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Periodontal Bleeding

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141. Indocyanine green-mediated photothermal therapy in treatment of chronic periodontitis: A clinico-microbiological study. Full Text available with Trip Pro

of photothermal therapy using ICG in the treatment of chronic periodontitis with scaling and root planing (SRP).This was a randomized, controlled, clinical trial where fifty participants were equally divided into two groups, i.e., control group (SRP) and test group (SRP + photothermal therapy). Clinical parameters were evaluated at baseline and 6-month follow-up. These were plaque index (PI), bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL). Microbiological analysis of plaque (...) Indocyanine green-mediated photothermal therapy in treatment of chronic periodontitis: A clinico-microbiological study. Photodynamic therapy (PDT) has developed as an alternative treatment modality in periodontitis patients. Different photosensitizers used over the years have shown contradictory results. Thus, recently indocyanine green (ICG)-mediated photothermal therapy has emerged for the treatment of chronic periodontitis.The present study aimed at comparing and evaluating the effects

2019 Journal of Indian Society of Periodontology Controlled trial quality: uncertain

142. Efficacy of Locally Administered 1.2% Rosuvastatin Gel in Patients with Periodontitis: A Randomized Placebo Controlled Clinical Trial. Full Text available with Trip Pro

(RSV) in intrabony defects (IBD) in periodontitis patients.One-hundred patients were randomly allotted into two treatment groups: group A received 1. 2% RSV gel, scaling and root debridement and group B received placebo gel, scaling and root debridement. Clinical parameters, including modified sulcus bleeding index (mSBI), probing depth (PD), clinical attachment level (CAL), and plaque index (PI), were recorded at baseline before phase 1 and after 6 months. Radiographic assessment of IBD was done (...) Efficacy of Locally Administered 1.2% Rosuvastatin Gel in Patients with Periodontitis: A Randomized Placebo Controlled Clinical Trial. Periodontitis initiation and progression are a result of host immune inflammatory response to oral pathogens. Several pharmacological agents are being delivered locally, to improve periodontal health. Hence, the present randomized placebo controlled clinical trial is designed to check the clinical and antimicrobial efficacy of locally delivered 1.2% rosuvastatin

2019 European journal of dentistry Controlled trial quality: uncertain

143. A comparative study of synbiotic as an add-on therapy to standard treatment in patients with aggressive periodontitis. Full Text available with Trip Pro

the groups were analyzed by Student's paired t-test. Pearson's Chi-square test was applied to measure gingival bleeding index.On comparison at 12 weeks, there was a statistically significant reduction (P < 0.01) in probing depth, clinical attachment loss, oral hygiene index, and bleeding on probing in study group. No Adverse drug reactions were noted.Co-administration of synbiotic lozenge along with standard therapy is highly efficacious in improving periodontal health in patients with AP. (...) A comparative study of synbiotic as an add-on therapy to standard treatment in patients with aggressive periodontitis. The role of synbiotic in the management of aggressive periodontitis (AP) is not well established.We designed this study to evaluate the efficacy and safety of synbiotic as an add-on therapy in the management of AP.This was a randomized, double-blind, placebo-controlled study.Sixty patients with AP were randomized to two groups of 30 each. Study group received standard treatment

2019 Journal of Indian Society of Periodontology Controlled trial quality: uncertain

144. Impact of Yoga on Periodontal Disease and Stress Management. Full Text available with Trip Pro

of modified plaque index (PI), bleeding on probing (BOP), probing depth, and clinical attachment loss (CAL). The Cohen's perceived stress questionnaire was also used to determine stress severity. The yogic intervention consists of lectures and practical sessions on asanas, pranayama, kriyas, and meditation.Repeated measure analysis of variance revealed a significant difference (P < 0.001) in all the outcome variables with respect to time in both groups. It was observed that mean PI score reduced by 1.35 (...) Impact of Yoga on Periodontal Disease and Stress Management. Yoga is considered to be one of the most important, effective, and valuable tools available for man to overcome various physical and psychological problems. Stress contributes significantly to the pathogenesis of periodontal diseases; hence, it becomes important to reduce the level of stress for prevention and management of diseases.The present study was aimed: (1) To understand and analyze the possibilities of employing yogic

