How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

3,198 results for

Periodic Limb Movement

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

3161. Excitability changes in human corticospinal projections to forearm muscles during voluntary movement of ipsilateral foot Full Text available with Trip Pro

cortical area a simultaneous lesser co-activation of the forearm area produces a subliminal cyclic modulation of cervical motoneurones excitability. Should the two limbs be moved together, the time course of this modulation would favour isodirectional movements of the prone hand and foot, indeed the preferential coupling observed when hand and foot are voluntarily oscillated. (...) Excitability changes in human corticospinal projections to forearm muscles during voluntary movement of ipsilateral foot Excitability of the H-reflex in the relaxed flexor carpi radialis (FCR) muscle was tested during voluntary oscillations of the ipsilateral foot at five evenly spaced delays during a 600 ms cycle. In some experiments the H-reflex was conditioned by transcranial magnetic stimulation (TMS). With the hand prone, the amplitude of the FCR H-reflex was modulated sinusoidally

2002 The Journal of physiology

3162. Effect of pergolide on restless legs and leg movements in sleep in uremic patients. (Abstract)

Effect of pergolide on restless legs and leg movements in sleep in uremic patients. Restless legs syndrome (RLS) and periodic limb movements in sleep (PLMS) are disorders that are common and disturbing to uremic patients. The treatment of these is problematic. Eight patients on chronic hemodialysis and continuous peritoneal dialysis completed a double-blind placebo-controlled crossover study using incremental doses of pergolide up to 0.25 mg at bedtime for treatment of RLS and sleep disruption (...) . Five patients (62.5%) noted subjective improvement in restless legs symptoms and sleep quality. Objective results were improved only slightly by treatment. The percentage of the first hour in bed during which leg movements occurred decreased from 20.5 +/- 6.0 to 11.5 +/- 3.3, p < 0.05. However, findings during sleep were less positive. The following measures were not significant between placebo and treatment: leg movements per hour of sleep [53.7 +/- 22.3 vs 35.8 +/- 11.8 (p = 0.2)]; and percentage

1998 Sleep

3163. L-DOPA/carbidopa for nocturnal movement disorders in uremia. (Abstract)

L-DOPA/carbidopa for nocturnal movement disorders in uremia. Restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) are sleep disorders that are common and distressing to uremic patients. There are few data regarding effective treatment in this population. Five chronic hemodialysis patients completed a double-blind, placebo-controlled, crossover study using a single bedtime dose of controlled release L-DOPA/carbidopa (100/25 mg) for treatment of RLS and sleep disruption (...) on placebo, mean 23 +/- 9 events/hour on drug) were decreased by active medication (p = 0.03 and 0.04, respectively). Patients, however, continued to have very disrupted sleep and we could not document consistent subjective or objective improvement in overall sleep except for an increase in slow-wave sleep (SWS) from 9.0% to 22.8% (p = 0.01). The patterns of movements during sleep were not uniform in different patients, and the movements, although often periodic, were much longer than defined for PLMS

1996 Sleep Controlled trial quality: uncertain

3164. Training improves the speed of aimed movements in Parkinson's disease. (Abstract)

, without any deterioration in accuracy. These effects transferred to an untrained limb and were at least partially maintained after a 1-h delay. While patients remained impaired relative to control subjects at all phases of training and follow-up, the patients' performance at the end of training did not differ significantly from the control subjects' baseline function. Contrary to expectation, rhythmic auditory cues did not enhance improvement in the speed of aimed movements in either patients (...) or control subjects. If anything, less improvement was shown in the cued groups, although there were suggestions that the aiming skill was retained better over the delay period. The results demonstrate preserved abilities to improve speed of single ballistic aiming movements in Parkinson's disease patients and the possibility of reducing bradykinesia by training.

1998 Brain Controlled trial quality: uncertain

3165. Automated Constraint-Induced Therapy for Restoring Movement After Stroke

Automated Constraint-Induced Therapy for Restoring Movement After Stroke Automated Constraint-Induced Therapy for Restoring Movement After Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Automated (...) Constraint-Induced Therapy for Restoring Movement After Stroke The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00037960 Recruitment Status : Completed First Posted : May 27, 2002 Last Update Posted : January 21, 2009 Sponsor: US Department of Veterans Affairs Information provided by: VA Office of Research

