3 in their sciatic functional index (SFI) values or histological findings at 2 weeks postinjury. However, SFI differences were statistically significant at 6 weeks postinjury in group 3. The gross findings with H&E staining showed that the number of axons was higher in group 3

2017 Pain research & management

171. Combination therapy using evening primrose oil and electrical stimulation to improve nerve function following a crush injury of sciatic nerve in male rats Full Text available with Trip Pro

Combination therapy using evening primrose oil and electrical stimulation to improve nerve function following a crush injury of sciatic nerve in male rats Peripheral nerve injuries with a poor prognosis are common. Evening primrose oil (EPO) has beneficial biological effects and immunomodulatory properties. Since electrical activity plays a major role in neural regeneration, the present study investigated the effects of electrical stimulation (ES), combined with evening primrose oil (EPO (...) significantly in rats with sciatic nerve injury in the injury + EPO + ES group than in the EPO or ES group. Totally speaking, the combined use of EPO and ES may produce an improving effect on the function of sciatic nerves injured by a crush. The increased expression of P0 may have contributed to improving the functional effects of combination therapy with EPO and ES as well as the electrophysiological and histopathological features of the injured peripheral nerve.

2017 Neural Regeneration Research

172. Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury Full Text available with Trip Pro

Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury Wallerian degeneration (WD) in injured peripheral nerves is associated with a large number of up- or down-regulated genes, but the effects of these changes are poorly understood. In our previous studies, we reported some key factors that are differentially expressed to activate nerve degeneration and regeneration during WD. Here, we determined the effects of secreted phosphoprotein 1 (Spp1) on WD after rat (...) sciatic nerve injury.Spp1 was upregulated from 6 h to 14 days after sciatic nerve injury. Altered expression of Spp1 in Schwann cells (SC) resulted in altered mRNA and protein expression levels for cytokines, c-Fos, PKCα and phospho-ERK/ERK and affected SC apoptosis in vitro. Silencing of Spp1 expression in SCs using siRNA technology reduced proliferation and promoted migration of SCs in vitro. By contrast, overexpression of Spp1 promoted proliferation and reduced migration in SCs in vitro

2017 BMC neuroscience

173. Recombinant human fibroblast growth factor-2 promotes nerve regeneration and functional recovery after mental nerve crush injury Full Text available with Trip Pro

Recombinant human fibroblast growth factor-2 promotes nerve regeneration and functional recovery after mental nerve crush injury Several studies have shown that fibroblast growth factor-2 (FGF2) can directly affect axon regeneration after peripheral nerve damage. In this study, we performed sensory tests and histological analyses to study the effect of recombinant human FGF-2 (rhFGF2) treatment on damaged mental nerves. The mental nerves of 6-week-old male Sprague-Dawley rats were crush-injured (...) for 1 minute and then treated with 10 or 50 μg/mL rhFGF2 or PBS in crush injury area with a mini Osmotic pump. Sensory test using von Frey filaments at 1 week revealed the presence of sensory degeneration based on decreased gap score and increased difference score. However, at 2 weeks, the gap score and difference score were significantly rebounded in the mental nerve crush group treated with 10 μg/mL rhFGF2. Interestingly, treatment with 10 μg/mL rhFGF had a more obviously positive effect

2017 Neural Regeneration Research

174. Light-Activated Sealing of Nerve Graft Coaptation Sites Improves Outcome following Large Gap Peripheral Nerve Injury. (Abstract)

Light-Activated Sealing of Nerve Graft Coaptation Sites Improves Outcome following Large Gap Peripheral Nerve Injury. Nerve repair using photochemically bonded human amnion nerve wraps can result in superior outcomes in comparison with standard suture. When applied to nerve grafts, efficacy has been limited by proteolytic degradation of bonded amnion during extended periods of recovery. Chemical cross-linking of amnion before bonding may improve wrap durability and efficacy.Three nerve wraps (...) (amnion, cross-linked amnion, and cross-linked swine intestinal submucosa) and three fixation methods (suture, fibrin glue, and photochemical bonding) were investigated. One hundred ten Lewis rats had 15-mm left sciatic nerve gaps repaired with isografts. Nine groups (n = 10) had isografts secured by one of the aforementioned wrap/fixation combinations. Positive and negative control groups (n = 10) were repaired with graft and suture and no repair, respectively. Outcomes were assessed using sciatic

2015 Plastic and reconstructive surgery

175. Emergent Expanded Access for ahSC Augmentation of Nerve Autografts After Severe Peripheral Nerve Injury.

Emergent Expanded Access for ahSC Augmentation of Nerve Autografts After Severe Peripheral Nerve Injury. Emergent Expanded Access for ahSC Augmentation of Nerve Autografts After Severe Peripheral Nerve Injury. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Emergent Expanded Access for ahSC Augmentation of Nerve Autografts After Severe Peripheral Nerve Injury. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02510079 Expanded Access Status : Temporarily not available First Posted : July 28, 2015 Last

