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Periodontal Bleeding

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81. Efficacy of interdental calibrated brushes on bleeding reduction in adults: a 3-month randomized controlled clinical trial. Full Text available with Trip Pro

Efficacy of interdental calibrated brushes on bleeding reduction in adults: a 3-month randomized controlled clinical trial. This study investigated the effect of interdental brushes on the reduction of interproximal bleeding in adults without periodontal disease. Forty-six adults were enrolled in a 3-month, observer-blinded, parallel-group randomized control trial. The test group used a standard manual toothbrush twice daily and an interdental brush daily. The control group used a standard (...) manual toothbrush. At each visit, a calibrated colorimetric probe was used in all interdental spaces to determine the appropriate size of the interdental brush required, the brush of the corresponding size was introduced into the interproximal space, and the presence of bleeding was recorded. The outcome was the frequency of bleeding after application of the appropriate interdental brush. All participants were evaluated 1 wk, 1 month, and 3 months after the baseline visit. The overall preventive

2016 European journal of oral sciences Controlled trial quality: uncertain

82. The Effect of Mouthwash Containing Pomegranate Peel Extract and Chlorhexidine Mouthwash on Bleeding on Brushing

information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Heba Moahmed Fouad, Cairo University: Gingival Bleeding on probing Additional relevant MeSH terms: Layout table for MeSH terms Hemorrhage Gingival Hemorrhage Pathologic Processes Oral Hemorrhage Mouth Diseases Stomatognathic Diseases Gingival Diseases Periodontal Diseases Chlorhexidine Chlorhexidine gluconate Anti-Infective Agents, Local Anti-Infective Agents Disinfectants (...) The Effect of Mouthwash Containing Pomegranate Peel Extract and Chlorhexidine Mouthwash on Bleeding on Brushing The Effect of Mouthwash Containing Pomegranate Peel Extract and Chlorhexidine Mouthwash on Bleeding on Brushing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2016 Clinical Trials

83. Metal versus Plastic Partial Dentures for Patients with Periodontal Disease

and periodontal outcomes. Thirty- eight patients experienced further tooth loss, with no significant differences between Metal Versus Plastic Partial Dentures for Patients with Periodontal Disease 8 study groups. Reasons given for extraction were endodontic, caries, fracture, and periodontal disease. Pocket depth and bleeding on probing were assessed for inclusion into a multivariate model, but neither they nor any of the other baseline covariates were significantly associated. In a separate paper (...) , periodontal outcomes were assessed by the plaque index according to Silness and Löe, vertical clinical attachment loss, probing pocket depth and bleeding with probing. The results suggested slightly poorer outcomes with the removable partial denture as opposed to the shortened dental arch alone, but the differences were small. Studies excluded because they did not report material for denture construction 6. Müller S, Eickholz P, Reitmeir P, Eger T. Long-term tooth loss in periodontally compromised

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

84. Increased levels of Porphyromonas gingivalis are associated with ischemic and hemorrhagic cerebrovascular disease in humans: an in vivo study Full Text available with Trip Pro

was not detected in any of the groups by conventional or real-time PCR.Stroke patients had deeper pockets, more severe attachment loss, increased bleeding on probing, increased plaque indexes, and in their pockets harbored increased levels of P. gingivalis. These findings suggest that periodontal disease is a risk factor for the development of cerebral hemorrhage or infarction. Early treatment of periodontitis may counteract the development of cerebrovascular episodes. (...) Increased levels of Porphyromonas gingivalis are associated with ischemic and hemorrhagic cerebrovascular disease in humans: an in vivo study This study investigated the role of periodontal disease in the development of stroke or cerebral infarction in patients by evaluating the clinical periodontal conditions and the subgingival levels of periodontopathogens.Twenty patients with ischemic (I-CVA) or hemorrhagic (H-CVA) cerebrovascular episodes (test group) and 60 systemically healthy patients

2012 Journal of Applied Oral Science

85. Fretibacterium sp. human oral taxon 360 is a novel biomarker for periodontitis screening in the Japanese population. Full Text available with Trip Pro

Fretibacterium sp. human oral taxon 360 is a novel biomarker for periodontitis screening in the Japanese population. Periodontitis is a common inflammatory disease, leading to bone destruction and tooth loss. Screening for periodontitis is important in preventing the progress of this disease. Various types of bacteria have been examined as potential screening targets, but only culturable pathogenic bacteria have been considered candidates. Recently, the various uncultivable bacteria have been (...) of uncultivable bacterial species TM7 sp. HOT 356 and Fretibacterium sp. HOT 360 were significantly higher in periodontitis group than in healthy group. Only Fretibacterium sp. HOT 360 showed a significantly positive correlation with such periodontal parameters as probing pocket depth (PPD) and bleeding on probing (BOP).These findings indicate that uncultivable bacteria Fretibacterium sp. HOT 360 can be used as a saliva-based diagnostic bacterial biomarker for periodontitis screening.

