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Periodontal Bleeding

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221. Etiological periodontal treatment with and without low-level laser therapy on IL-1β level in gingival crevicular fluid: an in vivo multicentric pilot study. (Abstract)

Etiological periodontal treatment with and without low-level laser therapy on IL-1β level in gingival crevicular fluid: an in vivo multicentric pilot study. Cytokine proteins may have important roles during different human physiological and pathological processes. In the oral cavity, the bone loss and periodontal tissue pathology was related to inflammatory process activation. The aim of the present study was to assess the effects of etiological periodontal therapy with and without the use (...) and LLLT (group 2). In all sites, at baseline before treatment, the periodontal pocket depth (PPD) and bleeding on probing (BOP) were measured. In the PPD sites, the GCF samples were collected from 30 deep (≥5 mm) and shallow (≤3 mm) sites and IL-1β were evaluated at baseline, after 10 days and 1 month. In all the samples at baseline, the IL-1β concentration in GCF and BOP rate were significantly higher at deep PPD sites than at the shallow ones. After 10 days in all samples no PPD improvement

2018 Journal of biological regulators and homeostatic agents Controlled trial quality: uncertain

222. Influence of manual and power toothbrushes on clinical and microbiological findings in initial treatment of periodontitis - A randomized clinical study. (Abstract)

). At baseline, after 4 weeks and after 12 weeks, the following parameters were assessed:modified Quigley-Hein-Index (QHI), papilla bleeding index (PBI), periodontal pocket depth (PPD), bleeding on probing (BOP) and recession. For microbiological analysis (PCR) of 11 periodontal pathogenic bacteria, samples of sulcular fluid were taken from the deepest pockets. Statistical analysis was performed using ANOVA, with the level of significance set at α= 5%.All clinical parameters:PBI, modified QHI, PPD, BOP (...) Influence of manual and power toothbrushes on clinical and microbiological findings in initial treatment of periodontitis - A randomized clinical study. This randomized clinical study compared the influence of manual and power toothbrushes on clinical and microbiological findings in initial treatment of periodontitis.A total of 72 participants with a mean age of 55.7 years were randomly assigned to three groups (n= 24):oscillating-rotating (OR), sonic-active (SA) and manual toothbrush (MTB

2018 American journal of dentistry Controlled trial quality: uncertain

223. Periodontal Evaluation in Noncarious Cervical Lesions Restored with Resin-modified Glass-Ionomer Cement and Resin Composite: A Randomised Controlled Study. (Abstract)

), relative gingival recession (rGR), relative clinical attachment level (rCAL), visible plaque index (VPI) and gingival bleeding index (GBI) were measured.No statistically significant differences were found when comparing within groups (p > 0.05). However, the intergroup analysis demonstrated a decrease in GR and rCAL gain for teeth restored with the resin-modified glass-ionomer cement (RM-GIC).Both materials behaved similarly when in close contact with periodontal tissues and did not influence (...) Periodontal Evaluation in Noncarious Cervical Lesions Restored with Resin-modified Glass-Ionomer Cement and Resin Composite: A Randomised Controlled Study. To assess periodontal parameters of noncarious cervical lesions (NCCLs) restored with glass-ionomer cement (RM-GIC) and composite resin at baseline, three and six months.Eighteen patients with bilateral lesions were included in the study. Lesions (1 mm in depth) were randomly restored with each type of restorative material. Probing depth (PD

2018 Oral health & preventive dentistry Controlled trial quality: uncertain

224. Treatment of periodontitis in smokers with multiple sessions of antimicrobial photodynamic therapy or systemic antibiotics: A randomized clinical trial. (Full text)

Treatment of periodontitis in smokers with multiple sessions of antimicrobial photodynamic therapy or systemic antibiotics: A randomized clinical trial. The aim of this study was to evaluate the effects of non-surgical periodontal therapies on smokers with chronic periodontitis, involving multiple adjunctive applications of antimicrobial photodynamic therapy (aPDT), and systemic metronidazole (MTZ) with amoxicillin (AMX).All participants were treated with scaling and root planing (SRP (...) lower mean probing depths, more clinical attachment level gains and less bleeding on probing. At 180 days, in the moderate pocket there was a reduction in the levels of Porphyromonas gingivalis and Prevotella nigrescens in the MTZ + AMX group, while group aPDT showed a reduction in Prevotella nigrescens. Furthermore, at 180 days, in the deep pocket a reduction in Porphyromonas gingivalis, Prevotella intermedia and Prevotella nigrescens was observed in group MTZ + AMX, as well as a reduction

