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Periodontal Bleeding

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141. Randomized controlled clinical effectiveness of adjunct 660-nm light-emitting diode irradiation during non-surgical periodontal therapy. Full Text available with Trip Pro

Randomized controlled clinical effectiveness of adjunct 660-nm light-emitting diode irradiation during non-surgical periodontal therapy. The irradiation of 660-nm light-emitting diodes (LEDs) has exhibited potential to accelerate oral wound healing and prevent periodontal breakdown in rodents. This study was to evaluate the clinical effectiveness of 660-nm LEDs during non-surgical periodontal therapy (NSPT).Nineteen patients with at least one periodontitis-involved tooth in three quadrants (...) .At T2, all examined sites exhibited significantly reduced probing pocket depth (PD), clinical attachment level (CAL), gingival bleeding index, plaque score, and visual analog scale. In the sites with greatest initial PD and CAL, LED01 and LED02 significantly reduced PD and CAL compared with the control treatment. IL-1β and MMP-8 were reduced in all groups at T1 and T2, and the reduction of MMP-8 was the most notable in LED01.LED light irradiation during or after scaling and root planing assisted

2019 Journal of the Formosan Medical Association = Taiwan yi zhi Controlled trial quality: uncertain

142. The application of antimicrobial photodynamic therapy (aPDT, 670 nm) and diode laser (940 nm) as adjunctive approach in the conventional cause-related treatment of chronic periodontal disease: a randomized controlled split-mouth clinical trial. (Abstract)

, but not statistically significant.After 6 months of evaluation, the high intensity diode laser and the antimicrobial photodynamic therapy have not shown any additional benefits to the conventional periodontal treatment.The diode or photodynamic laser therapy in conjunction with conventional SRP does not seem to be superior in reducing probing depth and bleeding on probing than SRP alone 6 months after treatment. More studies are necessary to prove the actual need of these types of lasers in the periodontal clinical (...) The application of antimicrobial photodynamic therapy (aPDT, 670 nm) and diode laser (940 nm) as adjunctive approach in the conventional cause-related treatment of chronic periodontal disease: a randomized controlled split-mouth clinical trial. The aim of the present randomized controlled split-mouth clinical trial is to evaluate the effectiveness of the adjunctive use of photodynamic low-level laser therapy (670 nm), applying methylene blue as photosensitizer, and the effectiveness

2019 Clinical oral investigations Controlled trial quality: uncertain

143. Indocyanine green-based adjunctive antimicrobial photodynamic therapy for treating chronic periodontitis: A randomized clinical trial. (Abstract)

Indocyanine green-based adjunctive antimicrobial photodynamic therapy for treating chronic periodontitis: A randomized clinical trial. The objective was to evaluate the efficiency of indocyanine green (ICG)-based adjunctive antimicrobial photodynamic therapy (aPDT) in a prospective clinical study regarding non-surgical treatment of chronic periodontitis.Affected teeth of twenty patients were treated with scaling and root planing (control group). Using a split-mouth design, two quadrants (...) received additional ICG-based (perio green®, 0.1 mg/ml) aPDT (test group) with a diode laser at 808 nm (100 mW at 2 kHz). Clinical assessment of bleeding on probing (BOP), sulcus fluid flow rate (SFFR) and microbiological analysis were performed at baseline, two weeks, three and six months after treatment. Relative attachment level (RAL), probing depths (PD) and gingival recession (GR), were also analyzed.At baseline, none of the assessed parameters showed significant differences between the test

2019 Photodiagnosis and Photodynamic Therapy Controlled trial quality: uncertain

144. Clinical, in vitro and phytochemical, studies of Scrophularia striata mouthwash on chronic periodontitis disease. (Abstract)

Clinical, in vitro and phytochemical, studies of Scrophularia striata mouthwash on chronic periodontitis disease. Chronic periodontitis is an inflammatory process of the oral cavity that is caused by different reasons. Streptococcus mutans bacteria is the main cause of the disease. Scrophularia striata in Iranian traditional medicine is used to heal inflammation of gum and mouth. Also, In vitro anti-bacterial effect of S. striata in S. mutans have been demonstrated.Clinical, in vitro (...) and chemical constituent studies of S. striata on chronic periodontitis disease.This study is a randomized clinical trial that was performed in Dental College, Hamadan University of Medical Sciences. Fifty patients with chronic periodontitis (20-50 years old) were selected and the study was approved and registered in Iranian Registry of Clinical Trials as number IRCT2015081323468N1 prior to the experiment. The 50 patients were divided into two groups. One group used herbal mouthwash that was made from

