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Peptic Ulcer Disease

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161. Effects of early oral feeding on relapse and symptoms of upper gastrointestinal bleeding in peptic ulcer disease. (PubMed)

Effects of early oral feeding on relapse and symptoms of upper gastrointestinal bleeding in peptic ulcer disease. Peptic ulcer is the most common cause of upper gastrointestinal bleeding (GIB) and nutritional support is a helpful strategy in malnutrition prevention during treatment. As early oral feeding in patients with GIB may shorten hospital stay and decrease costs and risk of infection, the present study was carried out to investigate the effects of early oral feeding on relapse (...) and symptoms of upper GIB.The present clinical trial was conducted with the participation of 100 patients with upper GIB due to gastric or duodenum ulcer at Emam Reza University Hospital in Tabriz. Subjects were randomly allocated to two groups (n=50). In one group, patients received oral diet from day 1 and in other group patients were nil by mouth until day 3 and then received oral diet. Endoscopic and clinical findings of patients were recorded from day 1 to 3.The mean age of subjects was 57.6±1.7

2013 Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

162. Laparoscopic repair for perforated peptic ulcer disease. (PubMed)

Laparoscopic repair for perforated peptic ulcer disease. Perforated peptic ulcer is a common abdominal disease that is treated by surgery. The development of laparoscopic surgery has changed the way to treat such abdominal surgical emergencies. The results of some clinical trials suggest that laparoscopic surgery could be a better strategy than open surgery in the correction of perforated peptic ulcer but the evidence is not strongly in favour for or against this intervention.To measure (...) the effect of laparoscopic surgical treatment versus open surgical treatment in patients with a diagnosis of perforated peptic ulcer in relation to abdominal septic complications, surgical wound infection, extra-abdominal complications, hospital length of stay and direct costs.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) on The Cochrane Library (2004, Issue 2), PubMed/MEDLINE (1966 to July 2004), EMBASE (1985 to November 2004) and LILACS (1988 to November 2004) as well

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2013 Cochrane database of systematic reviews (Online)

163. Peptic ulcer disease: one in five is related to neither Helicobacter pylori nor to aspirin/NSAID intake. (PubMed)

Peptic ulcer disease: one in five is related to neither Helicobacter pylori nor to aspirin/NSAID intake. The proportion (and even the reality) of peptic ulcer disease (PUD) not related to H. pylori or NSAID/aspirin is debated.To analyse the current epidemiological and clinical characteristics of peptic ulcer disease in French general hospitals.Prospective multicentre study of patients with peptic ulcer disease in 32 French general hospitals over 1 year. H. pylori status was assessed (...) infection; 133 (18.7%) only gastrotoxic drugs; 141 (19.8%) had both and 154 (21.6%) neither H. pylori infection nor gastrotoxic drug intake ('idiopathic ulcers'). Patients with idiopathic ulcers differed in many ways both from H. pylori and NSAID/aspirin groups. However, multivariate analysis identified only three independent predictors: age, French metropolitan origin and the presence of comorbidities.In a general hospital-based population in France, peptic ulcer disease appears idiopathic in a fifth

2013 Alimentary Pharmacology & Therapeutics

164. Doppler-guided Endoscopic Treatment in Peptic Ulcer Bleeding

Information provided by (Responsible Party): Stig Borbjerg Laursen, Odense University Hospital Study Details Study Description Go to Brief Summary: The present study is a randomized controlled trial (RCT) that examines if the outcome of peptic ulcer bleeding could be improved by use of doppler-guided endoscopic treatment. Condition or disease Intervention/treatment Phase Peptic Ulcer Bleeding Device: Supplementary endoscopy with doppler-guided therapy Drug: IV. PPI Other: Endoscopic treatment at primary (...) , PhD, Odense University Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: S-20130140 First Posted: May 6, 2015 Last Update Posted: April 20, 2017 Last Verified: April 2017 Additional relevant MeSH terms: Layout table for MeSH terms Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Stomach Diseases Gastrointestinal Hemorrhage

2014 Clinical Trials

165. Multicenter Validation on Predicting Mortality for Patients With Bleeding Peptic Ulcers

or disease Bleeding Peptic Ulcer Detailed Description: Despite advances in management of patients with bleeding peptic ulcers, mortality is still 10%. We previously reported a prediction score for ulcer bleeding related mortality developed from a local cohort. The risk factors for mortality included patients older than 70, presence of co-morbidity, more than one listed co-morbidity, hematemesis, SBP < 100 mmHg, in-hospital bleeding, rebleeding, and need for surgery. Study objective This study aimed (...) Multicenter Validation on Predicting Mortality for Patients With Bleeding Peptic Ulcers Multicenter Validation on Predicting Mortality for Patients With Bleeding Peptic Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2014 Clinical Trials

