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Periodic Limb Movement

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1. Periodic limb movement disorder

Periodic limb movement disorder Periodic limb movement disorder - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Periodic limb movement disorder Last reviewed: February 2019 Last updated: March 2018 Summary Defined as a periodic limb movements of sleep index (PLMS-I) of 5 or more that is associated with disturbed sleep and excessive daytime sleepiness. The diagnosis is confirmed by polysomnography, and other causes (...) of sleep-wake disturbance must be excluded. The PLMS-I is used to determine the frequency of periodic limb movements of sleep (PLMS) and is calculated as the number of PLMS per total hours of sleep time. PLMS are repetitive limb movements (mostly of the legs), occurring mainly during non-rapid eye movement (non-REM) sleep; they are characterised by dorsiflexion of the toes and ankles and occasionally flexion of the hip and knee. PLMS may arise in normal individuals, and their clinical significance

2018 BMJ Best Practice

2. The level of observed physical movement accompanying periodic limb movements measured in a clinical sleep population (Full text)

The level of observed physical movement accompanying periodic limb movements measured in a clinical sleep population Periodic limb movements (PLMs) are routinely measured during polysomnogram (PSG) testing. During the early years of sleep testing, physical movements were identified and over time, consensus ultimately led to the current definitions of movement disorders including criteria used to measure PLMs on PSG testing. There has been considerable debate about the clinical importance (...) of the PLMs measured during PSG testing. Over the last decade, the author has observed significant variations in the actual visible physical movements observed with a PLM event. This report is the result of work to quantify the amount of movement and the frequency of movements observed among individuals who have PLMs.Consecutive PSGs performed in a suburban sleep center for an initial diagnosis of a sleep disorder were retrospectively reviewed to identify those with measured PLMs. Of 646 studies

2018 Nature and science of sleep PubMed

3. The efficacy and tolerability of rotigotine on patients with periodic limb movement in sleep: A systematic review and meta-analysis. (Full text)

The efficacy and tolerability of rotigotine on patients with periodic limb movement in sleep: A systematic review and meta-analysis. There is still no consensus on the treatment for periodic limb movement in sleep (PLMS). This study aimed to determine the efficacy and tolerability of rotigotine in patients suffering from PLMS.Publications listed in PubMed, ScienceDirect, The Cochrane Library, and ClinicalTrials.gov were reviewed to assess the efficacy of rotigotine on PLMS. Analyses of PLMS (...) participants receiving rotigotine and 70 participants receiving a placebo were available from an additional three articles. In the pre- and post-intervention studies, the periodic limb movement index was significantly decreased after therapy with rotigotine with a difference in means of -5.866/h (95% CI, -10.570 to -1.162, p = 0.015). In comparison with the placebo, the use of rotigotine significantly lowered the periodic limb movement index, with a difference in means of -32.105/h (95% CI, -42.539

2018 PLoS ONE PubMed

4. Periodic limb movements during sleep in stroke/TIA: Prevalence, course, and cardiovascular burden. (PubMed)

Periodic limb movements during sleep in stroke/TIA: Prevalence, course, and cardiovascular burden. To define the prevalence, time course, and associated factors of periodic limb movements during sleep (PLMS) in patients with ischemic stroke or TIA.Patients enrolled in the prospective Sleep-Disordered Breathing in Transient Ischemia Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy (SAS-CARE) study underwent a double polysomnographic investigation

2018 Neurology

5. Periodic Limb Movement and Genetic Generalized Epilepsy

Periodic Limb Movement and Genetic Generalized Epilepsy Periodic Limb Movement and Genetic Generalized Epilepsy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Periodic Limb Movement and Genetic Generalized (...) Study Description Go to Brief Summary: The study aimed to study the correlation between periodic limb movement occurring during sleep and the different parameters of genetic generalized epilepsy Condition or disease Epilepsy Generalized Idiopathic Not Intractable Detailed Description: Although periodic limb movements are prevalent among patients with epilepsy, the exact relationship between these movements and epilepsy remains elusive. Objective: The aim of this work was to study the periodic limb

