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Peripheral Nerve Injury

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181. Emergent Expanded Access for ahSC Augmentation of Nerve Autografts After Severe Peripheral Nerve Injury.

Emergent Expanded Access for ahSC Augmentation of Nerve Autografts After Severe Peripheral Nerve Injury. Emergent Expanded Access for ahSC Augmentation of Nerve Autografts After Severe Peripheral Nerve Injury. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Emergent Expanded Access for ahSC Augmentation of Nerve Autografts After Severe Peripheral Nerve Injury. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02510079 Expanded Access Status : Temporarily not available First Posted : July 28, 2015 Last

2015 Clinical Trials

182. Neural regeneration after peripheral nerve injury repair is a system remodelling process of interaction between nerves and terminal effector Full Text available with Trip Pro

Neural regeneration after peripheral nerve injury repair is a system remodelling process of interaction between nerves and terminal effector 25788919 2015 03 19 2018 11 13 1673-5374 10 1 2015 Jan Neural regeneration research Neural Regen Res Neural regeneration after peripheral nerve injury repair is a system remodelling process of interaction between nerves and terminal effector. 52 10.4103/1673-5374.150705 Zhang Pei-Xun PX Department of Trauma and Orthopedics, Peking University People's

2015 Neural Regeneration Research

183. Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit Full Text available with Trip Pro

Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit The clinical effects of 2-mm small gap sleeve bridging of the biological conduit to repair peripheral nerve injury are better than in the traditional epineurium suture, so it is possible to replace the epineurium suture in the treatment of peripheral nerve injury. This study sought to identify the regeneration law of nerve fibers in the biological conduit. A nerve (...) regeneration (2-8 weeks), the number of Schwann cells and nerve fibers was higher in both proximal and distal ends, and the effects of the small gap sleeve bridging method were better than those of the traditional epineurium suture. The above results provide an objective and reliable theoretical basis for the clinical application of the biological conduit small gap sleeve bridging method to repair peripheral nerve injury.

2015 Neural Regeneration Research

184. Nerve transfers and neurotization in peripheral nerve injury, from surgery to rehabilitation. (Abstract)

Nerve transfers and neurotization in peripheral nerve injury, from surgery to rehabilitation. Peripheral nerve injury (PNI) and recent advances in nerve reconstruction (such as neurotization with nerve transfers) have improved outcomes for patients suffering peripheral nerve trauma. The purpose of this paper is to bridge the gap between the electromyographer/clinical neurophysiologist and the peripheral nerve surgeon. Whereas the preceding literature focuses on either the basic science behind (...) nerve injury and reconstruction, or the surgical options and algorithms, this paper demonstrates how electromyography is not just a 'decision tool' when deciding whether to operate but is also essential to all phases of PNI management including surgery and rehabilitation. The recent advances in the reconstruction and rehabilitation of PNI is demonstrated using case examples to assist the electromyographer to understand modern surgical techniques and the unique demands they ask from electrodiagnostic

2015 Neurosurgery and Psychiatry

185. Pathophysiology and Etiology of Nerve Injury Following Peripheral Nerve Blockade. (Abstract)

Pathophysiology and Etiology of Nerve Injury Following Peripheral Nerve Blockade. This review synthesizes anatomical, anesthetic, surgical, and patient factors that may contribute to neurologic complications associated with peripheral nerve blockade. Peripheral nerves have anatomical features unique to a given location that may influence risk of injury. Peripheral nerve blockade-related peripheral nerve injury (PNI) is most severe with intrafascicular injection. Surgery and its associated (...) requirements such as positioning and tourniquet have specific risks. Patients with preexisting neuropathy may be at an increased risk of postoperative neurologic dysfunction. Distinguishing potential causes of PNI require clinical assessment and investigation; a definitive diagnosis, however, is not always possible. Fortunately, most postoperative neurologic dysfunction appears to resolve with time, and the incidence of serious long-term nerve injury directly attributable to peripheral nerve blockade

2015 Regional Anesthesia and Pain Medicine

186. Peripheral Nerve Impairment and Recurrent Falls Among Women: Results from the Study of Women's Health Across the Nation. Full Text available with Trip Pro

