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Peripheral Nerve Injury

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81. Risk factors for peripheral nerve injuries following neuraxial labour analgesia: a nested case-control study. (Abstract)

Risk factors for peripheral nerve injuries following neuraxial labour analgesia: a nested case-control study. Post-partum lower extremity motor and sensory dysfunctions occur in 0.1-9.2‰ of deliveries. While macrosomia, lithotomy position and forceps use are well-identified causes of peripheral nerve injuries, additional contributors such as patient condition and anaesthesia care may also have to be considered.We performed a case-control study nested in a cohort of 19,840 patients having (...) neuraxial anaesthesia for childbirth. Cases were all patients who developed motor or sensory dysfunction of lower extremities in the post-partum period. These were compared, using Chi-square, Fisher's exact test, logistic regression and time series, to a random sample of controls without any neurological symptoms or injury.We identified 19 (0.96‰) patients with peripheral nerve injuries of which 15 (0.76‰) were likely associated with obstetrical care. In four additional cases (0.20‰), a nerve root

2017 Acta Anaesthesiologica Scandinavica

82. "State of the Art Techniques in Treating Peripheral Nerve Injury". (Abstract)

"State of the Art Techniques in Treating Peripheral Nerve Injury". Peripheral nerve injuries remain a major clinical concern, as they often lead to chronic disability and significant health care expenditures. Despite advancements in microsurgical techniques to enhance nerve repair, biological approaches are needed to augment nerve regeneration and improve functional outcomes after injury.Presented herein is a review of the current literature on state-of-the-art techniques to enhance functional (...) future of treating peripheral nerve injury will include multimodality use of electroconductive conduits, fat grafting, neuronal stimulation, and optogenetics. Further clinical investigation is needed to confirm the efficacy of these technologies on peripheral nerve recovery in humans, and how best to implement this treatment for a diverse population of nerve-injured patients.

2017 Plastic and reconstructive surgery

83. Mid-term Effect Observation of Biodegradable Conduit Small Gap Tublization Repairing Peripheral Nerve Injury

Mid-term Effect Observation of Biodegradable Conduit Small Gap Tublization Repairing Peripheral Nerve Injury Mid-term Effect Observation of Biodegradable Conduit Small Gap Tublization Repairing Peripheral Nerve Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Mid-term Effect Observation of Biodegradable Conduit Small Gap Tublization Repairing Peripheral Nerve Injury The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier

2017 Clinical Trials

84. Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells. Full Text available with Trip Pro

Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells. Increasing evidence suggests the potential involvement of metalloproteinase family proteins in the pathogenesis of neuropathic pain, although the underlying mechanisms remain elusive.Using the spinal nerve ligation model, we investigated whether ADAM10 proteins participate in pain regulation. By implementing invitro methods, we produced a purified (...) peripheral nerve injury-induced neuropathic pain by cleaving E-cadherin in satellite glial cells.© 2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

2017 Pain Medicine

85. Mrpl10 and Tbp Are Suitable Reference Genes for Peripheral Nerve Crush Injury Full Text available with Trip Pro

Mrpl10 and Tbp Are Suitable Reference Genes for Peripheral Nerve Crush Injury Peripheral nerve injury triggers the dysregulation of a large number of genes at multiple sites, including neurons, peripheral nerve stump, and the target organ. Housekeeping genes were frequently used as reference genes to normalize the expression values of target genes. Suitable selection of housekeeping genes that are stably expressed after nerve injury minimizes bias elicited by reference genes and thus helps (...) peripheral nerve injury, Mrpl10 and Tbp might be used as suitable reference genes for sciatic nerve stump and DRGs, respectively.

2017 International journal of molecular sciences

86. AlphaB-crystallin regulates remyelination after peripheral nerve injury Full Text available with Trip Pro

AlphaB-crystallin regulates remyelination after peripheral nerve injury AlphaB-crystallin (αBC) is a small heat shock protein that is constitutively expressed by peripheral nervous system (PNS) axons and Schwann cells. To determine what role this crystallin plays after peripheral nerve damage, we found that loss of αBC impaired remyelination, which correlated with a reduced presence of myelinating Schwann cells and increased numbers of nonmyelinating Schwann cells. The heat shock protein also (...) seems to regulate the cross-talk between Schwann cells and axons, because expected changes in neuregulin levels and ErbB2 receptor expression after PNS injury were disrupted in the absence of αBC. Such dysregulations led to defects in conduction velocity and motor and sensory functions that could be rescued with therapeutic application of the heat shock protein in vivo. Altogether, these findings show that αBC plays an important role in regulating Wallerian degeneration and remyelination after PNS