2018 Clinical Trials

6. Effect of Adaptive Servo-Ventilation on Periodic Limb Movements in Sleep in Patients With Heart Failure. (PubMed)

Effect of Adaptive Servo-Ventilation on Periodic Limb Movements in Sleep in Patients With Heart Failure. Periodic limb movements in sleep (PLMS) are associated with adverse outcomes in patients with heart failure (HF). The aim of this study was to investigate whether PLMS change in response to adaptive servo-ventilation (ASV) for central sleep apnea (CSA) in patients with HF. We examined polysomnographic studies conducted between 2010 and 2014 at Mayo Clinic, Rochester, Minnesota (n = 14,444

2018 American Journal of Cardiology

7. The influence of antidepressants on restless legs syndrome and periodic limb movements: A systematic review. (PubMed)

The influence of antidepressants on restless legs syndrome and periodic limb movements: A systematic review. Restless legs syndrome is commonly co-morbid with medical conditions that are treated with antidepressant medications, such as depression, anxiety, fibromyalgia, and chronic insomnia disorder. Evidence from case reports and cross-sectional studies suggests that antidepressants may induce or worsen restless legs syndrome and increase periodic limb movements. We undertook a systematic (...) review of the literature to identify and collate all prospective studies that measured restless legs syndrome symptoms and/or periodic limb movements following the introduction of an antidepressant. Eighteen studies were eligible for inclusion. Current data indicate that onset or exacerbation of restless legs syndrome and rise in frequency of periodic limb movements are uncommon following the initiation of an antidepressant. Among the various antidepressants, mirtazapine may be associated with higher

2017 Sleep medicine reviews

8. Periodic limb movement in sleep and sickle cell disease: a neglected association? (Full text)

Periodic limb movement in sleep and sickle cell disease: a neglected association? High frequency of periodic limb movements in sleep (PLMS) has been described among children with sickle cell disease (SCD), but there is little information about PLMS among adults with SCD. We aim to determine the frequency of PLMS among adults with SCD and to identify possible associations with iron status and haemolytic parameters. We analysed polysomnography on 99 adults: 74 with sickle cell anaemia (HbSS), 19

2017 British journal of haematology PubMed

9. Periodic limb movements of sleep are associated with an increased prevalence of atrial fibrillation in patients with mild sleep-disordered breathing. (PubMed)

Periodic limb movements of sleep are associated with an increased prevalence of atrial fibrillation in patients with mild sleep-disordered breathing. Growing evidence indicates that periodic limb movements of sleep (PLMS) may be related to increased risk of developing cardiovascular disease. However, the association of PLMS with atrial fibrillation (AF) is unclear, especially in patients with sleep-disordered breathing (SDB). This study sought to investigate whether PLMS were associated (...) with increased AF prevalence, independent of established risk factors.We performed a cross-sectional study of patients who underwent attended polysomnography at Mayo Clinic from 2011 to 2014. The association of PLMS with AF prevalence was estimated by using logistic regression models.15,414 patients were studied, 76.3% of individuals with SDB defined by apnea-hypopnea index (AHI) ≥5/h, and 15.3% with a diagnosis of AF. In univariate logistic modelling, individuals with periodic limb movement index (PLMI) ≥30

2017 International journal of cardiology

10. Incident Cardiovascular Events and Death in Individuals with Restless Legs Syndrome or Periodic Limb Movements in Sleep: A Systematic Review. (Full text)

Incident Cardiovascular Events and Death in Individuals with Restless Legs Syndrome or Periodic Limb Movements in Sleep: A Systematic Review. To systematically review the current evidence examining restless legs syndrome (RLS) and periodic limb movements in sleep (PLMS) as prognostic factors for all-cause mortality and incident cardiovascular events (CVE) in longitudinal studies published in the adult population.All English language studies (from 1947 to 2016) found through Medline and Embase (...) , as well as bibliographies of identified articles, were considered eligible. Quality was evaluated using published guidelines.Among 18 cohorts (reported in 13 manuscripts), 15 evaluated the association between RLS and incident CVE and/or all-cause mortality and 3 between PLMS and CVE and mortality. The follow-up periods ranged from 2 to 20 years. A significant relationship between RLS and CVE was reported in four cohorts with a greater risk suggested for severe RLS with longer duration and secondary

