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Periodic Limb Movement

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3121. Prediction of upper limb muscle activity from motor cortical discharge during reaching Full Text available with Trip Pro

Prediction of upper limb muscle activity from motor cortical discharge during reaching Movement representation by the motor cortex (M1) has been a theoretical interest for many years, but in the past several years it has become a more practical question, with the advent of the brain-machine interface. An increasing number of groups have demonstrated the ability to predict a variety of kinematic signals on the basis of M1 recordings and to use these predictions to control the movement (...) of a cursor or robotic limb. We, on the other hand, have undertaken the prediction of myoelectric (EMG) signals recorded from various muscles of the arm and hand during button pressing and prehension movements. We have shown that these signals can be predicted with accuracy that is similar to that of kinematic signals, despite their stochastic nature and greater bandwidth. The predictions were made using a subset of 12 or 16 neural signals selected in the order of each signal's unique, output-related

2007 Journal of neural engineering

3122. IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Post-stroke Spasticity of the Upper Limb

movement. It is a 5-point scale that ranges from 0 (=no increase in tone) to 4 (=limb rigid in flexion or extension). Subjects with a reduction of one point were defined as responder for the aim of the primary efficacy analysis. Responders Based on a Responder Definition of at Least 1 Point Improvement From Baseline in the Ashworth Score for Treated Forearm Pronators at All Post Baseline Visits [ Time Frame: Baseline, Week 2, Week 4, Week 8, Week 12, Final Visit of the Main Period (to be performed (...) movement. It is a 5-point scale that ranges from 0 (=no increase in tone) to 4 (=limb rigid in flexion or extension). Subjects with a reduction of one point were defined as responder for the aim of the primary efficacy analysis. Change From Baseline to Final Visit in Ashworth Scale Score for Treated Forearm Pronators [ Time Frame: Baseline, Final Visit of the Main Period (to be performed at week 12 after 1st injection at earliest, at week 20 at latest) ] The Ashworth Scale is a well known and commonly

2007 Clinical Trials

3123. Robotic Assisted Upper-Limb Neurorehabilitation in Stroke Patients

). Willingness to avoid any new alternative arm rehabilitative approaches for the duration of the study. Written informed consent to participate in the study. Exclusion Criteria: A fixed contracture in the affected limb that prevents movement along the entire dynamic range required by either robot-assisted or intensive comparison therapy. Joint pain that occurs within the range of motion required by the intervention protocols (intensive comparison therapy and robot-assisted therapy). Enrolled in or planning (...) Robotic Assisted Upper-Limb Neurorehabilitation in Stroke Patients Robotic Assisted Upper-Limb Neurorehabilitation in Stroke Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Robotic Assisted Upper

2006 Clinical Trials

3124. A randomized controlled trial of modified constraint-induced movement therapy for elderly stroke survivors: changes in motor impairment, daily functioning, and quality of life. (Abstract)

patients (mean age, 72 y) with 0.5 to 31 months postonset of a first-ever cerebrovascular accident.Twenty-six patients received either mCIMT (restraint of the unaffected limb combined with intensive training of the affected limb) or traditional rehabilitation for a period of 3 weeks.Outcome measures included the Fugl-Meyer Assessment (FMA), FIM instrument, Motor Activity Log (MAL), and Stroke Impact Scale (SIS). The FMA evaluated the severity of motor impairment; the FIM instrument and MAL reported (...) A randomized controlled trial of modified constraint-induced movement therapy for elderly stroke survivors: changes in motor impairment, daily functioning, and quality of life. To examine the benefits of modified constraint-induced movement therapy (mCIMT) on motor function, daily function, and health-related quality of life (HRQOL) in elderly stroke survivors.Two-group randomized controlled trial, with pretreatment and posttreatment measures.Rehabilitation clinics.Twenty-six elderly stroke

2007 Archives of physical medicine and rehabilitation Controlled trial quality: uncertain

3125. Constraint-induced movement therapy in patients with stroke: a pilot study on effects of small group training and of extended mitt use. (Abstract)

Constraint-induced movement therapy in patients with stroke: a pilot study on effects of small group training and of extended mitt use. (1) To evaluate constraint-induced movement therapy for chronic stroke patients modified into group practice to limit the demand on therapist resources. (2) To explore whether extended mitt use alone may enhance outcome.A combined case-control and randomized controlled study with pre- and post-treatment measures by blinded observers.A university hospital (...) rehabilitation department.Sixteen stroke patients (nine men and seven women; mean age 56.7 years; on average 28.9 months post stroke, five of whom were 6-9 months post stroke) with moderate motor impairments in the contralateral upper limb.Constraint-induced therapy (mitt on the less affected hand 90% of waking hours for 12 days) with 2-3 patients per therapist and 6 h of group training per day. After the training period, the patients were randomized either to using the mitt at home every other day for two

