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Periodic Limb Movement

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3181. Prevalence of obstructive sleep apnoea and periodic limb movement in 45 subjects with heart transplantation. Full Text available with Trip Pro

Prevalence of obstructive sleep apnoea and periodic limb movement in 45 subjects with heart transplantation. Obesity, a major risk factor for obstructive sleep apnoea, is common after cardiac transplantation. Case reports have shown development of obstructive sleep apnoea in cardiac transplantation recipients. The present study represents the first systematic evaluation of sleep disorders after cardiac transplantation.To determine the prevalence and clinical impact of sleep disorders (...) , excessive arousals, unrefreshing sleep, excessive daytime sleepiness, poor health-related quality of life, and hypertension (all P values <0.05). Weight gain since transplantation was significantly greater in recipients with obstructive sleep apnoea than those without. Thirty-three percent of patients had periodic limb movement with an index of >?15/hour and an average of 55+/-43/hour. Forty-five percent of these patients had restless legs syndrome.Thirty-six percent of cardiac transplant recipients

2004 European Heart Journal

3182. A double-blind, placebo-controlled study of the treatment of periodic limb movements in sleep using carbidopa/levodopa and propoxyphene. (Abstract)

A double-blind, placebo-controlled study of the treatment of periodic limb movements in sleep using carbidopa/levodopa and propoxyphene. We studied the relative benefits of carbidopa/levodopa (25/100 mg and 50/200 mg) and propoxyphene (100 mg and 200 mg) in six subjects with periodic limb movements (PLM) using a randomized, double-blind, placebo-controlled, cross-over design with a 4-day placebo wash-out period between test medications. Each subject received, for successive 2-week periods, 4 (...) days of placebo followed by 5 days of low-dose and then 5 days of high-dose medication. Outcome was measured with polysomnograms and sleep latency tests on the last night of the high dose, and leg activity was monitored for each night of the study. Carbidopa/levodopa normalized PLM and improved sleep, particularly in the first 3 hours in most subjects. Propoxyphene had marginal benefit and significantly decreased arousals and mildly decreased leg movements for leg activity monitoring

1993 Sleep Controlled trial quality: uncertain

3183. Comparison of cognitive-behavioral therapy and clonazepam for treating periodic limb movement disorder. (Abstract)

Comparison of cognitive-behavioral therapy and clonazepam for treating periodic limb movement disorder. Many patients with periodic limb movement disorder (PLMD) display inadequate sleep hygiene, and others decline conventional pharmacologic intervention for their form of sleep disturbance. Nonetheless, the use of nonpharmacologic therapies with PLMD remains unexplored. The current study was designed to compare the short-term treatment effects of a cognitive-behavioral therapy (CBT (...) - and post-treatment data suggested that the two treatments led to equal improvements in sleep log measures of sleep-wake times and ISQ measures of subjective sleep concerns. Patients treated with CBT showed a decrease in daytime napping, whereas the clonazepam group reported increased napping. Conversely, those treated with clonazepam showed larger declines in periodic limb movement-arousals per hour of sleep than did the CBT group. Post-treatment interviews suggested that both CBT and clonazepam

1996 Sleep Controlled trial quality: uncertain

3184. Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): acute placebo-controlled sleep laboratory studies with clonazepam. (Abstract)

Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): acute placebo-controlled sleep laboratory studies with clonazepam. Restless legs syndrome (RLS) - a common sensorimotor disorder - and periodic limb movement disorder (PLMD) are currently treated with substances of four classes: dopaminergic agents, which are considered the drugs of choice, benzodiazepines, opioids and anticonvulsants. As their effects on sleep variables differ considerably, the aim of the present placebo

2001 European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Controlled trial quality: uncertain

3185. Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled trial. (Abstract)

Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled trial. To evaluate the effect of estrogen replacement therapy on nocturnal periodic limb movements in a randomized, double-masked, placebo-controlled, crossover trial.Seventy-one healthy postmenopausal women volunteered in answer to a newspaper announcement; 62 women completed the follow-up. Frequency of nocturnal body movements was measured with the static-charge-sensitive bed and all-night (...) polysomnographic recordings. Serum estradiol (E2) and FSH concentrations were also measured at baseline and after each treatment period. The power of the study setup was 94%.Nearly half the women presented with episodes of periodic limb movements (30 of 62 women, or 48%, during placebo and 27, or 44%, during estrogen therapy). In 17 (27%) during placebo and 19 (31%) during estrogen therapy, frequency of periodic limb movements exceeded index level 5 per hour while subjects were in bed. Incidence or intensity

2001 Obstetrics and Gynecology Controlled trial quality: uncertain

3186. Periodic limb movement syndrome Full Text available with Trip Pro

Periodic limb movement syndrome 12235312 2002 10 23 2017 11 14 0022-3050 73 4 2002 Oct Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Periodic limb movement syndrome. 428 Knoblauch A A Center for Sleep Medicine and Home Ventilation, Kantonsspital, St Gallen, Switzerland. anknoblauch@kssg.ch Leuppi J D JD eng Case Reports Journal Article England J Neurol Neurosurg Psychiatry 2985191R 0022-3050 IM Aged Electromyography methods Female Humans Nocturnal Myoclonus

2002 Journal of neurology, neurosurgery, and psychiatry

3187. Periodic limb movement during sleep developed after pontine lesion. (Abstract)

Periodic limb movement during sleep developed after pontine lesion. We describe 2 patients who suffered a pontine infarction and subsequently developed periodic leg movement (PLM). The temporal relationship between a stroke and subsequent PLM, as well as the absence of sleep-related disorders in patients' histories, favors the argument of a cause-and-effect relationship, with the observed association providing evidence for an anatomic substrate for PLM.

2003 Movement Disorders

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