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Peripheral Nerve Injury

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81. Correction: MHC-I and PirB Upregulation in the Central and Peripheral Nervous System Following Sciatic Nerve Injury. (PubMed)

Correction: MHC-I and PirB Upregulation in the Central and Peripheral Nervous System Following Sciatic Nerve Injury. [This corrects the article DOI: 10.1371/journal.pone.0161463.].

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2016 PLoS ONE

82. Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury. (PubMed)

Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury. P2X4 receptors (P2X4R) are a family of ATP-gated non-selective cation channels. We previously demonstrated that activation of P2X4R in spinal microglia is crucial for neuropathic pain, a highly debilitating chronic pain condition, suggesting that P2X4R is a potential therapeutic target for treating neuropathic pain. Thus, the identification of a compound that has a potent (...) of nerve injury-induced mechanical allodynia, a cardinal symptom of neuropathic pain. In rats that were pretreated with a serotonin-depleting agent and a noradrenaline neurotoxin, the antiallodynic effect of duloxetine was reduced, but still remained. Based on these results, we suggest that, in addition to duloxetine's primary inhibitory action on serotonin and noradrenaline transporters, an inhibitory effect on P2X4R may be involved at least in part in an antiallodynic effect of intrathecal duloxetine

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2016 PLoS ONE

83. Incidence, Risk Factors, and Trends of Motor Peripheral Nerve Injury After Colorectal Surgery: Analysis of the National Surgical Quality Improvement Program Database. (PubMed)

Incidence, Risk Factors, and Trends of Motor Peripheral Nerve Injury After Colorectal Surgery: Analysis of the National Surgical Quality Improvement Program Database. Motor peripheral nerve injury is a rare but serious event after colorectal surgery, and a nationwide study of this complication is lacking.The purpose of this study was to report the incidence, trends, and risk factors of motor peripheral nerve injury during colorectal surgery.The National Surgical Quality Improvement Program (...) database was surveyed for motor peripheral nerve injury complicating colorectal procedures. Risk factors for this complication were identified using logistic regression analysis.The study used a national database.Patients undergoing colorectal resection between 2005 and 2013 were included.The incidence, trends, and risk factors for motor peripheral nerve injury complicating colorectal procedures were measured.We identified 186,936 colorectal cases, of which 50,470 (27%) were performed laparoscopically

2017 Diseases of the Colon & Rectum

84. A Long-Gap Peripheral Nerve Injury Therapy Using Human Skeletal Muscle-Derived Stem Cells (Sk-SCs): An Achievement of Significant Morphological, Numerical and Functional Recovery. (PubMed)

A Long-Gap Peripheral Nerve Injury Therapy Using Human Skeletal Muscle-Derived Stem Cells (Sk-SCs): An Achievement of Significant Morphological, Numerical and Functional Recovery. Losses in vital functions of the somatic motor and sensory nervous system are induced by severe long-gap peripheral nerve transection injury. In such cases, autologous nerve grafts are the gold standard treatment, despite the unavoidable sacrifice of other healthy functions, whereas the prognosis is not always (...) in both groups with the expression of key factors (mRNA and protein levels), suggesting the paracrine effects to angiogenesis. These results suggested that the human Sk-SCs may be a practical source for autologous stem cell therapy following severe peripheral nerve injury.

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2016 PLoS ONE

85. Advance of Peripheral Nerve Injury Repair and Reconstruction (PubMed)

Advance of Peripheral Nerve Injury Repair and Reconstruction 29237933 2018 11 21 2018 11 21 2542-5641 130 24 2017 Dec 20 Chinese medical journal Chin. Med. J. Advance of Peripheral Nerve Injury Repair and Reconstruction. 2996-2998 10.4103/0366-6999.220299 Jiang Bao-Guo BG Department Trauma and Orthopedics, Peking University People's Hospital, Beijing 100044, China. Han Na N Center Laboratory, Peking University People's Hospital, Beijing 100044, China. Rao Feng F Department Trauma (...) Procedures Peripheral Nerve Injuries surgery Peripheral Nerves Reconstructive Surgical Procedures 2017 12 15 6 0 2017 12 15 6 0 2018 11 22 6 0 ppublish 29237933 ChinMedJ_2017_130_24_2996_220299 10.4103/0366-6999.220299 PMC5742928 Am J Phys Med Rehabil. 2008 May;87(5):381-5 18334923 Yale J Biol Med. 2012 Jun;85(2):201-15 22737049 Eur J Neurosci. 2016 Feb;43(3):297-308 26174154 Eur Neurol. 2007;58(1):12-20 17483580 Am J Transl Res. 2016 Jul 15;8(7):2897-911 27508011 Clin Orthop Relat Res. 2008 Jun;466(6

