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Peptic Ulcer Disease

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101. Prevalence of Specific Helicobacter Pylori cagA, vacA, iceA, ureC Genotypes and its Clinical Relevance in the Patients with Acid-Peptic Diseases (PubMed)

oesophagitis and 3(17.64%) in patients with diodenal ulcer. We found 0% prevalence of iceA gene; conversely we had three peptic ulcer patients with only cagA positivity.The cagA positive strain mainly affects the patients with gastritis specifically of female gender and iceA genotype is not a useful marker associated with peptic ulcer disease. Patients should be screened for cagA genotype when reported to be a case of gastritis for early treatment to prevent further complications such as cancer. (...) Prevalence of Specific Helicobacter Pylori cagA, vacA, iceA, ureC Genotypes and its Clinical Relevance in the Patients with Acid-Peptic Diseases Virulent markers of H. pylori, the vacuolating cytotoxin (vacA), cytotoxin-associated gene A (cagA), induced by contact with epithelium factor antigen (iceA gene) and the urease C gene (ureC) may plays a major role in determining the clinical outcome of Helicobacter infections.To detect the prevalence of the cagA, vacA, ureC and iceA genotypes of H

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2017 Journal of clinical and diagnostic research : JCDR

102. Predicting risk factors for rebleeding, infections, mortality following peptic ulcer bleeding in patients with cirrhosis and the impact of antibiotics prophylaxis at different clinical stages of the disease. (PubMed)

Predicting risk factors for rebleeding, infections, mortality following peptic ulcer bleeding in patients with cirrhosis and the impact of antibiotics prophylaxis at different clinical stages of the disease. Infections in cirrhotic patients with upper gastrointestinal bleeding are a common event causing severe complication and mortality. This study aimed to identify risk factors that may predict rebleeding, bacterial infections, and the impact of antibiotic prophylaxis on mortality at different (...) stages of cirrhosis following acute peptic ulcer bleeding (PUB).A hospital-based retrospective cohort study was conducted on 235 cirrhotic patients with acute peptic ulcer hemorrhage who underwent therapeutic endoscopic procedures between January 2008 and January 2014 (n = 235); of these, 88 patients received prophylactic intravenous ceftriaxone (antibiotic group) and 147 patients did not (nil-antibiotic group). The recorded outcomes were length of hospital stay, bacterial infection, rebleeding

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2015 BMC Gastroenterology

103. Antroduodenectomy with Gastroduodenal Anastomosis: Salvage Emergency Surgery for Complicated Peptic Ulcer Disease-Results of a Double Institution Study of 35 Patients. (PubMed)

Antroduodenectomy with Gastroduodenal Anastomosis: Salvage Emergency Surgery for Complicated Peptic Ulcer Disease-Results of a Double Institution Study of 35 Patients. Endoscopic and interventional techniques are currently the mainstay of management of bleeding duodenal ulcer. As well, for patients with perforated duodenal ulcer, laparoscopic simple closure is nowadays usually performed. Although indications for emergency antroduodenectomy have declined, this procedure is still necessary (...) , and postoperative medical complications were associated with an increased risk of in-hospital mortality. In the multivariate analysis, age and ASA score remained independent risk factors. No recurrence of complicated duodenal disease was observed.Antroduodenectomy with gastroduodenal anastomosis is a safe and effective long-term strategy, with a low and acceptable rate of surgical complications, for complicated duodenal ulcer not responding to conservative measures.