2019 International journal of yoga Controlled trial quality: uncertain

145. Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity in Periodontitis. (Abstract)

Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity in Periodontitis. Periodontitis (PD) is a common dysbiotic inflammatory disease that leads to local bone deterioration and tooth loss. PD patients experience low-grade bacteremias with oral microbes implicated in the risk of heart disease, cancer, and kidney failure. Although Th17 effectors are vital to fighting infection, functional imbalance of Th17 effectors and regulatory T cells (Tregs (...) ) promote inflammatory diseases. In this study, we investigated, in a small pilot randomized clinical trial, whether expansion of inflammatory blood myeloid dendritic cells (DCs) and conversion of Tregs to Th17 cells could be modulated with antibiotics (AB) as part of initial therapy in PD patients. PD patients were randomly assigned to either 7 d of peroral metronidazole/amoxicillin AB treatment or no AB, along with standard care debridement and chlorhexidine mouthwash. 16s ribosomal RNA analysis

2019 Journal of immunology (Baltimore, Md. : 1950) Controlled trial quality: uncertain

146. Clinical effect of Lactobacillus on the treatment of severe periodontitis and halitosis: A double-blinded, placebo-controlled, randomized clinical trial. (Abstract)

Clinical effect of Lactobacillus on the treatment of severe periodontitis and halitosis: A double-blinded, placebo-controlled, randomized clinical trial. To evaluate the clinical association between Lactobacillus and the efficacy of adjuvant treatment of severe periodontitis, periodontal parameters, and halitosis.60 healthy volunteers with severe periodontitis were randomized into two groups to receive periodontal therapy in a single session and lactobacillus or a placebo for 90 days. The test (...) group received Lactobacillus reuteri, salivarius and acidophilus, and the control group received placebo with xylitol.There was a reduction in the depth levels of the probing pocket and the level of relative attachment after 90 days (P< 0.01). Regarding bleeding after pocket probing, the full-mouth with lactobacillus groups also showed more reduction than the placebo group (P< 0.01). The same results were observed with the halitosis parameters (P< 0.01). Oral administration of lactobacillus reduced

2019 American journal of dentistry Controlled trial quality: uncertain

147. Fenugreek, diabetes, and periodontal disease: A cross-link of sorts! Full Text available with Trip Pro

consisted of uncontrolled noninsulin-dependent diabetes mellitus (NIDDM) patients with chronic generalized periodontitis, who received SRP and treatment with metformin. Group 2 consisted of uncontrolled NIDDM with chronic generalized periodontitis, who received SRP and metformin plus fenugreek powder. Periodontal parameters such as gingival index, plaque index, bleeding on probing, pocket depth, and clinical attachment levels were evaluated before treatment and 1 month after nonsurgical periodontal (...) Fenugreek, diabetes, and periodontal disease: A cross-link of sorts! The aim of this study was to observe the sequelae of fenugreek adjunctive to nonsurgical periodontal therapy and its comparison to a group treated with scaling and root planing (SRP) and metformin alone by assessing their respective effects on periodontal parameters, glycemic status, and serum lipid levels.The study comprised eighty patients who were further divided into two groups. Each group consisted of 40 patients. Group 1

2019 Journal of Indian Society of Periodontology Controlled trial quality: uncertain

148. The effects of ozone therapy on periodontal therapy: A randomized placebo-controlled clinical trial. (Abstract)

. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm CAL, were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non-surgically. Topical gaseous ozone was applied into periodontal pockets twice a week for 2 weeks during active periodontal therapy. Gingival crevicular fluid pentraxin-3 (...) The effects of ozone therapy on periodontal therapy: A randomized placebo-controlled clinical trial. The aim of this randomized split-mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non-surgical periodontal therapy.A total of 36 moderate to severe generalized periodontitis patients were included in the study. The patients were systemically healthy and 18 to 64 years of age

2019 Oral diseases Controlled trial quality: uncertain

149. Risk factors for recurrence of periodontal disease in patients in maintenance care in a private practice. (Abstract)

