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Peptic Ulcer Disease

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141. Sleep Apnea and Risk of Peptic Ulcer Bleeding: A Nationwide Population-based Study (PubMed)

28,384 controls), 84 (0.24%) experienced peptic ulcer bleeding during a follow-up period of 3.57±2.61 years, including 32 (0.45% of patients with sleep apnea) from the sleep apnea cohort and 52 (0.18% of control) from the control group (log-rank test, P<.0001). In comparison with subjects without development of peptic ulcer bleeding, those with peptic ulcer bleeding were older and had a higher percentage of sleep apnea, coronary artery disease, peptic ulcer, ischemic stroke, and medication (...) Sleep Apnea and Risk of Peptic Ulcer Bleeding: A Nationwide Population-based Study Patients with sleep apnea sustain cessation of breath during sleep, leading to intermittent hypoxia, systemic inflammation, and sympathetic activation. These insults may contribute to initiation or progression of peptic ulcers. This retrospective matched-control cohort study explored the relationship of sleep apnea and subsequent development of peptic ulcer bleeding.From 2000 to 2009, patients with newly

2013 EvidenceUpdates

142. Machine learning model to predict recurrent ulcer bleeding in patients with history of idiopathic gastroduodenal ulcer bleeding. (PubMed)

Machine learning model to predict recurrent ulcer bleeding in patients with history of idiopathic gastroduodenal ulcer bleeding. Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have an increased risk of recurring ulcer complications.To build a machine learning model to identify patients at high risk for recurrent ulcer bleeding.Data from a retrospective cohort of 22 854 patients (training cohort) diagnosed with peptic ulcer disease in 2007-2016 were analysed (...) (age, baseline haemoglobin, and presence of gastric ulcer, gastrointestinal diseases, malignancies, and infections) identified patients with bleeding recurrence within 1 year with an area under the receiver operating characteristic curve (AUROC) of 0.648. When we set the IPU-ML cutoff value at 0.20, 27.5% of patients were classified as high risk for rebleeding with a sensitivity of 41.4%, specificity of 74.6%, and a negative predictive value of 91.1%. In the validation cohort, the IPU-ML identified

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2019 Alimentary Pharmacology & Therapeutics

143. Efficacy of vonoprazan compared to proton pump inhibitors for patients with peptic ulcers: a systematic review with meta-analysis

Efficacy of vonoprazan compared to proton pump inhibitors for patients with peptic ulcers: a systematic review with meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne (...) studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome, the choice of effect measure, how subgroup variables are stratified etc. In order to assess the robustness of the findings of the meta

2018 PROSPERO

144. Proton Pump Inhibitor Versus Histamine-2 Receptor Antagonist for the Prevention of Recurrent Peptic Ulcers

Recruitment Status : Recruiting First Posted : September 16, 2015 Last Update Posted : September 29, 2017 See Sponsor: Kaohsiung Veterans General Hospital. Information provided by (Responsible Party): Ping-I (William) Hsu, M.D., Kaohsiung Veterans General Hospital. Study Details Study Description Go to Brief Summary: Whether pantoprazole versus famotidine for the prevention of recurrent peptic ulcers in thienopyridine users remains unclear. Condition or disease Intervention/treatment Phase Peptic Ulcer (...) examination (within 2 months) reveals normal appearance or erythematous patches only (without subepithelial hemorrhages, erosions or ulcers). Peptic ulcers (a mucosal break ³ 5 mm in diameter) have been documented by a previous endoscopic examination. Subjects have received thienopyridine therapy for at least two weeks. Requiring long-term anti-platelet therapy for ischemic cardiovascular diseases. Exclusion Criteria: A history of gastric or duodenal surgery other than oversewing of a perforation

2015 Clinical Trials

145. The effect of statins on the occurrence of peptic ulcer. (PubMed)

The effect of statins on the occurrence of peptic ulcer. This study was to determine the association between the use of statins and the occurrence of peptic ulcer diseases (PUD).Using the National Health Insurance Research Database to conduct a population-based cohort study. We identified 48,562 patients who were newly diagnosed with hyperlipidemia during the period of 1998 to 2011 and who were divided into two groups based on their use of statins. The non-statin cohort (without statin (...) might be associated with the protection of peptic ulcer in a dose-respondent manner.Copyright © 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