2015 Journal of Gastrointestinal Surgery

104. Upper gastrointestinal bleeding due to peptic ulcer disease is not associated with air pollution: a case-crossover study. (PubMed)

Upper gastrointestinal bleeding due to peptic ulcer disease is not associated with air pollution: a case-crossover study. Recent studies have demonstrated an association between short-term elevations in air pollution and an increased risk of exacerbating gastrointestinal disease. The objective of the study was to evaluate if day-to-day increases in air pollution concentrations were positively associated with upper gastrointestinal bleeding (UGIB) secondary to peptic ulcer disease (PUD).A time

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2015 BMC Gastroenterology

105. Surgery for Peptic Ulcer Disease in sub-Saharan Africa: Systematic Review of Published Data. (PubMed)

Surgery for Peptic Ulcer Disease in sub-Saharan Africa: Systematic Review of Published Data. Peptic ulcer disease is a significant cause of morbidity and mortality worldwide, with a significant burden in low- and middle-income countries. However, there is limited information regarding management of peptic ulcer disease in these countries. This study describes surgical interventions for peptic ulcer disease in sub-Saharan Africa.A systematic review was performed using PubMed, EMBASE, and African (...) Index Medicus for studies describing surgical management of peptic ulcer disease in sub-Saharan Africa.From 55 published reports, 6594 patients underwent surgery for peptic ulcer disease. Most ulcers (86%) were duodenal with the remainder gastric (14%). Thirty-five percent of operations were performed for perforation, 7% for bleeding, 30% for obstruction, and 28% for chronic disease. Common operations included vagotomy (60%) and primary repair (31%). The overall case fatality rate for peptic ulcer

2015 Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

106. Prescription Patterns of Traditional Chinese Medicine for Peptic Ulcer Disease in Taiwan: A Nationwide Population-based Study. (PubMed)

Prescription Patterns of Traditional Chinese Medicine for Peptic Ulcer Disease in Taiwan: A Nationwide Population-based Study. Peptic ulcer disease is a common digestive disease. There is a lack of large-scale survey on the use of traditional Chinese medicine (TCM) for the treatment of peptic ulcer disease. This study aimed to investigate the utilization of TCM for the treatment of peptic ulcer disease in Taiwan.We analyzed a random sample comprised of one million individuals with newly (...) diagnosed peptic ulcer disease between 2001 and 2010 from the National Health Insurance Research Database in Taiwan. Demographic characteristics and TCM usage, including Chinese herbal formulas and the single herbs prescribed for patients with peptic ulcer disease, were analyzed.A total of 96,624 newly diagnosed subjects with peptic ulcer disease were included. 14,983 (15.5%) patients were TCM users. People residing in highly urbanized areas, younger people and female (compared with male) were more

2015 Journal of Ethnopharmacology

107. Duodenal perforation following esophagogastroduodenoscopy (EGD) with cautery and epinephrine injection for peptic ulcer disease: An interesting case of nonoperative management in the medical intensive care unit (MICU) (PubMed)

Duodenal perforation following esophagogastroduodenoscopy (EGD) with cautery and epinephrine injection for peptic ulcer disease: An interesting case of nonoperative management in the medical intensive care unit (MICU) The utilization of esophagogastroduodenoscopy (EGD) and related procedures continues to rise. Due to this increase in utilization is an inevitable rise in serious complications such as hemorrhage and perforation. One understudied and dreaded complication of EGD causing significant (...) morbidity and mortality is duodenal perforation.We present the case of a 63-year-old male who presented to our institution's emergency room with dyspepsia, melanic stools, tachycardia, and hypotension. Initial laboratory evaluation was significant for severe anemia, lactic acidosis, and acute kidney injury, while CT scan of the abdomen pelvis did not suggest retroperitoneal hematoma or bowel perforation. An emergent EGD was performed which showed multiple bleeding duodenal ulcers that were cauterized

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2015 International journal of surgery case reports

108. Decreased stress resilience in young men significantly increases the risk of subsequent peptic ulcer disease - a prospective study of 233 093 men in Sweden. (PubMed)

Decreased stress resilience in young men significantly increases the risk of subsequent peptic ulcer disease - a prospective study of 233 093 men in Sweden. Psychosocial stress may influence peptic ulcer disease (PUD) risk, but it can be difficult to identify reliably whether stressful exposures pre-dated disease. The association of stress resilience (susceptibility to stress) with subsequent PUD risk has been incompletely investigated.To assess if stress resilience in adolescence is associated