2019 Journal of Ethnopharmacology Controlled trial quality: uncertain

145. Efficacy of Er:YAG laser on periodontitis as an adjunctive non-surgical treatment: A split-mouth randomized controlled study. Full Text available with Trip Pro

laser (ERL; 100 mJ/pulse; 15 Hz to hard tissue and 50 mJ/pulse; 30 Hz to soft tissue) plus SRP treatment, while the control quadrants received SRP only. We evaluated periodontal indexes, including probing depth (PD), clinical attachment level (CAL), bleeding index (BI), and plaque index (PLI) at baseline, 3 months, and 6 months.The PD and CAL means in the ERL + SRP group were significantly lower than those in the SRP group at 3-month follow-up (PD: 2.98 ± 0.38 mm vs. 3.09 ± 0.35 mm; CAL: 4.51 ± 0.69 (...) Efficacy of Er:YAG laser on periodontitis as an adjunctive non-surgical treatment: A split-mouth randomized controlled study. To evaluate the adjunctive efficacy of Er:YAG laser use with mechanical scaling and root planing (SRP) for non-surgical treatment of periodontitis.In a randomized, single-blinded, controlled trial, 27 patients were recruited. Using a split-mouth design, two quadrants were randomly allocated into either a test group or a control group. The test quadrants received Er:YAG

2019 Journal of Clinical Periodontology Controlled trial quality: uncertain

146. Periodontal status correlates with anti-citrullinated protein antibodies (ACPAs) in first degree relatives of individuals with rheumatoid arthritis. (Abstract)

assessed in 34 ACPA positive (ACPA+) and 65 ACPA negative (ACPA-) subjects: gingival index (GI), plaque Index (PI), probing depth (PD), bleeding on probing (BOP) and clinical attachment level (CAL). We compared the two groups using conditional logistic regression.In ACPA+ individuals, the mean PI, PD, BOP, CAL and number of sites per person with PD>4mm and BOP was significantly higher compared to ACPA- group. All ACPA+ subjects had periodontitis: 44.1% presenting moderate and 47.1% severe periodontitis (...) Periodontal status correlates with anti-citrullinated protein antibodies (ACPAs) in first degree relatives of individuals with rheumatoid arthritis. To evaluate periodontal status in first-degree relatives of patients with rheumatoid arthritis (FDR-RA) and detect correlation with presence of anti-citrullinated protein antibodies (ACPA).Rheumatologic and periodontal status were evaluated in a nested case-control study of FDR-RA with no diagnosis of RA at enrolment. The following parameters were

2019 Journal of Clinical Periodontology

147. Comparison of two measures to determine the oral health-related quality of life in elders with periodontal disease. (Abstract)

the psychometric properties of the scales in older people with periodontal disease.Participants were 155 elderly patients with periodontal disease attending a university periodontal department. Periodontal measures included gingival index, plaque index, probing pocket depth, clinical attachment level, and bleeding on probing. GOHAI and OHIP-14 scales were used to assess OHQoL. In addition, participants completed a checklist of symptoms related to periodontal disease.Using the additive method for scoring, 22 (...) Comparison of two measures to determine the oral health-related quality of life in elders with periodontal disease. The Oral Health Impact Profile (OHIP) and Geriatric Oral Health Assessment Index (GOHAI) are accepted as comprehensive and widely used tools for assessing oral health-related quality of life (OHQoL). However, OHQoL assessment of elders with periodontal disease has not yet been investigated.To assess the discriminative performance of GOHAI and OHIP-14 and to compare

2019 Community dental health

148. Topical oral 1-tetradecanol complex in the treatment of periodontal diseases in cats. (Abstract)

periodontal disease except tooth mobility at 6 weeks. The 1-TDC group exhibited a statistically significant reduction in pocket depth, clinical attachment loss, gingival index and bleeding on probing after treatment at 6 weeks, whereas the placebo group did not show any significant change.Chronic inflammation associated with periodontal diseases leads to periodontal tissue destruction. As a result, modulation of the host response has been included in the treatment protocol for periodontal diseases. Fatty (...) Topical oral 1-tetradecanol complex in the treatment of periodontal diseases in cats. The aim of this study was to evaluate the outcomes of the treatment of chronic periodontal disease with an oral application of tetradecanol complex (1-TDC) in cats.The test group (n = 9) received 1-TDC (525 mg per gel capsule/day) and the placebo group (n = 4) received olive oil (0.25 ml per gel capsule/day) for 6 weeks.Oral treatment with 1-TDC resulted in significant reductions in all parameters of clinical

