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Hospitalizations associated with malignantneoplasia and in situcarcinoma in the anus and penis in men and women during a 5-year period (2009â€“2013) in Spain: An epidemiological study Approximately 40,000 new cases of anal cancer and 26,000 new cases of penilecancer occurred in 2012 worldwide. Human Papillomavirus (HPV) infection is responsible for 88.3% and 33.0% of these cancers, respectively. The aim of this study was to describe the hospital burden associated with malignantneoplasm (MN (...) ) and in situcarcinoma (ISC) in the anus and penis in Spain from 2009 to 2013.This observational, retrospective study used discharge information obtained from the national surveillance system for hospital data, Conjunto Mínimo Básico de Datos, provided by the Ministry of Health.We found 3,668 hospitalizations due to MN and ISC in the anus for both genders, and more than 55% of these hospitalizations occurred in men and were associated with a lower median age of hospitalization (p < 0.001), higher average
Simultaneous Occurrence of Balanoposthitis Circumscripta Plasmacellularis Zoon, Phimosis and in SituCarcinoma of the Penis: Case Report with An Unusual Ulcerated Polypoid Variant of Zoonâ€™s Disease and a Carcinoma in Situ of Reserve Cell Type Zoon's balanitis is a benign disease characterized by an asymptomatic, chronic, solitary, shiny, red-orange plaque of the glans and/ or prepuce. In rare cases of Zoon's disease, penile squamous cell carcinoma developed in the chronic inflammatory (...) lesions.We report on a 68-year-old male patient presenting with phimosis and coexistent Zoon's disease and penilecarcinoma in situ treated successfully by circumcision.Coexistence of both lesions in contrast to the development of cancerous lesions within pre-existent Zoon's disease is a very rare observation.
Pulsed-dye laser therapy for carcinoma in situ of the penis. 29368336 2018 08 29 1365-2133 179 1 2018 Jul The British journal of dermatology Br. J. Dermatol. Pulsed-dye laser therapy for carcinoma in situ of the penis. 195-196 10.1111/bjd.16377 Niederkorn A A Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. Sadoghi B B http://orcid.org/0000-0003-2342-022X Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. Komericki P P
of penile carcinogenesis has facilitated understanding and classification of these tumours, handling and subtyping of penilemalignancies presents a challenge to the reporting pathologist, in part due to their rarity. This article reviews the terminology and classification of in situ and invasive carcinomas and their relationship to human papilloma virus status. In addition, associated non-neoplastic dermatological conditions of relevance and appropriate ancillary investigations will be addressed (...) Review of in situ and invasive penile squamous cell carcinoma and associated non-neoplastic dermatological conditions. Penilecarcinoma is a rare genitourinary malignancy in North America and Europe with highest rates recorded in South America, Africa and Asia. Recent classifications have refined the terminology used in classifying intraepithelial/in situ lesions and additionally newer entities have been recognised in the invasive category. While increasing recognition of a bimodal pathway
, Queyrat's erythroplasia (disorder) , Queyrat's erythroplasia (morphologic abnormality) , Carcinoma in situ of penis, NOS , Grade III Penile Intraepithelial Neoplasia , Grade III Squamous Intraepithelial Lesion of Penis , Grade III Squamous Intraepithelial Lesion of the Penis , Queyrat Erythroplasia , Queyrat's Erythroplasia , Bowen's Disease of Penis , Bowen's Disease of the Penis , Carcinoma in situ of Penis , Carcinoma in situ of the Penis , PenileCarcinoma In Situ Italian Carcinomi in situ del pene (...) Carcinoma in Situ Aka: PenileCarcinoma in Situ , PenileCancer in Situ , Penile Erythroplasia of Queyrat , Bowen Disease of the Penis , Carcinoma in Situ of Penis II. Epidemiology Occurs in uncircumsized men over age 60 years III. Causes s due to HPV infection (key causative factor) Local from heat, friction or inflammation IV. Symptoms Asymptomatic in 50% of men (other than the lesions being present) Pain V. Signs Velvet-like s on glans penis (erythroplasia of Queyrat) Raised, beefy red irregularly
