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Peptic Ulcer Disease

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121. Association between Helicobacter pylori genotypes and severity of chronic gastritis, peptic ulcer disease and gastric mucosal interleukin-8 levels: Evidence from a study in the Middle East (PubMed)

Association between Helicobacter pylori genotypes and severity of chronic gastritis, peptic ulcer disease and gastric mucosal interleukin-8 levels: Evidence from a study in the Middle East The varied clinical presentations of Helicobacter pylori (H. pylori) infection are most likely due to differences in the virulence of individual strains, which determines its ability to induce production of interleukin-8 (IL-8) in the gastric mucosa. The aim of this study was to examine association between (...) cagA, vacA-s1 and vacA-s2 genotypes of H. pylori and severity of chronic gastritis and presence of peptic ulcer disease (PUD), and to correlate these with IL-8 levels in the gastric mucosa.Gastric mucosal biopsies were obtained from patients during esophagogastroduodenoscopy. The severity of chronic gastritis was documented using the updated Sydney system. H. pylori cagA and vacA genotypes were detected by PCR. The IL-8 levels in the gastric mucosa were measured by ELISA.H. pylori cagA and/or vacA

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2014 Gut pathogens

122. Risk factors influencing morbidity and mortality in perforated peptic ulcer disease (PubMed)

Risk factors influencing morbidity and mortality in perforated peptic ulcer disease Peptic ulcer perforation continues to be a major surgical problem. In this study, risk factors that influence morbidity and mortality in perforated peptic ulcer disease were examined.Files of 148 patients who were included in the study due to peptic ulcer perforation between January 2006 and December 2010 were retrospectively analyzed. Data regarding age, gender, complaints, time elapsed between onset (...) patients (18.2%). The most common cause of mortality was sepsis. Multivariate analysis revealed age over 60 years, presence of co-morbidities and Mannheim peritonitis index as independent risk factors for morbidity. Age over 60 years, time to admission and Mannheim peritonitis index were detected as independent risk factors for mortality.Early diagnosis and proper treatment are important in patients presenting with peptic ulcer perforation.

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2014 Turkish Journal of Surgery/Ulusal cerrahi dergisi

123. Peptic ulcers, Nobel Prizes and Multiple Sclerosis

Peptic ulcers, Nobel Prizes and Multiple Sclerosis Peptic ulcers, Nobel Prizes and Multiple Sclerosis | JNNP blog by It has been a decade now since Barry Marshall and Robin Warren from the University of Western Australia (UWA) were awarded the Nobel Prize for Medicine for discovering the link between Helicobacter Pylori (H.pylori) and the development of peptic ulcers. Famously, their discovery involved Marshall ingesting the bacteria himself in order to prove his hypothesis. In keeping (...) with very many Nobel Prize winners, the duo had to contend with fierce opposition from colleagues within the medical fraternity who simply refused to believe that there was any suggestion that ulcers could be due to infectious organisms. A decade on, the multiple sclerosis (MS) research group from UWA have collaborated with Barry Marshall to investigate the possible connections between H.pylori and MS development. In a paper that appears in this month’s issue of JNNP, the authors have explored

2015 JNNP blog

124. Peptic Ulcer Disease (Overview)

Peptic Ulcer Disease (Overview) Peptic Ulcer Disease: Background, Anatomy, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLW92ZXJ2aWV3 processing > Peptic Ulcer Disease Updated: Dec 21 (...) , 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Overview Background Gastric and duodenal ulcers usually cannot be differentiated based on history alone, although some findings may be suggestive (see ). Epigastric pain is the most common symptom of both gastric and duodenal ulcers. It is characterized by a gnawing or burning sensation and occurs after meals—classically, shortly after meals with gastric

2014 eMedicine.com

125. Peptic Ulcer Disease (Treatment)

Peptic Ulcer Disease (Treatment) Peptic Ulcer Disease Treatment & Management: Approach Considerations, Bleeding Peptic Ulcers, H pylori Infection Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLXRyZWF0bWVudA== processing > Peptic Ulcer Disease Treatment & Management Updated: Dec 21, 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Treatment Approach Considerations The 2017 American College of Gastroenterology (ACG) guidelines for the treatment of H pylori infection (HPI) indicates that selection of an HPI management regimen should take into account any previous antibiotic exposure(s). The ACG also

2014 eMedicine.com

126. Peptic Ulcer Disease (Follow-up)

Peptic Ulcer Disease (Follow-up) Peptic Ulcer Disease Treatment & Management: Approach Considerations, Bleeding Peptic Ulcers, H pylori Infection Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLXRyZWF0bWVudA== processing > Peptic Ulcer Disease Treatment & Management Updated: Dec 21, 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Treatment Approach Considerations The 2017 American College of Gastroenterology (ACG) guidelines for the treatment of H pylori infection (HPI) indicates that selection of an HPI management regimen should take into account any previous antibiotic exposure(s). The ACG also