2018 Photodiagnosis and Photodynamic Therapy Controlled trial quality: uncertain PubMed abstract

225. Efficacy of grape seed extract gel in the treatment of chronic periodontitis: A randomized clinical study. (Abstract)

Efficacy of grape seed extract gel in the treatment of chronic periodontitis: A randomized clinical study. The aim of the present study was to assess the effectiveness of applying grape seed extract (GSE) gel in periodontal pockets for the treatment of chronic periodontitis.Eighty-six sites with pocket depth (PD) >4 mm were selected from five systemically-healthy patients in whom scaling, and root planing were performed, and oral instructions were given, a week earlier. PD, gingival index (GI (...) ), plaque index (PI), and bleeding on probing (BOP) were measured, and sites were then divided into the control group (N = 38) and GSE group (N = 48). Four doses of formulated 2% mucoadhesive GSE gel were applied to GSE group sites at baseline visit (T0), and 3, 6, and 9 days after T0. Similarly, a control gel was applied to the control sites. PD, PI, GI and BOP were re-evaluated after 4 weeks and 6 months of first gel application.Paired t test for both the control and GSE groups showed a significant

2018 Journal of investigative and clinical dentistry Controlled trial quality: uncertain

226. Treatment of severe periodontitis with a laser and light-emitting diode (LED) procedure adjunctive to scaling and root planing: a double-blind, randomized, single-center, split-mouth clinical trial investigating its efficacy and patient-reported outcomes (Abstract)

with photoablative λ 810 nm laser, (2) disinfection with λ 405 nm LED, (3) SRP, and (4) 10 weekly antiseptic/anti-inflammatory photodynamic treatments with λ 635 nm laser and 0.1% toluidine blue as photosensitizer. Clinical and cytofluorescent periodontal markers and patient-reported results were analyzed. At 1-year follow-up, both groups showed a significant reduction of several severity markers of periodontitis, namely probing depth (PD) and bleeding on probing (BoP), as well as of bacteria, polymorphonuclear (...) Treatment of severe periodontitis with a laser and light-emitting diode (LED) procedure adjunctive to scaling and root planing: a double-blind, randomized, single-center, split-mouth clinical trial investigating its efficacy and patient-reported outcomes Broad methodological heterogeneity makes the literature on the clinical effects of laser treatment in periodontitis, both as monotherapy and adjunct to non-surgical therapy, which is difficult to interpret. The present split-mouth study

2018 Lasers in medical science Controlled trial quality: uncertain

227. [Preliminary study of subgingival microorganism changes after glycine powder air-polishing treatment during periodontal maintenance phase]. (Abstract)

of 35-72 (8 males and 13 females) who were systematically healthy were recruited in this study. According to splitting-mouth design, one side of a mouth was randomly assigned to the experiment group (21 patients, 248 teeth, 1 488 sites) with 65 μm GPAP therapy while the opposite side served as the control group (21 patients, 249 teeth, 1 494 sites) with ultrasonic scaling plus polishing paste therapy. The clinical periodontal parameters including probing depth (PD), bleeding index (BI), bleeding (...) [Preliminary study of subgingival microorganism changes after glycine powder air-polishing treatment during periodontal maintenance phase]. Objective: To research the variation of subgingival microorganisms after 65 μm glycine powder air-polishing (GPAP) in patients with periodontitis during periodontal maintenance phase and make comparison with conventional method. Methods: From Department of Periodontology, Peking University School and Hospital of Stomatology, twenty-one patients at the age

2018 Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology Controlled trial quality: uncertain

228. Antimicrobial photodynamic therapy as adjunct to non-surgical periodontal treatment in smokers: a randomized clinical trial. (Abstract)

Antimicrobial photodynamic therapy as adjunct to non-surgical periodontal treatment in smokers: a randomized clinical trial. This study aims to investigate the additional influence of multiple applications of antimicrobial photodynamic therapy (aPDT) in smokers with chronic periodontitis.Twenty smokers with chronic periodontitis were treated in a split-mouth design study with aPDT adjunct to Scaling and Root Planing (SRP) or SRP. aPDT was performed by using a laser light source with 660 nm (...) wavelength associated with a photosensitizer. The applications were performed in four episodes (at days 0, 2, 7, and 14). All patients were monitored for 90 days. Plaque index, probing depth, clinical attachment level, and bleeding on probing were performed at baseline, 30, and 90 days after the SRP. Gingival crevicular fluid and subgingival plaque samples were collected for immunological and microbiological analysis, respectively. Data obtained were statistically analyzed.aPDT as an adjunct to SRP did

