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Perinatal Hepatitis C Exposure

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1. Perinatal Hepatitis C Exposure

Perinatal Hepatitis C Exposure Perinatal Hepatitis C Exposure Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Perinatal Hepatitis C (...) Exposure Perinatal Hepatitis C Exposure Aka: Perinatal Hepatitis C Exposure , Infants born to Mothers with Hepatitis C , HCV Vertical Transmission II. Indications: Screening in pregnant women See for risk factors III. Pathophysiology Vertical transmission Risk Mother HCV Ab positive and HCV RNA negative: 1.7% vertical transmission rate of HCV Mother HCV Ab Positive and HCV RNA positive: 4.3% vertical transmission rate of HCV Mother HCV Ab Positive and Comorbid HIV positive: 19.4% vertical transmission

2018 FP Notebook

2. Public health guidance on HIV, hepatitis B and C testing in the EU/EEA

prevention interventions, such as behavioural advice, harm reduction services, HBV vaccination and HIV pre- and post-exposure prophylaxis (PrEP and PEP). In addition, through partner notification and/or contact tracing, testing can be offered to a diagnosed individual’s sexual partners, injecting partners and, for HBV, household contacts (Section 4.5). SCIENTIFIC ADVICE Public health guidance on HIV, hepatitis B and C testing in the EU/EEA – An integrated approach 7 2.4 Diagnostics for HBV, HCV and HIV (...) Public health guidance on HIV, hepatitis B and C testing in the EU/EEA SCIENTIFIC AD VICE www.ecdc.europa.eu Public health guidance on HIV, hepatitis B and C testing in the EU/EEA An integrated approachECDC SCIENTIFIC ADVICE Public health guidance on HIV, hepatitis B and C testing in the EU/EEA An integrated approach ii This guidance was commissioned by the European Centre for Disease Prevention and Control (ECDC), coordinated by Andrew J Amato-Gauci and Lara Tavoschi with the support of Helena

2019 European Centre for Disease Prevention and Control - Public Health Guidance

3. Impact of perinatal exposure to sucrose or high fructose corn syrup (HFCS‐55) on adiposity and hepatic lipid composition in rat offspring Full Text available with Trip Pro

Impact of perinatal exposure to sucrose or high fructose corn syrup (HFCS‐55) on adiposity and hepatic lipid composition in rat offspring Fructose-containing sugars, including sucrose and high fructose corn syrup (HFCS), have been implicated in the epidemics of obesity and type 2 diabetes. Few studies have evaluated the impact of perinatal exposure to these sugars on metabolic and physiological outcomes in the offspring. Using a rat model, offspring exposed to a maternal sucrose or HFCS diet (...) ) during the prenatal and/or suckling periods on offspring at 3 and 12 weeks, utilising a cross-fostering approach in a rodent model. Perinatal sucrose exposure decreased plasma glucose concentrations in offspring at 3 weeks, but did not alter glucose tolerance. Increased adiposity was observed in 3-week-old offspring exposed to sucrose or HFCS-55 during suckling, with increased hepatic fat content in HFCS-55-exposed offspring. In terms of specific fatty acids, hepatic monounsaturated (omega-7 and -9

2017 The Journal of physiology

4. Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease Full Text available with Trip Pro

Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease Exposure to chemicals during critical windows of development may re-program liver for increased risk of nonalcoholic fatty liver disease (NAFLD). Bisphenol A (BPA), a plastics component, has been described to impart adverse effects during gestational and lactational exposure. Our work has pointed to nuclear factor E2-related factor 2 (Nrf2 (...) ) being a modulator of hepatic lipid accumulation in models of NAFLD.To determine if chemical exposure can prime liver for steatosis via modulation of NRF2 and epigenetic mechanisms.Utilizing BPA as a model exposure, pregnant CD-1 mice were administered 25μg/kg/day BPA via osmotic minipumps from gestational day 8 through postnatal day (PND)16. The offspring were weaned on PND21 and exposed to same dose of BPA via their drinking water through PND35. Tissues were collected from pups at week 5 (W5