Peripheral Nerve Impairment and Recurrent Falls Among Women: Results from the Study of Women's Health Across the Nation. Falls and related injuries are important public health concerns yet underappreciated in early aging. This study examined the association of peripheral nerve impairment (PNI) with fall outcomes in early old aged women (60-72 years).Women (n=1,725; mean age 65.1 ± 2.7 years) from the longitudinal cohort Study of Women's Health Across the Nation completed a PNI questionnaire (...) on presence, frequency, and severity of symptoms, and 10g and 1.4g monofilament testing in 2016-17. PNI was defined as ≥4 self-reported symptoms or monofilament insensitivity. Recurrent falls (≥2) and recurrent fall injuries (≥2 falls with ≥1 injury) in the previous 12 months were assessed via questionnaire. Poisson regression was used to generate risk ratios (RR) and corresponding 95% confidence intervals for the fall outcomes (CI), adjusting for covariates.Approximately 12.3% of participants reported ≥2

2019 Biological Sciences and Medical Sciences

187. Evaluation of the B-Smart manometer and the CompuFlo computerized injection pump technology for accurate needle-tip injection pressure measurement during peripheral nerve blockade. (Abstract)

Evaluation of the B-Smart manometer and the CompuFlo computerized injection pump technology for accurate needle-tip injection pressure measurement during peripheral nerve blockade. The exact mechanism of peripheral nerve blocks causing/leading to nerve injury remains controversial. Evidence from animal experiments suggests that intrafascicular injection resulting in high injection pressure has the potential to rupture nerve fascicles and may consequently cause permanent nerve injury

2019 Regional Anesthesia and Pain Medicine

188. Acute pain management in trauma: anatomy, ultrasound-guided peripheral nerve blocks and special considerations. (Abstract)

several examples of injuries, to elucidate the precise anatomy of fractured bones (osteotomes), and to elaborate on certain peripheral nerve blocks employed in pain management of trauma patients. Controversies/special considerations pertaining to peripheral nerve blocks also dictate thorough analysis: as such, acute compartment syndrome, acute peripheral nerve injuries, regional anesthesia in awake or anesthetized patients, continuous peripheral nerve blocks, positioning limitations and, finally (...) Acute pain management in trauma: anatomy, ultrasound-guided peripheral nerve blocks and special considerations. Pain is the most common complaint amongst trauma patients throughout the perioperative period. Multimodal analgesia is currently being regarded the mainstay, with regional anesthesia techniques constituting an integral part of it. Ultrasound imaging techniques display a plethora of advantages that have pervaded regional anesthesia practice. In this review, we set out to provide

2019 Minerva anestesiologica

189. Peripheral nerve stimulation: black, white and shades of grey. (Abstract)

Peripheral nerve stimulation: black, white and shades of grey. Unbearable chronic neuropathic pain, which can often not be resolved by conservative pain management techniques, calls for peripheral nerve stimulation. The technique, based on the Gate control hypothesis, uses low intensity current to block depolarization and conduction of neuronal membrane. Conditions such as intractable migraine, occipital and trigeminal neuralgia, burn injury pain, transformed migraine, among others, which cause (...) intense pain can be treated by PNS, especially when the pain is localised and can be traced back to a specific nerve. Complication rates in PNS vary from 5% in some cases to 43% in others. Common complications include lead breakage, electrode migration, etc., meanwhile complications associated with every surgery like risks of anaesthesia, bleeding etc., are also present. PNS shows great potential in the treatment of intractable pain, and with its less invasiveness, high success rate, and development

2019 British Journal of Neurosurgery

190. Management of large peripheral nerve defects with autografting. (Abstract)

Management of large peripheral nerve defects with autografting. A segmental nerve defect from trauma results in significant loss of function of the extremity, and rarely occurs in isolation. Autografting of the nerve defect is the current gold standard.A review of the recent literature regarding peripheral nerve defects after trauma treated with autograft.Identification of the zone of nerve injury is difficult and appropriate resection is critical for good outcomes. Meaningful recovery is more (...) likely with application of excellent technique. Many of the factors affecting outcomes are not modifiable.Nerve grafting for segmental nerve injuries continues to be an essential and appropriate treatment.Copyright © 2019. Published by Elsevier Ltd.

