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Peptic Ulcer Disease

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161. Effects of early oral feeding on relapse and symptoms of upper gastrointestinal bleeding in peptic ulcer disease. (PubMed)

Effects of early oral feeding on relapse and symptoms of upper gastrointestinal bleeding in peptic ulcer disease. Peptic ulcer is the most common cause of upper gastrointestinal bleeding (GIB) and nutritional support is a helpful strategy in malnutrition prevention during treatment. As early oral feeding in patients with GIB may shorten hospital stay and decrease costs and risk of infection, the present study was carried out to investigate the effects of early oral feeding on relapse (...) and symptoms of upper GIB.The present clinical trial was conducted with the participation of 100 patients with upper GIB due to gastric or duodenum ulcer at Emam Reza University Hospital in Tabriz. Subjects were randomly allocated to two groups (n=50). In one group, patients received oral diet from day 1 and in other group patients were nil by mouth until day 3 and then received oral diet. Endoscopic and clinical findings of patients were recorded from day 1 to 3.The mean age of subjects was 57.6±1.7

2013 Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

162. Laparoscopic repair for perforated peptic ulcer disease. (PubMed)

Laparoscopic repair for perforated peptic ulcer disease. Perforated peptic ulcer is a common abdominal disease that is treated by surgery. The development of laparoscopic surgery has changed the way to treat such abdominal surgical emergencies. The results of some clinical trials suggest that laparoscopic surgery could be a better strategy than open surgery in the correction of perforated peptic ulcer but the evidence is not strongly in favour for or against this intervention.To measure (...) the effect of laparoscopic surgical treatment versus open surgical treatment in patients with a diagnosis of perforated peptic ulcer in relation to abdominal septic complications, surgical wound infection, extra-abdominal complications, hospital length of stay and direct costs.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) on The Cochrane Library (2004, Issue 2), PubMed/MEDLINE (1966 to July 2004), EMBASE (1985 to November 2004) and LILACS (1988 to November 2004) as well

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2013 Cochrane database of systematic reviews (Online)

163. Peptic ulcer disease: one in five is related to neither Helicobacter pylori nor to aspirin/NSAID intake. (PubMed)

Peptic ulcer disease: one in five is related to neither Helicobacter pylori nor to aspirin/NSAID intake. The proportion (and even the reality) of peptic ulcer disease (PUD) not related to H. pylori or NSAID/aspirin is debated.To analyse the current epidemiological and clinical characteristics of peptic ulcer disease in French general hospitals.Prospective multicentre study of patients with peptic ulcer disease in 32 French general hospitals over 1 year. H. pylori status was assessed (...) infection; 133 (18.7%) only gastrotoxic drugs; 141 (19.8%) had both and 154 (21.6%) neither H. pylori infection nor gastrotoxic drug intake ('idiopathic ulcers'). Patients with idiopathic ulcers differed in many ways both from H. pylori and NSAID/aspirin groups. However, multivariate analysis identified only three independent predictors: age, French metropolitan origin and the presence of comorbidities.In a general hospital-based population in France, peptic ulcer disease appears idiopathic in a fifth

2013 Alimentary Pharmacology & Therapeutics

164. End-stage renal disease is associated with worse outcomes in hospitalized patients with peptic ulcer bleeding. (PubMed)

End-stage renal disease is associated with worse outcomes in hospitalized patients with peptic ulcer bleeding. Patients with end-stage renal disease (ESRD) are at increased risk of peptic ulcer bleeding (PUB). To our knowledge, there are no population-based studies of the impact of ESRD on PUB.To determine nationwide impact of ESRD on outcomes of hospitalized patients with PUB.Cross-sectional study.Hospitals from a 2008 Nationwide Inpatient Sample.We used the International Classification (...) of Diseases, the 9th Revision, Clinical Modification codes to identify patients who had a primary discharge diagnosis of PUB.In-hospital mortality, length of stay, and hospitalization charges.Comparison of PUB outcomes in patients with and without ESRD.Of a total of 102,525 discharged patients with PUB, 3272 had a diagnosis of both PUB and ESRD, whereas 99,253 had a diagnosis of PUB alone without ESRD. The mortality of ESRD patients with PUB was significantly higher than that of the control group without