2014 eMedicine.com

127. Peptic Ulcer Disease (Diagnosis)

Peptic Ulcer Disease (Diagnosis) Peptic Ulcer Disease: Background, Anatomy, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLW92ZXJ2aWV3 processing > Peptic Ulcer Disease Updated: Dec 21 (...) , 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Overview Background Gastric and duodenal ulcers usually cannot be differentiated based on history alone, although some findings may be suggestive (see ). Epigastric pain is the most common symptom of both gastric and duodenal ulcers. It is characterized by a gnawing or burning sensation and occurs after meals—classically, shortly after meals with gastric

2014 eMedicine Pediatrics

128. Peptic Ulcer Disease (Follow-up)

Peptic Ulcer Disease (Follow-up) Peptic Ulcer Disease Treatment & Management: Approach Considerations, Bleeding Peptic Ulcers, H pylori Infection Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLXRyZWF0bWVudA== processing > Peptic Ulcer Disease Treatment & Management Updated: Dec 21, 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Treatment Approach Considerations The 2017 American College of Gastroenterology (ACG) guidelines for the treatment of H pylori infection (HPI) indicates that selection of an HPI management regimen should take into account any previous antibiotic exposure(s). The ACG also

2014 eMedicine Pediatrics

129. Peptic Ulcer Disease (Overview)

Peptic Ulcer Disease (Overview) Peptic Ulcer Disease: Background, Anatomy, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLW92ZXJ2aWV3 processing > Peptic Ulcer Disease Updated: Dec 21 (...) , 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Overview Background Gastric and duodenal ulcers usually cannot be differentiated based on history alone, although some findings may be suggestive (see ). Epigastric pain is the most common symptom of both gastric and duodenal ulcers. It is characterized by a gnawing or burning sensation and occurs after meals—classically, shortly after meals with gastric

2014 eMedicine Pediatrics

130. Peptic Ulcer Disease (Treatment)

Peptic Ulcer Disease (Treatment) Peptic Ulcer Disease Treatment & Management: Approach Considerations, Bleeding Peptic Ulcers, H pylori Infection Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLXRyZWF0bWVudA== processing > Peptic Ulcer Disease Treatment & Management Updated: Dec 21, 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Treatment Approach Considerations The 2017 American College of Gastroenterology (ACG) guidelines for the treatment of H pylori infection (HPI) indicates that selection of an HPI management regimen should take into account any previous antibiotic exposure(s). The ACG also

2014 eMedicine Pediatrics

131. Gastritis and Peptic Ulcer Disease (Follow-up)

Gastritis and Peptic Ulcer Disease (Follow-up) Peptic Ulcer Disease Treatment & Management: Approach Considerations, Bleeding Peptic Ulcers, H pylori Infection Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLXRyZWF0bWVudA== processing > Peptic Ulcer Disease Treatment & Management Updated: Dec 21, 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Treatment Approach Considerations The 2017 American College of Gastroenterology (ACG) guidelines for the treatment of H pylori infection (HPI) indicates that selection of an HPI management regimen should take into account any previous antibiotic exposure(s). The ACG also

2014 eMedicine Emergency Medicine

132. Peptic Ulcer Disease (Diagnosis)

Peptic Ulcer Disease (Diagnosis) Peptic Ulcer Disease: Background, Anatomy, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLW92ZXJ2aWV3 processing > Peptic Ulcer Disease Updated: Dec 21 (...) , 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Overview Background Gastric and duodenal ulcers usually cannot be differentiated based on history alone, although some findings may be suggestive (see ). Epigastric pain is the most common symptom of both gastric and duodenal ulcers. It is characterized by a gnawing or burning sensation and occurs after meals—classically, shortly after meals with gastric

2014 eMedicine.com

133. Gastritis and Peptic Ulcer Disease (Treatment)

Gastritis and Peptic Ulcer Disease (Treatment) Peptic Ulcer Disease Treatment & Management: Approach Considerations, Bleeding Peptic Ulcers, H pylori Infection Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLXRyZWF0bWVudA== processing > Peptic Ulcer Disease Treatment & Management Updated: Dec 21, 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Treatment Approach Considerations The 2017 American College of Gastroenterology (ACG) guidelines for the treatment of H pylori infection (HPI) indicates that selection of an HPI management regimen should take into account any previous antibiotic exposure(s). The ACG also

2014 eMedicine Emergency Medicine

134. Gastritis and Peptic Ulcer Disease (Diagnosis)

Gastritis and Peptic Ulcer Disease (Diagnosis) Peptic Ulcer Disease: Background, Anatomy, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLW92ZXJ2aWV3 processing > Peptic Ulcer Disease (...) Updated: Dec 21, 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Overview Background Gastric and duodenal ulcers usually cannot be differentiated based on history alone, although some findings may be suggestive (see ). Epigastric pain is the most common symptom of both gastric and duodenal ulcers. It is characterized by a gnawing or burning sensation and occurs after meals—classically, shortly after meals

2014 eMedicine Emergency Medicine

135. Gastritis and Peptic Ulcer Disease (Overview)

Gastritis and Peptic Ulcer Disease (Overview) Peptic Ulcer Disease: Background, Anatomy, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTgxNzUzLW92ZXJ2aWV3 processing > Peptic Ulcer Disease (...) Updated: Dec 21, 2018 Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG Share Email Print Feedback Close Sections Sections Peptic Ulcer Disease Overview Background Gastric and duodenal ulcers usually cannot be differentiated based on history alone, although some findings may be suggestive (see ). Epigastric pain is the most common symptom of both gastric and duodenal ulcers. It is characterized by a gnawing or burning sensation and occurs after meals—classically, shortly after meals

