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Periodic Limb Movement

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3181. Estimation of Muscle Area and Thickness of Deep Cervical Muscle Contraction During Cervical and Limb Movements

Estimation of Muscle Area and Thickness of Deep Cervical Muscle Contraction During Cervical and Limb Movements Estimation of Muscle Area and Thickness of Deep Cervical Muscle Contraction During Cervical and Limb Movements - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Estimation of Muscle Area and Thickness of Deep Cervical Muscle Contraction During Cervical and Limb Movements The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00155948 Recruitment Status : Completed First Posted : September 12, 2005

2005 Clinical Trials

3182. Electromyographic activity in the immobilized shoulder girdle musculature during contralateral upper limb movements. (Abstract)

Electromyographic activity in the immobilized shoulder girdle musculature during contralateral upper limb movements. The purpose of this study was to quantify electromyographic (EMG) activity in the immobilized shoulder girdle musculature at rest and during a battery of contralateral upper limb activities. Six asymptomatic men, aged 22 to 33 years, volunteered to participate. Fine-wire (supraspinatus, infraspinatus) and surface (deltoids, trapezii, biceps, serratus anterior) electrodes recorded (...) produced high trapezius activity (>45% MVC) with low supraspinatus, biceps, and anterior deltoid activities (<10% MVC). Our findings suggest that (1) immobilized shoulder girdle muscle EMG activity during quiet standing is negligible in asymptomatic individuals; (2) contralateral upper limb motions at self-selected speeds are not likely to be harmful to healing tissues; (3) during early healing periods, patients with biceps-labral injury should minimize bimanual activities, those with supraspinatus

2004 Journal of Shoulder and Elbow Surgery

3183. A genetic risk factor for periodic limb movements in sleep. (Abstract)

A genetic risk factor for periodic limb movements in sleep. The restless legs syndrome (RLS) is a common neurologic disorder characterized by an irresistible urge to move the legs. It is a major cause of sleep disruption. Periodic limb movements in sleep are detectable in most patients with RLS and represent an objective physiological metric.To search for sequence variants contributing to RLS, we performed a genomewide association study and two replication studies. To minimize phenotypic (...) heterogeneity, we focused on patients with RLS who had objectively documented periodic limb movements in sleep. We measured serum ferritin levels, since iron depletion has been associated with the pathogenesis of RLS.In an Icelandic discovery sample of patients with RLS and periodic limb movements in sleep, we observed a genomewide significant association with a common variant in an intron of BTBD9 on chromosome 6p21.2 (odds ratio, 1.8; P=2x10(-9)). This association was replicated in a second Icelandic

2007 NEJM

3184. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. (Abstract)

Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Periodic limb movements during sleep (PLMS), with or without symptoms of a restless legs syndrome (RLS), may cause sleep disturbances. The pharmacologic treatments of choice are dopaminergic drugs. Their use, however, may be limited due to tolerance development or rebound phenomena. Anecdotal observations have shown that oral magnesium therapy may ameliorate symptoms in patients (...) with moderate RLS. We report on an open clinical and polysomnographic study in 10 patients (mean age 57 +/- 9 years; 6 men, 4 women) suffering from insomnia related to PLMS (n = 4) or mild-to-moderate RLS (n = 6). Magnesium was administered orally at a dose of 12.4 mmol in the evening over a period of 4-6 weeks. Following magnesium treatment, PLMS associated with arousals (PLMS-A) decreased significantly (17 +/- 7 vs 7 +/- 7 events per hour of total sleep time, p < 0.05). PLMS without arousal were also

1998 Sleep

3185. Long-term efficacy of botulinum toxin A in treatment of various movement disorders over a 10-year period. (Abstract)

Long-term efficacy of botulinum toxin A in treatment of various movement disorders over a 10-year period. Although botulinum toxin A (BTX) has been licensed in Canada for treatment of various movement disorders since 1990, few clinical studies regarding its long-term efficacy and side effects have been reported. We conducted a retrospective analysis of 235 patients who received BTX from our movement disorders clinic over a 10-year period (January 1990 to December 1999). A total of 2,616 (...) treatment cycles (multiple injections) were administered to 235 patients with cervical dystonia (CD), hemifacial spasm (HS), blepharospasm (BP), and other movement disorders. Substantial benefit at 5 years was seen in most patients (90% in BP, 88% in HS, 63% in CD, 100% in jaw closing and lower limb dystonia, and 56% in writer's cramp). Benefit was maintained for up to 10 years in CD, HS, and BP data, with a 75.8% benefit reported. Twenty-eight percent of patients discontinued treatment during

2002 Movement Disorders

3186. Levetiracetam can be effective in the treatment of restless legs syndrome with periodic limb movements in sleep: report of two cases Full Text available with Trip Pro

Levetiracetam can be effective in the treatment of restless legs syndrome with periodic limb movements in sleep: report of two cases 16543548 2006 05 18 2018 12 01 0022-3050 77 4 2006 Apr Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Levetiracetam can be effective in the treatment of restless legs syndrome with periodic limb movements in sleep: report of two cases. 566-7 Della Marca G G Vollono C C Mariotti P P Mazza M M Mennuni G F GF Tonali P P Mazza S S