2019 PLoS ONE

86. Platelet-Rich Fibrin for the Treatment of Intrabony Periodontal Defects in Patients with Generalized Aggressive Periodontitis: A Randomized Controlled Clinical Study. (Abstract)

of intrabony periodontal defects in patients with generalized aggressive periodontitis (GAgP).Using a split-mouth design, sixteen GAgP patients with paired contralateral intrabony defects were randomly assigned to the test group (composite bone graft {autogenous bone mixed with xenograft} + PRF, n = 16 sites) and control group (composite bone graft + CM, n = 16 sites). Plaque index, papillary bleeding index, probing pocket depth (PPD), clinical attachment level (CAL) and position of gingival margin (GML (...) Platelet-Rich Fibrin for the Treatment of Intrabony Periodontal Defects in Patients with Generalized Aggressive Periodontitis: A Randomized Controlled Clinical Study. Platelet-rich fibrin (PRF) is a fibrin matrix in which platelet cytokines, growth factors and cells are embedded; therefore, it has the potential to be used as regenerative therapy. The aim of this randomized clinical study was to evaluate the regenerative capacity of PRF when compared to collagen membrane (CM) for the treatment

2017 Journal of the International Academy of Periodontology Controlled trial quality: uncertain

87. Glycemic control and adipokines after periodontal therapy in patients with Type 2 diabetes and chronic periodontitis. Full Text available with Trip Pro

randomly divided into two groups according to whether they underwent PT. Periodontal status, blood glucose, and the levels of serum tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), adiponectin (APN), and fibroblast growth factor-21 (FGF-21) were measured at baseline and after 3 months. The results revealed that the probing depth (PD) and attachment loss (AL) were significantly improved, the serum levels of TNF-α and IL-6 were significantly decreased, and APN and FGF-21 exhibited substantial (...) Glycemic control and adipokines after periodontal therapy in patients with Type 2 diabetes and chronic periodontitis. The mechanism by which chronic periodontitis (CP) affects type 2 diabetes (T2DM) remains unclear. Therefore, the aim of this study is to evaluate the effects of periodontal therapy (PT) on the glycemic control and adipokines of patients with T2DM and CP with the purpose of elucidating the possible mechanisms by which CP influences T2DM. Forty-four patients with T2DM and CP were

2017 Brazilian oral research Controlled trial quality: uncertain

88. Efficacy of combined orthodontic-periodontic treatment for patients with periodontitis and its effect on inflammatory cytokines: A comparative study. (Abstract)

) and the combined group (receiving combined orthodontic-periodontic treatment, n = 59). In addition, 52 healthy people without periodontal disease were selected as the normal group. Probing depth, tooth mobility, plaque index, clinical attachment level, and sulcus bleeding index were recorded. ELISA was applied to detect gingival crevicular fluid (GCF) and serum levels of inflammatory cytokines. A 2-year clinical follow-up was conducted.Before treatment, the periodontal parameters (probing depth, tooth mobility (...) , plaque index, clinical attachement level, and sulcus bleeding index) and GCF and serum levels of inflammatory cytokines (high-sensitivity C-reactive protein, interleukin-1β, interleukin-5, interleukin-6, interleukin-8, tumor necrosis factor-α, and prostaglandin E2) in the combined and basic groups were higher than those in the normal group. After 6 and 18 months of treatment, the periodontal parameters and GCF and serum levels of inflammatory cytokines decreased in the combined and basic groups