2006 Clinical rehabilitation Controlled trial quality: predicted high

3126. Efficacy of a child-friendly form of constraint-induced movement therapy in hemiplegic cerebral palsy: a randomized control trial. (Abstract)

extremity, which were sustained through the 6-month evaluation period, as measured by the Jebsen-Taylor Test of Hand Function and fine motor-subtests of the Bruininks-Oseretsky Test of Motor Proficiency (p<0.05 in both cases). Initial severity of hand impairment and testing compliance were strong predictors of improvement. Caregivers reported significant increases in involved limb frequency of use and quality of movement. However, there was no change in strength, sensibility, or muscle tone (p>0.05 (...) Efficacy of a child-friendly form of constraint-induced movement therapy in hemiplegic cerebral palsy: a randomized control trial. Constraint-induced (CI) movement therapy is a promising therapy for improving upper limb function in adults after stroke. It involves restraint of the non-involved limb and extensive movement practice with the involved limb. In this study, a single-blinded, randomized, control study was performed to examine the efficacy of CI therapy, modified to be child friendly

2006 Developmental Medicine and Child Neurology Controlled trial quality: uncertain

3127. Changes in spastic muscle tone increase in patients with spinal cord injury using functional electrical stimulation and passive leg movements. (Abstract)

Changes in spastic muscle tone increase in patients with spinal cord injury using functional electrical stimulation and passive leg movements. Comparison of cycling interventions to reduce spastic muscle tone increase in patients with spinal cord injury.Neuroprosthetic outpatient clinic in a university hospital.Five patients with spinal cord injury took part in a crossover study in which the lower limbs (1) were stimulated by functional neuromuscular electrical stimulation (FES) to induce leg (...) cycling movements and (2) were passively moved by an ergometer machine. Patients sat in a comfortable chair fastened to the ergometer while FES was done to induce leg cycling (active session). During the passive leg movement session the ergometer moved their legs for the same period of time at the same velocity and frequency.The change in spastic muscle tone increase before and after each training session was tested with the modified Ashworth Scale and the pendulum test of spasticity (relaxation index

2008 Clinical rehabilitation Controlled trial quality: uncertain

3128. The distinctive movement disorder of ovarian teratoma-associated encephalitis. (Abstract)

The distinctive movement disorder of ovarian teratoma-associated encephalitis. The movement disorder observed in four cases of ovarian teratoma associated encephalitis is described. The illness began with neuropsychiatric symptoms and was followed by prolonged unresponsiveness, respiratory failure, and autonomic instability. The movement disorder consisted of semirhythmic repetitive bulbar and limb movements and persisted during prolonged periods of unresponsiveness, diminishing as awareness (...) returned. The characteristics of the movement disorder differed from recognized dyskinesias. It is suggested that interruption of forebrain corticostriatal inputs by anti-N-methyl-D-aspartate (NMDA) receptor antibodies removes tonic inhibition of brainstem pattern generators releasing primitive patterns of bulbar and limb movement. Recognition of the distinctive movements should prompt a search for an ovarian teratoma since the condition is responsive to tumor resection and immunomodulation.(c) 2008

2008 Movement Disorders

3129. Measurement of pruritus in a Chinese woman with pemphigoid gestationis using a wrist movement detector. (Abstract)

Measurement of pruritus in a Chinese woman with pemphigoid gestationis using a wrist movement detector. Pemphigoid gestationis (PG) is a rare itching bullous disease of pregnancy and the postpartum period. We describe the use of a new methodology for measuring the nature and intensity of itching in a 21-year-old woman with pemphigoid gestationis. At 19 weeks gestation, she developed an itchy rash over the limbs, which spread to the trunk. Blisters then appeared on the hands which subsequently (...) also involved the feet. Intense nocturnal wrist activities in this patient, measured with a wrist monitor and defined as average acceleration in the early hours of sleep, were even higher than that in patients with severe eczema, with an average value of 181.00 +/- 43.49 (mean +/- standard error) g/min for the first three hours, versus 84.47 +/- 8.53 g/min for the group of 24 eczema subjects. Most wrist activities were slower movements at 0 to 1 Hz. This is in striking contrast to the scratching