2006 Journal of neurology, neurosurgery, and psychiatry

3187. Comparison between dopaminergic agents and physical exercise as treatment for periodic limb movements in patients with spinal cord injury. Full Text available with Trip Pro

Comparison between dopaminergic agents and physical exercise as treatment for periodic limb movements in patients with spinal cord injury. Randomized controlled trial of physical exercise and dopaminergic agonist in persons with spinal cord injury and periodic leg movement (PLM).The objective of the present study was to compare the effectiveness of physical exercise and of a dopaminergic agonist in reducing the frequency of PLM.Centro de Estudos em Psicobiologia e Exercício. Universidade

2004 Spinal cord Controlled trial quality: uncertain

3188. Cluster headache with obstructive sleep apnea and periodic limb movements during sleep: a case report. (Abstract)

Cluster headache with obstructive sleep apnea and periodic limb movements during sleep: a case report. We report the case of a man with episodic cluster headache who suffered from severe obstructive sleep apnea (OSA) as well as periodic limb movements during sleep (PLMS). His attacks of headache occurred primarily during sleep being timely to REM sleep as 90 to 120 minutes interval. OSAs were more frequent and prolonged during REM sleep and oxygen saturation decreased to 81% during this sleep (...) period. Periodic limb movements were also observed in our patient that were more frequent during the first half of the polysomnographic recordings. This case is one of the few reporting cases with CH who had both OSA and PLMS.

2005 Headache

3189. Prevalence of obstructive sleep apnoea and periodic limb movement in 45 subjects with heart transplantation. Full Text available with Trip Pro

Prevalence of obstructive sleep apnoea and periodic limb movement in 45 subjects with heart transplantation. Obesity, a major risk factor for obstructive sleep apnoea, is common after cardiac transplantation. Case reports have shown development of obstructive sleep apnoea in cardiac transplantation recipients. The present study represents the first systematic evaluation of sleep disorders after cardiac transplantation.To determine the prevalence and clinical impact of sleep disorders (...) , excessive arousals, unrefreshing sleep, excessive daytime sleepiness, poor health-related quality of life, and hypertension (all P values <0.05). Weight gain since transplantation was significantly greater in recipients with obstructive sleep apnoea than those without. Thirty-three percent of patients had periodic limb movement with an index of >?15/hour and an average of 55+/-43/hour. Forty-five percent of these patients had restless legs syndrome.Thirty-six percent of cardiac transplant recipients

2004 European Heart Journal

3190. Akathisia, restless legs and periodic limb movements in sleep in Parkinson's disease. (Abstract)

Akathisia, restless legs and periodic limb movements in sleep in Parkinson's disease. Restless legs syndrome (RLS) symptoms are often reported in Parkinson's disease (PD), but prevalence studies of RLS in PD are few and the results are inconsistent. In addition, clinical overlapping between RLS, "wearing-off"-related lower limb discomfort and restlessness, and akathisia complicate the clinical assessments of true RLS in PD. Underlying pathophysiology potentially shared by RLS and PD is mainly

2004 Neurology

3191. Activity patterns of leg muscles in periodic limb movement disorder. Full Text available with Trip Pro

Activity patterns of leg muscles in periodic limb movement disorder. The movements of leg muscles in reference to periodic limb movement disorder (PLMD) have only been described in global terms. The sequences of contracting muscles that cause the PLMs are said to be stereotypical. There is, however, doubt about this fixed sequencing in PLMD. Our goal was to define the sequence of muscle movements in PLMs and then analyse their patterns. We recorded with surface EMG all movements of the muscles (...) said to be involved in PLMs (extensor digitorum brevis, EDB; tibialis anterior, TA; biceps femoris, BF; tensor fasciae latae; TFL) as well as the quadriceps (Q) and soleus (S) muscles in 12 patients with restless legs syndrome combined with PLMD. Accompanying polysomnography provided the sleep parameters. In total, 469 movements were analysed. In only 12% was there the appearance of the classic movement (EDB-TA-BF-TFL) or its direct variants. The most frequent sequences were characterised

2004 Neurosurgery and Psychiatry

3192. Propriospinal myoclonus: a motor phenomenon found in restless legs syndrome different from periodic limb movements during sleep. (Abstract)

Propriospinal myoclonus: a motor phenomenon found in restless legs syndrome different from periodic limb movements during sleep. Three patients presented with a 25-, 15-, and 5-year history of restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS). For 1, 4, and 5 years, they reported additional involuntary trunk and limbs jerks preceding falling asleep and occasionally during intrasleep wakefulness. Videopolysomnography revealed jerks during relaxed wakefulness arising (...) in axial muscles with a caudal and rostral propagation at a slow conduction velocity, characteristic of propriospinal myoclonus (PSM). Jerk-related EEG-EMG back-averaging did not disclose any preceding cortical potential. During relaxed wakefulness preceding falling asleep and during intrasleep wakefulness, PSM coexisted with motor restlessness and sensory discomfort in the limbs. PSM disappeared when spindles and K-complexes appeared on the EEG. At this time, typical PLMS appeared every 20 to 40