2017 Proceedings of the National Academy of Sciences of the United States of America

87. Priming the stump in peripheral nerve injury (Commentary on Zhang et al. (2017)) Full Text available with Trip Pro

Priming the stump in peripheral nerve injury (Commentary on Zhang et al. (2017)) 28102017 2018 07 30 2018 12 02 1460-9568 45 6 2017 03 The European journal of neuroscience Eur. J. Neurosci. Priming the stump in peripheral nerve injury (Commentary on Zhang et al. (2017)). 748-749 10.1111/ejn.13523 Elfar John C JC The Del Monte Institute for Neuroscience and the Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA. eng K08 AR060164 AR (...) NIAMS NIH HHS United States Journal Article Comment 2017 02 06 France Eur J Neurosci 8918110 0953-816X IM Eur J Neurosci. 2017 Mar;45(6):750-762 27973754 Humans Motor Activity Nerve Regeneration Peripheral Nerve Injuries Sciatic Nerve 2017 1 20 6 0 2018 7 31 6 0 2017 1 20 6 0 ppublish 28102017 10.1111/ejn.13523 PMC5821056 NIHMS942244 J Hand Surg Am. 2010 Feb;35(2):332-41 20141906 Ann Plast Surg. 2015 Jun;74 Suppl 4:S222-8 25978554 J Hand Surg Am. 2013 Mar;38(3):617-8 23428193 J Hand Surg Am. 2012

2017 The European journal of neuroscience

88. The Glia Response after Peripheral Nerve Injury: A Comparison between Schwann Cells and Olfactory Ensheathing Cells and Their Uses for Neural Regenerative Therapies Full Text available with Trip Pro

The Glia Response after Peripheral Nerve Injury: A Comparison between Schwann Cells and Olfactory Ensheathing Cells and Their Uses for Neural Regenerative Therapies The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems. PNS glia respond rapidly to nerve injury by clearing debris from the injury site, supplying essential growth factors (...) and providing structural support; all of which enhances neuronal regeneration. Thus, transplantation of glial cells from the PNS is a very promising therapy for injuries to both the PNS and the CNS. There are two key types of PNS glia: olfactory ensheathing cells (OECs), which populate the olfactory nerve, and Schwann cells (SCs), which are present in the rest of the PNS. These two glial types share many similar morphological and functional characteristics but also exhibit key differences. The olfactory

2017 International journal of molecular sciences

89. Chaperone Proteins in the Central Nervous System and Peripheral Nervous System after Nerve Injury Full Text available with Trip Pro

Chaperone Proteins in the Central Nervous System and Peripheral Nervous System after Nerve Injury Injury to axons of the central nervous system (CNS) and the peripheral nervous system (PNS) is accompanied by the upregulation and downregulation of numerous molecules that are involved in mediating nerve repair, or in augmentation of the original damage. Promoting the functions of beneficial factors while reducing the properties of injurious agents determines whether regeneration and functional

2017 Frontiers in neuroscience

90. Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System Full Text available with Trip Pro

Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System This review summarizes the role of melatonin (MLT) in defense against toxic-free radicals and its novel effects in the development of the nervous system, and the effect of endogenously produced and exogenously administered MLT in reducing the degree of tissue and nerve injuries. MLT was recently reported to be an effective free radical scavenger and antioxidant. Since endogenous MLT levels fall (...) significantly in senility, these findings imply that the loss of this antioxidant could contribute to the incidence or severity of some age-related neurodegenerative diseases. Considering the high efficacy of MLT in overcoming much of the injury not only to the peripheral nerve but also to other organs, clinical trials for this purpose should be seriously considered.

2017 Journal of brachial plexus and peripheral nerve injury

91. Transplantation of Embryonic Spinal Cord Derived Cells Helps to Prevent Muscle Atrophy after Peripheral Nerve Injury Full Text available with Trip Pro

Transplantation of Embryonic Spinal Cord Derived Cells Helps to Prevent Muscle Atrophy after Peripheral Nerve Injury Injuries to peripheral nerves are frequent in serious traumas and spinal cord injuries. In addition to surgical approaches, other interventions, such as cell transplantation, should be considered to keep the muscles in good condition until the axons regenerate. In this study, E14.5 rat embryonic spinal cord fetal cells and cultured neural progenitor cells from different spinal (...) , are beneficial in the treatment of peripheral nerve injuries due to their ability to prevent the muscle atrophy.