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2015 Alimentary Pharmacology & Therapeutics

109. Chronic liver disease and 90-day mortality in 21 359 patients following peptic ulcer bleeding - a Nationwide Cohort Study. (PubMed)

Chronic liver disease and 90-day mortality in 21 359 patients following peptic ulcer bleeding - a Nationwide Cohort Study. Bleeding is a serious and frequent complication of peptic ulcer disease. Hepatic dysfunction can cause coagulopathy and increases the risk of peptic ulcer bleeding. However, whether chronic liver disease increases mortality after peptic ulcer bleeding remains unclear.To examine the prognostic impact of chronic liver disease on mortality after peptic ulcer bleeding.We used (...) population-based medical registries to conduct a cohort study of all Danish residents hospitalised with incident peptic ulcer bleeding from 2004 through 2011. We identified patients diagnosed with liver cirrhosis or non-cirrhotic chronic liver disease before their admission for peptic ulcer bleeding. We then computed 90-day mortality after peptic ulcer bleeding based on the Kaplan-Meier method (1 - survival function) and used a Cox regression model to estimate mortality rate ratios (MRRs), controlling

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2015 Alimentary Pharmacology & Therapeutics

110. Increased Subsequent Risk of Peptic Ulcer Diseases in Patients With Bipolar Disorders. (PubMed)

Increased Subsequent Risk of Peptic Ulcer Diseases in Patients With Bipolar Disorders. Previous studies have reported that patients with bipolar disorders (BDs) exhibit increased physical comorbidity and psychological distress. Studies have shown that schizophrenia and anxiety increase the risk of peptic ulcer diseases (PUDs). Therefore, we conducted this study to determine the association between these 2 diseases and examine the possible risk factors. We used patients diagnosed with BDs from

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2015 Medicine

111. A tool to predict risk for gastric cancer in patients with peptic ulcer disease on the basis of a nationwide cohort. (PubMed)

A tool to predict risk for gastric cancer in patients with peptic ulcer disease on the basis of a nationwide cohort. Patients with gastric ulcers have significantly higher risk of gastric cancer, especially within 2 years after diagnosis. We used data from a national database to develop a personalized risk prediction model for patients with peptic ulcer diseases.We collected data from Taiwan's National Health Insurance Research Database on 278,898 patients admitted for the first time (...) with a primary diagnosis of peptic ulcer disease. We used the data to develop a nomogram, which we validated by discrimination and calibration, and in a test cohort. Cumulative incidences of study subjects predicted by the nomogram were examined.In total, 1269 subjects developed gastric cancer. Age, sex, peptic ulcer sites, peptic ulcer complications, Helicobacter pylori eradication, nonsteroidal anti-inflammatory drug use, and surveillance endoscopy were independent factors associated with risk of gastric

2015 Clinical Gastroenterology and Hepatology

112. Genome Sequencing of 10 Helicobacter pylori Pediatric Strains from Patients with Nonulcer Dyspepsia and Peptic Ulcer Disease (PubMed)

Genome Sequencing of 10 Helicobacter pylori Pediatric Strains from Patients with Nonulcer Dyspepsia and Peptic Ulcer Disease We present draft genome sequences of 10 Helicobacter pylori clinical strains isolated from children. This will be important for future studies of comparative genomics in order to better understand the virulence determinants underlying peptic ulcer disease. Copyright © 2015 Nunes et al.

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2015 Genome Announcements

113. Cost effectiveness of high-dose intravenous esomeprazole for peptic ulcer bleeding

Cost effectiveness of high-dose intravenous esomeprazole for peptic ulcer bleeding Cost effectiveness of high-dose intravenous esomeprazole for peptic ulcer bleeding Cost effectiveness of high-dose intravenous esomeprazole for peptic ulcer bleeding Barkun AN, Adam V, Sung JJ, Kuipers EJ, Mossner J, Jensen D, Stuart R, Lau JY, Naucler E, Kilhamn J, Granstedt H, Liljas B, Lind T Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED (...) . Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study assessed the cost-effectiveness of high-dose intravenous esomeprazole, versus no intravenous proton-pump inhibitor, to prevent re-bleeding, after successful endoscopic haemostasis, in patients with peptic ulcer bleeding. The authors concluded that high-dose intravenous esomeprazole improved

