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Periodic Limb Movement

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3101. Successful treatment of the idiopathic restless legs syndrome in a randomized double-blind trial of oxycodone versus placebo. (Abstract)

of commercial preparation), there was a statistically significant reduction in the number of periodic limb movements in sleep [(PLMS)/hour sleep (p < 0.004)] and in the number of arousals/hour sleep (p < 0.009) on drugs as compared to baseline or placebo. A statistically significant improvement was also noted in sleep efficiency (p < 0.006) and 10 of the 11 patients preferred oxycodone over placebo. We conclude that oxycodone is an effective treatment for RLS and PLMS.

1993 Sleep Controlled trial quality: uncertain

3102. Motor signs of wakefulness during general anaesthesia with propofol, isoflurane and flunitrazepam/fentanyl and midlatency auditory evoked potentials. (Abstract)

every 20 to 30 s (group 3). Heart rate and arterial pressure were recorded continuously. Purposeful movements of the limbs, eye-opening or other movements as well as coughing were documented as motor signs of intra-operative wakefulness. Auditory evoked potentials were recorded in the awake state, after induction and during maintenance of general anaesthesia. Motor signs of intra-operative wakefulness occurred statistically significantly more often in the patients of the flunitrazepam/fentanyl group (...) than in those of the propofol and isoflurane group. There was no correlation between wakefulness and cardiocirculatory parameters. In the awake patients midlatency auditory evoked potentials had high peak to peak amplitudes and a periodic waveform.(ABSTRACT TRUNCATED AT 250 WORDS)

1994 Anaesthesia Controlled trial quality: uncertain

3103. Estimating three-dimensional spinal repositioning error: the impact of range, posture, and number of trials. (Abstract)

lower limb postures on the repositioning performance.Joint position sense and kinesthesia play an important role in the control of normal movement of the spine. This has important implications for the diagnosis and assessments of specific movement disorders in individuals with spinal pain syndromes. The literature is varied in methods and results in assessing spinal repositioning sense. For some studies, the inability to determine effects for range or differences between patients with low back pain (...) to incorporate an asymmetric flexion rotation movement pattern. The three-dimensional coordinates of the repositioning tasks were used to determine accuracy (mean and median of trials) and precision (variable error-standard deviation of trials). The coefficient of variation and statistical power analysis using variables derived from progressively larger numbers of trials were examined. Analysis of variance was used to detect differences for the three ranges and three postures.After the familiarization period

2003 Spine

3104. Daytime sleepiness in patients with CRF: impact of nocturnal hemodialysis. (Abstract)

repeated in 15 patients after conversion to NHD.The majority (54%) of patients on CHD were pathologically sleepy (somnolent group, mean sleep latency <5 minutes), and, in comparison with the remaining patients (alert group, mean sleep latency >5 minutes), their blood urea nitrogen (BUN; 77.9 +/- 9.8 v 60.2 +/- 12.0 mg/dL, P < 0.001; 27.8 +/- 3.5 v 21.5 +/- 4.3 mmol/L; P < 0.001), and periodic limb movement (PLM) index (57 +/- 47 v 6 +/- 10/hr; P = 0.002) were significantly higher. Furthermore, sleep

2003 American Journal of Kidney Diseases

3105. Sleep disruption and objective sleepiness in children with beta-thalassemia and congenital dyserythropoietic anemia. Full Text available with Trip Pro

hour) of the arousals in patients with CDA-1 were induced by periodic limb movements during sleep. In the control group, most (98%) arousals were spontaneous and unrelated to any definable event. The multiple sleep latency test average was 7.8 minutes for patients with beta-thalassemia (n = 6) and 10.7 minutes for patients with CDA-1 (n = 8). Five patients with beta-thalassemia and 4 patients with CDA-1 underwent a second polysomnographic study on the next night to confirm reproducibility (...) . There was no significant change in the total number or index of arousals and no difference in the severity of the periodic limb movements during sleep compared with the results of the first polysomnographic study.Children and adolescents with beta-thalassemia or CDA-1 have evidence of impaired sleep function that is partially due to periodic limb movements during sleep and arousals that result in objective diurnal sleepiness.