166. Argon Plasma Coagulation for Bleeding Peptic Ulcers

) patients with high-risk peptic ulcer bleeding. Exclusion Criteria: (i) the presence of another possible bleeding site (eg, gastroesophageal varix, gastric cancer, reflux esophagitis); (ii) coexistence of actively severe ill diseases (eg, septic shock, stroke, myocardial infarction, surgical abdomen); (iii) treatment with an anticoagulant (eg, warfarin); (iv) pregnancy; (v) the presence of operated stomach or; (vi) refusal to participate in the study. Contacts and Locations Go to Information from (...) . ClinicalTrials.gov Identifier: Other Study ID Numbers: VGHKS98-CT8-13 First Posted: September 16, 2014 Last Update Posted: September 16, 2014 Last Verified: September 2014 Keywords provided by Huay-Min Wang, Kaohsiung Veterans General Hospital.: argon plasma coagulation, bleeding peptic ulcer Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System

2014 Clinical Trials

167. The Selection Criteria for the Second-look Endoscopy Among Patients With Bleeding Peptic Ulcers

endoscopic hemostasis and high-dose PPI infusion. These risk factors will be the selection criteria for patients who are indicated to receive second-look endoscopy. Condition or disease Intervention/treatment Peptic Ulcer Hemorrhage Drug: esomeprazole or pantoprazole Procedure: Endoscopic hemostasis Detailed Description: Peptic ulcer bleeding is a common disease, and recurrent bleeding is an independent risk factor leading to mortality. The appearance of stigmata of recent hemorrhage (SRH) indicates (...) infusion among patients with end stage renal diseases. Although endoscopic treatment plus a 72-hour intravenous PPI infusion and followed by oral PPI has already been adopted as a standard treatment in peptic ulcer bleeding currently, several studies showed limited effectiveness of such treatment for high risk patients. The reasons may be because lesions of SRH were not completely faded after initial treatment including endoscopic hemostasis and intravenous PPI infusion. Thus, it is an important issue

2014 Clinical Trials

168. Efficacy and Safety of PMK-S005 in the Prevention of Recurrent Peptic Ulcer in Low-dose Aspirin Users

, 2018 Sponsor: PharmaKing Information provided by (Responsible Party): PharmaKing Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the efficacy and safety by comparing prevention of recurrent peptic ulcer in low-dose aspirin users between PMK-S005 and Placebo. Condition or disease Intervention/treatment Phase Peptic Ulcer Drug: Placebo Drug: PMK-S005 1 Drug: PMK-S005 2 Drug: PMK-S005 3 Phase 2 Study Design Go to Layout table for study information Study (...) Drug : PMK-S005 2 (100mg) Experimental: PMK-S005 3 Total 150mg, by mouth, bid Drug: PMK-S005 3 Drug : PMK-S005 3 (150mg) Outcome Measures Go to Primary Outcome Measures : The incidence of endoscopic peptic ulcer [ Time Frame: 12 weeks ] Secondary Outcome Measures : The incidence of endoscopic stomach / duodenal mucosal disease(erosion, ulcer) [ Time Frame: 12 weeks ] The incidence of endoscopic stomach / duodenal erosion [ Time Frame: 12 weeks ] The incidence of endoscopic stomach / duodenal ulcer

2014 Clinical Trials

169. Second-look Endoscopy in High Risk Patients After Endoscopic Hemostasis to Their Bleeding Peptic Ulcers Improves Their Outcomes

in selected high risk patients can further reduce bleeding and improve their outcomes. After endoscopic hemostasis to their bleeding peptic ulcers, patients are risk stratified based on the score. Those with a score of 5 or more are randomized to receive the standard treatment (a high dose PPI infusion) or a second look endoscopy with treatment in addition to PPI infusion. The primary outcome to the trial is further significant clinical bleeding. Condition or disease Intervention/treatment Phase Ulcer (...) : No Keywords provided by James Yun-wong Lau, Chinese University of Hong Kong: haemostasis Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Stomach Diseases Gastrointestinal Hemorrhage Epinephrine Racepinephrine Epinephryl borate Hemostatics Adrenergic alpha-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents

2014 Clinical Trials

170. Hemospray Versus the Combined Conventional Technique for Endoscopic Hemostasis of Bleeding Peptic Ulcers : A Pilot Study

as endoscopically verified cessation of bleeding for at least 5 minutes after endoscopic treatment), rebleeding rate (recurrent hemorrhage during a 4-week period following the initial hemostasis) and its safety profile. Condition or disease Intervention/treatment Phase Bleeding Peptic Ulcers Device: Hemospray Device: Combined Conventional Technique Phase 1 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 20 participants Allocation (...) Hospital More Information Go to Layout table for additonal information Responsible Party: Andrew Kwek Boon Eu, Consultant, Changi General Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: 2013/575/E First Posted: March 14, 2014 Last Update Posted: February 5, 2015 Last Verified: February 2015 Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases

