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Periodic Limb Movement

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3141. Limb-kinetic apraxia in corticobasal degeneration: clinical and kinematic features. (Abstract)

and cortical inhibition. All five patients in the apraxic group exhibited a unilateral praxic deficit characterised by derangement of fractionated and segmental finger movements. QMC was significantly greater in apraxic than in nonapraxic patients (P < 0.02), revealing a chaotic movement with marked interfinger uncoordination. Conventional transcranial magnetic stimulation parameters were within normal limits in both groups of patients; however, the silent period was significantly shorter in the apraxic (...) limb when compared with control subjects (P < 0.001). Limb-kinetic apraxia is a distinctive disorder affecting the performance of finger and hand postures and movements over and above a corticospinal or basal ganglion deficit. Disruption of the frontoparietal circuit devoted to grasping and manipulation, together with defective cortical inhibition, which would also interfere with the selection and control of hand muscle activity, are the most likely underlying physiopathological mechanisms of limb

2003 Movement Disorders

3142. Excitability changes in human corticospinal projections to forearm muscles during voluntary movement of ipsilateral foot Full Text available with Trip Pro

cortical area a simultaneous lesser co-activation of the forearm area produces a subliminal cyclic modulation of cervical motoneurones excitability. Should the two limbs be moved together, the time course of this modulation would favour isodirectional movements of the prone hand and foot, indeed the preferential coupling observed when hand and foot are voluntarily oscillated. (...) Excitability changes in human corticospinal projections to forearm muscles during voluntary movement of ipsilateral foot Excitability of the H-reflex in the relaxed flexor carpi radialis (FCR) muscle was tested during voluntary oscillations of the ipsilateral foot at five evenly spaced delays during a 600 ms cycle. In some experiments the H-reflex was conditioned by transcranial magnetic stimulation (TMS). With the hand prone, the amplitude of the FCR H-reflex was modulated sinusoidally

2002 The Journal of physiology

3143. Startle response of human neck muscles sculpted by readiness to perform ballistic head movements Full Text available with Trip Pro

Startle response of human neck muscles sculpted by readiness to perform ballistic head movements 1. An acoustic startle stimulus delivered in place of a 'go' signal in a voluntary reaction time (RT) task has been shown previously to advance the onset latency of a prepared distal limb movement without affecting the amplitude of the muscle response or movement kinematics. The primary goal of this study was to use muscles with a larger startle response to investigate whether the startling stimulus (...) only triggered the RT movement or whether some form of interaction occurred between a startle response and a temporally advanced RT movement. 2. Twenty healthy male or female subjects were instructed to react as quickly as possible to an acoustic 'go' stimulus by performing a ballistic head flexion or right axial rotation. The 'go' stimulus was periodically replaced by an acoustic stimulus capable of eliciting a startle reflex. Separate startle-inducing stimuli under relaxed conditions before

2001 The Journal of physiology

3144. Neurophysiological Studies in Patients With Paroxysmal Hyperkinetic Movement Disorders

younger than 8 years old. B. Patients with attacks that involve head and neck movements, axial movements, bilateral limb involvement, or violent attacks that typically make patients fall to the ground. With respect to children, violent attacks are defined as any attack that can potentially result in injury (hitting the head, falls, violent flailing, hitting furniture or walls) C. Previous history of or MRI findings consistent with brain tumors, strokes, trauma or arterial venous malformations. D (...) Neurophysiological Studies in Patients With Paroxysmal Hyperkinetic Movement Disorders Neurophysiological Studies in Patients With Paroxysmal Hyperkinetic Movement Disorders - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2003 Clinical Trials

3145. Treatment for Movement Problems in Elderly Stroke Patients

the more affected upper limb. This gives rise to massed or concentrated repetitive use of the more affected extremity. CI therapy leads to a large increase in use-dependent cortical reorganization involving the recruitment of other regions of the brain in the innervation of the more affected extremity movement. One of the main aims of the proposed research is to determine if CI therapy can be used with therapeutic success for increasing the amount of real-world extremity use in patients with chronic (...) Treatment for Movement Problems in Elderly Stroke Patients Treatment for Movement Problems in Elderly Stroke Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Treatment for Movement Problems

2003 Clinical Trials

3146. Automated Constraint-Induced Therapy for Restoring Movement After Stroke

Automated Constraint-Induced Therapy for Restoring Movement After Stroke Automated Constraint-Induced Therapy for Restoring Movement After Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Automated (...) Constraint-Induced Therapy for Restoring Movement After Stroke The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00037960 Recruitment Status : Completed First Posted : May 27, 2002 Last Update Posted : January 21, 2009 Sponsor: US Department of Veterans Affairs Information provided by: VA Office of Research