. The longer the time, the more frequent the recall visits, and the more was spent during the maintenance phase, the greater was the reduction. Multivariate analysis rendered BMI and smoking as factors influencing number of sites with PD ≥ 4 mm and bleeding on probing.Tooth loss and periodontal tissue damage can be contained over prolonged periods if periodontal disease is treated and patients attend regular maintenance care.© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. (...) Risk factors for recurrence of periodontal disease in patients in maintenance care in a private practice. To assess periodontal and dental conditions in individuals in maintenance care after periodontal therapy in private practice, and to identify risk factors for recurrence of disease and tooth loss.One hundred patients attending a routine recall visit were included. All had been treated for periodontal disease and were in maintenance since ≥ 2 years.Examinations took place 18.0 (±8.71) years

2019 Journal of Clinical Periodontology

150. Periodontitis in individuals with liver cirrhosis: A case-control study. (Abstract)

Periodontitis in individuals with liver cirrhosis: A case-control study. The aim of this study was to evaluate the association between liver cirrhosis and periodontitis.This case-control study included 294 individuals, 98 cases with liver cirrhosis and 196 controls. A full-mouth periodontal examination was performed and plaque index, probing depth, clinical attachment level and bleeding on probing were recorded. The association of risk variables with periodontitis was tested through univariate (...) analysis and multivariate logistic regression, stratified by alcohol status.A high prevalence of periodontitis was observed among cases (62.2%) when compared to controls (41.8%). Individuals with cirrhosis presented a chance ~2 higher of having periodontitis than controls (OR = 2.28; 95% CI 1.39-3.78; p < .001). Significant variables associated with periodontitis in the final logistic models were as follows: (a) no/occasional alcohol use model-number of teeth up 14, age ≥45-55 years, male sex

2019 Journal of Clinical Periodontology

151. Microbiome in maintained periodontitis and its shift over a single maintenance interval of 3 months. (Abstract)

Microbiome in maintained periodontitis and its shift over a single maintenance interval of 3 months. To assess the subgingival microbial shift of maintained periodontitis treated by ultrasonic scaling (US) or air polishing (AP) during a 3-month maintenance interval.We conducted a 12-week randomized split-mouth controlled trial with US and AP in 17 maintained subjects (bleeding on probing [BOP%] ≤25%, probing depth [PD] ≤5 mm). They were monitored at baseline, week 2, week 8 and week 12. The V3 (...) -V4 region of the 16S rDNA from 136 subgingival plaque samples was sequenced and analysed.Treatment by US or AP could effectively reduce the PD, microbial richness, diversity, periodontitis-associated microbiota and pathogenic metabolism in maintained periodontitis. Bacteria recolonized after treatment and returned to the pre-treatment level 12 weeks after treatment. Ultrasonic scaling group demonstrated slight advantage in reducing BOP (%), pathogenic bacteria and metabolism than AP group

2019 Journal of Clinical Periodontology Controlled trial quality: uncertain

152. A double-blind, paralleled-arm, placebo-controlled, randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care. (Abstract)

A double-blind, paralleled-arm, placebo-controlled, randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care. This study aimed to evaluate the clinical effectiveness of the probiotic Lactobacillus reuteri as an adjunct to non-surgical periodontal therapy (NSPT).A double-blind, paralleled-arm, placebo-controlled, randomized clinical trial was conducted. Probiotics L. reuteri or placebo lozenges were randomly prescribed for use twice-daily for 28 days (...) . Primary outcome were clinical attachment levels (CAL) and probing pocket depths (PPD). All participants underwent NSPT and follow-up clinical assessments were performed at Day 90 and Day 180.The trial response rate was 69.5% (41 out of 59). Among the test and control groups, there were significant intra-group differences in primary outcomes: CAL (both, p<0.001) and PPD (both, p<0.001); and in secondary outcomes: percentage of sites with 'bleeding on probing' (both, p<0.001) and visible plaque (both, p