2014 Clinical Trials

171. Risk Factors of Rebleeding After Peptic Ulcer Bleeding: a Nationwide Cohort Study

by (Responsible Party): Joon Sung Kim, Incheon St.Mary's Hospital Study Details Study Description Go to Brief Summary: The purpose of the investigators study is to investigate the factors associated with rebleeding in patients with peptic ulcer bleeding. Condition or disease Peptic Ulcer Bleeding Detailed Description: The investigators are performing a nationwide population based cohort study to investigate the factors associated with rebleeding in patients with peptic ulcer bleeding. The results (...) , Incheon St.Mary's Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: KPUB First Posted: June 2, 2014 Last Update Posted: August 4, 2016 Last Verified: August 2016 Keywords provided by Joon Sung Kim, Incheon St.Mary's Hospital: Peptic ulcer bleeding rebleeding mortality nationwide Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive

2014 Clinical Trials

172. Increased mortality with peptic ulcer bleeding in patients with both compensated and decompensated cirrhosis. (PubMed)

Increased mortality with peptic ulcer bleeding in patients with both compensated and decompensated cirrhosis. Cirrhosis is associated with worse outcomes in peptic ulcer bleeding (PUB). There are no population-based studies from the United States on the impact of cirrhosis on PUB outcomes.To investigate the impact of cirrhosis on outcomes of patients with PUB.Cross-sectional study.Nationwide Inpatient Sample 2009.International Classification of Diseases, the 9th revision, codes were used

2014 Gastrointestinal endoscopy

173. Simple Patch Closure for Perforated Peptic Ulcer in Children Followed by Helicobacter Pylori Eradication (PubMed)

Simple Patch Closure for Perforated Peptic Ulcer in Children Followed by Helicobacter Pylori Eradication Peptic ulcer disease in children is rare. Therefore, the diagnosis can be missed until complications such as perforation or hemorrhage occur. Few reports have investigated the procedures and outcomes of children who have undergone operations for perforated duodenal ulcers. We report our experience with the modified Graham technique for perforated duodenal ulcers in nine children and review (...) (range 3-94) months. Conclusions : Peptic ulcer perforation should be suspected in children who have acute abdominal pain and peritoneal signs, especially when their suffering is intense. The simple patch repair and postoperative triple therapy for Helicobacter Pylori are safe and satisfactory for treating peptic ulcer perforation in children.

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2014 Pakistan Journal Of Medical Sciences

174. Influence of body mass index on mortality after surgery for perforated peptic ulcer. (PubMed)

Influence of body mass index on mortality after surgery for perforated peptic ulcer. Body mass index (BMI) is a strong predictor of mortality in the general population. In spite of the medical hazards of obesity, a protective effect on mortality has been suggested in surgical patients: the obesity paradox. The aim of the present nationwide cohort study was to examine the association between BMI and mortality in patients treated surgically for perforated peptic ulcer (PPU).This was a national (...) prospective cohort study of all Danish patients treated surgically for PPU between 1 February 2003 and 31 August 2009, for whom BMI was registered. Non-surgically treated patients and those with malignant ulcers were excluded. The primary outcome measure was 90-day mortality. The association between BMI and mortality was calculated as crude and adjusted relative risks (RRs) with 95 per cent confidence intervals (c.i.).Of 2668 patients who underwent surgical treatment for PPU, 1699 (63.7 per cent) had BMI

2014 British Journal of Surgery

175. Association of mortality with out-of-hours admission in patients with perforated peptic ulcer. (PubMed)

Association of mortality with out-of-hours admission in patients with perforated peptic ulcer. Perforated peptic ulcer is a serious emergency surgical condition. The aim of the present nationwide cohort study was to evaluate the association between mortality and out-of-hours admission in patients surgically treated for perforated peptic ulcer.All Danish patients surgically treated for benign gastric or duodenal perforated peptic ulcer in Denmark between September 1, 2011 and August 31, 2013 (...) for perforated peptic ulcer.© 2014 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

2014 Acta Anaesthesiologica Scandinavica

176. Health related quality of life in patients with chronic gastritis and peptic ulcer and factors with impact: a longitudinal study. (PubMed)