2008 International Journal of Dermatology

3130. Angle stable locking reduces interfragmentary movements and promotes healing after unreamed nailing. Study of a displaced osteotomy model in sheep tibiae. (Abstract)

. Each pair of tibiae was also mechanically tested until torsional failure, after which the whole callus region was subjected to histological and histomorphometric analysis.Throughout the examination period, the interfragmentary movements in all directions were significantly smaller in the group treated with the angle stable tibial nail than they were in the group treated with standard unreamed tibial nailing. The limbs treated with the angle stable tibial nails returned to almost full weight-bearing (...) during the period of the investigation, whereas those treated with standard nailing did not. Histomorphometric analysis, radiographic data, and mechanical testing showed superior bone-healing following treatment with the angle stable tibial nail.Use of an angle stable tibial nail may help to reduce interfragmentary movements in vivo and thus lead to superior bone-healing compared with that following standard unreamed tibial nailing.

2005 The Journal of Bone and Joint Surgery. American Volume

3131. Movement disorders associated with complex regional pain syndrome in children. Full Text available with Trip Pro

Movement disorders associated with complex regional pain syndrome in children. The aim of the present study was to review the history, clinical course, treatment, and outcome of movement disorders in children and young people with complex regional pain syndrome (CRPS). Case notes were reviewed retrospectively of children and young people who presented with movement disorders in CRPS to our tertiary paediatric pain service over a period of 13 years. Ten children with CRPS presented with movement (...) disorders (eight females, two males). The age at first presentation with symptoms of CRPS ranged from 8 to 15 years (mean 11 y 2 mo, median 13 y). The most common movement disorder was dystonia (n=8), followed by tremors (n=3) and myoclonus (n=3); two patients had all three movement disorders. The movement disorder affected mainly the lower limb (n=9) with a predilection for the foot (n=7) and was frequently initiated by minor trauma (n=7). Follow-up ranged from 6 months to 14 years. The outcome

2008 Developmental Medicine and Child Neurology

3132. Efficacy and Tolerability of Ramelteon in Patients With Rapid Eye Movement (REM) Behavior Disorder and Parkinsonism

(defined as an apnea-hypopnea index>15 events/hr of sleep on screening PSG), significant periodic limb movement disorder (defined as a PLM index>10 events/hr of sleep with awakening on screening PSG) Travel through two time zones within a month prior to the study initiation Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please (...) Efficacy and Tolerability of Ramelteon in Patients With Rapid Eye Movement (REM) Behavior Disorder and Parkinsonism Efficacy and Tolerability of Ramelteon in Patients With Rapid Eye Movement (REM) Behavior Disorder and Parkinsonism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2008 Clinical Trials

3133. Botulinum Toxin Type A and Modified Constraint-Induced Movement Therapy for Poststroke Upper Extremity Spasticity

Botulinum Toxin Type A and Modified Constraint-Induced Movement Therapy for Poststroke Upper Extremity Spasticity Botulinum Toxin Type A and Modified Constraint-Induced Movement Therapy for Poststroke Upper Extremity Spasticity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Botulinum Toxin Type A and Modified Constraint-Induced Movement Therapy for Poststroke Upper Extremity Spasticity The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00723866 Recruitment Status : Completed First Posted : July 29, 2008

2008 Clinical Trials

3134. Changes in and Determinants of Movement Performance, Functional Status, and Health-Related Quality of Life After Stroke Rehabilitation

by senior occupational therapists. Brain and movement reorganization will be evaluated with fMRI and kinematic instrument, respectively before and after the 4-week intervention period. Clinical measures on motor impairment, daily function and quality of life will be assessed before, immediately and six months after intervention. Two examiners blind to group allocation will collaborate to provide both fMRI and kinematic evaluations and one of them will administer clinical measures. Before being allowed (...) Changes in and Determinants of Movement Performance, Functional Status, and Health-Related Quality of Life After Stroke Rehabilitation Changes in and Determinants of Movement Performance, Functional Status, and Health-Related Quality of Life After Stroke Rehabilitation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning

2008 Clinical Trials

3135. Early effects of embryonic movement: ‘a shot out of the dark’ Full Text available with Trip Pro

by developing novel models and schemes to examine the influence of defined periods of movement during musculoskeletal development. Utilizing drugs with known neuromuscular actions to provoke hyperactivity (4-aminopyridine, AP) and either rigid (decamethonium bromide, DMB) or flaccid (pancuronium bromide, PB) paralysis, we have examined the role of movement in joint, osteochondral and muscle development. Our initial studies focusing on the joint showed that AP-induced hyperactivity had little, if any, effect (...) , with different developmental periods preferentially modifying specific osteochondral components. Changes in cartilage and bone growth induced by 3-day periods of flaccid immobilization, imposed at distinct developmental phases, provides support for a diminution in cartilage elaboration at an early phase and for a relatively delayed influence of movement on osteogenesis, invoking critical periods during which the developing skeleton becomes receptive to the impact of movement. Immobilization also exerts