2002 Clinical Trials

3166. Treatment for Movement Problems in Elderly Stroke Patients

the more affected upper limb. This gives rise to massed or concentrated repetitive use of the more affected extremity. CI therapy leads to a large increase in use-dependent cortical reorganization involving the recruitment of other regions of the brain in the innervation of the more affected extremity movement. One of the main aims of the proposed research is to determine if CI therapy can be used with therapeutic success for increasing the amount of real-world extremity use in patients with chronic (...) Treatment for Movement Problems in Elderly Stroke Patients Treatment for Movement Problems in Elderly Stroke Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment for Movement Problems

2003 Clinical Trials

3167. Neurophysiological Studies in Patients With Paroxysmal Hyperkinetic Movement Disorders

younger than 8 years old. B. Patients with attacks that involve head and neck movements, axial movements, bilateral limb involvement, or violent attacks that typically make patients fall to the ground. With respect to children, violent attacks are defined as any attack that can potentially result in injury (hitting the head, falls, violent flailing, hitting furniture or walls) C. Previous history of or MRI findings consistent with brain tumors, strokes, trauma or arterial venous malformations. D (...) Neurophysiological Studies in Patients With Paroxysmal Hyperkinetic Movement Disorders Neurophysiological Studies in Patients With Paroxysmal Hyperkinetic Movement Disorders - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2003 Clinical Trials

3168. The development of the segmental pattern of skin sensory innervation in embryonic chick hind limb Full Text available with Trip Pro

The development of the segmental pattern of skin sensory innervation in embryonic chick hind limb 1. The development of dermatomes in the chick hind limb was investigated with both electrophysiological recording from and horseradish peroxidase (HRP) labelling of neurones in lumbosacral dorsal root ganglia (d.r.g.s). The embryonic stages studied spanned the period before and after cell death.2. In mature embryos, after the bulk of cell death, physiological mapping showed that the location (...) on the limb during the stages studied.6. Together these findings show that dermatomes on the chick hind limb do not develop by skin sensory axons simply growing to the nearest available skin, nor are axons towed to their final location by skin movements. Moreover, dermatomes are not shaped by cell death and the elimination of random or excessive axonal projections in the limb or the skin. It appears that skin sensory axons from each d.r.g. grow directly to their target skin along a defined set of pathways

1982 The Journal of physiology

3169. Activation patterns of embryonic chick hind limb muscles recorded in ovo and in an isolated spinal cord preparation. Full Text available with Trip Pro

Activation patterns of embryonic chick hind limb muscles recorded in ovo and in an isolated spinal cord preparation. Muscle activation patterns of embryonic chick hind limb muscles were determined from electromyographic (e.m.g.) recordings in an isolated spinal cord/hind limb preparation of stage 34-36 embryos, and were compared with in ovo e.m.g. activity from similarly staged embryos. Muscle activity in ovo consisted of periodically recurring sequences of bursts during which antagonistic (...) muscles often alternated and synergistic muscles were co-active, as compatible with their mature function. However, more variable behaviour was also observed. Burst sequences in ovo were often initiated by a short-duration, high-amplitude discharge that occurred synchronously in all muscles studied, and which was followed by a period of electrical silence that was longest in the flexor muscles. This type of activity has not been described previously in mature animals. In ovo movement sequences were

1984 The Journal of physiology

3170. Functional outcome of botulinum toxin A injections to the lower limbs in cerebral palsy. (Abstract)

. At the end of this period, group 2 received BTX-A and physiotherapy and group 1 continued with physiotherapy alone. Assessment measures were the Gross Motor Function Measure (GMFM), the Vulpe Assessment Battery (VAB), joint range of movement, the Modified Ashworth Scale, and a parental questionnaire. Sustained gains in gross motor function were found in both groups of children but the only additional benefit found in group 1 was a significant increase in fine motor rating on the VAB. By contrast, parents (...) Functional outcome of botulinum toxin A injections to the lower limbs in cerebral palsy. We evaluated gross motor function following botulinum toxin A (BTX-A) injections in the lower limbs of children with spastic cerebral palsy in a randomized clinical trial, using a cross-over design. Forty-nine children (24 males, 25 females, age range 22 to 80 months) were randomly allocated to two groups: group 1 received BTX-A and physiotherapy, and group 2 received physiotherapy alone for 6 months