2015 European journal of internal medicine

146. Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer

Sponsor: Kaohsiung Veterans General Hospital. Information provided by (Responsible Party): Ping-I (William) Hsu, M.D., Kaohsiung Veterans General Hospital. Study Details Study Description Go to Brief Summary: Whether H2 receptor antagonist can prevent thienopyridine-related peptic ulcer remains unclear. Condition or disease Intervention/treatment Phase Peptic Ulcer Drug: histamine-2 receptor antagonist Drug: Placebo Not Applicable Detailed Description: The aim of the prospective, randomized study (...) General Hospital.: histamine-2 receptor antagonist peptic ulcer thienopyridine prevention Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Peptic Ulcer Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Stomach Diseases Histamine Histamine phosphate Famotidine Histamine H2 Antagonists Histamine Agonists Histamine Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Anti

2015 Clinical Trials

147. Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients

esomeprazole therapy in high-risk patients whose Rockall score ≥ 6. Condition or disease Intervention/treatment Phase Peptic Ulcer Hemorrhage Drug: oral esomeprazole 20 mg twice daily Drug: oral esomeprazole 20 mg once daily Phase 4 Detailed Description: This study is conducted at the inpatient wards of National Cheng Kung University Hospital, a tertiary health care center in Tainan, Taiwan. All participants give written informed consent before enrollment. Each enrolled patient receives an 80 mg loading (...) ) First Posted: May 28, 2015 Last Update Posted: January 31, 2019 Last Verified: January 2019 Keywords provided by Hsiu-Chi Cheng, National Cheng-Kung University Hospital: peptic ulcer hemorrhage comorbidity clinical trial Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Hemorrhage Peptic Ulcer Peptic Ulcer Hemorrhage Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Stomach Diseases Gastrointestinal Hemorrhage Esomeprazole

2015 Clinical Trials

148. Is the neutrophil-to-lymphocyte ratio a potential diagnostic marker for peptic ulcer perforation? A retrospective cohort study. (PubMed)

ratio (NLR) in early diagnosis of PUP; we asked whether this ratio allowed PUP and peptic ulcer disease to be distinguished.We enrolled the following patients: 58 with PUP, 62 with noncomplicated peptic ulcer diseases (NCPU), and 62 controls, between May 2010 and 2015. Patients who underwent surgical repair to treat PUP were included in the study group. Another group consisted of NCPU patients who had a noncomplicated peptic ulcer. The control group consisted of patients presenting with nonspecific (...) in the diagnosis of PUP and can be used to distinguish this condition from peptic ulcer disease. Thus, the NLR should be calculated in addition to the clinical examination.Copyright © 2015 Elsevier Inc. All rights reserved.

2015 American Journal of Emergency Medicine

149. Laparoscopic versus open operation for perforated peptic ulcer in pediatric patients: A 10-year experience. (PubMed)

details and surgical outcomes, were analyzed.Thirteen patients were identified, and all presented with abdominal pain. The median age of the study group was 14.9years (range 6.3 to 18.4years). Radiological evidence of pneumoperitoneum on erect chest x-ray (CXR) was found only in five patients (38.5%). None of the patients had a known history of peptic ulcer disease. Diagnosis other than PPU was made in five patients preoperatively. Laparoscopic repair was attempted in eight patients with one of them (...) Laparoscopic versus open operation for perforated peptic ulcer in pediatric patients: A 10-year experience. Perforated peptic ulcer (PPU) is a relatively uncommon condition in children. We aim to evaluate and compare the outcomes of laparoscopic omental patch repair versus open repair for PPU in pediatric patients.Children who underwent omental patch repair for PPU from 2004 to 2014 in our hospital were reviewed retrospectively. Patient demographics, perioperative as well as intraoperative

2015 Journal of Pediatric Surgery

150. Efficacy and safety of Sijunzi decoction in treating peptic ulcers: a systematic review and meta-analysis of randomized controlled trials

Efficacy and safety of Sijunzi decoction in treating peptic ulcers: a systematic review and meta-analysis of randomized controlled trials Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne (...) studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome, the choice of effect measure, how subgroup variables are stratified etc. In order to assess the robustness of the findings of the meta