2013 Gastrointestinal endoscopy

165. Association of Helicobacter pylori babA2 with peptic ulcer disease and gastric cancer. (PubMed)

Association of Helicobacter pylori babA2 with peptic ulcer disease and gastric cancer. To investigate the association between babA2 gene and peptic ulcer disease (PUD) and gastric cancer (GC) in Helicobacter pylori-infected populations.We evaluated the relationship between babA2 and clinical outcomes (PUD and GC) using a meta-analysis. A literature search was performed using the PubMed and Web of Science databases for relevant case-control studies that met the defined inclusion criteria (...) in the subgroup of duodenal ulcer (OR = 1.588, 95%CI: 1.141-2.209, P = 0.006). Moreover, a significant association between babA2 gene and PUD and duodenal ulcer (OR = 2.739, 95%CI: 1.860-4.032, P < 0.001; OR = 2.239, 95%CI: 1.468-3.415, P < 0.001, respectively) was observed in western countries but not in Asian countries.We demonstrated that the presence of babA2 may be associated with increased risks for PUD, especially duodenal ulcer, in western countries.

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2013 World journal of gastroenterology : WJG

166. The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient

The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01944878 Recruitment Status : Completed First Posted : September 18, 2013 Results First Posted : July 24, 2014 Last Update Posted : July 24, 2014 Sponsor: Chuncheon Sacred Heart Hospital

2013 Clinical Trials

167. Peptic ulceration, Helicobacter pylori seropositivity and chronic obstructive pulmonary disease. (PubMed)

Peptic ulceration, Helicobacter pylori seropositivity and chronic obstructive pulmonary disease. We have suggested that chronic inflammation of other foregut derivatives might be associated with airway inflammation and amplification of the response to inhaled stimuli such as cigarette smoke leading to chronic obstructive pulmonary disease (COPD). One of the commonest causes of chronic foregut inflammation is gastritis secondary to Helicobacter Pylori infection. We tested the hypothesis (...) that peptic ulceration and H. Pylori seropositivity are associated with COPD independently of other shared risk factors.We reviewed primary care medical records and performed full lung function tests on 329 miners seen over 2 years as part of a compensation scheme. We also performed H. Pylori serology in patients with varying degrees of severity of COPD compared with a matched control population.The prevalence of peptic ulcer disease in the groups classed as normal, chronic bronchitis, mild, moderate

2013 Respirology

168. Doppler-guided Endoscopic Treatment in Peptic Ulcer Bleeding

Information provided by (Responsible Party): Stig Borbjerg Laursen, Odense University Hospital Study Details Study Description Go to Brief Summary: The present study is a randomized controlled trial (RCT) that examines if the outcome of peptic ulcer bleeding could be improved by use of doppler-guided endoscopic treatment. Condition or disease Intervention/treatment Phase Peptic Ulcer Bleeding Device: Supplementary endoscopy with doppler-guided therapy Drug: IV. PPI Other: Endoscopic treatment at primary (...) , PhD, Odense University Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: S-20130140 First Posted: May 6, 2015 Last Update Posted: April 20, 2017 Last Verified: April 2017 Additional relevant MeSH terms: Layout table for MeSH terms Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Stomach Diseases Gastrointestinal Hemorrhage

2014 Clinical Trials

169. Influence of body mass index on mortality after surgery for perforated peptic ulcer. (PubMed)

Influence of body mass index on mortality after surgery for perforated peptic ulcer. Body mass index (BMI) is a strong predictor of mortality in the general population. In spite of the medical hazards of obesity, a protective effect on mortality has been suggested in surgical patients: the obesity paradox. The aim of the present nationwide cohort study was to examine the association between BMI and mortality in patients treated surgically for perforated peptic ulcer (PPU).This was a national (...) prospective cohort study of all Danish patients treated surgically for PPU between 1 February 2003 and 31 August 2009, for whom BMI was registered. Non-surgically treated patients and those with malignant ulcers were excluded. The primary outcome measure was 90-day mortality. The association between BMI and mortality was calculated as crude and adjusted relative risks (RRs) with 95 per cent confidence intervals (c.i.).Of 2668 patients who underwent surgical treatment for PPU, 1699 (63.7 per cent) had BMI

2014 British Journal of Surgery

170. Association of mortality with out-of-hours admission in patients with perforated peptic ulcer. (PubMed)

Association of mortality with out-of-hours admission in patients with perforated peptic ulcer. Perforated peptic ulcer is a serious emergency surgical condition. The aim of the present nationwide cohort study was to evaluate the association between mortality and out-of-hours admission in patients surgically treated for perforated peptic ulcer.All Danish patients surgically treated for benign gastric or duodenal perforated peptic ulcer in Denmark between September 1, 2011 and August 31, 2013 (...) for perforated peptic ulcer.© 2014 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

