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Periodic Limb Movement

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3001. A Double-blind, Parallel Group, Placebo-Controlled Outpatient Trial of PD 00200390 in Adults With Nonrestorative Sleep

with and periodic limb movement disorder, narcolepsy or other dyssomnia or parasomnia including apnea-hypopnea index > 10/hr; or period limb movement with arousal index > 10/hr. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00655369 Sponsors and Collaborators (...) Official Title: PD 0200390 Dose-Ranging Trial: A Randomized, Double-Blind, Parallel Group, Placebo-Controlled, Multicenter Outpatient Trial of PD 0200390 in Adults With Nonrestorative Sleep Study Start Date : April 2008 Actual Primary Completion Date : December 2008 Actual Study Completion Date : December 2008 Arms and Interventions Go to Arm Intervention/treatment Experimental: 15 mg Drug: PD 0200390 oral 15 mg daily dose, 3 capsules per dose during a six week treatment period. Experimental: 25 mg

2008 Clinical Trials

3002. Hypersomnia Full Text available with Trip Pro

, such as sleeping sickness) and hypersomnia, hypersomnia associated with metabolic or endocrine diseases, breathing-related sleep disorders and sleep apnea syndromes, and periodic limb movements in sleep.

2005 Dialogues in Clinical Neuroscience

3003. Sleep and psychiatry Full Text available with Trip Pro

disorder), substance abuse disorders, eating disorders, and attention deficit/hyperactivity disorders. The spectrum of associated sleep disorders includes insomnia, hypersomnia, nocturnal panic, sleep paralysis, hypnagogic hallucinations, restless legs/periodic limb movements of sleep, obstructive sleep apnea, and parasomnias. The effects on sleep of various psychotropic medications utilized to treat the above psychiatric disorders are summarized.

2005 Dialogues in Clinical Neuroscience

3004. Psychiatric aspects of organic sleep disorders Full Text available with Trip Pro

not be immediately apparent. This article reviews the evidence for a relationship between organic sleep disorders and psychiatric morbidity. Generally, it can be concluded that organic sleep disorders have a profound negative impact on most domains of health-related quality of life. Results for the sleep disorders that have been studied (narcolepsy idiopathic hypersomnia, sleep apnea/hypopnea syndrome, restless legs syndrome, periodic limb movement disorder, and circadian sleep disorders) show strong evidence

2005 Dialogues in Clinical Neuroscience

3005. Characteristics of Sleep Patterns in Young Adults With and Without Insomnia

, antianxiety medications or medications for sleep disorders Currently experiencing symptoms of psychiatric disorders such as major depressive disorder, bipolar disorder, generalized anxiety disorder Significant or unstable acute or chronic medical conditions, such as seizure disorder, tumor, liver disease, active peptic ulcer disease, arthritis, irritable bowel disease Meets DSM-IV criteria for sleep apnea or periodic limb movement disorder Contacts and Locations Go to Information from the National Library (...) treatment. Secondary Outcome Measures : Change in PSG Sleep Efficiency for the Second Night in the Sleep Lab at Each Timepoint [ Time Frame: post treatment minus baseline PSG sleep studies. This averaged 70 days ] Change in PSG Sleep Efficiency (SE) between post-treatment and baseline: Sleep efficiency is the percent of time spent asleep divided by the total sleep recording period in the sleep lab. This value is calculated using the results of the polysomnographic sleep study. It ranges from 0 (no sleep

2005 Clinical Trials

3006. Prosthetic Components and Stability in Amputee Gait

of wearing a rigid pylon and after a one-month period of wearing a transverse plane rotation adaptor (within-subject comparison). In addition to these field measurements, we will also compare the distance traveled during a six-minute walk. Patient opinions about their prosthesis and mobility measures over long periods of time can play a significant role in prosthesis evaluation. For veteran amputees who experience discomfort and increased risk for residual limb skin problems, it seems reasonable (...) of prosthetic components to facilitate transverse plane movement. The clinical impact of this investigation is the development of interventions that increase functional mobility, stability and safety while turning. The researchers propose to investigate three sets of hypotheses. The first set addresses the fundamental biomechanical mechanisms associated with walking along a circular trajectory, how intact subjects differ from amputees, and the effect of a rotation adaptor pylon. The second set of hypotheses