2017 Sleep PubMed

11. Periodic limb movements in sleep are followed by increases in EEG activity, blood pressure, and heart rate during sleep (Full text)

Periodic limb movements in sleep are followed by increases in EEG activity, blood pressure, and heart rate during sleep Periodic limb movements in sleep (PLMS) are related to arousal, sympathetic activation, and increases in blood pressure (BP), but whether they are part of the arousal process or causative of it is unclear. Our objective was to assess the temporal distribution of arousal-related measures around PLMS.Polysomnographic recordings of six patients with restless legs syndrome were (...) analyzed. We analyzed 15 PLMS, plus three 5-s epochs before and after each movement, for every patient. Mean values per epoch of blood pressure (BP), heart rate (HR), and electroencephalographic (EEG) power were calculated. For each patient, six 5-s epochs of undisturbed sleep were analyzed as controls.Alpha + beta EEG power, systolic BP, and HR were significantly increased following PLMS. The EEG power and HR increases were noticed in the first epoch after PLMS, whereas that of systolic BP

2017 Sleep & breathing = Schlaf & Atmung PubMed

12. Periodic Limb Movements in Sleep is Associated with Increased Mortality (Full text)

Periodic Limb Movements in Sleep is Associated with Increased Mortality To elucidate the association between periodic limb movements in sleep (PLMS) and mortality.Nocturnal polysomnographic recordings of 1,344 subjects obtained from 1995 to 2008 were reviewed. The subjects were divided into four groups based on PLMS and insomnia: reference group (PLMS≤5), insomnia group (PLMS≤5 with insomnia symptoms), 515 group. We searched each subject's Identification Number

2017 Psychiatry investigation PubMed

13. The effects of periodic limb movements in sleep (PLMS) on cardiovascular disease. (PubMed)

The effects of periodic limb movements in sleep (PLMS) on cardiovascular disease. Periodic limb movements in sleep (PLMS) are uncontrollable nocturnal movements that occur during sleep and increase with age. Research has implicated PLMS as a contributing factor to the development of cardiovascular disease (CVD). The purpose of this manuscript is to 1) explain the sleep disorder of PLMS and implications on CVD; 2) identify the impact of PLMS on CVD; 3) discuss treatment options for PLMS; 4

2017 Heart & Lung

14. Significant association between systolic and diastolic blood pressure elevations and periodic limb movements in patients with idiopathic restless legs syndrome. (PubMed)

Significant association between systolic and diastolic blood pressure elevations and periodic limb movements in patients with idiopathic restless legs syndrome. A new and unique methodology was developed to evaluate the association between periodic limb movements (PLMs) and nocturnal blood pressure (BP) excursions in patients with restless legs syndrome (RLS).All data were collected at baseline of the ENCORE (Effects of Neupro on Cardiovascular Observations in Patients with Restless Legs

2016 Sleep medicine

15. Sleep architecture alterations in patients with periodic limb movements disorder during sleep and sleep breathing disorders (Full text)

Sleep architecture alterations in patients with periodic limb movements disorder during sleep and sleep breathing disorders Sleep movement disorders includes mainly periodic limb movement and others. The more frequent breathing disorders are: obstructive sleep apnea-hypopnea syndrome and primary snoring.To compare sleep architecture in periodic limb movements and breathing disorders of different severity, and weight their interactions.We compared sleep architecture in 160 patients, divided (...) in six groups: periodic limb movements (n=25), obstructive apnea only (n=30), periodic limb movements/snoring (n=30), periodic limb movements/mild apnea (n=25), periodic limb movements/moderate apnea (n=25), periodic limb movements/severe apnea (n=26). Polysomnographic variables were compared by analysis of variance and Tukey test.We observed an increase of percentage of awakenings in the group with periodic limb movements/severe apnea. We found an increase of percentage of light sleep in the group

2016 Sleep science PubMed

16. Periodic limb movements of sleep: empirical and theoretical evidence supporting objective at-home monitoring (Full text)