2017 American journal of orthodontics and dentofacial orthopedics Controlled trial quality: uncertain

89. The Effect of Nonsurgical Periodontal Therapy on HNP1-3 Level in Gingival Crevicular Fluid of Chronic Periodontitis Patients Full Text available with Trip Pro

after it, clinical periodontal parameters were measured and GCF was collected from previously chosen site. The level of HNP1-3 in GCF was determined by means of a commercially available enzyme-linked immunoassay kit. The periodontal therapy caused a statistically significant (p < 0.001) decrease in all the assessed clinical parameters at the sites of sample collection except for bleeding on probing. The level of HNP1-3 per measure point showed a statistically significant increase (baseline-3 months (...) The Effect of Nonsurgical Periodontal Therapy on HNP1-3 Level in Gingival Crevicular Fluid of Chronic Periodontitis Patients The rich bacterial flora of oral cavity is controlled by innate immune response, including antibacterial peptides and among them human neutrophil peptides 1-3 (HNP1-3). The knowledge of the involvement of HNPs in innate and acquired immunity of the periodontium is fragmentary. The aim of the study was to assess alterations in HNP1-3 levels in the gingival crevicular fluid

2017 Archivum Immunologiae et Therapiae Experimentalis

90. The risk reduction of recurrent periodontal pathogens of local application minocycline HCl 2% gel, used as an adjunct to scaling and root planing for chronic periodontitis treatment Full Text available with Trip Pro

periodontal destruction such as loss of attachment and bone destruction occurred.A total of 81 subjects with moderate to severe periodontitis whose baseline clinical attachment loss (CAL) was ≥4 mm were randomly assigned to receive SRP alone (control group, N=39) or SRP followed by four times of local application of minocycline HCl gel (Periocline) once a week (test group, N=42). Pocket depth, CAL, and papilla bleeding index were examined at baseline, 21 days, 2, 3, and 6 months. Subgingival plaque (...) The risk reduction of recurrent periodontal pathogens of local application minocycline HCl 2% gel, used as an adjunct to scaling and root planing for chronic periodontitis treatment The aim of this study was to evaluate the clinical and microbiological effects of local application minocycline HCl 2% gel, used as an adjunct to scaling and root planing (SRP) for treatment of chronic periodontitis (CP). CP is an inflammation of periodontal tissue that is caused mainly by bacterial infection, where

2017 Therapeutics and clinical risk management Controlled trial quality: uncertain

91. Effect of initial periodontal therapy on gingival crevicular fluid cytokine profile in subjects with chronic periodontitis Full Text available with Trip Pro

fluid (GCF) discriminated periodontally diseased sites from healthy ones, or periodontally diseased persons from healthy ones, and assessed the impact of nonsurgical periodontal therapy on these readings. This study included 20 periodontally healthy persons (H) and 24 patients with chronic periodontitis (P). In every participant, we measured the plaque index, gingival index, probing pocket depth (PD), bleeding on probing, and recession at six sites of every tooth. GCF was collected with Durapore® (...) -csf, gm-csf, ifn-γ, mip-1β, vegf, and tnf-α) were assessed using the Bio-Plex suspension array system. Mean plaque index, gingival index, bleeding on probing, PD, and recession were significantly different between groups H and P. Differences between PP and PH sites were not significant for any of the cytokines. Il-1ra, il-6, il-17, b-fgf, gm-csf, mip-1β, and tnf-α differed significantly between HH sites and both PH and PP sites, whereas il-8 was significantly higher only at PP sites. Periodontal

2017 Clinical and Experimental Dental Research

92. Periodontal inflamed surface area as a novel numerical variable describing periodontal conditions Full Text available with Trip Pro

Periodontal inflamed surface area as a novel numerical variable describing periodontal conditions A novel index, the periodontal inflamed surface area (PISA), represents the sum of the periodontal pocket depth of bleeding on probing (BOP)-positive sites. In the present study, we evaluated correlations between PISA and periodontal classifications, and examined PISA as an index integrating the discrete conventional periodontal indexes.This study was a cross-sectional subgroup analysis of data (...) <0.01, respectively; Pearson correlation test). Porphyromonas gingivalis (P. gingivalis) expression and the presence of serum P. gingivalis antibodies were significant factors affecting PISA values in a simple linear regression analysis, together with periodontal classification, PI, bleeding index, and smoking, but not in the multivariate analysis. In the multivariate linear regression analysis, PISA values were positively correlated with the quantity of current smoking, PI, and severity