2005 Clinical Trials

3007. Testing the Nocturnal Sleep Latency Profile in Primary Insomnia

. After a 2-week baseline period, the subjects undergo a screening sleep study to rule out sleep apnea and periodic limb movement disorder. Then they undergo the NSLP procedure. In that procedure, there pre-bedtime EEG recordings and questionnaire responses taken. Then at a planned time, the subjects go to bed and try to sleep while there EEG signals are recorded. After the first and second sleep cycles, they are awakened for one minute, then asked to return to sleep. In the morning additional

2005 Clinical Trials

3008. Gait Adaptations to Passive Dynamic Ankle-Foot Orthosis Use

function by providing natural support to the lower limb as it progresses over the stance foot. However, a fundamental design characteristic of all PD-AFOs is that they are not capable of replicating all dynamic characteristics of the natural ankle complex. As a result, the efficient use of PD-AFOs during gait requires the wearer to develop an adapted, lower limb movement control strategy that effectively optimizes positive PD-AFO characteristics while compensating for characteristics detrimental (...) pictures of their legs, a procedure lasting up to 2 hours. Patients will be asked to return to learn how to walk with the custom Passive Dynamic Ankle-Foot Orthosis (PD-AFO)-a unique ankle brace designed to improve walking ability by providing natural support to the lower limb. Patients 4 and older who are in good health and able to walk repeatedly a distance of 15 meters (approximately 49 feet) independently and unsupervised may be eligible for this study. With this training, patients may return

2005 Clinical Trials

3009. Using Behavioral Programs to Treat Sleep Problems in Individuals With Alzheimer's Disease

in a residential home with a family member caregiver Able to walk without assistance Exclusion Criteria for Alzheimer's Disease Patients: Pre-existing diagnosis of a primary sleep disorder, such as sleep apnea or periodic limb movement disorder Blindness Current use of photosensitizing medication Inclusion Criteria for Family Caregiver: Currently caring for a family member with Alzheimer's disease Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you (...) disturbance education. Walking program participants will have three 1-hour visits with a therapist over an 8-week period. The therapist and the participant will set an initial daily walking goal and develop a plan for gradually increasing the participants' walking to 30 minutes/day, to be increased at a participant-selected pace. Pedometers will be given to participants to monitor daily activity. The therapist will also discuss exercise safety and will review ways to prevent muscle soreness. Light program

2005 Clinical Trials

3010. Provigil (Modafinil) Study by Taiwan Biotech Co.

, or suspected long sleeper. Patients with concomitant neurological disorder and psychiatric disorders. Patients with sleep-related breathing disorders whose apnea/hypopnea index (AHI) was 5 pauses per hour above. Patients with Restless Leg Syndrome & Periodic Limbs Movements whose index was more than 5 per hour. Patients who are pregnant or breast-feeding. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study

2005 Clinical Trials

3011. Assess Efficacy and Safety of the Dopamine Agonist Pramipexole Versus Levodopa / Benserazide (Madopar® DR) in Patients With Restless Legs Syndrome

Per Day) Versus Levodopa / Benserazide (Madopar® DR, 125-375 mg Per Day) in Patients With Restless Legs Syndrome Study Start Date : February 2003 Actual Primary Completion Date : February 2005 Study Completion Date : February 2005 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Outcome Measures Go to Primary Outcome Measures : Frequency of periodic limb movements while in bed (PLM-I) [ Time Frame: after 4 weeks (...) with idiopathic restless legs syndrome fulfilling the International Diagnostic Criteria. The efficacy parameters include an objective measure of the leg movements during the time spent in bed, and a quantitative clinical assessment of the severity of RLS, in the form of the RLS-score. In addition, the efficacy evaluations aim at comparing the impact of pramipexole and levodopa on outcome measures such as quality of life and sleep. Condition or disease Intervention/treatment Phase Restless Legs Syndrome Drug