Health related quality of life in patients with chronic gastritis and peptic ulcer and factors with impact: a longitudinal study. The assessment of Health Related Quality of Life (HRQOL) has been applied as a significant outcome indicator for patients with chronic diseases. No HRQOL study, however, has looked at HRQOL in patients with chronic gastritis and peptic ulcers. This paper focuses on comparing HRQOL in patients with chronic gastritis and peptic ulcers and examining the factors (...) that influence the HRQOL of such patients. Results can be used for making decisions in clinical trials as well as aiding individual management and preventive care of these diseases.The Chinese version of the SF-36 (CSF-36) was administered twice to 244 patients with chronic gastritis and peptic ulcers. Mean scores across the two disease groups were compared using t-tests, change over time was analyzed with paired samples t-tests, and factors predicting HRQOL were investigated using the univariate general

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2014 BMC Gastroenterology

177. Prevention of Recurrent Ulcer Bleeding in Patients With Idiopathic Gastroduodenal Ulcer

Intervention/treatment Phase Active Peptic Ulcer Disease/GI Bleeding Drug: Misoprostol Oral Tablet Drug: Placebo Oral Tablet Phase 4 Detailed Description: HYPOTHESIS The hypothesis that a combination therapy of misoprostol and lansoprazole is superior to lansoprazole alone for the prevention of recurrent ulcer bleeding in patients with a history of idiopathic ulcer bleeding. STUDY DESIGN OVERVIEW It is a two-year, double blinded, randomized trial of a combination therapy with misoprostol with PPI (...) Numbers: NRT_MISO Study First Posted: September 18, 2018 Last Update Posted: September 19, 2018 Last Verified: September 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Hemorrhage Peptic Ulcer Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Stomach Diseases Misoprostol Abortifacient

2018 Clinical Trials

178. A Study of Esomeplazole (D961H) in Japanese Paediatric Patients With Reflux Esophagitis, Gastric Ulcer or Duodenal Ulcer

ulcer Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Gastroesophageal Reflux Esophagitis Stomach Ulcer Duodenal Ulcer Esophagitis, Peptic Pathologic Processes Esophageal Motility Disorders Deglutition Disorders Esophageal Diseases Gastrointestinal Diseases Digestive System Diseases Gastroenteritis Peptic Ulcer Duodenal Diseases Intestinal Diseases Stomach Diseases Esomeprazole Anti-Inflammatory Agents, Non-Steroidal Anti-Ulcer Agents Gastrointestinal Agents Proton Pump Inhibitors (...) -steroidal anti-inflammatory drugs or low-dose aspirin therapy group, Primary endpoints are evaluated at week 32. Further, this study is designed to evaluate the long term efficacy and safety of D961H for a maximum of 52 weeks, in consideration of the medical needs for long term proton pump inhibitor treatment. Patient can continue study treatment up to 52 weeks, if they want. Condition or disease Intervention/treatment Phase Reflux Esophagitis Gastric Ulcer Duodenal Ulcer Drug: D961H capsule 10mg Drug

2018 Clinical Trials

179. Peptic ulcer disease and heart disease are associated with periprosthetic fractures after total hip replacement. (PubMed)

Peptic ulcer disease and heart disease are associated with periprosthetic fractures after total hip replacement. There have been no published studies assessing the possible association of medical comorbidities with periprosthetic fracture risk. We therefore assessed whether medical comorbidity is associated with risk of periprosthetic fractures after total hip replacement (THR).We used prospectively collected data from 1989-2008 in the Mayo Clinic Total Joint Registry for 2 cohorts: primary THR (...) postoperative periprosthetic fractures in the primary THR cohort and 330 in the revision THR cohort. In patients who underwent primary THR, 2 comorbidities were associated with higher risk of periprosthetic fracture: peptic ulcer disease with adjusted hazard ratio of 1.5 (95% CI: 1.1-2.2) and heart disease with adjusted hazard ratio of 1.7 (CI: 1.2-2.4). In patients with revision THR, peptic ulcer disease was associated with a higher adjusted risk of periprosthetic fracture, 1.6 (CI: 1.1-2.3).Peptic ulcer

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2012 Acta Orthopaedica

180. Very long-term treatment of peptic ulcer with cimetidine. (PubMed)

Very long-term treatment of peptic ulcer with cimetidine. In an open trial, 96 patients with endoscopically proven peptic ulcers were randomly allocated to treatment with cimetidine (1 g/day) for periods of 3, 6, 9, or 12 months. After their courses of treatment, the patients were followed up for at least 6 months. In 92% the ulcers had healed after treatment for 1 month, and in a further 5% the ulcers healed during the next 2 months. Ulcers recurred during treatment in 24% of patients (...) and within 6 months of withdrawal of treatment in a further 43%. In nearly a third of patients the recurrences were asymptomatic and were discovered only through routine endoscopic studies. Continuous treatment with full doses of cimetidine for a year seems to prevent relapse of the majority of ulcers which have healed during treatment; but it does not cure the ulcer disease, since relapse generally occurs quite rapidly when treatment is discontinued.

1978 Lancet

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