2019 Injury

191. Macrophage Biology in the Peripheral Nervous System after Injury. Full Text available with Trip Pro

Macrophage Biology in the Peripheral Nervous System after Injury. Neuroinflammation has positive and negative effects. This review focuses on the roles of macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of the distal nerve and to changes in the region of the axotomized cell bodies. In both locations, resident and infiltrating macrophages are found. Macrophages enter these areas in response to expression of the chemokine CCL2 acting on the macrophage receptor (...) CCR2. In the distal nerve, macrophages and other phagocytes are involved in clearance of axonal debris, which removes molecules that inhibit nerve regeneration. In the cell body region, macrophage trigger the conditioning lesion response, a process in which neurons increase their regeneration after a prior lesion. In mice in which the genes for CCL2 or CCR2 are deleted, neither macrophage infiltration nor the conditioning lesion response occurs in dorsal root ganglia (DRG). Macrophages exist

2018 Progress in Neurobiology

192. Development and validation of an in vitro model system to study peripheral sensory neuron development and injury Full Text available with Trip Pro

nociceptive neurons that include tetrodotoxin-resistant sodium currents and repetitive action potentials. Moreover, the derived cells associate with human donor Schwann cells and can be used as a model system to investigate the molecular mechanisms underlying neuronal death following peripheral nerve injury. The quick and efficient derivation of genetically diverse peripheral sensory neurons from human embryonic stem cells offers unlimited access to these specialised cell types and provides an invaluable (...) Development and validation of an in vitro model system to study peripheral sensory neuron development and injury The ability to discriminate between diverse types of sensation is mediated by heterogeneous populations of peripheral sensory neurons. Human peripheral sensory neurons are inaccessible for research and efforts to study their development and disease have been hampered by the availability of relevant model systems. The in vitro differentiation of peripheral sensory neurons from human

2018 Scientific reports

193. Locally Produced BDNF Promotes Sclerotic Change in Alveolar Bone after Nerve Injury. Full Text available with Trip Pro

Locally Produced BDNF Promotes Sclerotic Change in Alveolar Bone after Nerve Injury. Brain-derived neurotrophic factor (BDNF), which is released due to nerve injury, is known to promote the natural healing of injured nerves. It is often observed that damage of mandibular canal induces local sclerotic changes in alveolar bone. We reported that peripheral nerve injury promotes the local production of BDNF; therefore, it was possible to hypothesize that peripheral nerve injury affects sclerotic (...) and osteocytes, continued after 28 days. In conclusion, BDNF stimulated the differentiation of MC3T3-E1 cells and it promoted new bone formation and maturation. These results suggested that local BDNF produced by peripheral nerve injury contributes to accelerating sclerotic changes in the alveolar bone.

2017 PLoS ONE

194. Nerve injury in severe trauma with upper extremity involvement: evaluation of 49,382 patients from the TraumaRegister DGU® between 2002 and 2015. Full Text available with Trip Pro

Nerve injury in severe trauma with upper extremity involvement: evaluation of 49,382 patients from the TraumaRegister DGU® between 2002 and 2015. Peripheral nerve injury (PNI) as an adjunct lesion in patients with upper extremity trauma has not been investigated in a Central European setting so far, despite of its devastating long-term consequences. This study evaluates a large multinational trauma registry for prevalence, mechanisms, injury severity and outcome characteristics of upper limb (...) nerve lesions.After formal approval the TraumaRegister DGU® (TR-DGU) was searched for severely injured cases with upper extremity involvement between 2002 and 2015. Patients were separated into two cohorts with regard to presence of an accompanying nerve injury. For all cases demographic data, trauma mechanism, concomitant lesions, severity of injury and outcome characteristics were obtained and group comparisons performed.About 3,3% of all trauma patients with upper limb affection (n = 49,382

2018 Scandinavian journal of trauma, resuscitation and emergency medicine

195. Atypical sensory processing pattern following median or ulnar nerve injury - a case-control study. Full Text available with Trip Pro

Atypical sensory processing pattern following median or ulnar nerve injury - a case-control study. Due to brain plasticity a transection of a median or ulnar nerve results in profound changes in the somatosensory areas in the brain. The permanent sensory deprivation after a peripheral nerve injury might influence the interaction between all senses. The aim of the study was to investigate if a median and/or ulnar nerve injury gives rise to a changed sensory processing pattern. In addition we (...) in this Quadrant compared to 16% of the controls. No correlation between atypical sensory processing pattern and age or time since injury was seen.A peripheral nerve injury entails altered sensory processing pattern with increased proportion of patients with low registration to sensory stimulus overall. Our results can guide us into more client centered rehabilitation strategies.