2005 Clinical Trials

3012. Nightmares: from anxiety symptom to sleep disorder. (Abstract)

tend to underestimate nightmare frequency, and persons with frequent nightmares may feel reluctant to fill out (daily) prospective measurements. For studying nightmares, it is necessary to distinguish idiopathic nightmares from posttraumatic nightmares, which are part of a posttraumatic stress reaction or disorder that may result from experiencing a traumatic event. Both types of nightmares have been associated with an elevated level of periodic limb movements, although only posttraumatic

2006 Sleep medicine reviews

3013. Machines to support motor rehabilitation after stroke: 10 years of experience in Berlin. (Abstract)

Machines to support motor rehabilitation after stroke: 10 years of experience in Berlin. The group at Klinik Berlin/Charite University Hospital in Berlin, Germany, began studies to promote motor recovery after stroke in the early 1990s. Following the introduction of treadmill training with partial body-weight support, the group designed an electromechanical gait trainer, GT I, based on movable foot plates that relieve therapist effort (e.g., when assisting the movement of the paretic limbs (...) with severe arm paresis (n = 44) had significantly more upper-limb muscle strength and control at the end of the 6-week intervention period and at follow-up. The laboratory's most recent and cost-effective development, the Nudelholz, is a purely mechanical device that bilaterally trains the shoulder, elbow, and wrist joints. It is intended for home therapy.

2006 Journal of rehabilitation research and development

3014. Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia. (Abstract)

) as well as delusions, hallucinations, agitation/aggression, anxiety, and irritability/lability, whereas MMSE scores were unchanged. PSG revealed increases in total sleep time, sleep efficiency, stage 2 sleep, and decreases in the number of arousals and periodic limb movements. Subjective sleep quality was also improved. No adverse effects were observed.YGS was effective for BPSD and sleep disturbances, and well tolerated in patients with dementia. Further examinations using a double-blind placebo

2008 Progress in neuro-psychopharmacology & biological psychiatry

3015. Rheumatic Fever

important. In hot countries, skin infection is a more important source of streptococci than pharyngitis. Young age is a risk factor [ ] . Presentation [ ] Symptoms appear between one and five weeks after a sore throat, with an average of three weeks. In recurrent cases this incubation period is shorter, in keeping with a faster immune response. The diagnosis is based on major and minor criteria. In the acute disease the arthritis and toxicity are obvious but it can be more insidious with mild carditis (...) infection (eg, history of scarlet fever, positive throat swab or rising or increased antistreptolysin O titre (ASOT) >200 U/mL or DNase B titre). Plus two major criteria; or One major and two minor criteria. Definitions of these criteria are set out below. Major criteria Arthritis: The most obvious presenting feature is a flitting or migratory arthritis affecting large joints like the knees, ankles, wrists and elbows. The joints are hot and red with decreased range of movement. Typically, one joint

2008 Mentor

3016. Rett Syndrome

as a consequence of altered autonomic control. Secondary vascular changes in the long-term lead to abiotrophic changes in the lower limb and feet. Stage 3 - stationary or pseudostationary phase Typically aged 2-10 years. There may be an improvement in behaviour, use of the hands and communication skills. Eye contact returns and non-verbal communication may be exploited. There is persisting intellectual impairment with stereotyped hand movements. Generalised rigidity, bruxism and movements of the tongue may (...) deterioration or regression Typically age 1-4 years. May be a sudden onset of deterioration with an identifiable day when things changed; however, it may be a more subtle onset and progression in some cases. Early growth restriction may be noted in falling off of head circumference from growth curve. There are autism-like behaviours with loss of verbal and other communication, hand use and social interaction. There are abnormalities of hand movements when the patient is awake, with the hands usually held