2002 Clinical Trials

3147. Effect of pergolide on restless legs and leg movements in sleep in uremic patients. (Abstract)

Effect of pergolide on restless legs and leg movements in sleep in uremic patients. Restless legs syndrome (RLS) and periodic limb movements in sleep (PLMS) are disorders that are common and disturbing to uremic patients. The treatment of these is problematic. Eight patients on chronic hemodialysis and continuous peritoneal dialysis completed a double-blind placebo-controlled crossover study using incremental doses of pergolide up to 0.25 mg at bedtime for treatment of RLS and sleep disruption (...) . Five patients (62.5%) noted subjective improvement in restless legs symptoms and sleep quality. Objective results were improved only slightly by treatment. The percentage of the first hour in bed during which leg movements occurred decreased from 20.5 +/- 6.0 to 11.5 +/- 3.3, p < 0.05. However, findings during sleep were less positive. The following measures were not significant between placebo and treatment: leg movements per hour of sleep [53.7 +/- 22.3 vs 35.8 +/- 11.8 (p = 0.2)]; and percentage

1998 Sleep

3148. L-DOPA/carbidopa for nocturnal movement disorders in uremia. (Abstract)

L-DOPA/carbidopa for nocturnal movement disorders in uremia. Restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) are sleep disorders that are common and distressing to uremic patients. There are few data regarding effective treatment in this population. Five chronic hemodialysis patients completed a double-blind, placebo-controlled, crossover study using a single bedtime dose of controlled release L-DOPA/carbidopa (100/25 mg) for treatment of RLS and sleep disruption (...) on placebo, mean 23 +/- 9 events/hour on drug) were decreased by active medication (p = 0.03 and 0.04, respectively). Patients, however, continued to have very disrupted sleep and we could not document consistent subjective or objective improvement in overall sleep except for an increase in slow-wave sleep (SWS) from 9.0% to 22.8% (p = 0.01). The patterns of movements during sleep were not uniform in different patients, and the movements, although often periodic, were much longer than defined for PLMS

1996 Sleep Controlled trial quality: uncertain

3149. Training improves the speed of aimed movements in Parkinson's disease. (Abstract)

, without any deterioration in accuracy. These effects transferred to an untrained limb and were at least partially maintained after a 1-h delay. While patients remained impaired relative to control subjects at all phases of training and follow-up, the patients' performance at the end of training did not differ significantly from the control subjects' baseline function. Contrary to expectation, rhythmic auditory cues did not enhance improvement in the speed of aimed movements in either patients (...) or control subjects. If anything, less improvement was shown in the cued groups, although there were suggestions that the aiming skill was retained better over the delay period. The results demonstrate preserved abilities to improve speed of single ballistic aiming movements in Parkinson's disease patients and the possibility of reducing bradykinesia by training.

1998 Brain Controlled trial quality: uncertain

3150. Hypertensive extracorporeal limb perfusion (HELP): a new technique for managing critical lower limb ischemia. Full Text available with Trip Pro

compared with 1.1 +/- 0.28 for the hyperperfusion group (P < .001). The collateral flow was superior to normal flow (ie, with the superficial femoral not occluded). Continuous access to the carotid arterial tree via the access device was 25.3 +/- 8.8 days with 5 of 8 devices open for the entire observational period (maximum 37 days). The human ischemic limbs were hyperperfused at 2-4 times the mean arterial pressure producing 3-6 times an increase in pump flow measurements intermittently for 53 +/- 16 (...) Hypertensive extracorporeal limb perfusion (HELP): a new technique for managing critical lower limb ischemia. The concept of repeatedly connecting an extracorporeal blood pump to produce pancycle suprasystolic inflow pressures to ischemic limbs is introduced. Balloon catheters allow for limb isolation from the systemic circulation. In the acute phase, it is assumed that pressure is proportion to flow (Poiseuille's Law) and in the chronic phase that collateral growth is related to endothelial

2008 Journal of Vascular Surgery

3151. EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep.

EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep. Guidelines and Measures | Agency for Healthcare Research & Quality HHS.gov Search ahrq.gov Search ahrq.gov Menu Topics A - Z Healthcare Delivery Latest available findings on quality of and access to health care Searchable database of AHRQ Grants, Working Papers & HHS Recovery Act Projects AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund You are here Guidelines