2017 Journal of periodontal & implant science

93. The Association between Periodontal Status, Serum Lipid Levels, Lipoprotein Associated Phosholipase A2 (Lp-PLA2) in Chronic Periodontitis Subjects and Healthy Controls Full Text available with Trip Pro

cell apoptosis, inflammatory cell chemotaxis and endothelial cell dysfunction in CVD. Owing to its role in inflammation, it may influence the development and progression of periodontitis as well.To compare the demographic variables, Gingival Index(GI), Bleeding On Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL) with serum lipid profile and Lp-PLA2 level in Chronic Periodontitis (CP) subjects.A total of 75 subjects were selected and divided into three groups; based (...) The Association between Periodontal Status, Serum Lipid Levels, Lipoprotein Associated Phosholipase A2 (Lp-PLA2) in Chronic Periodontitis Subjects and Healthy Controls Lipoprotein associated phospholipase A2 (Lp-PLA2) has been explored as a potential biomarker for Cardiovascular Disease (CVD). The human Lp-PLA2 is a serine-dependent, Ca2+- independent enzyme. It gives way to oxidised free fatty acids and lysophosphatidyl choline by hydrolysing oxidised phospholipids, that leads to smooth muscle

2017 Journal of clinical and diagnostic research : JCDR

94. Evaluation of Efficacy of Surgical Periodontal Therapy with the Use of Bone Graft in the Treatment of Periodontal Intrabony Defects Full Text available with Trip Pro

replacement material in the treatment of deep intrabony pockets, compared to surgical treatment (flap surgery) without the use of bone replacement in advanced periodontitis.The study included 50 patients of both sexes with advanced periodontitis, divided into two groups. After initial periodontal therapy was performed, plaque index (PI), papillary bleeding index (PBI) were verified, and depth of periodontal pockets was measured in both groups. One group (group 1) of the patients underwent surgical therapy (...) Evaluation of Efficacy of Surgical Periodontal Therapy with the Use of Bone Graft in the Treatment of Periodontal Intrabony Defects One of the most important goals of periodontitis therapy is the elimination of deep periodontal pockets. In regenerative periodontal therapy, different types of bone grafts, membranes, growth factors, etc. are used to improve regeneration of lost periodontal tissue. The aim of this study was to evaluate the effect of surgical therapy supported by the use of bone

2017 Medical Archives

95. Periodontal and glycemic effects of nonsurgical periodontal therapy in patients with type 2 diabetes stratified by baseline HbA1c. Full Text available with Trip Pro

periodontal therapy was compared among diabetic patients with good glycemic control, those with poor glycemic control, and 25 nondiabetic individuals. Periodontal and metabolic status was recorded at baseline, 3 months, and 6 months. In patients receiving treatment, periodontal parameters significantly improved and HbA1c decreased by 10.8%. Improvements in gingival index and bleeding on probing were greater in the nondiabetic participants and the treated patients with good glycemic control than (...) Periodontal and glycemic effects of nonsurgical periodontal therapy in patients with type 2 diabetes stratified by baseline HbA1c. We evaluated the effects of nonsurgical periodontal therapy in 100 patients with type 2 diabetes and chronic periodontitis. The participants were classified as having good (n = 48) or poor (n = 52) glycemic control and were further randomly allocated to receive either scaling and root planning treatment group or no treatment (n = 50 each). The effect of nonsurgical

2017 Journal of oral science Controlled trial quality: uncertain

96. Efficacy of scaling and root planning with and without adjunct Nd:YAG laser therapy on clinical periodontal parameters and gingival crevicular fluid interleukin 1-beta and tumor necrosis factor-alpha levels among patients with periodontal disease: A prosp (Abstract)

Efficacy of scaling and root planning with and without adjunct Nd:YAG laser therapy on clinical periodontal parameters and gingival crevicular fluid interleukin 1-beta and tumor necrosis factor-alpha levels among patients with periodontal disease: A prosp Limited evidence exists regarding the role of scaling and root planning (SRP) with adjunct neodymium yttrium aluminum garnet (Nd:YAG) laser therapy in reducing periodontal parameters (plaque index [PI], bleeding on probing [BOP] and probing (...) pocket depth [PPD]) and levels of proinflammatory cytokines in the gingival crevicular fluid (GCF) among patients with periodontal disease (PD). The aim was to assess the effect of SRP with and without adjunct Nd:YAG laser therapy on clinical periodontal parameters and GCF interleukin 1-beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels among patients with PD.Demographic data was collected using a questionnaire. Mandibular right and left quadrants were randomly divided into test- (SRP+Nd:YAG