2008 Mentor

3017. Restless Legs Syndrome

cannot be accounted for as symptoms primary to another medical or a behavioural condition. Examples given in the criteria are myalgia, venous stasis, leg oedema, arthritis, leg cramps, positional discomfort, or habitual foot tapping. Supportive criteria: Positive response to dopaminergic treatment. Periodic limb movements during wakefulness or sleep. Positive family history of RLS amongst first-degree relatives. Lack of profound daytime sleepiness. Clinical course may be: Chronic-persistent (...) with iron deficiency. Renal function: RLS may be associated with end-stage chronic kidney disease. Other investigations for underlying possible cause include fasting blood glucose, magnesium, TSH, vitamin B12 and folate. If the neurological examination suggests an associated peripheral neuropathy or radiculopathy, electromyography and nerve conduction studies should be undertaken. Associated disorders Periodic limb movement disorder (PLMD) [ ] PLMD is a disorder characterised by periodic episodes

2008 Mentor

3018. Snake Bites

, an affected limb should be immobilised. In Australia most of the venomous snakes are systemically neurotoxic. [ ] Where a venomous snake other than an adder is thought to have been involved (or snake not identified) the first aim is to prevent the snake venom from being systemically absorbed. In such cases a pressure immobilisation (PIM) bandage including a splint to reduce movement should be applied to the affected limb as soon as possible following the bite. The wound should not be cleaned prior (...) ). Mark the site of the bite on the outside of the bandage to allow a small window to be cut in the bandage for venom swabs to be taken. Apply a splint to immobilise the limb; transport the patient to the nearest accident and emergency department. Keep movement to a minimum. For bites to the head neck and torso, local pressure should be applied. Hospital care In the UK, experience of treating snake bites is likely to be limited. Patients should be resuscitated and monitored appropriately in the normal

2008 Mentor

3019. Shoulder Pain

suggests a significant tear of the acromioclavicular ligament . Acromioclavicular osteoarthritis may cause subacromial impingement. Referred neck pain See also separate article . Typically, this presents with pain and tenderness of the lower neck and suprascapular area, with pain referred to the shoulder and upper arm. There may be a restriction of shoulder movement and movement of the neck and shoulder may reproduce more generalised upper back, neck and shoulder pain. There may also be upper limb (...) cuff tendon. [ ] Epidemiology [ ] Shoulder pain is the third most common cause of musculoskeletal consultation in primary care. 1% of adults with new shoulder pain consult their GP each year. Self-reported prevalence of shoulder pain is between 16% and 26%. Risk factors Physical factors related to occupation including repetitive movements and exposure to vibration from machine tools. [ ] Psychosocial factors related to work may also be risk factors for shoulder pain, including stress, job pressure

2008 Mentor

3020. Insomnia Full Text available with Trip Pro

, sleepwalking, sleep talking, limb movement disorders, . . Stress Situational stress: Relationships Financial problems Academic stress Job-related stress Medical worries Noise stress Psychiatric comorbidity and . . . . Paranoia and . Medication and substance abuse Alcohol. Caffeine. Recreational drugs. Nicotine. Drug withdrawal - eg, hypnotics, alcohol (reduces the time to onset of sleep, but disrupts it later in the night). Chronic benzodiazepine misuse. Some antidepressants, especially selective serotonin (...) identify sleep trends or predominant sleep patterns. Sleep diaries can be used as a starting point for managing insomnia and for monitoring progress. An example of a sleep diary is available on the American Academy of Sleep Medicine website. [ ] Polysomnography (overnight sleep study): this measures brain and muscle activity and assesses oxygen saturation overnight. It can be used to confirm sleep apnoea and limb movement disorders or restless legs syndrome. Management Treatment is appropriate when

2008 Mentor

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