2018 Clinical oral investigations Controlled trial quality: uncertain

229. [Impact of oral health promotion project on periodontal condition and life quality of the elderly in long-term care institutions]. (Abstract)

[Impact of oral health promotion project on periodontal condition and life quality of the elderly in long-term care institutions]. To assess the impact of oral health promotion project on periodontal condition and life quality of the elderly in long-term care institutions.Elder people from 5 nursing homes in Wuhan city were selected and assigned to either the experimental group or the control group by random cluster grouping method. A six-month oral health promotion project was provided (...) to the experimental group. The changes of geriatric oral health assessment index (GOHAI), oral hygiene index-simplified (OHI-S), gingival index (GI), bleeding on probing (BOP) and probing depth (PD) were compared with student's t test and repetitive measure analysis of variance using SPSS21.0 software package.A total of 322 subjects completed the study for 6 months, with 144 from the experimental group and 178 from the control group. No significant difference was observed between the two groups in social

2018 Shanghai kou qiang yi xue = Shanghai journal of stomatology Controlled trial quality: uncertain

230. Laser reduction of specific microorganisms in the periodontal pocket using Er:YAG and Nd:YAG lasers: a randomized controlled clinical study. (Abstract)

Laser reduction of specific microorganisms in the periodontal pocket using Er:YAG and Nd:YAG lasers: a randomized controlled clinical study. The objective of this study was to evaluate the microbiological and clinical outcomes following nonsurgical treatment by either scaling and root planing, combination of Nd:YAG and Er:YAG lasers, or by Er:YAG laser treatment alone. The study involved 60 patients with generalized chronic periodontitis, randomly assigned into one of three treatment groups (...) of 20 patients. The first group received scaling and root planing by hand instruments (SRP group), the second group received Er:YAG laser treatment alone (Er group), and the third group received combined treatment with Nd:YAG and Er:YAG lasers (NdErNd group). Microbiological samples, taken from the periodontal pockets at baseline and 6 months after treatments, were assessed with PET Plus tests. The combined NdErNd laser (93.0%), followed closely by Er:YAG laser (84.9%), treatment resulted

2018 Lasers in medical science Controlled trial quality: uncertain

231. Clinical Impact and Cosmetic Acceptability of Chlorhexidine-enriched Toothpaste and Mouthwash Application on Periodontal Disease: A Randomized Clinical Study. (Abstract)

Clinical Impact and Cosmetic Acceptability of Chlorhexidine-enriched Toothpaste and Mouthwash Application on Periodontal Disease: A Randomized Clinical Study. Oral hygiene is key to prevent periodontal disease (PD). The efficacy of chlorhexidine-containing products has been largely proven, often being tooth discoloration an unwanted associated side-effect. Importantly, some differences related to the pharmaceutical presentation of these products have also been reported. This study aimed (...) ) and the other one receiving MW (n = 30). Periodontal disease index (PDI) was used to evaluate clinical signs at baseline (T0) and after 21 days (T21) of daily use of the products. Satisfaction was assessed through the affirmative/negative answers obtained with the visual analog scale (VAS).All participants completed the study. A significant improvement of PDI score after treatment was reported in both groups (T21/T0) (p < 0.001). Thus, gingivitis improved from moderate to negative [increase = 20.0% (TP

2018 The journal of contemporary dental practice Controlled trial quality: uncertain

232. Is dietary melatonin supplementation a viable adjunctive therapy for chronic periodontitis?-A randomized controlled clinical trial. (Abstract)

Is dietary melatonin supplementation a viable adjunctive therapy for chronic periodontitis?-A randomized controlled clinical trial. Melatonin is synthesized naturally by pineal gland and responsible for regulation of sleep/waking cycle. It showed appreciated anti-inflammatory and antioxidant properties. The aim of this randomized clinical trial (RCT) was to assess the additive effect of melatonin supplementation in insomniac individuals with generalized chronic periodontitis (gCP) after scaling (...) of therapy, whereas the measurements of pocket depth reduction (PD reduction), bleeding on probing (BOP %), and the changes in salivary TNF-α levels and Athens insomnia scale (AIS) scores represented the secondary endpoints.Melatonin group showed significantly greater CAL gain and PD reduction measurements compared to the control group at 3 and 6 months of therapy, P < 0.01. Likewise, salivary TNF-α levels and AIS scores were significantly lower in the melatonin group compared to placebo group. BOP

2018 Journal of periodontal research Controlled trial quality: uncertain

233. Trehalose powder for subgingival air-polishing during periodontal maintenance therapy: A randomized controlled trial. (Abstract)

