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Periodontal Bleeding

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241. Periodontitis and multiple markers of cardiometabolic risk in the fourth decade: A cohort study. (Full text)

Periodontitis and multiple markers of cardiometabolic risk in the fourth decade: A cohort study. To examine associations between periodontitis at ages 32 and 38 and a range of early cardiometabolic risk biomarkers at age 38.Periodontal probing depth and bleeding on probing data collected during the age-32 and age-38 assessments in the Dunedin Multidisciplinary Health and Development Study were used to quantify periodontal inflammatory load. Retinal microvascular abnormalities, endothelial (...) dysfunction, and metabolic syndrome data were collected during the age-38 assessment. Regression models were used to examine associations between these cardiometabolic risk markers and (1) the inflammatory load at age 38 and (2) the change in inflammatory load between ages 32 and 38.Periodontal inflammatory load was recorded for 890 Study members at age 32, 891 at age 38, and 856 at both ages. Retinal vessel data were available for 922, endothelial dysfunction data for 909 and metabolic syndrome data

2018 Community Dentistry and Oral Epidemiology PubMed abstract

242. Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis

. Individuals were randomly selected to a control and test groups. At baseline, all subjects completed a questionnaire and carried out an examination. Standard periodontal outcome variables were assessed. For both groups, the plaque index (PI), gingival index (GI), pocket depth (PD), bleeding on probing (BOP) and clinical attachment level (CAL) scores were enrolled at baseline and after 30 days. Volatile sulphur compound (VSC) levels were evaluated by a Halimeter (Interscan Corp., Chatsworth, CA, USA (...) Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

243. Periodontal Wound Healing With CHX and Hyaluronic Acid

of the following patient-related criteria: pregnancy or lactation; genetic defects (e.g. Down's syndrome) with an established impact on periodontal status; diabetes mellitus; immune system disorders (e.g. HIV/AIDS); heavy smokers (≥ 10 cigarettes/day); severe blood disorders, with a documented qualitative and/or quantitative deficit of polymorphonuclears and/or platelets; assumption of medications affecting the gingiva and/or the oral mucosa (e.g. diphenylhydantoin, calcium channel blockers, cyclosporin (...) Periodontal Wound Healing With CHX and Hyaluronic Acid Periodontal Wound Healing With CHX and Hyaluronic Acid - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Periodontal Wound Healing With CHX

2018 Clinical Trials

244. Effectiveness of Locally Delivered Morus Alba Gel on Moderate Periodontitis

by (Responsible Party): Dr. Shilpa Gunjal, KLE VK Institute of Dental Sciences Study Details Study Description Go to Brief Summary: Background: Periodontitis is a chronic inflammatory disease of tooth and supporting tissues with clinical signs of bone and connective tissue loss and is mediated by a combination of periodontal pathogens and host defense systems. Currently the use of herbal products in dentistry is increasing due to their easy availability, low cost and lesser side effects. One such herbal plant (...) assessed at baseline and after 45 days. Condition or disease Intervention/treatment Phase Chronic Periodontitis Other: Chlorhexidine gel Other: Morus alba gel Not Applicable Detailed Description: Morus alba is invaluable member of the plant kingdom belonging to the family Moraceae and the genus Morus. It is extensively cultivated for leaf yield in sericulture. Morus alba have long been used in traditional medicine to improve eyesight, lower blood pressure, prevent diabetes, protect the liver

2018 Clinical Trials

245. Association of Keratinised Mucosa Around Implants and Teeth With Peri-implant/Periodontal Disease and Soft Tissue Conditioning

Frame: 12 months after implant loading ] Probing pocket depth measured in mm, bleeding on probing recorded as yes/no (I/0), suppuration as recorded as yes/no (I/0) Secondary Outcome Measures : Association of keratinised mucosa/gingiva with periodontal and peri-implant conditions [ Time Frame: 12 months after implant loading ] keratinised mucosa (mm) and keratinised gingiva (mm) Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study (...) Association of Keratinised Mucosa Around Implants and Teeth With Peri-implant/Periodontal Disease and Soft Tissue Conditioning Association of Keratinised Mucosa Around Implants and Teeth With Peri-implant/Periodontal Disease and Soft Tissue Conditioning - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2018 Clinical Trials