2010 NHS Economic Evaluation Database.

114. Dyspepsia - proven peptic ulcer

Dyspepsia - proven peptic ulcer Dyspepsia - proven peptic ulcer - NICE CKS Clinical Knowledge Summaries Share Dyspepsia - proven peptic ulcer: Summary The term 'dyspepsia' is used to describe a complex of upper gastrointestinal tract symptoms which are typically present for four or more weeks, including upper abdominal pain or discomfort, heartburn, acid reflux, nausea and/or vomiting. If symptoms of heartburn and acid regurgitation predominate, then gastro-oesophageal reflux disease (GORD (...) ) is the more likely diagnosis. Gastric or duodenal ulcers (peptic ulcer disease) describe a breach in the epithelium of the gastric or duodenal mucosa, which is confirmed on endoscopy. The most common risk factors for the development of peptic ulcer disease are Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin. Complications of peptic ulcer disease include haemorrhage, perforation, and gastric outlet obstruction. Initial management of peptic ulcer disease includes

2015 NICE Clinical Knowledge Summaries

115. Effect of licorice versus bismuth on eradication of Helicobacter pylori in patients with peptic ulcer disease. (PubMed)

Effect of licorice versus bismuth on eradication of Helicobacter pylori in patients with peptic ulcer disease. Different therapeutic regimens were used for eradication of Helicobacter pylori, based on the cost, effectiveness and patient's compliance. The aim of this study was the evaluation of licorice compared with bismuth in quadruple regimen on eradication of H. pylori in patients with peptic ulcer disease (PUD).In a double-blind clinical trial study, 60 patients with PUD and positive rapid (...) eradication.Mean age of the patients in the control and case groups were 40.8 ± 15.5 and 42.2 ± 15.8 years, respectively (P = 0.726). Seventeen (56.7%) patients in control group and 16 (53.3%) in the case group were female (P = 0.795). Both groups were similar based on frequency of gastric or duodenal ulcer. Response to treatment were seen in 20 (67%) and 17 (57%) patients of case and control groups, respectively (P > 0.05).Our study showed that licorice is as effective as bismuth in H. pylori eradication

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2014 Pharmacognosy research

116. Peptic Ulcer Disease in Helicobacter Pylori-Infected Children: Clinical Findings and Mucosal Immune Response. (PubMed)

Peptic Ulcer Disease in Helicobacter Pylori-Infected Children: Clinical Findings and Mucosal Immune Response. Peptic ulcer disease (PUD) is highly prevalent among adults but less common in children. Helicobacter pylori infection, the main cause of PUD, is, however, acquired extremely early in life. The aim of the study was to analyze clinical characteristics of children with PUD in a country with a high prevalence of the disease and to evaluate which host factors could determine this clinical (...) outcome.Children referred for upper gastrointestinal (GI) endoscopy with suspicion of peptic diseases were included prospectively during an 8-year period. Antral biopsies were performed to determine H pylori presence and mucosal cytokines profile.A total of 307 children between 3 and 18 years old were enrolled. Of the total, 237 children (46% boys) with complete data were included. H pylori infection was confirmed in 133 (56.1%) participants. Duodenal ulcer (DU) was diagnosed in 32 patients (13.5%); among them

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2014 Journal of Pediatric Gastroenterology and Nutrition

117. INCREASED INCIDENCE OF PEPTIC ULCER DISEASE IN CENTRAL SEROUS CHORIORETINOPATHY PATIENTS: A Population-Based Retrospective Cohort Study. (PubMed)