2019 Journal of Clinical Periodontology Controlled trial quality: predicted high

153. Periodontal regeneration using bone morphogenetic protein 2 incorporated biomimetic calcium phosphate in conjunction with barrier membrane: A pre-clinical study in dogs. Full Text available with Trip Pro

in 15 dogs' mandibles. After the initial periodontal therapy, the defects were randomly assigned to the following groups: (a) control; (b) barrier membrane; (c) deproteinized bovine bone mineral + barrier membrane; (d) BioCaP + barrier membrane and (e) BMP-2/BioCaP + barrier membrane (6 quadrants with 18 teeth per group). Eight weeks later, clinical examinations, micro-CT, and histomorphometric analyses were performed.Clinical examinations, including plaque index, bleeding index, and probing depth (...) Periodontal regeneration using bone morphogenetic protein 2 incorporated biomimetic calcium phosphate in conjunction with barrier membrane: A pre-clinical study in dogs. To evaluate the effect of bone morphogenetic protein 2 (BMP-2) incorporated biomimetic calcium phosphate (BMP-2/BioCaP) in conjunction with barrier membrane on periodontal regeneration in chronic periodontitis experimental model.Chronic periodontitis experimental model with critical-sized supra-alveolar defects was created

2019 Journal of Clinical Periodontology

154. Status of periodontal health in German patients suffering from chronic kidney disease - Data from GCKD study. (Abstract)

(GCKD) project was analyzed by recording bleeding on probing (BOP), pocket probing depth (PPD) and clinical attachment level (CAL). Furthermore, the awareness of the study subjects of their periodontal conditions was evaluated by a self-reported questionnaire.24.4% of the CKD study patients showed no or only mild signs of periodontal disease, 47.6% displayed moderate and 27% severe periodontitis. Questionnaire data revealed that 62.3% of the study subjects with severe periodontitis, were not aware (...) Status of periodontal health in German patients suffering from chronic kidney disease - Data from GCKD study. To assess the prevalence and severity of periodontitis in patients with moderate chronic kidney disease (CKD) and comparing the results with the self-reported periodontitis awareness of the study subjects.The periodontal status of 270 patients with moderate CKD randomly selected from a cohort of 5.217 subjects participating in the prospective observational German Chronic Kidney Disease

2019 Journal of Clinical Periodontology

155. Patients' perception of their oral and periodontal health and its impact: a cross-sectional study in the NHS. (Abstract)

probing depths (mm), gingival recession (mm), gingival bleeding (yes/no), dentine hypersensitivity (Schiff score, and yes/no) and tooth wear (basic erosive wear examination score) were measured.Results Participants were regular dental attenders, with good oral hygiene practices and a low prevalence of periodontal disease (probing depth of 4 mm or more) (25%). For all conditions assessed, self-reported data and clinical indices were significantly positively associated, with the strongest associations (...) Patients' perception of their oral and periodontal health and its impact: a cross-sectional study in the NHS. Aims To determine patient awareness of periodontal health, dentine hypersensitivity and tooth wear, and their impact on oral health quality of life in patients attending NHS practices in South West England.Method In this cross-sectional, multi-centre epidemiological study 814 adult NHS patients completed an oral health questionnaire and then underwent a clinical examination. Pocket

2019 British Dental Journal

156. The application of antimicrobial photodynamic therapy (aPDT, 670 nm) and diode laser (940 nm) as adjunctive approach in the conventional cause-related treatment of chronic periodontal disease: a randomized controlled split-mouth clinical trial. (Abstract)

, but not statistically significant.After 6 months of evaluation, the high intensity diode laser and the antimicrobial photodynamic therapy have not shown any additional benefits to the conventional periodontal treatment.The diode or photodynamic laser therapy in conjunction with conventional SRP does not seem to be superior in reducing probing depth and bleeding on probing than SRP alone 6 months after treatment. More studies are necessary to prove the actual need of these types of lasers in the periodontal clinical (...) The application of antimicrobial photodynamic therapy (aPDT, 670 nm) and diode laser (940 nm) as adjunctive approach in the conventional cause-related treatment of chronic periodontal disease: a randomized controlled split-mouth clinical trial. The aim of the present randomized controlled split-mouth clinical trial is to evaluate the effectiveness of the adjunctive use of photodynamic low-level laser therapy (670 nm), applying methylene blue as photosensitizer, and the effectiveness

2019 Clinical oral investigations Controlled trial quality: uncertain

157. Randomized controlled clinical effectiveness of adjunct 660-nm light-emitting diode irradiation during non-surgical periodontal therapy. Full Text available with Trip Pro