2019 Journal of feline medicine and surgery Controlled trial quality: uncertain

149. Association of Periodontitis with Oral Cancer: A Case-Control Study. (Abstract)

, and smoking to controls ( n = 278) from the Yangpyeong health and periodontal cohort in Korea. OSCC was diagnosed through biopsy and radiographs, including computed tomography and magnetic resonance imaging. Tumor location and TNM stage were classified after the surgery. Periodontitis was defined by alveolar bone loss with panoramic radiographs following the guidelines of the Fifth European Workshop in Periodontology. Alcohol intake, education, physical activity, obesity by body mass index, hypertension (...) males (aOR = 6.55), elders aged >60 y (aOR = 4.98), and those with more tooth loss (aOR = 9.99). Our data showed that periodontitis was independently associated with OSCC. Thus, the risk of OSCC could be modulated by reducing periodontitis.

2019 Journal of Dental Research

150. Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age. An exploratory sub-analysis of the ABPARO-trial. Full Text available with Trip Pro

(% of sites with new attachment loss ≥ 1.3 mm at 27.5 months post-treatment) was calculated.Adjunctive antimicrobials reduced median new attachment loss in patients < 55 years (5.2%), or with ≥ 35% PPD ≥ 5 mm (4.5%), or with a mean attachment level > 5 mm (5.2%) at baseline compared to the placebo (9.0%, 11.6%, and 12.5%, respectively; p < 0.005).The clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age. This article is protected by copyright. All (...) Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age. An exploratory sub-analysis of the ABPARO-trial. The aim was to identify benefit thresholds for clinical variables. We hypothesize, if variables fall below or exceed these threshold levels, systemic amoxicillin/metronidazole may contribute to reducing progression of periodontitis.This is an explorative per-protocol collective analysis (n = 345) conducted on the placebo-controlled

2019 Journal of Clinical Periodontology Controlled trial quality: uncertain

151. UTILISATION OF ANTIMICROBIAL PHOTODYNAMIC THERAPY AS AN ADJUNCTIVE TOOL FOR OPEN FLAP DEBRIDEMENT IN THE MANAGEMENT OF CHRONIC PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL. (Abstract)

UTILISATION OF ANTIMICROBIAL PHOTODYNAMIC THERAPY AS AN ADJUNCTIVE TOOL FOR OPEN FLAP DEBRIDEMENT IN THE MANAGEMENT OF CHRONIC PERIODONTITIS: A RANDOMIZED CONTROLLED CLINICAL TRIAL. Antimicrobial photodynamic therapy (aPDT) has proved to be an effective adjunctive modality with potential benefits in the management of chronic periodontitis. The combination of photothermal and photodynamic effects of Indocyanine green (ICG) dye, when it is photoactivated with a diode laser of 810 nm wavelength (...) clinical parameters were assessed at baseline and 3 months: probing pocket depth (PPD), relative attachment level (RAL), relative gingival margin level (RGML), plaque index (PI), gingival index (GI), and gingival bleeding index (GBI).Intragroup comparison using paired t-test revealed a statistically significant improvement from baseline visit (p < 0.05). Intergroup comparison using independent samples t-test showed a statistically significant improvement in RAL, RGML and GI in the test group (p < 0.05

2019 Photodiagnosis and Photodynamic Therapy Controlled trial quality: uncertain

152. Effectiveness of scaling and root planning with and without adjunct antimicrobial photodynamic therapy in the treatment of chronic periodontitis among cigarette-smokers and never-smokers: A randomized controlled clinical trial. (Abstract)