INCREASED INCIDENCE OF PEPTIC ULCER DISEASE IN CENTRAL SEROUS CHORIORETINOPATHY PATIENTS: A Population-Based Retrospective Cohort Study. To investigate peptic ulcer disease and other possible risk factors in patients with central serous chorioretinopathy (CSR) using a population-based database.In this population-based retrospective cohort study, longitudinal data from the Taiwan National Health Insurance Research Database were analyzed. The study cohort comprised 835 patients with CSR (...) and the control cohort comprised 4175 patients without CSR from January 2000 to December 2009. Conditional logistic regression was applied to examine the association of peptic ulcer disease and other possible risk factors for CSR, and stratified Cox regression models were applied to examine whether patients with CSR have an increased chance of peptic ulcer disease and hypertension development.The identifiable risk factors for CSR included peptic ulcer disease (adjusted odd ratio: 1.39, P = 0.001) and higher

2014 Retina

118. What Is the Best Predictor of Mortality in Perforated Peptic Ulcer Disease? A Population-Based, Multivariable Regression Analysis Including Three Clinical Scoring Systems. (PubMed)

What Is the Best Predictor of Mortality in Perforated Peptic Ulcer Disease? A Population-Based, Multivariable Regression Analysis Including Three Clinical Scoring Systems. Mortality rates in perforated peptic ulcer (PPU) have remained unchanged. The aim of this study was to compare known clinical factors and three scoring systems (American Society of Anesthesiologists (ASA), Boey and peptic ulcer perforation (PULP)) in the ability to predict mortality in PPU.This is a consecutive, observational (...) cohort study of patients surgically treated for perforated peptic ulcer over a decade (January 2001 through December 2010). Primary outcome was 30-day mortality.A total of 172 patients were included, of whom 28 (16 %) died within 30 days. Among the factors associated with mortality, the PULP score had an odds ratio (OR) of 18.6 and the ASA score had an OR of 11.6, both with an area under the curve (AUC) of 0.79. The Boey score had an OR of 5.0 and an AUC of 0.75. Hypoalbuminaemia alone (≤37 g/l

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2014 Journal of Gastrointestinal Surgery

119. Risk of uncomplicated peptic ulcer disease in a cohort of new users of low-dose acetylsalicylic acid for secondary prevention of cardiovascular events. (PubMed)

Risk of uncomplicated peptic ulcer disease in a cohort of new users of low-dose acetylsalicylic acid for secondary prevention of cardiovascular events. The aim of this study was to analyse the risk of uncomplicated peptic ulcer disease (PUD) in a cohort of new users of low-dose acetylsalicylic acid (ASA) for secondary prevention of cardiovascular events in a UK primary care setting.New users of low-dose ASA for secondary prevention of cardiovascular events, aged 50-84 years in 2000-2007, were (...) significantly increase the risk of development of uncomplicated PUD in new users of low-dose ASA. Therefore, physicians should monitor ASA users for gastrointestinal symptoms and signs of ulcer, particularly if they have additional risk factors.

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2014 BMC Gastroenterology

120. Correlation between the cystathionine-r-lyase (CES) and the severity of peptic ulcer disease (PubMed)

Correlation between the cystathionine-r-lyase (CES) and the severity of peptic ulcer disease The infection of Helicobacter pylori (H. pylori) is one of the most important causes of gastric ulcer disease. The role of hydrogen sulfide (H2S) production in H. pylori-induced gastric ulcer disease.The expression of cystathionine-γ-lyase (CSE) was determined, and correlated with the severity of gastric ulcer disease.One hundred and eight patients were selected based on the determination of gastric (...) ulcer and the infection of Helicobacter pylori (H. pylori), including 36 normal control, 36 patients with H. Pylori-negative gastric ulcer, and 36 patients with H. Pylori-positive gastric ulcer. RT-PCR determination was performed to determine the expression of CSE, NF-κB and IL-8.The expression of CSE, NF-κB and IL-8 was higher in the gastric ulcer group than control group (p<0.05). Compared with the H. pylori-negative gastric ulcer, the expression of CSE, NF-κB and IL-8 was higher than H. pylori

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2014 African health sciences

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