Periodic limb movements of sleep: empirical and theoretical evidence supporting objective at-home monitoring Periodic limb movements of sleep (PLMS) may increase cardiovascular and cerebrovascular morbidity. However, most people with PLMS are either asymptomatic or have nonspecific symptoms. Therefore, predicting elevated PLMS in the absence of restless legs syndrome remains an important clinical challenge.We undertook a retrospective analysis of demographic data, subjective symptoms (...) , and objective polysomnography (PSG) findings in a clinical cohort with or without obstructive sleep apnea (OSA) from our laboratory (n=443 with OSA, n=209 without OSA). Correlation analysis and regression modeling were performed to determine predictors of periodic limb movement index (PLMI). Markov decision analysis with TreeAge software compared strategies to detect PLMS: in-laboratory PSG, at-home testing, and a clinical prediction tool based on the regression analysis.Elevated PLMI values (>15 per hour

2016 Nature and science of sleep PubMed

17. Prevalence and Characteristics of Periodic Limb Movements during Sleep in Korean Adult Patients with Restless Legs Syndrome (Full text)

Prevalence and Characteristics of Periodic Limb Movements during Sleep in Korean Adult Patients with Restless Legs Syndrome The aim of this study was to investigate the prevalence and characteristics of periodic limb movements during sleep (PLMS) in Korean patients with restless legs syndrome (RLS).Unmedicated adult patients with idiopathic RLS (n = 354) who underwent polysomnography at three major sleep centers in tertiary hospitals were included. Characteristics of PLMS in RLS were analyzed (...) events/h). The PLMS index was positively correlated with age (r = 0.228; p < 0.001), the periodic limb movements in wakefulness index (r = 0.455, p < 0.001) and arousal index (r = 0.174, p = 0.014), but not with RLS severity and parameters of sleep quality. In multivariate analysis, age and male gender were independently associated with PLMS > 15 events/h.The prevalence of PLMS in Korean patients with RLS was lower than that observed in Western countries, but the characteristics of PLMS were

2016 Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine PubMed

18. The Comparisons of Cerebral Hemodynamics Induced by Obstructive Sleep Apnea with Arousal and Periodic Limb Movement with Arousal: A Pilot NIRS Study (Full text)

The Comparisons of Cerebral Hemodynamics Induced by Obstructive Sleep Apnea with Arousal and Periodic Limb Movement with Arousal: A Pilot NIRS Study Obstructive sleep apnea syndrome (OSA) and restless legs syndrome (RLS) with periodic limb movement during sleep (PLMS) are two sleep disorders characterized by repetitive respiratory or movement events associated with cortical arousals. We compared the cerebral hemodynamic changes linked to periodic apneas/hypopneas with arousals (AHA) in four OSA (...) -patients with periodic limb movements (PLMA) with arousals in four patients with RLS-PLMS using near-infrared spectroscopy (NIRS). AHA induced homogenous pattern of periodic fluctuations in oxygenated (HbO2) and deoxygenated (HHb) hemoglobin, i.e., the decrease of HbO2 was accompanied by an increase of HHb during the respiratory event and resolved to reverse pattern when cortical arousal started. Blood volume (BV) showed the same pattern as HHb but with relative smaller amplitude in most of the AHA

2016 Frontiers in neuroscience PubMed

19. Longitudinal Relationships of Periodic Limb Movements During Sleep and Incident Atrial Fibrillation (Full text)

Longitudinal Relationships of Periodic Limb Movements During Sleep and Incident Atrial Fibrillation This study aimed to examine relationship between periodic limb movements during sleep (PLMS) and incident atrial fibrillation/flutter (AF).Prospective multicenter cohort (n = 2273: adjudicated AF group; n = 843: self-reported AF group) of community-dwelling men without prevalent AF were followed for an average of 8.3 years (adjudicated) and 6.5 years (self-reported). PLMS index (PLMI, <5 (ref

2016 Sleep medicine PubMed

20. Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia (Full text)

Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia To examine the association between periodic limb movements in sleep (PLMS) and change in selected aspects of cognition in community-dwelling older men.We studied 2,636 older men without dementia who underwent in-home polysomnography with measurement of the periodic limb movement index (PLMI) and periodic limb movement arousal index (PLMAI) using piezoelectric sensors. Random-effects

2016 Sleep PubMed

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