2017 Environmental health perspectives

5. AASLD-IDSA Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection

for recommended weight-based dosages. Table 6. Recommendations for Hepatitis C Virus (HCV) Testing of Perinatally Exposed Children and Siblings of HCV-infected Children Recommendation Rating All children born to HCV-infected women should be tested for HCV infection. Testing is recommended using an antibody-based test at or after 18 months of age. I, A Testing with an HCV RNA assay can be considered in the first year of life, but the optimal timing of such a test is unknown. IIa, C Repetitive testing by HCV (...) childhood activities without restrictions. I, B Parents should be informed that universal precautions should be followed at school and in the home of children with HCV infection. Educate family members and children about the risk and routes of HCV transmission and the techniques for avoiding blood exposure, such as avoiding the sharing of toothbrushes, razors, and nail clippers and the use of gloves and dilute bleach to clean up blood. I, B Abbreviation: HCV, hepatitis C virus. Table 8. Recommendations

2019 American Association for the Study of Liver Diseases

6. Maternal exposure to an environmentally relevant dose of triclocarban results in perinatal exposure and potential alterations in offspring development in the mouse model. Full Text available with Trip Pro

Maternal exposure to an environmentally relevant dose of triclocarban results in perinatal exposure and potential alterations in offspring development in the mouse model. Triclocarban (TCC) is among the top 10 most commonly detected wastewater contaminants in both concentration and frequency. Its presence in water, as well as its propensity to bioaccumulate, has raised numerous questions about potential endocrine and developmental effects. Here, we investigated whether exposure (...) alterations in genes involved in lipid metabolism in exposed female offspring, which was consistent with the observed increased fat pad weights and hepatic triglycerides. This study represents the first report to quantify the transfer of an environmentally relevant concentration of TCC from mother to offspring in the mouse model and evaluate bio-distribution after exposure using AMS. Our findings suggest that early-life exposure to TCC may interfere with lipid metabolism and could have implications

2017 PLoS ONE

7. Hepatitis C in pregnancy: screening, treatment, and management Full Text available with Trip Pro

-coinfected women.J Pediatr Infect Dis Soc2013;2:126-35. 26.Snijdewind IJM, Smit C, Schutten M, et al. Low mother-to-child- transmission rate of hepatitis C virus in cART treated HIV-1 infected mothers. J Clin Virol2015;68:11-5. 27.European Pediatric Hepatitis C Virus Network. A signi?cant sexebut not elective cesarean sectioneeffect on mother-to-child transmission of hepatitisC virus infection. J Infect Dis 2005;192:1872-9. 28.Mast EE, Hwang LY, Seto DS, et al. Risk factors for perinatal trans- missionof (...) Hepatitis C in pregnancy: screening, treatment, and management Hepatitis C in pregnancy: screening, treatment, and management Society for Maternal-Fetal Medicine (SMFM); Brenna L. Hughes, MD, MSc; Charlotte M. Page, MD; Jeffrey A. Kuller, MD TheAmerican College ofObstetricians and Gynecologists (ACOG) endorses this document. In the United States, 1-2.5% of pregnant women are infected with hepatitis C virus, which carries an approximately5

2017 Society for Maternal-Fetal Medicine

8. Hepatitis C Screening

Guideline | Hepatitis C Screening Household contacts of a person with HCV infection Recommendation 4 Where a household contact is a child who was born to an infected mother or a sexual contact of a HCV-infected person please refer to Recommendation 2 and Recommendation 13, respectively. 4.1 In general, HCV screening of household contacts (with no sexual or vertical exposure to the HCV positive household member) is not necessary due to the low risk of horizontal household transmission. However, there may (...) indicated, e.g. an unexplained rise in ALT, a diagnosis of a new STI, or if a risk exposure has occurred such as contact with a known case of HCV, or other risk behaviours including chemsex. Quality/level of evidence: moderate for HIV positive MSM; low for HIV negative MSM Strength of recommendation: strong ____________________________ 3 The use of recreational drugs for or during sex. 12 | Hepatitis C Screening | A National Clinical Guideline People attending for a sexual health screen Recommendation

2017 National Clinical Guidelines (Ireland)

9. Perinatal Pb2+ exposure alters the expression of genes related to the neurodevelopmental GABA-shift in postnatal rats Full Text available with Trip Pro