Trehalose powder for subgingival air-polishing during periodontal maintenance therapy: A randomized controlled trial. Air-polishing appears to be a promising procedure for subgingival biofilm removal in periodontal treatment. The aim of this study was to compare trehalose powder for subgingival air-polishing with sonic debridement in residual periodontal pockets during maintenance therapy.In this blinded, randomized, controlled clinical trial conducted over 6 months with a split-mouth design (...) , single-rooted teeth in 44 participants with residual pocket depths of 5 mm and bleeding or >5 mm with and without bleeding were included in this study. Subgingival debridement was carried out using either trehalose powder with an air-polishing device (test) or a sonic device (control). The reduction in the probing depths after 3 and 6 months was defined as the primary endpoint. A visual analog scale was used to evaluate the discomfort of both procedures.Both procedures showed statistically

2018 Journal of periodontology Controlled trial quality: uncertain

234. Adjunctive use of an ethyl lauroyl arginate-(LAE-)-containing mouthwash in the nonsurgical therapy of periodontitis: a randomized clinical trial. (Abstract)

daily 1 hour after brushing for 4 weeks. Periodontal pocket depth (PPD), bleeding on probing (FMBS) and dental plaque (FMPS) were measured at baseline, 4 weeks and 3 months. Microbiological samples were taken at baseline, at 4 weeks and 3 months after plaque recording and prior to PPD and BoP measurements.Forty subjects were randomized to treatment. Both therapies resulted in reduced FMPS, FMBS and residual pockets at 4 weeks and 3 months. The differences were not statistically significant (...) Adjunctive use of an ethyl lauroyl arginate-(LAE-)-containing mouthwash in the nonsurgical therapy of periodontitis: a randomized clinical trial. This randomized clinical trial evaluated the clinical and microbiological effects of 0.147% ethyl lauroyl arginate (LAE)-containing mouthwash compared to 0.12% chlorhexidine (CHX) mouthwash in the treatment of periodontitis.Subjects were randomized to use 0.147% LAE and 0.12% CHX mouthwash after professional mechanical plaque removal (PMPR) twice

2018 Minerva stomatologica Controlled trial quality: uncertain

235. Plasma of Argon Cleaning Treatment on Implant Abutments in Periodontally Healthy Patients: Six Years Postloading Results of a Randomized Controlled Trial. (Abstract)

and the occurrence of any technical and biologic complications during the follow-up period. Secondary outcome measures were peri-implant marginal bone level changes, bleeding on probing, and plaque score. Two patients (one in test and one in control group) dropped out at the last follow-up. Neither implant nor prosthetic complications were detected in the analyzed patients of both groups during the 6-year follow-up examinations. Radiographic analysis revealed a statistically significant higher mean bone loss (...) Plasma of Argon Cleaning Treatment on Implant Abutments in Periodontally Healthy Patients: Six Years Postloading Results of a Randomized Controlled Trial. The aim of this randomized, match-paired, triple-blinded, controlled clinical trial was to assess the 6-year radiographic changes around customized platform-switched abutments placed according to the one abutment-one time concept, with and without plasma of argon cleaning treatment. A total of 20 periodontally healthy patients received one

2018 The International journal of periodontics & restorative dentistry Controlled trial quality: predicted high

236. The effects of a desiccant agent in the treatment of chronic periodontitis: a randomized, controlled clinical trial. (Abstract)

The effects of a desiccant agent in the treatment of chronic periodontitis: a randomized, controlled clinical trial. Chemotherapeutic agents have been widely used as adjuncts for the treatment of chronic periodontitis (CP). This study investigated and compared a desiccant agent as an adjunct to scaling and root planing (SRP) versus SRP alone for the treatment of CP.Thirty-six patients with CP were studied. Using a split-mouth design, the maxillary right and left quadrants were randomly assigned (...) to SRP plus desiccant (Hybenx® EPIEN Medical, Inc. St. Paul, MN, USA) or SRP alone. Patients were examined on a regular basis for clinical, microbiological, and inflammatory mediator changes over a 1-year period. Clinical attachment level (CAL) was the primary outcome variable. In addition, the red complex bacteria and gingival crevicular fluid (GCF) inflammatory mediators were monitored.Compared to baseline, both treatments demonstrated an improvement in periodontal parameters. Compared to SRP alone