2015 Clinical Trials

176. Neural regeneration after peripheral nerve injury repair is a system remodelling process of interaction between nerves and terminal effector Full Text available with Trip Pro

Neural regeneration after peripheral nerve injury repair is a system remodelling process of interaction between nerves and terminal effector 25788919 2015 03 19 2018 11 13 1673-5374 10 1 2015 Jan Neural regeneration research Neural Regen Res Neural regeneration after peripheral nerve injury repair is a system remodelling process of interaction between nerves and terminal effector. 52 10.4103/1673-5374.150705 Zhang Pei-Xun PX Department of Trauma and Orthopedics, Peking University People's

2015 Neural Regeneration Research

177. Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit Full Text available with Trip Pro

Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit The clinical effects of 2-mm small gap sleeve bridging of the biological conduit to repair peripheral nerve injury are better than in the traditional epineurium suture, so it is possible to replace the epineurium suture in the treatment of peripheral nerve injury. This study sought to identify the regeneration law of nerve fibers in the biological conduit. A nerve (...) regeneration (2-8 weeks), the number of Schwann cells and nerve fibers was higher in both proximal and distal ends, and the effects of the small gap sleeve bridging method were better than those of the traditional epineurium suture. The above results provide an objective and reliable theoretical basis for the clinical application of the biological conduit small gap sleeve bridging method to repair peripheral nerve injury.

2015 Neural Regeneration Research

178. Nerve transfers and neurotization in peripheral nerve injury, from surgery to rehabilitation. (Abstract)

Nerve transfers and neurotization in peripheral nerve injury, from surgery to rehabilitation. Peripheral nerve injury (PNI) and recent advances in nerve reconstruction (such as neurotization with nerve transfers) have improved outcomes for patients suffering peripheral nerve trauma. The purpose of this paper is to bridge the gap between the electromyographer/clinical neurophysiologist and the peripheral nerve surgeon. Whereas the preceding literature focuses on either the basic science behind (...) nerve injury and reconstruction, or the surgical options and algorithms, this paper demonstrates how electromyography is not just a 'decision tool' when deciding whether to operate but is also essential to all phases of PNI management including surgery and rehabilitation. The recent advances in the reconstruction and rehabilitation of PNI is demonstrated using case examples to assist the electromyographer to understand modern surgical techniques and the unique demands they ask from electrodiagnostic

2015 Neurosurgery and Psychiatry

179. Pathophysiology and Etiology of Nerve Injury Following Peripheral Nerve Blockade. (Abstract)

Pathophysiology and Etiology of Nerve Injury Following Peripheral Nerve Blockade. This review synthesizes anatomical, anesthetic, surgical, and patient factors that may contribute to neurologic complications associated with peripheral nerve blockade. Peripheral nerves have anatomical features unique to a given location that may influence risk of injury. Peripheral nerve blockade-related peripheral nerve injury (PNI) is most severe with intrafascicular injection. Surgery and its associated (...) requirements such as positioning and tourniquet have specific risks. Patients with preexisting neuropathy may be at an increased risk of postoperative neurologic dysfunction. Distinguishing potential causes of PNI require clinical assessment and investigation; a definitive diagnosis, however, is not always possible. Fortunately, most postoperative neurologic dysfunction appears to resolve with time, and the incidence of serious long-term nerve injury directly attributable to peripheral nerve blockade

2015 Regional Anesthesia and Pain Medicine

180. Peripheral Nerve Impairment and Recurrent Falls Among Women: Results from the Study of Women's Health Across the Nation. Full Text available with Trip Pro

Peripheral Nerve Impairment and Recurrent Falls Among Women: Results from the Study of Women's Health Across the Nation. Falls and related injuries are important public health concerns yet underappreciated in early aging. This study examined the association of peripheral nerve impairment (PNI) with fall outcomes in early old aged women (60-72 years).Women (n=1,725; mean age 65.1 ± 2.7 years) from the longitudinal cohort Study of Women's Health Across the Nation completed a PNI questionnaire (...) on presence, frequency, and severity of symptoms, and 10g and 1.4g monofilament testing in 2016-17. PNI was defined as ≥4 self-reported symptoms or monofilament insensitivity. Recurrent falls (≥2) and recurrent fall injuries (≥2 falls with ≥1 injury) in the previous 12 months were assessed via questionnaire. Poisson regression was used to generate risk ratios (RR) and corresponding 95% confidence intervals for the fall outcomes (CI), adjusting for covariates.Approximately 12.3% of participants reported ≥2

2019 Biological Sciences and Medical Sciences

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