Randomized controlled clinical effectiveness of adjunct 660-nm light-emitting diode irradiation during non-surgical periodontal therapy. The irradiation of 660-nm light-emitting diodes (LEDs) has exhibited potential to accelerate oral wound healing and prevent periodontal breakdown in rodents. This study was to evaluate the clinical effectiveness of 660-nm LEDs during non-surgical periodontal therapy (NSPT).Nineteen patients with at least one periodontitis-involved tooth in three quadrants (...) .At T2, all examined sites exhibited significantly reduced probing pocket depth (PD), clinical attachment level (CAL), gingival bleeding index, plaque score, and visual analog scale. In the sites with greatest initial PD and CAL, LED01 and LED02 significantly reduced PD and CAL compared with the control treatment. IL-1β and MMP-8 were reduced in all groups at T1 and T2, and the reduction of MMP-8 was the most notable in LED01.LED light irradiation during or after scaling and root planing assisted

2019 Journal of the Formosan Medical Association = Taiwan yi zhi Controlled trial quality: uncertain

158. Effectiveness of scaling and root planning with and without adjunct antimicrobial photodynamic therapy in the treatment of chronic periodontitis among cigarette-smokers and never-smokers: A randomized controlled clinical trial. (Abstract)

-smokers.Demographic information was collected using a questionnaire. Cigarette-smokers (group-1) and never-smokers (group-2) with CP were included. Treatment wise, these individuals were divided into two subgroups as follows: (a) SRP alone and (b) SRP with adjunct aPDT. Periodontal parameters (plaque index [PI], bleeding on probing [BOP], clinical attachment loss [AL] and probing pocket depth≥4 mm [PD] were measured at baseline and at 1 month and 3 months' follow-up. Group comparisons were done using the Kruskall (...) Effectiveness of scaling and root planning with and without adjunct antimicrobial photodynamic therapy in the treatment of chronic periodontitis among cigarette-smokers and never-smokers: A randomized controlled clinical trial. The aim of the present short-term randomized clinical trial was to assess the efficacy of scaling and root planing (SRP) with and without adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of chronic periodontitis (CP) among cigarette-smokers and never

2019 Photodiagnosis and Photodynamic Therapy Controlled trial quality: uncertain

159. Polyhexamethylene guanidine phosphate irrigation as an adjunctive to scaling and root planing in the treatment of chronic periodontitis. Full Text available with Trip Pro

Polyhexamethylene guanidine phosphate irrigation as an adjunctive to scaling and root planing in the treatment of chronic periodontitis. To evaluate the efficacy of adjunctive polyhexamethylene guanidine (PHMG) phosphate irrigation in periodontal treatment.The subjects comprised 59 patients with severe chronic periodontitis. Plaque index, bleeding on probing (BOP) and pocket probing depths (PPD) were recorded. The subjects were randomly allocated to one of three groups for scaling and root (...) no intergroup differences in PPDs persisted. While post study surgical treatment needs decreased in all three groups, no intergroup differences were observed in the number of deep periodontal pockets.Irrigation with PHMG phosphate significantly reduces PPDs in the short-term, but has no significant long-term effect on the mean pocket depth.

2019 Acta odontologica Scandinavica Controlled trial quality: uncertain

160. Alleviation of acute dental pain from localised apical periodontitis: A prospective randomised study comparing two emergency treatment procedures. (Abstract)

the emergency clinic at Malmö University met the inclusion criteria: spontaneous pain and/or pain on percussion and palpation, non-bleeding pulp in the canal orifice, pain ≥4 on a Numeric Rating Scale and ≥18 years of age. The diagnosis was symptomatic apical periodontitis, in the absence of swelling and/or fever. Pre-operative pain levels and intake of analgesics were registered. The patients were randomised to one of the two treatment groups. Three to five days post-operatively, the patients were (...) Alleviation of acute dental pain from localised apical periodontitis: A prospective randomised study comparing two emergency treatment procedures. To compare the outcomes of two emergency treatment procedures to alleviate pain from localised symptomatic apical periodontitis: complete chemo-mechanical disinfection (CMD) of the root canal system, or removal of necrotic tissue from the pulp chamber (RNT), that is without instrumentation of the root canals.Fifty-seven consecutive patients from

2019 Journal of oral rehabilitation Controlled trial quality: uncertain

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