2006 Journal of anatomy

3136. Post Stroke Hand Functions: Bilateral Movements and Electrical Stimulation Treatments

: University of Florida Information provided by (Responsible Party): University of Florida Study Details Study Description Go to Brief Summary: The purpose of this study was to determine the effect of two amounts of treatment therapy on post stroke motor recovery in the arms. The therapy is bilateral movement training combined with electrical stimulation on the impaired limb. Condition or disease Intervention/treatment Phase Cerebrovascular Accident Hemiplegia Behavioral: Bilateral movements (...) electrical stimulation triggered by the participants' own contracting muscles is provided to the paretic arm during the movements. Training period was 4 times per week for 2 weeks. Other Name: functional electrical stimulation Active Comparator: Low Intensity Bilateral training moving both arms coupled with neuromuscular electrical stimulation; two 90-minute sessions/week for 2 weeks. Behavioral: Bilateral movements and neuromuscular electrical stimulation Participants practice moving both their paretic

2006 Clinical Trials

3137. Study of Fetal Movements Using Multichannel Ultrasound Pulsed Doppler in Normal and Pathologic Pregnancy

abdomen. One of the transducers is aimed at the fetal heart, another at the lower limbs and one transducer at the thorax and the fetal upper limbs to detect heart and body movements. The signals are analysed and processed by software which computes a number of parameters describing the movements. Ninety pregnant women from 28 weeks gestation will be monitored over a 40 minute period every month or every 2 weeks in case of pathological pregnancy. The final purpose will be to develop a system of home (...) Study of Fetal Movements Using Multichannel Ultrasound Pulsed Doppler in Normal and Pathologic Pregnancy Study of Fetal Movements Using Multichannel Ultrasound Pulsed Doppler in Normal and Pathologic Pregnancy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2005 Clinical Trials

3138. Brain Control of Movements in Cerebral Palsy

or neurodegenerative disorders. Patient with spinal disorders in the absence of cerebral lesions. Patients with cerebral lesions caused by sickle cell disease or by emboli associated with congenital cardiac lesions. Patients with severe cognitive deficits who cannot follow simple verbal commands. Patients incapable of voluntary movement of either upper or lower limbs due to contractures. Patients who have had rhizotomy for upper extremity plasticity, who have had botulinum toxin within the last 3 months or have (...) Brain Control of Movements in Cerebral Palsy Brain Control of Movements in Cerebral Palsy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Brain Control of Movements in Cerebral Palsy The safety

2004 Clinical Trials

3139. Interhemispheric Interactions Associated With Performance of Voluntary Movements in Patients With Stroke Motor Disability

of motor response) testing. They will perform a series of movements with the index and middle fingers of either the left or right hand in response to a signal from a computer monitor. The time it takes to do the tasks will be measured and scored. There will be rest periods during each session. TMS will be done each session to examine how the motor cortex affects recovery of function after stroke. For this procedure, an insulated wire coil is placed on the scalp. A brief electrical current is passed (...) through the coil, creating a magnetic pulse that stimulates the brain. Depending on where the coil is placed, the stimulation may cause a muscle twitch (sometimes strong enough to move the limb), a feeling of movement or tingling in a limb, or twitching of the jaw. During stimulation, the subject may be asked to tense certain muscles slightly or to perform other simple actions. The electrical activity in the muscles activated by the stimulation will be recorded using metal electrodes taped to the skin

2006 Clinical Trials

3140. EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep Full Text available with Trip Pro

EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep Vignatelli L, Billiard M, Clarenbach P, Garcia-Borreguero D, Kaynak D, Liesiene V, Trenkwalder C, Montagna P CRD summary The authors concluded that level A recommendations support the use (...) of cabergoline, gabapentin, pergolide, ropinirole, and short-term levodopa and transdermal rotigotine for primary restless leg syndrome. The evidence appears to support the authors’ conclusions, but the poor reporting of review methods makes it difficult to comment on the reliability of these conclusions. Authors' objectives To evaluate the effectiveness of treatments for restless leg syndrome (RLS) and periodic limb movement disorder (PLMD) in sleep. Searching MEDLINE, EMBASE, CINAHL and the Cochrane

2006 DARE.

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