2017 International journal of molecular sciences

92. TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury Full Text available with Trip Pro

TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury Clinical studies show that chronic pain is accompanied by memory deficits and reduction in hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic nerve induces long-term potentiation (LTP) at C-fiber synapses in spinal dorsal horn, but impairs LTP in the hippocampus. The opposite changes may contribute (...) . Previous studies have shown that peripheral nerve injury produces both neuropathic pain and memory deficits and induces long-term potentiation (LTP) at C-fiber synapses in spinal dorsal horn (SDH) but inhibits LTP in hippocampus. The opposite changes in synaptic plasticity may contribute to chronic pain and memory deficits, respectively. However, the structural and molecular bases of these alterations of synaptic plasticity are unclear. Here, we show that the complexity of excitatory synaptic

2017 The Journal of Neuroscience

93. Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat Full Text available with Trip Pro

Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear whether and how MyD88 and related signaling pathways in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) are involved in neuropathic pain.Chronic constriction injury (CCI) was used to induce neuropathic pain (...) in the rat. The expression of MyD88, TRIF, IBA1, and GFAP was detected with immunofluorescent staining and Western blot. The expression of interleukin-1 beta (IL-1β), high mobility group box 1 (HMGB1), NF-κB-p65, phosphorylated NF-κB-p65, ERK, phosphorylated ERK, and tumor necrosis factor-alpha (TNF-α) was detected with Western blot. Pain-related behavioral effects of MyD88 homodimerization inhibitory peptide (MIP) were accessed up to 3 weeks after intrathecal administration.Peripheral nerve injury

2017 Journal of neuroinflammation

94. Inhibition of Mammalian Target of Rapamycin (mTOR) Signaling in the Insular Cortex Alleviates Neuropathic Pain after Peripheral Nerve Injury Full Text available with Trip Pro

Inhibition of Mammalian Target of Rapamycin (mTOR) Signaling in the Insular Cortex Alleviates Neuropathic Pain after Peripheral Nerve Injury Injury of peripheral nerves can trigger neuropathic pain, producing allodynia and hyperalgesia via peripheral and central sensitization. Recent studies have focused on the role of the insular cortex (IC) in neuropathic pain. Because the IC is thought to store pain-related memories, translational regulation in this structure may reveal novel targets (...) allodynia was assessed in adult male Sprague-Dawley rats after neuropathic surgery and following microinjections of rapamycin into the IC on postoperative days (PODs) 3 and 7. Optical recording was conducted to observe the neural responses of the IC to peripheral stimulation. Rapamycin reduced mechanical allodynia and downregulated the expression of postsynaptic density protein 95 (PSD95), decreased neural excitability in the IC, thereby inhibiting neuropathic pain-induced synaptic plasticity

2017 Frontiers in molecular neuroscience

95. Comparison of DNA Methylation in Schwann Cells before and after Peripheral Nerve Injury in Rats Full Text available with Trip Pro

Comparison of DNA Methylation in Schwann Cells before and after Peripheral Nerve Injury in Rats This study aims to find the difference of genomewide DNA methylation in Schwann cells (SCs) before and after peripheral nerve system (PNS) injury by Methylated DNA Immunoprecipitation Sequencing (MeDIP-Seq) and seek meaningful differentially methylated genes related to repairment of injured PNS. SCs harvested from sciatic nerve were named as activated Schwann cells (ASCs), and the ones harvested from (...) of these methylated genes were also conducted. The expression patterns of hypermethylated genes (Dgcr8, Zeb2, Dixdc1, Sox2, and Shh) and hypomethylated genes (Gpr126, Birc2) detected by qRT-PCR were opposite to the MeDIP analysis data with significance (p < 0.05), which proved MeDIP analysis data were real and believable. Our data serve as a basis for understanding the injury-induced epigenetic changes in SCs and the foundation for further studies on repair of PNS injury.