2018 BMC Neurology

196. Mesenchymal Stem Cell Exosomes as a Cell-Free Therapy for Nerve Injury-Induced Pain in Rats. (Abstract)

Mesenchymal Stem Cell Exosomes as a Cell-Free Therapy for Nerve Injury-Induced Pain in Rats. Nerve injury-induced neuropathic pain is difficult to treat. In this study, we used exosomes derived from human umbilical cord mesenchymal stem cell (UCMSC) as a cell-free therapy for nerve injury-induced pain in rats. Isolated UCMSC exosomes range in size from 30 to 160 nm and contain CD63, HSP60, and CD81 exosome markers. After L5/6 spinal nerve ligation surgery, single intrathecal injection (...) of exosomes reversed nerve ligation-induced mechanical and thermal hypersensitivities of right hindpaw of rats at initial and well-developed pain stages. Moreover, continuous intrathecal infusion of exosomes achieved excellent preventive and reversal effects for nerve ligation-induced pain. In immunofluorescent study, lots of Exo-green-labelled exosomes could be found majorly in the ipsilateral L5 spinal dorsal horn, dorsal root ganglion, and peripheral axons, suggesting the homing ability of UCMSC

2018 Pain

197. Home Neuromodulation of the Neurogenic Bladder in Chronic Spinal Cord Injury With Transcutaneous Tibial Nerve Stimulation

incontinence (ex: UTI, bladder stones, multiple sclerosis, etc.) 2+ pitting edema that does not resolve Known peripheral neuropathy or injury to the path of the tibial nerve Demand-type cardiac pacemaker or implanted defibrillator Cancer in the tibial nerve path and/or bladder Inability to elicit toe/plantar flexion with electric stimulation during the clinic visit. Inability to understand directions Non-English speaking Contacts and Locations Go to Information from the National Library of Medicine (...) Home Neuromodulation of the Neurogenic Bladder in Chronic Spinal Cord Injury With Transcutaneous Tibial Nerve Stimulation Home Neuromodulation of the Neurogenic Bladder in Chronic Spinal Cord Injury With Transcutaneous Tibial Nerve Stimulation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2018 Clinical Trials

198. Restoring Hand Function Utilizing Nerve Transfers in Persons With Cervical Spinal Cord Injuries

With Cervical Spinal Cord Injuries Actual Study Start Date : April 1, 2018 Estimated Primary Completion Date : December 31, 2022 Estimated Study Completion Date : December 31, 2022 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Upper extremity nerve transfer surgery Upper extremity nerve transfer surgery is a surgical procedure where axons from an intact, functioning upper extremity peripheral nerve are moved (...) to a target muscle that demonstrates significant weakness or paralysis as a result of spinal cord injury. After allowing time for recovery from surgery and for nerve growth to occur, the patient undergoes hand/occupational therapy in order to retrain motor skills. Procedure: Upper extremity nerve transfer surgery Upper extremity nerve transfer surgery is a surgical procedure where axons from an intact, functioning upper extremity peripheral nerve are moved to a target muscle that demonstrates significant

2018 Clinical Trials

199. Cortico-anorectal, Spino-anorectal, and Cortico-spinal Nerve Conduction and Locus of Neuronal Injury in Patients With Fecal Incontinence. Full Text available with Trip Pro

Cortico-anorectal, Spino-anorectal, and Cortico-spinal Nerve Conduction and Locus of Neuronal Injury in Patients With Fecal Incontinence. The neuropathophysiology of fecal incontinence (FI) is incompletely understood. We examined the efferent brain-anorectal and spino-anorectal motor-evoked potentials (MEP) to characterize the locus of neuronal injury in patients with FI.We performed bilateral transcranial, translumbar, and transsacral magnetic stimulations in 27 patients with FI (19 female (...) function or defects.Patients with FI have significant neuropathy that affects the cortico-anorectal and spino-anorectal efferent pathways. The primary loci are the lumbo-rectal, lumbo-anal, sacro-rectal, and sacro-anal nerves; the cortico-spinal segment appears intact. Peripheral spino-anal and spino-rectal neuropathy might therefore contribute to the pathogenesis of FI.Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

2018 Clinical Gastroenterology and Hepatology

200. Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury Full Text available with Trip Pro

, is a new treatment option for peripheral nerve injury. We hypothesized that PRP could stimulate healing of digital nerve injuries. In the current case report, intraoperative local administration of PRP was performed during neurolysis surgery for a healthy 28-year-old woman with digital nerve crush injury. Five weeks postinjury, surgery was performed due to severe uncontrollable neuropathic pain and no sensory nerve action potential derivation of the index finger. Therapeutic effects were assessed (...) by physical examination, visual analog scale for pain, and nerve conduction study. Postoperatively, early neuropathic pain relief and good functional recovery were obtained with no PRP-related adverse events. This case report demonstrates the therapeutic potential of intraoperative PRP to enhance the healing process of nerve crush injury in the acute phase and to decrease the neuropathic pain, thus enhancing healing of peripheral nerve crush injury.

2018 Case reports in orthopedics

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