2002 Developmental Medicine and Child Neurology Controlled trial quality: uncertain

3171. Intensive, time-series measurement of upper limb recovery in the subacute phase following stroke. (Abstract)

Intensive, time-series measurement of upper limb recovery in the subacute phase following stroke. To discover if intensive monitoring of wrist extension would produce consistent recovery curves during the subacute period, and whether any impact of additional physiotherapy could be detected. We also investigated improved approaches to statistical analysis in single-case experiments.A randomized multiple-baseline experiment with very frequent assessment.Stroke rehabilitation unit.Four patients (...) with some active wrist movement less than seven weeks after stroke.Wrist extension was measured twice daily with an electrogoniometer for 3-4 weeks. Additional upper limb physiotherapy 115 minutes, twice per day) commenced after a randomly determined period.Speed and range of wrist movement.A logarithmic function was fitted to the data to produce recovery curves. In all cases, active range and maximum velocity of wrist extension rose gradually over time. Mean variability in range was <5

2003 Clinical rehabilitation Controlled trial quality: uncertain

3172. A randomized, double-blind, placebo-controlled, dose-ranging study to compare the efficacy and safety of three doses of botulinum toxin type A (Dysport) with placebo in upper limb spasticity after stroke. (Abstract)

on functional disability was not statistically significant and was best at a dose of 1000 U. There were no statistically significant differences between the groups in the incidence of adverse events.The present study suggests that treatment with Dysport reduces muscle tone in patients with poststroke upper limb spasticity. Treatment was effective at doses of Dysport of 500, 1000, and 1500 U. The optimal dose for treatment of patients with residual voluntary movements in the upper limb appears to be 1000 U (...) A randomized, double-blind, placebo-controlled, dose-ranging study to compare the efficacy and safety of three doses of botulinum toxin type A (Dysport) with placebo in upper limb spasticity after stroke. We sought to define an effective and safe dose of botulinum toxin type A (Dysport) for the treatment of upper limb muscle spasticity due to stroke.This was a prospective, randomized, double-blind, placebo-controlled, dose-ranging study. Patients received either a placebo or 1 of 3 doses

2000 Stroke Controlled trial quality: predicted high

3173. Limb-kinetic apraxia in corticobasal degeneration: clinical and kinematic features. (Abstract)

and cortical inhibition. All five patients in the apraxic group exhibited a unilateral praxic deficit characterised by derangement of fractionated and segmental finger movements. QMC was significantly greater in apraxic than in nonapraxic patients (P < 0.02), revealing a chaotic movement with marked interfinger uncoordination. Conventional transcranial magnetic stimulation parameters were within normal limits in both groups of patients; however, the silent period was significantly shorter in the apraxic (...) limb when compared with control subjects (P < 0.001). Limb-kinetic apraxia is a distinctive disorder affecting the performance of finger and hand postures and movements over and above a corticospinal or basal ganglion deficit. Disruption of the frontoparietal circuit devoted to grasping and manipulation, together with defective cortical inhibition, which would also interfere with the selection and control of hand muscle activity, are the most likely underlying physiopathological mechanisms of limb

2003 Movement Disorders

3174. Hypertensive extracorporeal limb perfusion (HELP): a new technique for managing critical lower limb ischemia. Full Text available with Trip Pro

compared with 1.1 +/- 0.28 for the hyperperfusion group (P < .001). The collateral flow was superior to normal flow (ie, with the superficial femoral not occluded). Continuous access to the carotid arterial tree via the access device was 25.3 +/- 8.8 days with 5 of 8 devices open for the entire observational period (maximum 37 days). The human ischemic limbs were hyperperfused at 2-4 times the mean arterial pressure producing 3-6 times an increase in pump flow measurements intermittently for 53 +/- 16 (...) Hypertensive extracorporeal limb perfusion (HELP): a new technique for managing critical lower limb ischemia. The concept of repeatedly connecting an extracorporeal blood pump to produce pancycle suprasystolic inflow pressures to ischemic limbs is introduced. Balloon catheters allow for limb isolation from the systemic circulation. In the acute phase, it is assumed that pressure is proportion to flow (Poiseuille's Law) and in the chronic phase that collateral growth is related to endothelial

2008 Journal of Vascular Surgery

3175. EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep.

EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines

2008 European Federation of Neurological Societies

3176. The treatment of restless legs syndrome and periodic limb movement disorder

The treatment of restless legs syndrome and periodic limb movement disorder The treatment of restless legs syndrome and periodic limb movement disorder The treatment of restless legs syndrome and periodic limb movement disorder Hening W, Allen R, Earley C, Kushida C, Picchietti D, Silber M Authors' objectives To review the therapy of the restless legs syndromes or periodic movements in sleep. Searching MEDLINE was searched through April 1998 using the following keywords: restless legs both (...) medications; and non- pharmacological therapy including accommodative strategies and sleep hygiene, behavioural and stimulation therapies, invasive therapies, and nutritional considerations. Participants included in the review Patients with restless leg syndrome (RLS) or periodic limb movement disorder (PLMD) were included. Some studies appeared to have included patients with other diagnosis, such as narcolepsy, and some studies had unclear criteria for the diagnosis of RLS. Definitions were as reported