2003 Archives of Pediatrics & Adolescent Medicine

3106. GM1 Ganglioside Effects on Parkinson's Disease

than idiopathic PD. A tremor score on the UPDRS motor scale of >5. Tremor score greater than 3 in an individual limb. High-dose vitamin E therapy (more than 1000 I.U./day) any time during the period starting 3 months prior baseline. Transient ischemic attack any time during the period starting 6 months prior baseline. Hx of 2 or more strokes. Hx of any stroke that resulted in motor deficit, movement disorder, ataxia, cognitive impairment, or a hemi-inattention syndrome. Any stroke with residua (...) for at least 3 months prior to Screening. Mini Mental State Exam score > 25. Beck Depression Inventory score < 10. Signed informed consent. Exclusion criteria: Abrupt onset of Parkinsonism. Failure of Parkinsonian symptoms to have responded to l-dopa. Motor symptoms (such as peak dose dyskinesias (UPDRS score > 3), & random on-off phenomenon, other than end-of-dose wearing-off, persistently fluctuating over a 6 month or longer period, in response to l-dopa. Hx of findings of any movement disorder other

2002 Clinical Trials

3107. Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury

impulses. As a result, subjects with an incomplete spinal cord injury may have spasticity which is muscle spasms or muscle stiffness that makes movement difficult. Fampridine-SR is an experimental drug that increases the ability of the nerve to conduct electrical impulses. This study will examine the effects of Fampridine-SR on moderate to severe lower-limb spasticity, as well as the effects on bodily functions such as bladder control, bowel function and sexual function. The study will also examine (...) (twice daily) Placebo Comparator: Placebo Other: Placebo Placebo Outcome Measures Go to Primary Outcome Measures : Double-blind Change From Baseline in Ashworth Score Evaluating Spasticity [ Time Frame: Baseline (visits 2,3) average score days 7,14 and double blind treatment period (visits 4-7) average score days 28-98 ] The Ashworth Score is the average rating (based on a scale of 1 to 5) of four lower extremity muscle groups; left and right knee flexors and extensors (hamstrings and quadriceps

2002 Clinical Trials

3108. Combination Anti-Platelet and Anti-Coagulation Treatment After Lysis of Ischemic Stroke Trial (CATALIST)

is identified, that dose of eptifibatide will be investigated in a subsequent randomized placebo-controlled trial. MRI and CT are used as radiological measures of brain hemorrhage. The NIH Stroke Scale (NIHSS) is used to measure neurological worsening or recovery. The NIHSS is a 15-item neurologic examination stroke scale used to evaluate the effect of acute stroke on the levels of consciousness, language, neglect, visual-field loss, extra ocular movement, motor strength, ataxia, dysarthria, and sensory (...) ). The NIHSS is a 15-item neurologic examination stroke scale used to evaluate the effect of acute stroke on the levels of consciousness, language, neglect, visual-field loss, extra ocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patient's ability to answer questions and perform activities. Ratings for each of the 15 items are scored. Patients who have a score of 0 are considered to have "normal" examination. Patients with a score of 40 have the most

2003 Clinical Trials

3109. Constraint-Based Therapy to Improve Motor Function in Children With Cerebral Palsy

was derived from basic research with animal and human subjects. Randomized, controlled studies indicate that it can substantially reduce the motor deficit of adult patients with mild to moderately severe chronic strokes and can increase their independence over a period of years. CI therapy involves motor restriction of the less affected upper extremity for a period of 2 to 3 weeks while concurrently training the more affected upper limb. This gives rise to concentrated, repetitive use of the more affected (...) ). Recruitment status was: Recruiting First Posted : May 22, 2003 Last Update Posted : June 24, 2005 Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Information provided by: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Study Details Study Description Go to Brief Summary: Pediatric Constraint-Induced (CI) Movement therapy is a rehabilitation program designed to improve motor function in children with partial paralysis

2003 Clinical Trials

3110. Effect of Ropinirole on Spinal Cord Reflexes and Restless Legs Syndrome

disturbances. Ropinirole affects chemical messengers thought to be involved in spinal cord function and in modulating RLS symptoms. Healthy normal volunteers and patients with RLS between 18 and 80 years of age may be eligible for this study. Patients must have mild to moderate RLS and periodic limb movements. All candidates will be screened with a medical history, physical and neurological evaluations, electromyogram (see below), polysomnogram (see below), electrocardiogram (ECG), and blood and urine (...) provided by: National Institutes of Health Clinical Center (CC) Study Details Study Description Go to Brief Summary: This study will examine the effects of the drug Ropinirole on spinal cord reflexes and on symptoms of restless legs syndrome (RLS). Patients with RLS have uncomfortable sensations in the legs, usually in the evening or early part of the night. Most patients also have periodic involuntary leg movements. The condition tends to worsen over time, resulting in severe discomfort and sleep