2018 PROSPERO

151. ABCG2 in peptic ulcer: gene expression and mutation analysis (PubMed)

ABCG2 in peptic ulcer: gene expression and mutation analysis The aim of this study was to evaluate the participation of polymorphism at position C421A and mRNA expression of the ABCG2 gene in the development of peptic ulcers, which is a very common and severe disease. ABCG2, encoded by the ABCG2 gene, has been found inter alia in the gastrointestinal tract, where it plays a protective role eliminating xenobiotics from cells into the extracellular environment. The materials for the study were (...) biopsies of gastric mucosa taken during a routine endoscopy. For genotyping by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) at position C421A, DNA was isolated from 201 samples, while for the mRNA expression level by real-time PCR, RNA was isolated from 60 patients. The control group of healthy individuals consisted of 97 blood donors. The dominant genotype in the group of peptic ulcer patients and healthy individuals was homozygous CC. No statistically significant

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2015 Journal of applied genetics

152. Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study (PubMed)

, there was a significant difference in the decrease of malondialdehyde level compared to FAM commercial tablets or beads alone (P<0.05). The combined formula significantly improved the myeloperoxidase level compared to both the disease control group and commercial FAM tablet-treated group (P<0.05). Formulation of FAM as floating beads in combination with solid dispersion of QRT improved the anti-ulcer activity compared to commercially available tablets, which reveals a promising application for treatment of peptic (...) Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study The aim of this work was to prepare a combined drug dosage form of famotidine (FAM) and quercetin (QRT) to augment treatment of gastric ulcer. FAM was prepared as freeze-dried floating alginate beads using ion gelation method and then coated with Eudragit RL100 to sustain FAM release. QRT was prepared as solid dispersion with polyvinyl pyrrolidone K30 to improve its solubility. Photo images

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2015 Drug design, development and therapy

153. Role of dietary polyphenols in the management of peptic ulcer (PubMed)

Role of dietary polyphenols in the management of peptic ulcer Peptic ulcer disease is a multifactorial and complex disease involving gastric and duodenal ulcers. Despite medical advances, the management of peptic ulcer and its complications remains a challenge, with high morbidity and death rates for the disease. An accumulating body of evidence suggests that, among a broad reach of natural molecules, dietary polyphenols with multiple biological mechanisms of action play a pivotal part (...) in the management of gastric and duodenal ulcers. The current review confirmed that dietary polyphenols possess protective and therapeutic potential in peptic ulcer mediated by: improving cytoprotection, re-epithelialization, neovascularization, and angiogenesis; up-regulating tissue growth factors and prostaglandins; down-regulating anti-angiogenic factors; enhancing endothelial nitric oxide synthase-derived NO; suppressing oxidative mucosal damage; amplifying antioxidant performance, antacid, and anti

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2015 World journal of gastroenterology : WJG

154. Toll-Like Receptor 4 Wild Type Homozygozity of Polymorphisms +896 and +1196 Is Associated with High Gastrin Serum Levels and Peptic Ulcer Risk (PubMed)

Toll-Like Receptor 4 Wild Type Homozygozity of Polymorphisms +896 and +1196 Is Associated with High Gastrin Serum Levels and Peptic Ulcer Risk Toll-like receptor 4 is a part of the innate immune system and recognizes Helicobacter pylori lipopolysaccharide. The goal of this study was to analyze the role of Toll-like receptor 4 polymorphisms +896 (rs4986790) and +1196 (rs4986791) in the pathogenesis of Helicobacter pylori related gastroduodenal diseases in relation to gastric secretion (...) ) and this effect was independent of Helicobacter pylori. The homozygous wild types also displayed an increased risk for peptic ulcers (OR: 4.390). Toll-like receptor 4 genotypes did not show any association with Helicobacter pylori positivity or the features of gastric inflammation. Toll-like receptor 4 expression was seen in gastrin and somatostatin expressing cells of antral mucosa by immunohistochemistry. Our results suggest a role for Toll-like receptor 4 in gastric acid regulation and that the Toll-like

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2015 PloS one

155. Short-term use of glucocorticoids and risk of peptic ulcer bleeding: a nationwide population-based case-crossover study. (PubMed)

) for the 7-day window, 1.66 (95% CI: 1.38-2.00, P < 0.001) for the 14-day window and 1.84 (95% CI: 1.57-2.16, P < 0.001) for the 28-day window. Moderate to high, but not low dose glucocorticoids (methylprednisolone <4 mg/day or its equivalence) were associated with an increased risk of peptic ulcer bleeding. Concomitant use of a nonselective nonsteroidal anti-inflammatory drug (NSAID) or aspirin further elevated the risk. However, it does not eliminate the effect of underlying diseases flare-up that may (...) Short-term use of glucocorticoids and risk of peptic ulcer bleeding: a nationwide population-based case-crossover study. Controversy exists regarding glucocorticoids therapy and the risk of peptic ulcer bleeding (PUB).The present study was undertaken to determine whether short-term use of glucocorticoids is associated with the occurrence of peptic ulcer bleeding.The records of adult patients hospitalised for newly diagnosed peptic ulcer bleeding from 2000 to 2012 were retrieved from the Taiwan