2014 Acta Anaesthesiologica Scandinavica

171. Health related quality of life in patients with chronic gastritis and peptic ulcer and factors with impact: a longitudinal study. (PubMed)

Health related quality of life in patients with chronic gastritis and peptic ulcer and factors with impact: a longitudinal study. The assessment of Health Related Quality of Life (HRQOL) has been applied as a significant outcome indicator for patients with chronic diseases. No HRQOL study, however, has looked at HRQOL in patients with chronic gastritis and peptic ulcers. This paper focuses on comparing HRQOL in patients with chronic gastritis and peptic ulcers and examining the factors (...) that influence the HRQOL of such patients. Results can be used for making decisions in clinical trials as well as aiding individual management and preventive care of these diseases.The Chinese version of the SF-36 (CSF-36) was administered twice to 244 patients with chronic gastritis and peptic ulcers. Mean scores across the two disease groups were compared using t-tests, change over time was analyzed with paired samples t-tests, and factors predicting HRQOL were investigated using the univariate general

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2014 BMC Gastroenterology

172. Multicenter Validation on Predicting Mortality for Patients With Bleeding Peptic Ulcers

or disease Bleeding Peptic Ulcer Detailed Description: Despite advances in management of patients with bleeding peptic ulcers, mortality is still 10%. We previously reported a prediction score for ulcer bleeding related mortality developed from a local cohort. The risk factors for mortality included patients older than 70, presence of co-morbidity, more than one listed co-morbidity, hematemesis, SBP < 100 mmHg, in-hospital bleeding, rebleeding, and need for surgery. Study objective This study aimed (...) Multicenter Validation on Predicting Mortality for Patients With Bleeding Peptic Ulcers Multicenter Validation on Predicting Mortality for Patients With Bleeding Peptic Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies

2014 Clinical Trials

173. Argon Plasma Coagulation for Bleeding Peptic Ulcers

) patients with high-risk peptic ulcer bleeding. Exclusion Criteria: (i) the presence of another possible bleeding site (eg, gastroesophageal varix, gastric cancer, reflux esophagitis); (ii) coexistence of actively severe ill diseases (eg, septic shock, stroke, myocardial infarction, surgical abdomen); (iii) treatment with an anticoagulant (eg, warfarin); (iv) pregnancy; (v) the presence of operated stomach or; (vi) refusal to participate in the study. Contacts and Locations Go to Information from (...) . ClinicalTrials.gov Identifier: Other Study ID Numbers: VGHKS98-CT8-13 First Posted: September 16, 2014 Last Update Posted: September 16, 2014 Last Verified: September 2014 Keywords provided by Huay-Min Wang, Kaohsiung Veterans General Hospital.: argon plasma coagulation, bleeding peptic ulcer Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System

2014 Clinical Trials

174. The Selection Criteria for the Second-look Endoscopy Among Patients With Bleeding Peptic Ulcers

endoscopic hemostasis and high-dose PPI infusion. These risk factors will be the selection criteria for patients who are indicated to receive second-look endoscopy. Condition or disease Intervention/treatment Peptic Ulcer Hemorrhage Drug: esomeprazole or pantoprazole Procedure: Endoscopic hemostasis Detailed Description: Peptic ulcer bleeding is a common disease, and recurrent bleeding is an independent risk factor leading to mortality. The appearance of stigmata of recent hemorrhage (SRH) indicates (...) infusion among patients with end stage renal diseases. Although endoscopic treatment plus a 72-hour intravenous PPI infusion and followed by oral PPI has already been adopted as a standard treatment in peptic ulcer bleeding currently, several studies showed limited effectiveness of such treatment for high risk patients. The reasons may be because lesions of SRH were not completely faded after initial treatment including endoscopic hemostasis and intravenous PPI infusion. Thus, it is an important issue

2014 Clinical Trials

175. Efficacy and Safety of PMK-S005 in the Prevention of Recurrent Peptic Ulcer in Low-dose Aspirin Users

, 2018 Sponsor: PharmaKing Information provided by (Responsible Party): PharmaKing Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate the efficacy and safety by comparing prevention of recurrent peptic ulcer in low-dose aspirin users between PMK-S005 and Placebo. Condition or disease Intervention/treatment Phase Peptic Ulcer Drug: Placebo Drug: PMK-S005 1 Drug: PMK-S005 2 Drug: PMK-S005 3 Phase 2 Study Design Go to Layout table for study information Study (...) Drug : PMK-S005 2 (100mg) Experimental: PMK-S005 3 Total 150mg, by mouth, bid Drug: PMK-S005 3 Drug : PMK-S005 3 (150mg) Outcome Measures Go to Primary Outcome Measures : The incidence of endoscopic peptic ulcer [ Time Frame: 12 weeks ] Secondary Outcome Measures : The incidence of endoscopic stomach / duodenal mucosal disease(erosion, ulcer) [ Time Frame: 12 weeks ] The incidence of endoscopic stomach / duodenal erosion [ Time Frame: 12 weeks ] The incidence of endoscopic stomach / duodenal ulcer