2003 Clinical Trials

3111. Study of Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease

. The stimulation may cause muscle twitching in the scalp or face and may also cause small movements of the limbs. Just before and after each rTMS session, patients will have a neurologic examination, including an evaluation of walking. Their motor function tests will be recorded on videotape to document possible improvement and to allow physicians to rate the improvement. The physicians will not know which patients are receiving actual rTMS and which are receiving sham treatment. Ratings before the first (...) patients' symptoms improved; in some they worsened temporarily, and some showed no change. Patients between 40 and 80 years of age with moderately severe Parkinson's disease, whose main problem is slowness of movement and stiffness, may be eligible for this study. Participants will be randomly assigned to one of two treatment groups: one will receive rTMS to parts of the brain involved in controlling movement; the other will receive sham, or placebo, stimulation. Nine treatments will be given over a 4

2002 Clinical Trials

3112. Improving Arm Mobility and Use After Stroke

by constraining movement in the less impaired limb for most waking hours over a 2 week period. The constraint is a taped splint in which the hand rests to prevent limb use but enable protective responses. A micro-switch within the splint will permit monitoring of contact time (wearing). Each weekday for 2 weeks, patients come to the clinic/laboratory for specific task training. Evaluations in laboratory and actual use tests are made prior to treatment, 2 weeks later, and at 4 month intervals thereafter (...) . This study examines the effectiveness of CI therapy for improving arm motion after stroke. Condition or disease Intervention/treatment Phase Cerebrovascular Accident Procedure: Constraint-induced movement therapy Phase 3 Detailed Description: Profoundly impaired motor dysfunction is a major consequence of stroke. As a result, a large number of the more than 700,000 people in America sustaining a stroke each year have limitations in motor ability and compromised quality of life. Therapeutic interventions

2003 Clinical Trials

3113. Effects of Treating Obstructive Sleep Apnea in Epilepsy

, demyelination, metabolic illness, or progressive degenerative disease. Non-epileptic spells (e.g., pseudoseizures) alone or in combination with epileptic seizures. Narcolepsy or another primary sleep disorder that requires intervention with medications and which may affect results of study (e.g., severe periodic limb movement disorder). Effectively treated OSA or prior exposure to continuous positive airway pressure. History of poor compliance with antiepileptic medications. Current treatment with the vagus (...) nerve stimulator. Pregnancy. A significant history of medical or psychiatric disease which may impair participation in the trial. A history of alcohol or drug abuse during the one-year period prior to trial participation. Evidence of medical instability (e.g., congestive heart failure, cardiac arrhythmias, pulmonary disease) due to obstructive sleep apnea. Subjects who are unaware of the majority of their seizures and lack a reliable witness. Greater than ten seizures a day. Contacts and Locations

2002 Clinical Trials

3114. The Role of Dopamine in Motor Learning in Healthy Subjects and Patients With Parkinson's Disease

of a stimulus (e.g., white circle) below one of the markers by pressing the spatially corresponding key. About a second later, the next stimulus will be displayed below one of the other markers, and so on. Reaction times and accuracy will be recorded. After 3 to 10 minutes of practice (one block), there will be a rest period during which the computer will display information about the subject's accuracy of movements and reaction time. Then, a new block will start. There will be about 6 to 20 practice blocks (...) as the electrical activity during training. Indeed, patients with Parkinson's disease frequently complain of slowness and early fatigue during movements. These symptoms are believed to be related to a decrease of dopamine in the brain which may be associated with abnormalities in cerebral electrical activity. Adult patients with Parkinson's disease who are right-handed, do not have dementia, and are not depressed may be eligible for this study. Healthy volunteers who match patients in age, gender, handedness

2002 Clinical Trials

3115. Treatment of Cortical Myoclonus With Repetitive Transcranial Magnetic Stimulation

on patients participating in the study. The 10 day period will be broken into 5 days of active repetitive magnetic stimulation and 5 days of placebo "ineffective" stimulation. At the end of the 10 day period, if the results show that rTMS was beneficial, patients may undergo an additional 5 days of active rTMS. Condition or disease Intervention/treatment Phase Movement Disorder Myoclonus Nervous System Disease Device: Magstim Super Rapid Stimulator Phase 1 Detailed Description: Repetitive transcranial (...) and Stroke (NINDS) Information provided by: National Institutes of Health Clinical Center (CC) Study Details Study Description Go to Brief Summary: Myoclonus is a condition related to epilepsy of involuntary twitching or jerking of the limbs. The purpose of this study is to determine if stimulation of the brain with magnetic pulses can decrease myoclonus. Researchers believe that this may be possible because in studies on normal volunteers, magnetic stimulation made areas of the brain difficult