2008 European Federation of Neurological Societies

3152. The treatment of restless legs syndrome and periodic limb movement disorder

The treatment of restless legs syndrome and periodic limb movement disorder The treatment of restless legs syndrome and periodic limb movement disorder The treatment of restless legs syndrome and periodic limb movement disorder Hening W, Allen R, Earley C, Kushida C, Picchietti D, Silber M Authors' objectives To review the therapy of the restless legs syndromes or periodic movements in sleep. Searching MEDLINE was searched through April 1998 using the following keywords: restless legs both (...) medications; and non- pharmacological therapy including accommodative strategies and sleep hygiene, behavioural and stimulation therapies, invasive therapies, and nutritional considerations. Participants included in the review Patients with restless leg syndrome (RLS) or periodic limb movement disorder (PLMD) were included. Some studies appeared to have included patients with other diagnosis, such as narcolepsy, and some studies had unclear criteria for the diagnosis of RLS. Definitions were as reported

1999 DARE.

3153. Ropinirole decreases periodic leg movements and improves sleep parameters in patients with restless legs syndrome. (Abstract)

were included in the primary endpoint analysis. PLMS per hour decreased more with ropinirole (48.5 to 11.8), compared with placebo (35.7 to 34.2; adjusted treatment difference: -27.2; 95% confidence interval [CI]: -39.1, -15.4; P < .0001). Periodic limb movements with arousal per hour decreased from 7.0 to 2.5 with ropinirole but increased from 4.2 to 6.0 with placebo (adjusted treatment difference: -4.3, 95% CI: -7.6, -1.1; P = .0096). Periodic limb movements while awake per hour decreased from (...) Ropinirole decreases periodic leg movements and improves sleep parameters in patients with restless legs syndrome. Polysomnographic study evaluating the efficacy of ropinirole for the treatment of patients with restless legs syndrome (RLS) suffering from periodic leg movements in sleep (PLMS).Double-blinded, placebo-controlled, parallel-group study.15 tertiary referral centers in the USA.65 patients with RLS and PLMS.Ropinirole (0.25-4.0 mg per day) or placebo for 12 weeks.Data from 59 patients

2004 Sleep Controlled trial quality: predicted high

3154. Periodic leg movements in Cheyne-Stokes respiration. Full Text available with Trip Pro

Periodic leg movements in Cheyne-Stokes respiration. Periodic leg movements during sleep (PLMS) are repetitive jerks of the lower limbs. Their occurrence can be isolated or part of various sleep disorders, such as restless legs syndrome (RLS), narcolepsy and obstructive sleep apnoea. Dopamine agonists are very effective in suppressing PLMS in RLS from the first night of administration. PLMS are often associated with cortical and autonomic arousals and may contribute to sleep disruption. Herein (...) , a case of association between PLMS, Cheyne-Stokes respiration (CSR) and severe insomnia is described. Repeated polysomnographic studies demonstrated a clear synchronisation between PLMS and hyperventilation episodes, and the complete recovery of CSR, sleep quality and PLMS during nocturnal ventilation. In the same patient, pharmacological treatment with a dopamine agonist was ineffective on both PLMS and CSR. These results suggest that periodic leg movements during sleep coupled with central

2008 European Respiratory Journal

3155. Abnormal movements in Rett syndrome are present before the regression period: A case study. Full Text available with Trip Pro

Abnormal movements in Rett syndrome are present before the regression period: A case study. The suspicion of a diagnosis of Rett syndrome (RTT) is based on clinical criteria that are often not present in the first two stages of the disease, as many of its symptoms will appear at a later age. This sometimes postpones the genetic diagnosis and an early clinical intervention. We present the case of 19-months-old girl who came to the consultation because of an arrest of psychomotor development (...) noticed 5 months earlier without change in sleep pattern, behavior, or social communication. In the observation of 1 hour videotape, she presented subtle stereotypic movements of the face and hands as well as repetitive dystonic posturing of her limbs. A genetic test confirmed the diagnosis of RTT, showing a truncating mutation in the MECP2 gene (R270X). This case confirms that stereotypic movement anomalies, albeit infrequent and subtle, are already present before the regression stage and while