246. The Immune Response After Periodontal Treatment

] Serum antibody measurement Periodontal loss of attachment [ Time Frame: day 90 ] Index to determine the amount of connective tissue loss sustained by each tooth within the oral cavity as a result of the progressive, destructive periodontal disease process. Gingivitis Index [ Time Frame: day 90 ] Levels of gingivitis within the oral cavity as a percentage of all tooth surfaces Plaque Index [ Time Frame: day 90 ] Levels of plaque within the oral cavity as a percentage of all tooth surfaces Blood (...) interpreter/non English language written material to understand and provide, or any other reason for being unable to provide written, informed consent History of bleeding diathesis Females using contraceptive methods. Pregnant or lactacting females. Reported diagnosis of any systemic illnesses including cardiovascular, renal, and liver diseases. Any pharmacological treatment within 3 months before the beginning of periodontal treatment. Specialist Periodontal treatment in the previous 6 months. Patients

2018 Clinical Trials

247. Anti-infectious Therapy of Periodontitis

of periodontopathogenic marker bacteria A. actinomycetemcomitans, P. gingivitis, T. forsythia and P. intermedia; Assessment of the change of the occurrence of these bacteria 3 and 6 months after therapy compared to baseline Change of bleeding on probing [ Time Frame: Baseline, 3 months, 6 months ] Assessment of the change of the appearance of a bleeding spot immediately after the probing of periodontal pockets 3 and 6 months after therapy compared to baseline Change of gingival index [ Time Frame: Baseline, 3 months (...) Inclusion Criteria: patients with generalized moderate to severe chronic periodontitis presence of at least 18 teeth with at least 2 multi-rooted and / or 2 single-rooted teeth in the first quadrant with at least 6 sites with periodontal probing depth of ≥ 6 mm radiographic bone loss of at least 25% of the root length Exclusion Criteria: subgingival scaling and root planing within the last 12 months antimicrobial rinsing or intake of systemic antibiotics within the last 4 months systemic diseases

2018 Clinical Trials

248. Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients

or disease Intervention/treatment Phase Periodontitis, Adult Periodontal Pocket Periodontitis Periodontal Attachment Loss Device: SRP and Fotosan 630 Not Applicable Detailed Description: Periodontal parameters and cytokine IL-1β, IL-6, IL-8, TNF-α, MMP-8 levels were analysed. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 51 participants Allocation: Randomized Intervention Model: Parallel Assignment Intervention Model Description (...) table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Foo Lean Heong, National University, Singapore: Photodynamic therapy Interleukin 1-beta Tumour necrosis factor - alpha Interleukin-6 Interleukin-8 Matrix metalloproteinase-8 Additional relevant MeSH terms: Layout table for MeSH terms Periodontitis Periodontal Pocket Periodontal Attachment Loss Chronic Periodontitis Periodontal Diseases Mouth Diseases

2018 Clinical Trials

249. The Role of Visfatin in Obesity and Periodontal Disease

or bleeding on probing. Four sites from each tooth were used for Gingival crevicular fluid sampling. In the generalized chronic periodontitis groups, Gingival crevicular fluid samples were collected from four teeth with bleeding on probing, probing depth≥ 5 mm, clinical attachment level≥ 5 mm, and 30% bone loss. Visfatin, TNF alpha and IL-6 levels in these fluid samples were determined using an enzyme-linked immunosorbent assay (ELISA). Secondary Outcome Measures : Clinical attachment level [ Time Frame (...) and the buccal aspects of the interproximal contact area for mesial and distal sites using a William's periodontal probe at baseline and 3 months following Phase I periodontal therapy and metabolic control Bleeding on probing [ Time Frame: Change from baseline bleeding on probing score to 3rd month score ] The presence of bleeding after probing was noted from all teeth, excluding third molars at the baseline and 3 months following Phase I periodontal therapy and metabolic control Gingival index [ Time Frame