2017 Journal of photochemistry and photobiology. B, Biology Controlled trial quality: uncertain

97. Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis

≥5 mm with bleeding on probing and ≥2 sites with PD ≥7 mm (including incisors and first molars, in addition to two other non-contiguous teeth between them); presence of three non-adjacent periodontal pockets with probing depth ≥5 mm and bleeding on probing not located in furcation area; good general health (ASA I/II); 18-35 years old; agree to participate in the study and sign a written consent (Resolution # 196 of October 1996 and the Brazilian Professional Code of Dental Ethics - 179/93 (...) ). Exclusion Criteria: pregnant or nursing; suffer from any systemic disease (e.g. cardiovascular, diabetes, blood dyscrasias, immunodeficiency, etc - ASA III/IV/V); antimicrobials or anti-inflammatory drugs in the previous 6 months; periodontal treatment within the last 12 months; smoke ≥10 cigarettes/day; reported allergy to amoxicillin, metronidazole or clarithromycin; required antibiotic prophylaxis; current use of any medication that could interfere with periodontal response were excluded from

2017 Clinical Trials

98. Kiwifruit Effect on Periodontal Inflammation Kiwifruit Effect on Periodontal Inflammation

Inclusion Criteria: proximal attachment loss of ≥3 mm in ≥2 non-adjacent teeth, PPD≥4 mm and bleeding on probing on at least 25 % of their total sites documented radiographic bone loss Exclusion Criteria: younger than 18 years or older than 70 years, pregnant or lactating females, females using contraceptive pharmacological medications, reported diagnosis of any systemic illnesses including cardiovascular, renal, and liver diseases, in need of antibiotic treatment during initial periodontal treatment (...) examined and included in the study. After 2 months subjects also received non-surgical periodontal treatment and then followed for additional 3 months. Subjects in the control group didi not receive any dietary advice. Procedure: Non Surgical periodontal treatment Non-surgical treatment of periodontal pockets with hand and ultrasonic instrumentation Outcome Measures Go to Primary Outcome Measures : Full-mouth bleeding score (FMBS) [ Time Frame: Baseline, 2 months and 3 months after periodontal

2017 Clinical Trials

99. Effect of nonsurgical periodontal treatment on clinical periodontal variables and salivary resistin levels in obese Asians. Full Text available with Trip Pro

group (n = 31), which received no treatment. Plaque score (PS), gingival bleeding index (GBI), probing pocket depth (PPD), and clinical attachment loss (CAL) were measured at baseline and at 6 and 12 weeks after NSPT. Salivary resistin levels were evaluated by using an enzyme-linked immunosorbent assay. PS was significantly lower in patients who received NSPT than in the control group at 6 and 12 weeks (P < 0.05). In the NSPT group the percentages of sites with shallow and moderate pockets decreased (...) Effect of nonsurgical periodontal treatment on clinical periodontal variables and salivary resistin levels in obese Asians. This study investigated changes in periodontal outcomes after nonsurgical periodontal treatment (NSPT) and evaluated associations of change in salivary resistin level with periodontal outcomes in obese Malaysians with chronic periodontitis. Sixty-two obese adults with chronic periodontitis were randomly divided into a test group (n = 31), which received NSPT, and a control

2017 Journal of oral science Controlled trial quality: uncertain

100. Gingivitis and periodontitis

with the formation of periodontal pockets. Loss of multiple teeth. In gingivitis, discomfort from gums is rare; other features include: Reddening and swelling of the gum margins. Bleeding of gums with tooth brushing, flossing, or gentle probing. In periodontitis, symptoms (including pain) are commonly absent, but some people have: Halitosis. Foul taste in the mouth. Recession and associated root sensitivity. Drifting/loosening of teeth causing difficulty in eating. Periodontal abscess, which may cause pain (...) absent, but some people have: Halitosis. Foul taste in the mouth. Recession and associated root sensitivity. Drifting/loosening of teeth causing difficulty in eating. Periodontal abscess, which may cause pain. Signs include those of gingivitis, plus: Bleeding, pus, and debris expressible from gingival pockets. Loosening or drifting of teeth; eventual loss of teeth. Periodontal abscess. Suspect acute necrotizing ulcerative gingivitis if there is a sudden or rapid onset of: Intensely painful gums

2018 NICE Clinical Knowledge Summaries

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