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2017 Chinese medical journal

86. Mid-term Effect Observation of Biodegradable Conduit Small Gap Tublization Repairing Peripheral Nerve Injury

Mid-term Effect Observation of Biodegradable Conduit Small Gap Tublization Repairing Peripheral Nerve Injury Mid-term Effect Observation of Biodegradable Conduit Small Gap Tublization Repairing Peripheral Nerve Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Mid-term Effect Observation of Biodegradable Conduit Small Gap Tublization Repairing Peripheral Nerve Injury The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2017 Clinical Trials

87. Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration (PubMed)

Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration Wallerian degeneration (WD) is considered an essential preparatory stage to the process of axonal regeneration. In the peripheral nervous system, infiltrating monocyte-derived macrophages, which use the chemokine receptor CCR2 to gain entry to injured tissues from the bloodstream, are purportedly necessary for efficient WD. However, our laboratory has previously reported that myelin (...) substantially inhibits myelin clearance after nerve injury in both male WT and Ccr2-/- mice, highlighting a novel role for these cells in peripheral nerve degeneration that spans genotypes.SIGNIFICANCE STATEMENT The accepted view in the basic and clinical neurosciences is that the clearance of axonal and myelin debris after a nerve injury is directed primarily by inflammatory CCR2+ macrophages. However, we demonstrate that this clearance is nearly identical in WT and Ccr2-/- mice, and that neutrophils

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2017 The Journal of Neuroscience

88. Therapeutic capacities of human and mouse skeletal muscle-derived stem cells for a long gap peripheral nerve injury (PubMed)

Therapeutic capacities of human and mouse skeletal muscle-derived stem cells for a long gap peripheral nerve injury 29239325 2018 11 13 1673-5374 12 11 2017 Nov Neural regeneration research Neural Regen Res Therapeutic capacities of human and mouse skeletal muscle-derived stem cells for a long gap peripheral nerve injury. 1811-1813 10.4103/1673-5374.219042 Tamaki Tetsuro T Muscle Physiology & Cell Biology Unit, Department of Human Structure and Function, Tokai University School of Medicine, 143

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2017 Neural Regeneration Research

89. Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury (PubMed)

Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury. Accordingly, we predicted that long non-coding RNA NONMMUG014387 may promote Schwann cell proliferation after peripheral nerve injury, as bioinformatic analysis revealed that the target gene (...) increased in Schwann cells overexpressing lncRNA NONMMUG014387 compared with the other two groups. Further, compared with the control group, mRNA and protein levels of Cthrc1, Wnt5a, ROR2, RhoA, Rac1, JNK, and ROCK were visibly up-regulated in the Ad-NONMMUGO148387 group. Our findings confirm that long non-coding RNA NONMMUG014387 can promote proliferation of Schwann cells surrounding the injury site through targeting Cthrc1 and activating the Wnt/PCP pathway.

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2017 Neural Regeneration Research

90. Roles of neural stem cells in the repair of peripheral nerve injury (PubMed)

Roles of neural stem cells in the repair of peripheral nerve injury Currently, researchers are using neural stem cell transplantation to promote regeneration after peripheral nerve injury, as neural stem cells play an important role in peripheral nerve injury repair. This article reviews recent research progress of the role of neural stem cells in the repair of peripheral nerve injury. Neural stem cells can not only differentiate into neurons, astrocytes and oligodendrocytes, but can also (...) differentiate into Schwann-like cells, which promote neurite outgrowth around the injury. Transplanted neural stem cells can differentiate into motor neurons that innervate muscles and promote the recovery of neurological function. To promote the repair of peripheral nerve injury, neural stem cells secrete various neurotrophic factors, including brain-derived neurotrophic factor, fibroblast growth factor, nerve growth factor, insulin-like growth factor and hepatocyte growth factor. In addition, neural stem

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2017 Neural Regeneration Research

91. Biodegradable Bisvinyl Sulfonemethyl-crosslinked Gelatin Conduit Promotes Regeneration after Peripheral Nerve Injury in Adult Rats (PubMed)