Perinatal Pb2+ exposure alters the expression of genes related to the neurodevelopmental GABA-shift in postnatal rats Lead (Pb2+) is an environmental neurotoxicant that disrupts neurodevelopment, communication, and organization through competition with Ca2+ signaling. How perinatal Pb2+ exposure affects Ca2+-related gene regulation remains unclear. However, Ca2+ activates the L-Type voltage sensitive calcium channel β-3 subunit (Ca-β3), which autoregulates neuronal excitability and plays a role (...) (qRT-PCR). The effects of perinatal Pb2+ exposure on genes related to early neuronal development and the GABA-shift were evaluated through the expression of: Ca-β3, GABAAR-β3, NKCC1, KCC2, and GAD 80, 86, 65, and 67 isoforms.Perinatal Pb2+ exposure significantly altered the GABA-shift neurodevelopmental GOI expression as a function of Pb2+ exposure and age across postnatal development. Dramatic changes were observed with Ca-β3 expression consistent with a Pb2+ competition with L-type calcium

2018 Journal of biomedical science

10. Exposure to Traffic-Related Air Pollution and Perinatal Health

Exposure to Traffic-Related Air Pollution and Perinatal Health APRIL 2014 Exposure to Traffic-Related Air Pollution and Perinatal Health T Jason Curran 1 Summary • The period between conception and early childhood when vital organs are forming and rapidly developing is the most vulnerable of life stages to the effects of toxic environment exposures, including traffic-related air pollution (TRAP). • Epidemiologic studies on preterm birth have consistently shown elevated risks with a number (...) of measures of TRAP, including distance of residence from traffic corridors, traffic volume, air pollution surrogates, particularly PM 2.5 , and modeled estimates. • Fetal exposure to traffic-related pollutants is not consistently associated with indicators of fetal growth, including low birth weight, small for gestational age, and intrauterine growth restriction. • There is very limited evidence of weak associations between TRAP and perinatal mortality and congenital abnormalities. • Further research

2014 National Collaborating Centre for Environmental Health

11. Hepatitis B and C testing: people at risk of infection

infectious disease and the Hepatitis B antenatal screening and newborn immunisation programme, both published by the Department of Health, and in the NICE guidance on Reducing the differences in the uptake of immunisations. Whose health will benefit? In the UK, the majority (95%) of new chronic hepatitis B infections occur in migrant populations, having been acquired perinatally in the country of birth. In contrast, approximately 90% of chronic hepatitis C infections are seen in people who inject drugs (...) and alcohol services, prisons) exposure category, if provided the number of people testing positive: for hepatitis B, this should include acute, chronic and past infection for hepatitis C, this should include PCR positive/current and PCR negative/ resolved. [1] NICE has accredited the process used by the British HIV Association to produce UK national guidelines. Accreditation is valid for 5 years from 12 July 2012 and is applicable to guidance produced since 2011. The NICE Accreditation Scheme recognises

2012 National Institute for Health and Clinical Excellence - Clinical Guidelines

12. Incorporating Recognition and Management of Perinatal Depression Into Pediatric Practice

, and family dysfunction. In a retrospective 1998 study of a large adult population, it was found that ACEs were common, which may point to high levels of resiliency present in childhood. Those with high levels of risk behaviors and disease as adults (eg, obesity, smoking, depression, suicidality) reported being exposed to multiple ACEs as children. Childhood exposure to household mental illness, such as perinatal depression, was 1 of the more common ACEs reported, and it was often associated with other (...) Incorporating Recognition and Management of Perinatal Depression Into Pediatric Practice Incorporating Recognition and Management of Perinatal Depression Into Pediatric Practice | From the American Academy of Pediatrics | Pediatrics '); document.write(''); } function OAS_AD(pos) { if (OAS_version >= 11 && typeof(OAS_RICH)!='undefined') { OAS_RICH(pos); } else { OAS_NORMAL(pos); } } //--> Search for this keyword Source User menu Sections Sign up for highlighting editor-chosen studies

2019 American Academy of Pediatrics

13. Epigenome-wide DNA Methylation Analysis Implicates Neuronal and Inflammatory Signaling Pathways in Adult Murine Hepatic Tumorigenesis following Perinatal Exposure to Bisphenol A Full Text available with Trip Pro