2007 Movement Disorders

3156. Periodic leg movements in prepubertal children with sleep disturbance. (Abstract)

consecutively seen, prepubertal children with sleep disorders (156 males, 96 females; aged 15mo to 11y, mean 7y 1mo, SD3y 10mo). Sleep disorders unrelated to PLMs were treated, and six children received pramipexol for PLMs. Follow-up included clinical evaluation and polysomnography. Twenty-three per cent of children were diagnosed with PLMs on the basis of polysomnography. The presence of PLMs had usually been unrecognized clinically. The only clinical symptom that could be related to periodic limb movement (...) Periodic leg movements in prepubertal children with sleep disturbance. This study's aims were to determine: (1) prevalence of periodic leg movements (PLMs) in walking prepubertal children consulting a sleep clinic for any sleep disorder; (2) associations between PLMs and other sleep and medical disorders; and (3) the response of other sleep disorders to treatment with the dopamine agonist pramipexol. Clinical evaluation and polysomnography were carried out for a period of 12 months on 252

2004 Developmental Medicine and Child Neurology

3157. Estimation of Muscle Area and Thickness of Deep Cervical Muscle Contraction During Cervical and Limb Movements

Estimation of Muscle Area and Thickness of Deep Cervical Muscle Contraction During Cervical and Limb Movements Estimation of Muscle Area and Thickness of Deep Cervical Muscle Contraction During Cervical and Limb Movements - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Estimation of Muscle Area and Thickness of Deep Cervical Muscle Contraction During Cervical and Limb Movements The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00155948 Recruitment Status : Completed First Posted : September 12, 2005

2005 Clinical Trials

3158. Electromyographic activity in the immobilized shoulder girdle musculature during contralateral upper limb movements. (Abstract)

Electromyographic activity in the immobilized shoulder girdle musculature during contralateral upper limb movements. The purpose of this study was to quantify electromyographic (EMG) activity in the immobilized shoulder girdle musculature at rest and during a battery of contralateral upper limb activities. Six asymptomatic men, aged 22 to 33 years, volunteered to participate. Fine-wire (supraspinatus, infraspinatus) and surface (deltoids, trapezii, biceps, serratus anterior) electrodes recorded (...) produced high trapezius activity (>45% MVC) with low supraspinatus, biceps, and anterior deltoid activities (<10% MVC). Our findings suggest that (1) immobilized shoulder girdle muscle EMG activity during quiet standing is negligible in asymptomatic individuals; (2) contralateral upper limb motions at self-selected speeds are not likely to be harmful to healing tissues; (3) during early healing periods, patients with biceps-labral injury should minimize bimanual activities, those with supraspinatus

2004 Journal of Shoulder and Elbow Surgery

3159. A genetic risk factor for periodic limb movements in sleep. Full Text available with Trip Pro

A genetic risk factor for periodic limb movements in sleep. The restless legs syndrome (RLS) is a common neurologic disorder characterized by an irresistible urge to move the legs. It is a major cause of sleep disruption. Periodic limb movements in sleep are detectable in most patients with RLS and represent an objective physiological metric.To search for sequence variants contributing to RLS, we performed a genomewide association study and two replication studies. To minimize phenotypic (...) heterogeneity, we focused on patients with RLS who had objectively documented periodic limb movements in sleep. We measured serum ferritin levels, since iron depletion has been associated with the pathogenesis of RLS.In an Icelandic discovery sample of patients with RLS and periodic limb movements in sleep, we observed a genomewide significant association with a common variant in an intron of BTBD9 on chromosome 6p21.2 (odds ratio, 1.8; P=2x10(-9)). This association was replicated in a second Icelandic

2007 NEJM

3160. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. (Abstract)

Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Periodic limb movements during sleep (PLMS), with or without symptoms of a restless legs syndrome (RLS), may cause sleep disturbances. The pharmacologic treatments of choice are dopaminergic drugs. Their use, however, may be limited due to tolerance development or rebound phenomena. Anecdotal observations have shown that oral magnesium therapy may ameliorate symptoms in patients (...) with moderate RLS. We report on an open clinical and polysomnographic study in 10 patients (mean age 57 +/- 9 years; 6 men, 4 women) suffering from insomnia related to PLMS (n = 4) or mild-to-moderate RLS (n = 6). Magnesium was administered orally at a dose of 12.4 mmol in the evening over a period of 4-6 weeks. Following magnesium treatment, PLMS associated with arousals (PLMS-A) decreased significantly (17 +/- 7 vs 7 +/- 7 events per hour of total sleep time, p < 0.05). PLMS without arousal were also

1998 Sleep

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