2014 eMedicine Emergency Medicine

136. DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers

gastric-epithelial mucous and bicarbonate secretion; anti-oxidative activity; and endothelial-nitric oxide (NO) formation. Recent study of DLBS2411 in healthy volunteers demonstrated the effective role and safety of DLBS2411 in suppressing intragastric acidity. Having such mechanisms of action, DLBS2411 is hypothesized to benefit in peptic ulcers. Condition or disease Intervention/treatment Phase Non-Bleeding Peptic Ulcers Drug: Omeprazole Drug: Placebo caplet of DLBS2411 Drug: DLBS2411 Drug: Placebo (...) Peptic Ulcer Pathologic Processes Duodenal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Stomach Diseases Omeprazole Anti-Ulcer Agents Gastrointestinal Agents Proton Pump Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action

2014 Clinical Trials

137. Single nucleotide polymorphism markers for low-dose aspirin-associated peptic ulcer and ulcer bleeding. (PubMed)

Single nucleotide polymorphism markers for low-dose aspirin-associated peptic ulcer and ulcer bleeding. In our previous study, the SLCO1B1 521TT genotype and the SLCO1B1*1b haplotype were significantly associated with the risk of peptic ulcer in patients taking low-dose aspirin (LDA). The aim of the present study was to investigate pharmacogenomic profile of LDA-induced peptic ulcer and ulcer bleeding.Patients taking 100 mg of enteric-coated aspirin for cardiovascular diseases and with a peptic (...) sequencing.Of 593 patients enrolled, 111 patients had a peptic ulcer and 45 had ulcer bleeding. The frequencies of the SLCO1B1*1b haplotype and CHST2 2082 T allele were significantly greater in patients with peptic ulcer and ulcer bleeding compared to the controls. After adjustment for significant factors, the SLCO1B1*1b haplotype was associated with peptic ulcer (OR 2.20, 95% CI 1.24-3.89) and CHST2 2082 T allele with ulcer bleeding (2.57, 1.07-6.17).The CHST2 2082 T allele as well as SLCO1B1*1b haplotype

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2014 Journal of gastroenterology and hepatology

138. Prevention of peptic ulcers with esomeprazole in patients at risk of ulcer development treated with low-dose acetylsalicylic acid: a randomised, controlled trial (OBERON). (PubMed)

trial.Cardiology, primary care and gastroenterology centres (n=240).Helicobacter pylori-negative patients taking daily low-dose ASA (75-325 mg), who fulfilled one or more of the following criteria: age ≥18 years with history of uncomplicated peptic ulcer; age ≥60 years with either stable coronary artery disease, upper gastrointestinal symptoms and five or more gastric/duodenal erosions, or low-dose ASA treatment initiated within 1 month of randomisation; or age ≥65 years. All patients were ulcer-free at study (...) Prevention of peptic ulcers with esomeprazole in patients at risk of ulcer development treated with low-dose acetylsalicylic acid: a randomised, controlled trial (OBERON). To determine whether once-daily esomeprazole 40 mg or 20 mg compared with placebo reduces the incidence of peptic ulcers over 26 weeks of treatment in patients taking low-dose acetylsalicylic acid (ASA) and who are at risk for ulcer development.Multinational, randomised, blinded, parallel-group, placebo-controlled

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2011 EvidenceUpdates

139. Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn’s Disease and Ulcerative Colitis (PubMed)

Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn’s Disease and Ulcerative Colitis Cigarette smoking is a major risk factor for gastrointestinal disorders, such as peptic ulcer, Crohn's disease (CD), and several cancers. The mechanisms proposed to explain the role of smoking in these disorders include mucosal damage, changes in gut irrigation, and impaired mucosal immune response. Paradoxically, cigarette smoking is a protective factor (...) for the development and progression of ulcerative colitis (UC). UC and CD represent the two most important conditions of inflammatory bowel diseases, and share several clinical features. The opposite effects of smoking on these two conditions have been a topic of great interest in the last 30 years, and has not yet been clarified. In this review, we summarize the most important and well-understood effects of smoking in the gastrointestinal tract; and particularly, in intestinal inflammation, discussing available

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2018 Frontiers in immunology

140. Challenges in the management of acute peptic ulcer bleeding. (PubMed)

Challenges in the management of acute peptic ulcer bleeding. Acute upper gastrointestinal bleeding is a common medical emergency worldwide, a major cause of which are bleeding peptic ulcers. Endoscopic treatment and acid suppression with proton-pump inhibitors are cornerstones in the management of the disease, and both treatments have been shown to reduce mortality. The role of emergency surgery continues to diminish. In specialised centres, radiological intervention is increasingly used (...) literature about the management of patients with bleeding peptic ulcers, identify directions for future clinical research, and suggest how mortality can be reduced.Copyright © 2013 Elsevier Ltd. All rights reserved.

2013 Lancet

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