Epigenome-wide DNA Methylation Analysis Implicates Neuronal and Inflammatory Signaling Pathways in Adult Murine Hepatic Tumorigenesis following Perinatal Exposure to Bisphenol A Developmental exposure to the endocrine-active compound bisphenol A (BPA) has been linked to epigenotoxic and potential carcinogenic effects in rodent liver, prostate, and mammary glands. A dose-dependent increase in hepatic tumors in 10-month mice perinatally exposed to one of three doses of BPA (50 ng, 50 µg, or 50 mg (...) BPA/kg chow) was previously reported. These tumors represent early-onset disease and lack classical sexual dimorphism in incidence. Here, adult epigenome-wide liver DNA methylation profiles to identify gene promoters associated with perinatal BPA exposure and disease in 10-month mice with and without liver tumors were investigated. Mice with hepatic tumors showed 12,822 (1.8%) probes with differential methylation as compared with non-tumor animals, of which 8,656 (67.5%) were hypomethylated

2016 Environmental and molecular mutagenesis

14. Effects of perinatal exposure to nonylphenol on delivery outcomes of pregnant rats and inflammatory hepatic injury in newborn rats Full Text available with Trip Pro

Effects of perinatal exposure to nonylphenol on delivery outcomes of pregnant rats and inflammatory hepatic injury in newborn rats The current study aimed to investigate the effects of perinatal exposure to nonylphenol (NP) on delivery outcome of pregnant rats and subsequent inflammatory hepatic injury in newborn rats. The pregnant rats were divided into 2 groups: control group (corn oil) and NP exposure group. Thirty-four pregnant rats were administered NP or corn oil by gavage from the sixth (...) or cholesterol between the groups. Perinatal exposure to NP can interfere with the in vivo estrogen and progesterone levels of pregnant rats, resulting in threatened abortion, dystocia and other adverse delivery outcomes. High liver and serum NP levels of the newborn rats led to alteration of liver tissue structure and function. The NP-induced hepatotoxicity is probably mediated by inflammatory cytokines TNF-α and IL-1α.

2016 Brazilian Journal of Medical and Biological Research

15. Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease Full Text available with Trip Pro

Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease Essentially, all neonates are exposed to infections, antibiotics, or vaccines early in their lives. This is especially true for those neonates born underweight or premature. In contrast to septic adults and children who are at an increased risk for subsequent infections, exposure to infection during the neonatal period is not associated with an increased risk of subsequent (...) infection and may be paradoxically associated with reductions in late-onset sepsis (LOS) in the most premature infants. Perinatal inflammation is also associated with a decreased incidence of asthma and atopy later in life. Conversely, septic neonates are at increased risk of impaired long-term neurodevelopment. While the positive effects of antibiotics in the setting of infection are irrefutable, prolonged administration of broad-spectrum, empiric antibiotics in neonates without documented infection

2017 Frontiers in immunology

16. GENO PROTECTIVE AND ANTI-APOPTOTIC EFFECT OF GREEN TEA AGAINST PERINATAL LIPOPOLYSACCHARIDE-EXPOSURE INDUCED LIVER TOXICITY IN RAT NEWBORNS Full Text available with Trip Pro

GENO PROTECTIVE AND ANTI-APOPTOTIC EFFECT OF GREEN TEA AGAINST PERINATAL LIPOPOLYSACCHARIDE-EXPOSURE INDUCED LIVER TOXICITY IN RAT NEWBORNS This study aims to examine the protective effect of green tea on the disturbances in oxidative stress and apoptosis related factors, mostly produced due to perinatal lipopolysaccharide (LPS) exposure, that subsequently induces liver cell damage.Anti-free radical, Antioxidant, scavenging, geno-protective, and antiapoptotic activity of aqueous green tea (...) extract (AGTE) were assessed against LPS-induced hepatic dysfunction in newborn-rats. AGTE at doses of 100 & 200 mg/kg was orally administered daily to rat dams, during gestation and lactation.AGTE was observed to exhibit protective effects by significantly attenuating LPS-induced alterations in serum AST, ALT, bilirubin, and albumin levels. Significant increase in the total antioxidant capacity (TAC), DNA contents, and reduction in nitric oxide (NO) levels were observed in AGTE treated rats comparing