2017 BioMed research international

96. Therapeutic capacities of human and mouse skeletal muscle-derived stem cells for a long gap peripheral nerve injury Full Text available with Trip Pro

Therapeutic capacities of human and mouse skeletal muscle-derived stem cells for a long gap peripheral nerve injury 29239325 2018 11 13 1673-5374 12 11 2017 Nov Neural regeneration research Neural Regen Res Therapeutic capacities of human and mouse skeletal muscle-derived stem cells for a long gap peripheral nerve injury. 1811-1813 10.4103/1673-5374.219042 Tamaki Tetsuro T Muscle Physiology & Cell Biology Unit, Department of Human Structure and Function, Tokai University School of Medicine, 143

2017 Neural Regeneration Research

97. Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration Full Text available with Trip Pro

Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration Wallerian degeneration (WD) is considered an essential preparatory stage to the process of axonal regeneration. In the peripheral nervous system, infiltrating monocyte-derived macrophages, which use the chemokine receptor CCR2 to gain entry to injured tissues from the bloodstream, are purportedly necessary for efficient WD. However, our laboratory has previously reported that myelin (...) substantially inhibits myelin clearance after nerve injury in both male WT and Ccr2-/- mice, highlighting a novel role for these cells in peripheral nerve degeneration that spans genotypes.SIGNIFICANCE STATEMENT The accepted view in the basic and clinical neurosciences is that the clearance of axonal and myelin debris after a nerve injury is directed primarily by inflammatory CCR2+ macrophages. However, we demonstrate that this clearance is nearly identical in WT and Ccr2-/- mice, and that neutrophils

2017 The Journal of Neuroscience

98. Quantitative magnetic resonance (MR) neurography for evaluation of peripheral nerves and plexus injuries Full Text available with Trip Pro

Quantitative magnetic resonance (MR) neurography for evaluation of peripheral nerves and plexus injuries Traumatic conditions of peripheral nerves and plexus have been classically evaluated by morphological imaging techniques and electrophysiological tests. New magnetic resonance imaging (MRI) studies based on 3D fat-suppressed techniques are providing high accuracy for peripheral nerve injury evaluation from a qualitative point of view. However, these techniques do not provide quantitative (...) peripheral nerve analysis, providing valuable pathophysiological information about functional integrity of these structures. In the field of trauma and peripheral nerve or plexus injury, several derived parameters from DWI and DTI studies such as apparent diffusion coefficient (ADC) or fractional anisotropy (FA) among others, can be used as potential biomarkers of neural damage providing information about fiber organization, axonal flow or myelin integrity. A proper knowledge of physical basis

2017 Quantitative imaging in medicine and surgery

99. Erythropoietin enhanced recovery after peripheral nerve injury Full Text available with Trip Pro

Erythropoietin enhanced recovery after peripheral nerve injury 28966638 2018 11 13 1673-5374 12 8 2017 Aug Neural regeneration research Neural Regen Res Erythropoietin enhanced recovery after peripheral nerve injury. 1268-1269 10.4103/1673-5374.213544 Modrak Max M University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; Department of Orthopaedic Surgery and Rehabilitation, University of Rochester Medical Center, Rochester, NY, USA. Sundem Leigh L University of Rochester (...) Neurol. 2004 Dec;56(6):815-26 15470751 Injury. 2016 Aug;47(8):1819-23 27287740 Biomed Res Int. 2015;2015:478103 25821803

2017 Neural Regeneration Research

100. Patterns of production of collagen‐rich deposits in peripheral nerves in response to injury: A pilot study in a rabbit model Full Text available with Trip Pro

Patterns of production of collagen‐rich deposits in peripheral nerves in response to injury: A pilot study in a rabbit model Although collagen-rich deposits are the main component of neural scars, the patterns of their formation are ill defined. Essential to the biosynthesis of collagen fibrils are enzymes catalyzing posttranslational modifications and chaperones that control the formation of the collagen triple helix. Prolyl-4-hydroxylase (P4H) and heat shock protein-47 (HSP47) play a key (...) fibrotic tissue (FT) in response to peripheral nerve injury. To reach this goal, we employed a rabbit model of crush-injury and partial-transection injury of the sciatic nerves.Our study demonstrated that αSMA is expressed in a relatively small number of cells seen in neural FT. In contrast, cells producing P4H and HSP47 are ubiquitously present in sites of injury of the sciatic nerves.We contemplate that these proteins may serve as valuable markers that define fibrotic activities in the injured

2017 Brain and behavior

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