Biodegradable Bisvinyl Sulfonemethyl-crosslinked Gelatin Conduit Promotes Regeneration after Peripheral Nerve Injury in Adult Rats In our previous study, we found that gelatin-based materials exhibit good conductivity and are non-cytotoxic. In this study, gelatin was cross-linked with bisvinyl sulfonemethyl (BVSM) to fabricate a biodegradable conduit for peripheral nerve repair. First, BVSM on the prepared conduit was characterized to determine its mechanical properties and contact angle (...) localization and expression, as well as the expression levels of nerve regeneration-related proteins. The number of fluorogold-labelled cells and histological analysis of the gelatin-BVSM nerve conduits was similar to that observed with the clinical use of silicone rubber conduits after 8 weeks of repair. Therefore, our results demonstrate that gelatin-BVSM conduits are promising substrates for application as bioengineered grafts for nerve tissue regeneration.

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2017 Scientific reports

92. Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury

Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tesamorelin (...) to Improve Functional Outcomes After Peripheral Nerve Injury The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03150511 Recruitment Status : Recruiting First Posted : May 12, 2017 Last Update Posted : February 8, 2019 See

2017 Clinical Trials

93. Priming the stump in peripheral nerve injury (Commentary on Zhang et al. (2017)) (PubMed)

Priming the stump in peripheral nerve injury (Commentary on Zhang et al. (2017)) 28102017 2018 07 30 2018 12 02 1460-9568 45 6 2017 03 The European journal of neuroscience Eur. J. Neurosci. Priming the stump in peripheral nerve injury (Commentary on Zhang et al. (2017)). 748-749 10.1111/ejn.13523 Elfar John C JC The Del Monte Institute for Neuroscience and the Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA. eng K08 AR060164 AR (...) NIAMS NIH HHS United States Journal Article Comment 2017 02 06 France Eur J Neurosci 8918110 0953-816X IM Eur J Neurosci. 2017 Mar;45(6):750-762 27973754 Humans Motor Activity Nerve Regeneration Peripheral Nerve Injuries Sciatic Nerve 2017 1 20 6 0 2018 7 31 6 0 2017 1 20 6 0 ppublish 28102017 10.1111/ejn.13523 PMC5821056 NIHMS942244 J Hand Surg Am. 2010 Feb;35(2):332-41 20141906 Ann Plast Surg. 2015 Jun;74 Suppl 4:S222-8 25978554 J Hand Surg Am. 2013 Mar;38(3):617-8 23428193 J Hand Surg Am. 2012

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2017 The European journal of neuroscience

94. Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System (PubMed)

Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System This review summarizes the role of melatonin (MLT) in defense against toxic-free radicals and its novel effects in the development of the nervous system, and the effect of endogenously produced and exogenously administered MLT in reducing the degree of tissue and nerve injuries. MLT was recently reported to be an effective free radical scavenger and antioxidant. Since endogenous MLT levels fall (...) significantly in senility, these findings imply that the loss of this antioxidant could contribute to the incidence or severity of some age-related neurodegenerative diseases. Considering the high efficacy of MLT in overcoming much of the injury not only to the peripheral nerve but also to other organs, clinical trials for this purpose should be seriously considered.

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2017 Journal of brachial plexus and peripheral nerve injury

95. Transplantation of Embryonic Spinal Cord Derived Cells Helps to Prevent Muscle Atrophy after Peripheral Nerve Injury (PubMed)

Transplantation of Embryonic Spinal Cord Derived Cells Helps to Prevent Muscle Atrophy after Peripheral Nerve Injury Injuries to peripheral nerves are frequent in serious traumas and spinal cord injuries. In addition to surgical approaches, other interventions, such as cell transplantation, should be considered to keep the muscles in good condition until the axons regenerate. In this study, E14.5 rat embryonic spinal cord fetal cells and cultured neural progenitor cells from different spinal (...) , are beneficial in the treatment of peripheral nerve injuries due to their ability to prevent the muscle atrophy.