2017 African Journal of Traditional, Complementary, and Alternative Medicines

17. Cocaine Self-Administration in Male and Female Rats Perinatally Exposed to PCBs: Evaluating Drug Use in an Animal Model of Environmental Contaminant Exposure Full Text available with Trip Pro

Cocaine Self-Administration in Male and Female Rats Perinatally Exposed to PCBs: Evaluating Drug Use in an Animal Model of Environmental Contaminant Exposure Polychlorinated biphenyls (PCBs) are ubiquitous environmental toxicants known to adversely impact human health. Ortho-substituted PCBs affect the nervous system, including the brain dopaminergic system. The reinforcing effects of psychostimulants are typically modulated via the dopaminergic system, so this study used a preclinical (i.e (...) ., rodent) model to evaluate whether developmental contaminant exposure altered intravenous self-administration (IV SA) for the psychostimulant cocaine. Long-Evans rats were perinatally exposed to 6 or 3 mg/kg/day of PCBs throughout gestation and lactation and compared with nonexposed controls. Rats were trained to lever press for a food reinforcer in an operant chamber under a fixed-ratio 5 (FR5) schedule and later underwent jugular catheterization. Food reinforcers were switched for infusions of 250

2017 Experimental and clinical psychopharmacology

18. Guidelines for the screening, care and treatment of persons with chronic hepatitis C infection

inject drugs RAV resistance-associated variant RCT randomized controlled trial RNA ribonucleic acid RR relative risk SAE severe adverse event SVR sustained virological response TB tuberculosis WHO World Health Organization10 Anti-HCV antibody Presence of antibodies to hepatitis C virus (HCV) indicating history of exposure to HCV Chronic HCV Continued presence of HCV RNA in the blood six months or more after acquiring infection Delayed virological re- sponse More than 2 log reduction in HCV RNA viral (...) Guidelines for the screening, care and treatment of persons with chronic hepatitis C infection GUIDELINES FOR THE SCREENING, CARE AND TREATMENT OF PERSONS WITH CHRONIC HEPATITIS C INFECTION UPDATED VERSION APRIL 2016 GUIDELINESGUIDELINES FOR THE SCREENING, CARE AND TREATMENT OF PERSONS WITH CHRONIC HEPATITIS C INFECTION UPDATED VERSION APRIL 2016 GUIDELINESWHO Library Cataloguing-in-Publication Data Guidelines for the screening care and treatment of persons with chronic hepatitis C infection

2016 World Health Organisation Guidelines

19. Prenatal and Perinatal Human Immunodeficiency Virus Testing - Expanded Recommendations

by those organizations. The American College of Obstetricians and Gynecologists has neither solicited nor accepted any commercial involvement in the development of the content of this published product. INTERIM UPDATE: This Committee Opinion is updated as highlighted to reflect a limited, focused change in the language and evidence regarding opt-out testing, repeat testing, rapid testing, and hepatitis A testing. Prenatal and Perinatal Human Immunodeficiency Virus Testing ABSTRACT: Given the enormous (...) test results are positive, the patient should be given her results in person. The implications of HIV infection and the risks of vertical and horizontal transmission should be discussed with the patient. Additional laboratory work, including CD4 + count; HIV viral load; testing for antiretroviral resistance; hepatitis C virus antibody; hepatitis B surface antigen and viral load; and hepatitis A using antibody testing for immunoglobulin G for women who have hepatitis B virus infection and who have

2018 American College of Obstetricians and Gynecologists

20. Mental health care in the perinatal period: Australian clinical practice guideline

to provide specific advice on borderline personality disorder, bipolar disorder and schizophrenia and harms associated with pharmacological treatments (see Appendix A) and formal consultation with a wide range of experts, stakeholders and consumer representatives was undertaken. A systematic literature review, which identified and critically appraised the evidence, provided the basis for the Guideline (see Appendix C). Implementation and review As Australia’s peak body in perinatal mental health, COPE (...) of the systematic literature review and the public consultation process and provide copies of the tools used for psychosocial assessment and screening. Practice summaries are included in Parts B and C (Chapters 9 and 15). Part A – Background informationAustralian Clinical Practice Guideline | 16 1 Mental health conditions in the perinatal period 1.1 Understanding the woman’s context Every person has a right to health care that takes into consideration his or her individual social and emotional situation (UN

2018 Clinical Practice Guidelines Portal

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