1999 Clinical Trials

3116. Neurotropin to Treat Chronic Neuropathic Pain

or CRPS-II in one limb only, based on pain (1) that is post-traumatic and spread beyond the region of the injury; (2) has persisted for more than 2 weeks; and (3) is associated with swelling, altered skin color or skin temperature, altered sweating, allodynia or hyperesthesia or limitation of active movement. Atrophic changes in skin, hair loss or nail changes, or disuse atrophy of skeletal muscle may be present. Both sexes are to be studied. All ethnic and racial groups can participate. Patients must (...) Institutes of Health Clinical Center (CC) National Institute of Neurological Disorders and Stroke (NINDS) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Information provided by (Responsible Party): National Institutes of Health Clinical Center (CC) ( National Institute of Nursing Research (NINR) ) Study Details Study Description Go to Brief Summary: This study will examine the effectiveness of the drug neurotropin in treating chronic pain after injury to a limb

2000 Clinical Trials

3117. Reconstruction for chronic dysfunction of ileoanal pouches. Full Text available with Trip Pro

Reconstruction for chronic dysfunction of ileoanal pouches. A retrospective review was performed to determine the results after surgical reconstruction for chronic dysfunction of ileal pouch-anal procedures for ulcerative colitis and familial colonic polyposis at a university medical center.During the 20-year period from 1978 to 1998, 601 patients underwent colectomy and ileal pouch-anal anastomosis (IPAA) for ulcerative colitis, familial colonic polyposis, or Hirschsprung's disease. A J pouch (...) was used for 351 patients, a lateral pouch for 221, an S pouch for 6, and a straight pull-through for 23. Acute complications after pouch construction have been detailed in previous publications and are not included in this study. Chronic pouch stasis with diarrhea, frequency, urgency, and soiling gradually became more severe in 164 patients (27.3%), associated with pouch enlargement, an elongated efferent limb, and obstruction to pouch outflow, largely related to the pouch configuration used during

1999 Annals of Surgery

3118. Lifestyle modifications to prevent and control hypertension. 4. Recommendations on physical exercise training. Canadian Hypertension Society, Canadian Coalition for High Blood Pressure Prevention and Control, Laboratory Centre for Disease Control at Healt Full Text available with Trip Pro

according to level of evidence.A high value was placed on avoidance of cardiovascular morbidity and premature death caused by untreated hypertension.Physical activity of moderate intensity involving rhythmic movements with the lower limbs for 50-60 minutes, 3 or 4 times per week, reduces blood pressure and appears to be more effective than vigorous exercise. Harm is uncommon and is generally restricted to the musculoskeletal injuries that may occur with any repetitive activity. Injury occurs more often (...) . Because of insufficient evidence, no economic outcomes were considered.A MEDLINE search was conducted for the period 1966-1997 with the terms exercise, exertion, physical activity, hypertension and blood pressure. Both reports of trials and review articles were obtained. Other relevant evidence was obtained from the reference lists of these articles, from the personal files of the authors and through contacts with experts. The articles were reviewed, classified according to study design and graded

1999 CMAJ: Canadian Medical Association Journal

3119. Diagnosis and treatment of sleep disorders: a brief review for clinicians Full Text available with Trip Pro

circadian rhythm disorders are described in conjunction with interventions, including chronotherapy and light therapy. The diagnosis and treatment of restless legs syndrome/periodic limb movement disorder is addressed. Attention is focused on obstructive sleep apnea and upper airway resistance syndrome, and their treatment. The constellation of symptoms and findings in narcolepsy are reviewed together with diagnostic testing and therapy, Parasomnias, including sleep terrors, somnambulism, and rapid eye (...) movement (REM) behavior sleep disorders are described, together with associated laboratory testing results and treatment.

2003 Dialogues in Clinical Neuroscience

3120. Tardive dyskinesia. Full Text available with Trip Pro

Tardive dyskinesia. Tardive dyskinesia is a potentially irreversible syndrome of involuntary hyperkinetic movements that occur in predisposed persons receiving extended neuroleptic (antipsychotic) drug therapy. It is usually characterized by choreoathetoid dyskinesias in the orofacial, limb, and truncal regions, but subtypes of this syndrome may include tardive dystonia and tardive akathisia. Although the mechanisms underlying the pathogenesis and pathophysiology of this disorder are unproven (...) , altered dopaminergic functions will likely play a role in any explanation of it. Tardive dyskinesia develops in 20% of neuroleptic-treated patients, but high-risk groups such as the elderly have substantially higher rates. Risk factors include age, female sex, affective disorders, and probably those without psychotic diagnoses, including patients receiving drugs with antidopaminergic activity for nausea or gastrointestinal dysfunction for extended periods. Total drug exposure is positively correlated

1990 Western Journal of Medicine

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