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2017 International journal of molecular sciences

96. Chaperone Proteins in the Central Nervous System and Peripheral Nervous System after Nerve Injury (PubMed)

Chaperone Proteins in the Central Nervous System and Peripheral Nervous System after Nerve Injury Injury to axons of the central nervous system (CNS) and the peripheral nervous system (PNS) is accompanied by the upregulation and downregulation of numerous molecules that are involved in mediating nerve repair, or in augmentation of the original damage. Promoting the functions of beneficial factors while reducing the properties of injurious agents determines whether regeneration and functional

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2017 Frontiers in neuroscience

97. Role of dorsal root ganglion K2P1.1 in peripheral nerve injury-induced neuropathic pain (PubMed)

Role of dorsal root ganglion K2P1.1 in peripheral nerve injury-induced neuropathic pain Peripheral nerve injury-caused hyperexcitability and abnormal ectopic discharges in the primary sensory neurons of dorsal root ganglion (DRG) play a key role in neuropathic pain development and maintenance. The two-pore domain background potassium (K2P) channels have been identified as key determinants of the resting membrane potential and neuronal excitability. However, whether K2P channels contribute (...) to neuropathic pain is still elusive. We reported here that K2P1.1, the first identified mammalian K2P channel, was highly expressed in mouse DRG and distributed in small-, medium-, and large-sized DRG neurons. Unilateral lumbar (L) 4 spinal nerve ligation led to a significant and time-dependent reduction of K2P1.1 mRNA and protein in the ipsilateral L4 DRG, but not in the contralateral L4 or ipsilateral L3 DRG. Rescuing this reduction through microinjection of adeno-associated virus-DJ expressing full

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2017 Molecular pain

98. Inhibition of Mammalian Target of Rapamycin (mTOR) Signaling in the Insular Cortex Alleviates Neuropathic Pain after Peripheral Nerve Injury (PubMed)

Inhibition of Mammalian Target of Rapamycin (mTOR) Signaling in the Insular Cortex Alleviates Neuropathic Pain after Peripheral Nerve Injury Injury of peripheral nerves can trigger neuropathic pain, producing allodynia and hyperalgesia via peripheral and central sensitization. Recent studies have focused on the role of the insular cortex (IC) in neuropathic pain. Because the IC is thought to store pain-related memories, translational regulation in this structure may reveal novel targets (...) allodynia was assessed in adult male Sprague-Dawley rats after neuropathic surgery and following microinjections of rapamycin into the IC on postoperative days (PODs) 3 and 7. Optical recording was conducted to observe the neural responses of the IC to peripheral stimulation. Rapamycin reduced mechanical allodynia and downregulated the expression of postsynaptic density protein 95 (PSD95), decreased neural excitability in the IC, thereby inhibiting neuropathic pain-induced synaptic plasticity

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2017 Frontiers in molecular neuroscience

99. Comparison of DNA Methylation in Schwann Cells before and after Peripheral Nerve Injury in Rats (PubMed)

Comparison of DNA Methylation in Schwann Cells before and after Peripheral Nerve Injury in Rats This study aims to find the difference of genomewide DNA methylation in Schwann cells (SCs) before and after peripheral nerve system (PNS) injury by Methylated DNA Immunoprecipitation Sequencing (MeDIP-Seq) and seek meaningful differentially methylated genes related to repairment of injured PNS. SCs harvested from sciatic nerve were named as activated Schwann cells (ASCs), and the ones harvested from (...) of these methylated genes were also conducted. The expression patterns of hypermethylated genes (Dgcr8, Zeb2, Dixdc1, Sox2, and Shh) and hypomethylated genes (Gpr126, Birc2) detected by qRT-PCR were opposite to the MeDIP analysis data with significance (p < 0.05), which proved MeDIP analysis data were real and believable. Our data serve as a basis for understanding the injury-induced epigenetic changes in SCs and the foundation for further studies on repair of PNS injury.

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2017 BioMed research international

100. Afferent Fiber Remodeling in the Somatosensory Thalamus of Mice as a Neural Basis of Somatotopic Reorganization in the Brain and Ectopic Mechanical Hypersensitivity after Peripheral Sensory Nerve Injury (PubMed)

Afferent Fiber Remodeling in the Somatosensory Thalamus of Mice as a Neural Basis of Somatotopic Reorganization in the Brain and Ectopic Mechanical Hypersensitivity after Peripheral Sensory Nerve Injury Plastic changes in the CNS in response to peripheral sensory nerve injury are a series of complex processes, ranging from local circuit remodeling to somatotopic reorganization. However, the link between circuit remodeling and somatotopic reorganization remains unclear. We have previously (...) . The anatomical remodeling, emergence of ectopic receptive fields, and extraterritorial pain behavior all concomitantly developed within a week and lasted more than three months after the transection. Our findings, thus, indicate a strong linkage between these plastic changes after peripheral sensory nerve injury, which may provide a neural circuit basis underlying large-scale reorganization of somatotopic representation and abnormal ectopic sensations.

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2017 eNeuro

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