2018 Clinical oral investigations Controlled trial quality: uncertain

237. Effect of 1.2% of simvastatin gel as a local drug delivery system on Gingival Crevicular Fluid interleukin-6 & interleukin-8 levels in non surgical treatment of chronic periodontitis patients. (Abstract)

chronic periodontitis patients were equally divided into two groups. Group I patients were treated by SRP; Group II patients were treated by SRP followed by LDD of 1.2% simvastatin (SMV) gel. Plaque index (PI), Gingival index(GI), Sulcus Bleeding Index (SBI), Probing pocket depth (PPD) and Relative clinical attachment level (CAL) were recorded & GCF samples were collected at baseline (0day) and at 45th day from both the groups. The collected GCF samples were analysed for IL-6 and IL-8 levels (...) Effect of 1.2% of simvastatin gel as a local drug delivery system on Gingival Crevicular Fluid interleukin-6 & interleukin-8 levels in non surgical treatment of chronic periodontitis patients. The present study was carried out to evaluate the effect of 1.2% simvastatin gel as local drug delivery (LDD) system on Gingival Crevicular Fluid (GCF) Interleukin -6 (IL-6) and Interleukin-8 (IL-8) levels in chronic periodontitis patients, in addition to scaling and root planing (SRP).A total of 46

2018 Archives of oral biology Controlled trial quality: uncertain

238. A brief motivational interviewing as an adjunct to periodontal therapy-A potential tool to reduce relapse in oral hygiene behaviours. A three-year study. (Abstract)

-performed periodontal infection control were marginal bleeding index (MBI; primary efficacy variable) and plaque score (PI).The patterns of change in MBI and PI scores were similar for test and control groups over the observation period. At 3 years, both groups showed a desirable mean full-mouth MBI of 15%, a figure that was comparable to that at the short-term evaluation after active periodontal treatment. The post-treatment MBI was the only variable identified as a predictor of retained adequate oral (...) A brief motivational interviewing as an adjunct to periodontal therapy-A potential tool to reduce relapse in oral hygiene behaviours. A three-year study. To evaluate (ii) whether inclusion of a single motivational interviewing (MI) session, as an adjunct to periodontal therapy, might be beneficial for preventing relapse in oral hygiene behaviours among patients treated for chronic periodontitis and (ii) whether individual and clinical characteristics can be of predictive value for retention

2018 International journal of dental hygiene Controlled trial quality: uncertain

239. Clinical efficacy of subgingivally-delivered 0.75% boric acid gel as an adjunct to mechanotherapy in chronic periodontitis: A randomized, controlled clinical trial. (Abstract)

Clinical efficacy of subgingivally-delivered 0.75% boric acid gel as an adjunct to mechanotherapy in chronic periodontitis: A randomized, controlled clinical trial. Borinic acid quinoline esters are a recently-identified class of new antibacterial and anti-inflammatory compounds known to inhibit osteoclastic bone resorption. They have proposed to have osteostimulative properties by causing osteoblast differentiation in vivo and in vitro. The purpose of this double-masked, randomized, controlled (...) clinical trial was to evaluate the effects of the subgingival delivery of boric acid gel as an adjunct to scaling and root planing (SRP) on clinical and radiographic parameters, and compare this method with SRP plus placebo gel alone in chronic periodontitis (CP) patients.Thirty-nine systemically-healthy patients with CP were included in the present study. They were divided into two groups: (a) SRP + 0.75% boric acid gel (BA group); and (b) SRP + placebo gel (placebo group). At baseline, 3 and 6 months

2018 Journal of investigative and clinical dentistry Controlled trial quality: uncertain

240. Genetic and environmental contributions to the association between mood disorder and periodontal disease: a cross-sectional study amongst female twins in the UK. (Full text)

for all twins. Subsequently, co-twin control analysis within genetically identical twins who were discordant for periodontal traits was performed by controlling for genetic confounders.Data of twins aged 20-91 were available in 4,143 individuals for self-reported periodontitis and 4,244 for gum bleeding. Age-adjusted model showed increasing risk in the following: smoking, anxiety/stress and depression for both periodontal traits. Within discordant monozygotic (MZ) twins (514 individuals (...) for periodontitis and 754 for gum bleeding), the association of anxiety/stress remained significant for both periodontitis (OR 1.60, CI: 1.02-2.52) and gum bleeding (OR 1.60, CI: 1.06-2.40). A significant relationship for depression remained for periodontitis (OR 1.68, CI: 1.04-2.70), but it was no longer significant for gum bleeding. Age stratification showed that the association of mood disorders with periodontal traits was generally stronger in older group.Multivariate analysis among discordant MZ female

2018 Journal of Clinical Periodontology PubMed abstract

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