-smokers.Demographic information was collected using a questionnaire. Cigarette-smokers (group-1) and never-smokers (group-2) with CP were included. Treatment wise, these individuals were divided into two subgroups as follows: (a) SRP alone and (b) SRP with adjunct aPDT. Periodontal parameters (plaque index [PI], bleeding on probing [BOP], clinical attachment loss [AL] and probing pocket depth≥4 mm [PD] were measured at baseline and at 1 month and 3 months' follow-up. Group comparisons were done using the Kruskall (...) Effectiveness of scaling and root planning with and without adjunct antimicrobial photodynamic therapy in the treatment of chronic periodontitis among cigarette-smokers and never-smokers: A randomized controlled clinical trial. The aim of the present short-term randomized clinical trial was to assess the efficacy of scaling and root planing (SRP) with and without adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of chronic periodontitis (CP) among cigarette-smokers and never

2019 Photodiagnosis and Photodynamic Therapy Controlled trial quality: uncertain

153. Alleviation of acute dental pain from localised apical periodontitis: A prospective randomised study comparing two emergency treatment procedures. (Abstract)

the emergency clinic at Malmö University met the inclusion criteria: spontaneous pain and/or pain on percussion and palpation, non-bleeding pulp in the canal orifice, pain ≥4 on a Numeric Rating Scale and ≥18 years of age. The diagnosis was symptomatic apical periodontitis, in the absence of swelling and/or fever. Pre-operative pain levels and intake of analgesics were registered. The patients were randomised to one of the two treatment groups. Three to five days post-operatively, the patients were (...) Alleviation of acute dental pain from localised apical periodontitis: A prospective randomised study comparing two emergency treatment procedures. To compare the outcomes of two emergency treatment procedures to alleviate pain from localised symptomatic apical periodontitis: complete chemo-mechanical disinfection (CMD) of the root canal system, or removal of necrotic tissue from the pulp chamber (RNT), that is without instrumentation of the root canals.Fifty-seven consecutive patients from

2019 Journal of oral rehabilitation Controlled trial quality: uncertain

154. Polyhexamethylene guanidine phosphate irrigation as an adjunctive to scaling and root planing in the treatment of chronic periodontitis. Full Text available with Trip Pro

Polyhexamethylene guanidine phosphate irrigation as an adjunctive to scaling and root planing in the treatment of chronic periodontitis. To evaluate the efficacy of adjunctive polyhexamethylene guanidine (PHMG) phosphate irrigation in periodontal treatment.The subjects comprised 59 patients with severe chronic periodontitis. Plaque index, bleeding on probing (BOP) and pocket probing depths (PPD) were recorded. The subjects were randomly allocated to one of three groups for scaling and root (...) no intergroup differences in PPDs persisted. While post study surgical treatment needs decreased in all three groups, no intergroup differences were observed in the number of deep periodontal pockets.Irrigation with PHMG phosphate significantly reduces PPDs in the short-term, but has no significant long-term effect on the mean pocket depth.

2019 Acta odontologica Scandinavica Controlled trial quality: uncertain

155. Periodontal health: a national cross-sectional study of knowledge, attitudes and practices for the public oral health strategy in China. Full Text available with Trip Pro

periodontal attitudes and practices were estimated. Multiple logistic regression analyses were used to examine the related factors.Less than 20% of Chinese adults were knowledgeable about periodontal disease. Very few (2.6%) of Chinese adults use dental floss ≥once a day and undergo scaling ≥once a year, and visit a dentist (6.4%) in the case of gingival bleeding. Periodontal health KAP was associated with gender, age, body-mass index, marital status, place of residence, education level, income, smoking (...) status, and history of periodontal disease.Periodontal health KAP are generally poor among the Chinese adult population. Community based health strategies to improve periodontal health KAP need to be implemented. Increasing knowledge of periodontal disease, the cultivation of correct practices in response to gingival bleeding, and the development of good habits concerning the use of dental floss and regular scaling should be public oral health priorities. This article is protected by copyright. All

2019 Journal of Clinical Periodontology

156. Chronic periodontitis and reduced respiratory function. (Abstract)

Chronic periodontitis and reduced respiratory function. To investigate whether there was an association between chronic periodontitis (CP) and reduced respiratory function.A group of dentate 58- to 72-year-old men in Northern Ireland had a comprehensive periodontal examination. Parallel to the periodontal examination, participants completed questionnaires gathering information on their medical history, social circumstances, demographic background and tobacco use. A physical examination assessed (...) anthropometric measures. Fasting blood samples were obtained and analysed for high-sensitivity C-reactive protein (hs-CRP). Spirometry measures were performed using a wedge bellows spirometer (Vitalograph S Model). The primary outcome variable of interest was the percentage predicted forced expiratory volume in one-second (% predicted FEV1 ). Analysis included multiple linear regression with adjustment for various confounders and a regression-based mediation analysis.A total of 1,380 men were included