2018 Clinical Trials

250. Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis

Update Posted : May 23, 2018 Sponsor: Tatyasaheb Kore Dental College Information provided by (Responsible Party): Dr.Nibha Suneel Kulkarni, Tatyasaheb Kore Dental College Study Details Study Description Go to Brief Summary: Periodontal disease is an immune-inflammatory disease which consists of connective tissue breakdown, loss of attachment, and alveolar bone loss.In normal physiology, there is an equilibrium maintained between reactive oxygen species (ROS) activity and antioxidant defence capacity (...) Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2018 Clinical Trials

251. Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients

or medication which significantly impact periodontal inflammation or bone turnover (e.g. steroids, bisphosphonates, > 325 mg aspirin/day and in good general health, 4) one experimental quadrant of the mouth with an inflamed 6-9 mm interproximal posterior periodontal pocket with history of bleeding on probing (BOP), 5) willingness to sign consent form. Subjects will be divided into two groups for additional therapy in a 6-9 mm interproximal periodontal pocket at baseline: 1) local anesthesia and mini-flap (...) crevicular fluid (GCF) sample (markers of inflammation, bone turnover), 4) recession from the cemento-enamel junction, 5) probing pocket depth and bleeding on probing (BOP). Following the 12-month visit, the research-specific intervention and measurements in the experiment quadrant will be removed from routine PMT. Condition or disease Intervention/treatment Phase Periodontal Diseases Other: Methylcellulose Drug: Simvastatin-Methylcellulose Phase 4 Detailed Description: Dental records of patients

2018 Clinical Trials

252. Periodontal Outcomes After Sanative Therapy

and if untreated, will ultimately lead to tooth loss. In Canada, the first line of defense against periodontal disease is non-surgical sanative therapy (ST). Participants in this study have been attending a periodontal specialty clinic for routine periodontal maintenance appointments for at least 1 to 5 years following their initial scaling and root planing. Salivary flow rate will be measured to determine the level of dry mouth. At the regular maintenance appointment, clinical measures will be evaluated (...) (probing depth, bleeding on probing, plaque index, gingival index, thickness of tissues, mobility, and furcations). Patients will also complete a dry mouth questionnaire to determine if dry mouth influences the day to day life of a patient, and the patient's Registered Dental Hygienist will complete a short questionnaire outlining oral symptoms of dry mouth. Additionally, the investigators aim to see if a patient who has periodontal maintenance appointments at a specialty office has different clinical

2018 Clinical Trials

253. Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families.

: Change of the baseline bledding on probing at 45 days [ Time Frame: Baseline and 45 days for each test ] Bleeding induced at the depth of the gingival sulcus or periodontal pocket after probing Secondary Outcome Measures : Change of the baseline plaque index at 45 days [ Time Frame: Baseline and 45 days for each test ] Reduction in the amount of plaque accumulation around the gingival marginal after the therapy. Change of the baseline inflamatory markers levels in gingival crevicular fluid (pg/uL (...) Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

254. Quantification of Micro-RNA 146-a in Chronic Periodontitis and Coronary Heart Disease Subjects

on inclusion and exclusion criteria. Group I comprised of 30 subjects with Generalized chronic periodontitis diagnosed with coronary heart disease.Group II comprised of 30 subjects with Generalized chronic periodontitis without coronary heart disease and Group III comprised of 30 systemically healthy volunteers with no chronic periodontitis or coronary heart disease. Demographic variables such as age, weight,height,BMI and income and clinical parameters such as plaque index, bleeding on probing, probing (...) willing to participate in the study. Patients within the age group of 35-65 years. Should have ≥ 10 natural teeth. For group I Generalized chronic periodontitis patients with coronary heart disease: Generalised chronic periodontitis is defined as those having 30% or more sites with clinical attachment loss (CAL) ≥ 3mm. For group II Generalized chronic periodontitis patients without coronary heart disease. Healthy controls were selected based on the following criteria: Probing pocket depth (PD) less