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2015 Alimentary Pharmacology & Therapeutics

156. Peptic Ulcer Bleeding Risk. The Role of Helicobacter Pylori Infection in NSAID/Low-Dose Aspirin Users. (PubMed)

Peptic Ulcer Bleeding Risk. The Role of Helicobacter Pylori Infection in NSAID/Low-Dose Aspirin Users. Helicobacter pylori (H. pylori) infection and NSAID/low-dose aspirin (ASA) use are associated with peptic ulcer disease. The risk of peptic ulcer bleeding (PUB) associated with the interaction of these factors remains unclear. The objective of this study was to determine the risk of PUB associated with the interaction between H. pylori infection and current nonsteroidal anti-inflammatory drugs

2015 American Journal of Gastroenterology

157. Changing prevalence of Helicobacter pylori infection and peptic ulcer among dyspeptic Sardinian patients. (PubMed)

Changing prevalence of Helicobacter pylori infection and peptic ulcer among dyspeptic Sardinian patients. Over the past 50 years, the prevalence of Helicobacter pylori infection has fallen as standards of living improved. The changes in the prevalence of infection and its manifestations (peptic ulcer disease and gastric mucosal lesions) were investigated in a large cohort of Sardinians undergoing upper endoscopy for dyspepsia. A retrospective observational study was conducted involving patients (...) undergoing endoscopy for dyspepsia from 1995 to 2013. H. pylori status was assessed by histology plus the rapid urease test or 13C-UBT. Gastric mucosal lesions were evaluated histologically. Data including non-steroidal anti-inflammatory drugs (NSAIDs) use and the presence of peptic ulcers were collected. The prevalence of H. pylori was calculated for each quartile and for each birth cohort from 1910 to 2000. 11,202 records were retrieved for the analysis (62.9% women). The overall prevalence of H

2015 Internal and emergency medicine

158. A multicenter prospective study on the prevalence of Helicobacter pylori-negative and nonsteroidal anti-inflammatory drugs-negative idiopathic peptic ulcers in Japan. (PubMed)

enrolled patients with peptic ulcers, 46 (12%) were judged to have IPUs. Compared with those with simple H. pylori-positive ulcers, patients with IPUs were significantly older (P < 0.02) and more often had underlying comorbidities such as hypertension (P < 0.02) and hyperlipidemia (P < 0.05). Multivariate regression analysis indicated that the presence of multiple underlying diseases was the only significant risk factor for IPUs, with an odds ratio of 3.8 (95% confidence interval, 1.3-11.1).This study (...) revealed that the prevalence of IPUs in patients with peptic ulcers in Japan is 12%, much higher than previously reported. Presence of multiple underlying comorbid diseases, rather than aging itself, is an important risk factor for IPUs.© 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

2015 Journal of gastroenterology and hepatology

159. Association of presence/absence and on/off patterns of Helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks: a meta-analysis. (PubMed)

Association of presence/absence and on/off patterns of Helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks: a meta-analysis. There are increasing studies examining the relationship between the status of H. pylori oipA gene and peptic ulcer disease (PUD) and gastric cancer (GC) but the results turn out to be controversial. We attempted to clarify whether oipA gene status is linked with PUD and/or GC risks.A systematically literature search was performed through four

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2013 BMC Infectious Diseases

160. Safety and efficacy of 1-week levofloxacin-based triple therapy in first-line treatment for Helicobacter pylori-related peptic ulcer disease in Kashmir, India. (PubMed)

Safety and efficacy of 1-week levofloxacin-based triple therapy in first-line treatment for Helicobacter pylori-related peptic ulcer disease in Kashmir, India. There is no ideal therapy for eradication of Helicobacter pylori infection. We evaluated the efficacy and safety of 1-week triple therapy with rabeprazole, levofloxacin, and tinidazole in a metronidazole resistance prevalent region for eradicating H. pylori infection in patients with gastroduodenal ulcers.This was an open-label (...) with gastroduodenal ulcer disease associated with H. pylori infection. The regimen was well tolerated.

2013 Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

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