2014 Clinical Trials

176. Second-look Endoscopy in High Risk Patients After Endoscopic Hemostasis to Their Bleeding Peptic Ulcers Improves Their Outcomes

in selected high risk patients can further reduce bleeding and improve their outcomes. After endoscopic hemostasis to their bleeding peptic ulcers, patients are risk stratified based on the score. Those with a score of 5 or more are randomized to receive the standard treatment (a high dose PPI infusion) or a second look endoscopy with treatment in addition to PPI infusion. The primary outcome to the trial is further significant clinical bleeding. Condition or disease Intervention/treatment Phase Ulcer (...) : No Keywords provided by James Yun-wong Lau, Chinese University of Hong Kong: haemostasis Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Stomach Diseases Gastrointestinal Hemorrhage Epinephrine Racepinephrine Epinephryl borate Hemostatics Adrenergic alpha-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents

2014 Clinical Trials

177. Hemospray Versus the Combined Conventional Technique for Endoscopic Hemostasis of Bleeding Peptic Ulcers : A Pilot Study

as endoscopically verified cessation of bleeding for at least 5 minutes after endoscopic treatment), rebleeding rate (recurrent hemorrhage during a 4-week period following the initial hemostasis) and its safety profile. Condition or disease Intervention/treatment Phase Bleeding Peptic Ulcers Device: Hemospray Device: Combined Conventional Technique Phase 1 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 20 participants Allocation (...) Hospital More Information Go to Layout table for additonal information Responsible Party: Andrew Kwek Boon Eu, Consultant, Changi General Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: 2013/575/E First Posted: March 14, 2014 Last Update Posted: February 5, 2015 Last Verified: February 2015 Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases

2014 Clinical Trials

178. Risk Factors of Rebleeding After Peptic Ulcer Bleeding: a Nationwide Cohort Study

by (Responsible Party): Joon Sung Kim, Incheon St.Mary's Hospital Study Details Study Description Go to Brief Summary: The purpose of the investigators study is to investigate the factors associated with rebleeding in patients with peptic ulcer bleeding. Condition or disease Peptic Ulcer Bleeding Detailed Description: The investigators are performing a nationwide population based cohort study to investigate the factors associated with rebleeding in patients with peptic ulcer bleeding. The results (...) , Incheon St.Mary's Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: KPUB First Posted: June 2, 2014 Last Update Posted: August 4, 2016 Last Verified: August 2016 Keywords provided by Joon Sung Kim, Incheon St.Mary's Hospital: Peptic ulcer bleeding rebleeding mortality nationwide Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive

2014 Clinical Trials

179. Increased mortality with peptic ulcer bleeding in patients with both compensated and decompensated cirrhosis. (PubMed)

Increased mortality with peptic ulcer bleeding in patients with both compensated and decompensated cirrhosis. Cirrhosis is associated with worse outcomes in peptic ulcer bleeding (PUB). There are no population-based studies from the United States on the impact of cirrhosis on PUB outcomes.To investigate the impact of cirrhosis on outcomes of patients with PUB.Cross-sectional study.Nationwide Inpatient Sample 2009.International Classification of Diseases, the 9th revision, codes were used

2014 Gastrointestinal endoscopy

180. Simple Patch Closure for Perforated Peptic Ulcer in Children Followed by Helicobacter Pylori Eradication (PubMed)

Simple Patch Closure for Perforated Peptic Ulcer in Children Followed by Helicobacter Pylori Eradication Peptic ulcer disease in children is rare. Therefore, the diagnosis can be missed until complications such as perforation or hemorrhage occur. Few reports have investigated the procedures and outcomes of children who have undergone operations for perforated duodenal ulcers. We report our experience with the modified Graham technique for perforated duodenal ulcers in nine children and review (...) (range 3-94) months. Conclusions : Peptic ulcer perforation should be suspected in children who have acute abdominal pain and peritoneal signs, especially when their suffering is intense. The simple patch repair and postoperative triple therapy for Helicobacter Pylori are safe and satisfactory for treating peptic ulcer perforation in children.

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2014 Pakistan Journal Of Medical Sciences

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