2019 Journal of Clinical Periodontology

157. Comparative evaluation of subgingivally-delivered 1% metformin and Aloe vera gel in the treatment of intrabony defects in chronic periodontitis patients: A randomized, controlled clinical trial. (Abstract)

Comparative evaluation of subgingivally-delivered 1% metformin and Aloe vera gel in the treatment of intrabony defects in chronic periodontitis patients: A randomized, controlled clinical trial. The aim of the current study was to explore the effectiveness of locally-delivered 1% metformin (MtF) and Aloe vera (AV) gel as an adjunct to scaling and root planning (SRP) in the treatment of intrabony defects in chronic periodontitis patients.A total of 90 volunteers were randomly assigned to three (...) treatment groups: (a) SRP + placebo gel; (b) SRP + 1% MtF gel; and (c) SRP + AV gel. Clinical parameters, including gingival index (GI), bleeding on probing (BoP), pocket probing depth (PPD), and clinical attachment level (CAL), were recorded at baseline, and 6 and 12 months. The radiological assessment of bone defect fill was done at 6 and 12 months.GI, BoP, PPD, and CAL improved in all the groups; however, the mean PPD reduction, CAL gain, and percentage of bone fill was found to be greater in the MtF

2019 Journal of investigative and clinical dentistry

158. Two-Year Randomized Clinical Trial of Adjunctive Minocycline Microspheres in Periodontal Maintenance. (Abstract)

Two-Year Randomized Clinical Trial of Adjunctive Minocycline Microspheres in Periodontal Maintenance. Purpose: The purpose of this study was to evaluate the effects of repeated scaling and root planing (SRP), with or without locally-delivered minocycline microspheres (MM) on residual pockets in patients undergoing periodontal maintenance (PMT).Methods: Patients on PMT were randomized into two groups for treatment of one posterior interproximal inflamed pocket (≥5 mm) with a history of bleeding (...) planning alone, of moderately inflamed periodontal pockets at 6-month intervals, produced stable interproximal alveolar bone height as well as sustained improvements in probing depths, clinical attachment level, bleeding on probing over 24 months; minocycline microspheres were not shown to enhance these results.Copyright © 2018 The American Dental Hygienists’ Association.

2019 Journal of dental hygiene : JDH Controlled trial quality: uncertain

159. Periodontal therapy and endothelial function in coronary artery disease: A randomized controlled trial. (Abstract)

, whereas the control group received equal treatment after the study period. Endothelial function was assessed by measurement of brachial artery flow-mediated dilation, concentrations of sVCAM-1, sICAM-1, and P-selectin in serum before and 3 months after periodontal therapy.The test group exhibited statistically better periodontal parameters-plaque, probing depth, periodontal attachment loss, and bleeding on probing. No significant improvements were observed in the control (1.37%) and test (1.39 (...) in a short-term follow-up period, although it maintained blood concentrations of markers of vascular inflammation.© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.

2019 Oral diseases Controlled trial quality: uncertain

160. An Adiponectin Receptor Agonist Reduces Type 2 Diabetic Periodontitis. Full Text available with Trip Pro

. In the current study, we applied a newly discovered adiponectin receptor agonist AdipoRon (APR) in experimental periodontitis in diabetic animal models and demonstrated the underlying molecular mechanisms. We found that when APR systemically quenched the blood sugar level in diet-induced obesity (DIO) diabetic mice, it reduced osteoclast numbers and alveolar bone loss significantly due to APR's inhibition on osteoclast differentiation shown in our in vitro studies. APR also decreased the production (...) An Adiponectin Receptor Agonist Reduces Type 2 Diabetic Periodontitis. Periodontitis is twice as prevalent in diabetics as in nondiabetics, and type 2 diabetes (T2D)-associated periodontitis is severe in many cases due to the altered and aberrant functions of bone cells in hyperglycemic conditions. Therefore, developing an effective method to halt the disease process, as well as restore and regenerate lost alveolar bone to reserve the natural teeth in diabetics, is critically important

2019 Journal of Dental Research

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