2018 Clinical Trials

255. A Study of the C3 Complement Inhibitor AMY-101 in Adults With Periodontal Disease

: January 29, 2019 See Sponsor: Amyndas Pharmaceuticals S.A. Information provided by (Responsible Party): Amyndas Pharmaceuticals S.A. Study Details Study Description Go to Brief Summary: A Phase 2a Clinical Trial to Assess the Safety and Efficacy of Complement 3 Inhibitor Analog, AMY-101, in Adults with gingivitis. The study is a 3-month randomized, double-blind, split-mouth study of adults with existing chronic periodontal inflammation determined by the level of gingival index and bleeding on probing (...) A Study of the C3 Complement Inhibitor AMY-101 in Adults With Periodontal Disease A Study of the C3 Complement Inhibitor AMY-101 in Adults With Gingivitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

256. Clinical Effectiveness of Diode Laser as an Adjunct in the Treatment of Periodontitis

parameters such as pocket depth (PD), clinical attachment loss (CAL), gingival index (GI) and plaque index (PI) were evaluated at the baseline. All Patients underwent initial periodontal therapy; SRP which was performed using a sonic device and hand instruments and the sites were divided randomly into two groups SRP alone and SRP with adjunctive diode 810 nm laser in the contralateral sites in the same jaw. The Clinical parameters have been re-evaluated at 1, 3 and 6 months to test the effectiveness (...) Clinical Effectiveness of Diode Laser as an Adjunct in the Treatment of Periodontitis Clinical Effectiveness of Diode Laser as an Adjunct in the Treatment of Periodontitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2018 Clinical Trials

257. Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.

about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 35 Years to 50 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Individuals between 35 and 50 years of age; Be diagnosed with generalized chronic periodontitis: present a loss of interproximal clinical insertion> 3 mm in 2 nonadjacent teeth and loss (...) of interproximal clinical insertion ≥5 mm, in 30% or more of the teeth present; Present at least 16 teeth; Present good systemic health; Agree to participate in the study and sign the informed consent form Exclusion Criteria: Patients with systemic problems (cardiovascular changes, blood dyscrasias, immunodeficiency, among others), which do not indicate the periodontal procedure; Have undergone periodontal treatment in the last twelve months; Have used antibiotics and/or anti-inflammatories for the past six

2018 Clinical Trials

258. Impact of Periodontal Treatment on Gastric Helicobacter Pylori Eradication

severity Clinical Attachment level [ Time Frame: 3 months ] used as a surrogate marker to measure severity of the periodontal disease OHI (Oral Hygiene Index) [ Time Frame: 3 months ] this index used to determine patient oral hygiene status (Greene and Vermillion, 1964) Gingival Index [ Time Frame: 3 months ] Löe-Silness gingival index Plaque index [ Time Frame: 3 months ] this index used to determine patient oral hygiene status (Silness-Löe) Bleeding on Probing [ Time Frame: 3 months ] an index give (...) Impact of Periodontal Treatment on Gastric Helicobacter Pylori Eradication Impact of Periodontal Treatment on Gastric Helicobacter Pylori Eradication - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Impact

2018 Clinical Trials

259. Effects of Ozone Therapy as an Adjunct to Periodontal Treatment

. Total of 20 participants completed the study (10 males, 10 females). Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm clinical attachment level. Periodontal parameters were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non-surgically. Topical gaseous ozone was applied (...) Effects of Ozone Therapy as an Adjunct to Periodontal Treatment Effects of Ozone Therapy as an Adjunct to Periodontal Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Ozone Therapy

2018 Clinical Trials

260. Neurogenic Inflammation in Peri-implant and Periodontal Diseases

and their symmetrically matching teeth were evaluated using a split-mouth study design. Clinical periodontal examinations included the Silness-Löe plaque index, Löe-Silness gingival index, bleeding on probing, probing pocket depth and clinical attachment level parameters were determined. Gingival crevicular fluid (GCF)/Periimplant sulcular fluid (PISF) samples were collected, and the levels of the neuropeptides were determined by enzyme-linked immunosorbent assay. Correlations between GCF/PISF neuropeptide levels (...) Neurogenic Inflammation in Peri-implant and Periodontal Diseases Neurogenic Inflammation in Peri-implant and Periodontal Diseases - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Neurogenic Inflammation

2018 Clinical Trials

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