1999 DARE.

3177. Ropinirole decreases periodic leg movements and improves sleep parameters in patients with restless legs syndrome. (Abstract)

were included in the primary endpoint analysis. PLMS per hour decreased more with ropinirole (48.5 to 11.8), compared with placebo (35.7 to 34.2; adjusted treatment difference: -27.2; 95% confidence interval [CI]: -39.1, -15.4; P < .0001). Periodic limb movements with arousal per hour decreased from 7.0 to 2.5 with ropinirole but increased from 4.2 to 6.0 with placebo (adjusted treatment difference: -4.3, 95% CI: -7.6, -1.1; P = .0096). Periodic limb movements while awake per hour decreased from (...) Ropinirole decreases periodic leg movements and improves sleep parameters in patients with restless legs syndrome. Polysomnographic study evaluating the efficacy of ropinirole for the treatment of patients with restless legs syndrome (RLS) suffering from periodic leg movements in sleep (PLMS).Double-blinded, placebo-controlled, parallel-group study.15 tertiary referral centers in the USA.65 patients with RLS and PLMS.Ropinirole (0.25-4.0 mg per day) or placebo for 12 weeks.Data from 59 patients

2004 Sleep Controlled trial quality: predicted high

3178. Abnormal movements in Rett syndrome are present before the regression period: A case study. (Abstract)

Abnormal movements in Rett syndrome are present before the regression period: A case study. The suspicion of a diagnosis of Rett syndrome (RTT) is based on clinical criteria that are often not present in the first two stages of the disease, as many of its symptoms will appear at a later age. This sometimes postpones the genetic diagnosis and an early clinical intervention. We present the case of 19-months-old girl who came to the consultation because of an arrest of psychomotor development (...) noticed 5 months earlier without change in sleep pattern, behavior, or social communication. In the observation of 1 hour videotape, she presented subtle stereotypic movements of the face and hands as well as repetitive dystonic posturing of her limbs. A genetic test confirmed the diagnosis of RTT, showing a truncating mutation in the MECP2 gene (R270X). This case confirms that stereotypic movement anomalies, albeit infrequent and subtle, are already present before the regression stage and while

2007 Movement Disorders

3179. Periodic leg movements in Cheyne-Stokes respiration. Full Text available with Trip Pro

Periodic leg movements in Cheyne-Stokes respiration. Periodic leg movements during sleep (PLMS) are repetitive jerks of the lower limbs. Their occurrence can be isolated or part of various sleep disorders, such as restless legs syndrome (RLS), narcolepsy and obstructive sleep apnoea. Dopamine agonists are very effective in suppressing PLMS in RLS from the first night of administration. PLMS are often associated with cortical and autonomic arousals and may contribute to sleep disruption. Herein (...) , a case of association between PLMS, Cheyne-Stokes respiration (CSR) and severe insomnia is described. Repeated polysomnographic studies demonstrated a clear synchronisation between PLMS and hyperventilation episodes, and the complete recovery of CSR, sleep quality and PLMS during nocturnal ventilation. In the same patient, pharmacological treatment with a dopamine agonist was ineffective on both PLMS and CSR. These results suggest that periodic leg movements during sleep coupled with central

2008 European Respiratory Journal

3180. Periodic leg movements in prepubertal children with sleep disturbance. (Abstract)

consecutively seen, prepubertal children with sleep disorders (156 males, 96 females; aged 15mo to 11y, mean 7y 1mo, SD3y 10mo). Sleep disorders unrelated to PLMs were treated, and six children received pramipexol for PLMs. Follow-up included clinical evaluation and polysomnography. Twenty-three per cent of children were diagnosed with PLMs on the basis of polysomnography. The presence of PLMs had usually been unrecognized clinically. The only clinical symptom that could be related to periodic limb movement (...) Periodic leg movements in prepubertal children with sleep disturbance. This study's aims were to determine: (1) prevalence of periodic leg movements (PLMs) in walking prepubertal children consulting a sleep clinic for any sleep disorder; (2) associations between PLMs and other sleep and medical disorders; and (3) the response of other sleep disorders to treatment with the dopamine agonist pramipexol. Clinical evaluation and polysomnography were carried out for a period of 12 months on 252

2004 Developmental Medicine and Child Neurology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>