2005 Movement Disorders

3193. Periodic limb movement syndrome Full Text available with Trip Pro

Periodic limb movement syndrome 12235312 2002 10 23 2017 11 14 0022-3050 73 4 2002 Oct Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Periodic limb movement syndrome. 428 Knoblauch A A Center for Sleep Medicine and Home Ventilation, Kantonsspital, St Gallen, Switzerland. anknoblauch@kssg.ch Leuppi J D JD eng Case Reports Journal Article England J Neurol Neurosurg Psychiatry 2985191R 0022-3050 IM Aged Electromyography methods Female Humans Nocturnal Myoclonus

2002 Journal of neurology, neurosurgery, and psychiatry

3194. Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled trial. (Abstract)

Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled trial. To evaluate the effect of estrogen replacement therapy on nocturnal periodic limb movements in a randomized, double-masked, placebo-controlled, crossover trial.Seventy-one healthy postmenopausal women volunteered in answer to a newspaper announcement; 62 women completed the follow-up. Frequency of nocturnal body movements was measured with the static-charge-sensitive bed and all-night (...) polysomnographic recordings. Serum estradiol (E2) and FSH concentrations were also measured at baseline and after each treatment period. The power of the study setup was 94%.Nearly half the women presented with episodes of periodic limb movements (30 of 62 women, or 48%, during placebo and 27, or 44%, during estrogen therapy). In 17 (27%) during placebo and 19 (31%) during estrogen therapy, frequency of periodic limb movements exceeded index level 5 per hour while subjects were in bed. Incidence or intensity

2001 Obstetrics and Gynecology Controlled trial quality: uncertain

3195. Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): acute placebo-controlled sleep laboratory studies with clonazepam. (Abstract)

Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): acute placebo-controlled sleep laboratory studies with clonazepam. Restless legs syndrome (RLS) - a common sensorimotor disorder - and periodic limb movement disorder (PLMD) are currently treated with substances of four classes: dopaminergic agents, which are considered the drugs of choice, benzodiazepines, opioids and anticonvulsants. As their effects on sleep variables differ considerably, the aim of the present placebo

2001 European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Controlled trial quality: uncertain

3196. Comparison of cognitive-behavioral therapy and clonazepam for treating periodic limb movement disorder. (Abstract)

Comparison of cognitive-behavioral therapy and clonazepam for treating periodic limb movement disorder. Many patients with periodic limb movement disorder (PLMD) display inadequate sleep hygiene, and others decline conventional pharmacologic intervention for their form of sleep disturbance. Nonetheless, the use of nonpharmacologic therapies with PLMD remains unexplored. The current study was designed to compare the short-term treatment effects of a cognitive-behavioral therapy (CBT (...) - and post-treatment data suggested that the two treatments led to equal improvements in sleep log measures of sleep-wake times and ISQ measures of subjective sleep concerns. Patients treated with CBT showed a decrease in daytime napping, whereas the clonazepam group reported increased napping. Conversely, those treated with clonazepam showed larger declines in periodic limb movement-arousals per hour of sleep than did the CBT group. Post-treatment interviews suggested that both CBT and clonazepam

1996 Sleep Controlled trial quality: uncertain

3197. A double-blind, placebo-controlled study of the treatment of periodic limb movements in sleep using carbidopa/levodopa and propoxyphene. (Abstract)

A double-blind, placebo-controlled study of the treatment of periodic limb movements in sleep using carbidopa/levodopa and propoxyphene. We studied the relative benefits of carbidopa/levodopa (25/100 mg and 50/200 mg) and propoxyphene (100 mg and 200 mg) in six subjects with periodic limb movements (PLM) using a randomized, double-blind, placebo-controlled, cross-over design with a 4-day placebo wash-out period between test medications. Each subject received, for successive 2-week periods, 4 (...) days of placebo followed by 5 days of low-dose and then 5 days of high-dose medication. Outcome was measured with polysomnograms and sleep latency tests on the last night of the high dose, and leg activity was monitored for each night of the study. Carbidopa/levodopa normalized PLM and improved sleep, particularly in the first 3 hours in most subjects. Propoxyphene had marginal benefit and significantly decreased arousals and mildly decreased leg movements for leg activity monitoring

1993 Sleep Controlled trial quality: uncertain

3198. Periodic limb movement during sleep developed after pontine lesion. (Abstract)

Periodic limb movement during sleep developed after pontine lesion. We describe 2 patients who suffered a pontine infarction and subsequently developed periodic leg movement (PLM). The temporal relationship between a stroke and subsequent PLM, as well as the absence of sleep-related disorders in patients' histories, favors the argument of a cause-and-effect relationship, with the observed association providing evidence for an anatomic substrate for PLM.

2003 Movement Disorders

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