The analysis of human papillomavirus DNA in penilecancer tissue by in situ hybridization Primary penilecancer is a rare disease. Higher incidence rates occur in underdeveloped countries. Many studies have suggested an association between human papillomavirus (HPV) infection and penilecancer. Although HPV can affect the squamous epithelium of the male genitalia similarly to the female genital tract, the association between penilecancer and HPV remains unclear. In the present study, the HPV (...) gene expression was examined in penilecancer tissue using in situ hybridization (ISH). The present study included 41 cases in which penectomy was performed and 3 cases in which tumor resection was performed to treat pathologically-diagnosed penilecancer at Yokohama City University Medical Center, and its 7 affiliated hospitals between April 1990 and March 2010. The penilecancer tissue was subjected to an ISH analysis, and the clinicopathological features and prognosis were investigated. A total
squamous cell carcinoma of the penis and their relationship with associated carcinoma. J Am Acad Dermatol, 2010. 62: 284. 51. Brierley, J., et al., TNM Classification of MalignantTumours, 8th Edn. 2016. 52. Tang, V., et al. Should centralized histopathological review in penilecancer be the global standard? BJU Int, 2014. 114: 340. 53. Aumayr, K., et al. P16INK4A immunohistochemistry for detection of human papilloma virus-associated penile squamous cell carcinoma is superior to in-situ hybridization (...) of local routes of spread of penile squamous cell carcinoma. Am J Surg Pathol, 2004. 28: 384. 69. Mahesan, T., et al. Advances in Penile-Preserving Surgical Approaches in the Management of PenileTumors. Urol Clin North Am, 2016. 43: 427. 70. Bertolotto, M., et al. Primary and secondary malignancies of the penis: ultrasound features. Abdom Imaging, 2005. 30: 108. 71. Lont, A.P., et al. A comparison of physical examination and imaging in determining the extent of primary penilecarcinoma. BJU Int, 2003
Comparing outcomes of robotic and open inguinal lymph node dissection in patients with carcinomapenis. We compared outcomes between robot-assisted video endoscopic inguinal lymphadenectomy and open inguinal lymph node dissection in patients without bulky nodal metastasis in a tandem contemporary cohort.We retrospectively analyzed a prospectively maintained hospital registry of 51 patients who underwent robot-assisted video endoscopic inguinal lymphadenectomy and 100 treated with open inguinal (...) lymph node dissection from 2012 to 2016 for groins without bulky nodal metastasis and who had a minimum 9-month followup. Complications were graded by the Clavien-Dindo classification, and nodal yield and disease recurrence during followup were assessed. Elastic net regression was used to select variables associated with major complications (Clavien 3a or greater) for multivariable analysis of plausible factors, including patient age, diabetes, body mass index, smoking, nodal stage, surgery type
A Rare Variant of Penile Squamous Cell Carcinoma in a Man with Paraplegia Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma (SCC). It is described as a low grade, slow growing, locally infiltrative neoplasm that accounts for 3%-8% of penile SCCs. Here we report a case of destructive VC of the glans penis in a paraplegic man resulting in a hypospadias from the tip of the glans to the corona. Histology demonstrated exophytic squamous epithelial proliferation (...) with characteristic round, pushing borders. In situ hybridization was positive for both low-risk and high-risk strains of human papillomavirus.
MalignantTumors of the Penis. Although penilecancer is rare in developed countries, it occurs more frequently in other parts of the world and causes significant morbidity and mortality.To review the current literature on the pathogenesis, risk factors, clinical presentation, staging, and treatment of premalignant and malignanttumors of the penis.A literature review using PubMed was conducted searching for articles on penile malignancies.The majority of penilecancers are in situ or invasive (...) squamous cell carcinomas, although other rare tumors of the penis occur, such as melanoma, basal cell carcinoma, extramammary Paget's disease, and soft tissue sarcomas.Physicians should be aware of the risk factors and clinical presentation of penilemalignancies because early diagnosis is essential in effective management and cure. Accurate staging is imperative for risk stratification and treatment planning. Depending on the type of tumor, size of tumor, location, staging, and grading, treatment
of the penis and their relationship with associated carcinoma. J Am Acad Dermatol, 2010. 62: 284. 51. Brierley, J., et al., TNM Classification of MalignantTumours, 8th Edn. 2016. 52. Tang, V., et al. Should centralized histopathological review in penilecancer be the global standard? BJU Int, 2014. 114: 340. 53. Aumayr, K., et al. P16INK4A immunohistochemistry for detection of human papilloma virus-associated penile squamous cell carcinoma is superior to in-situ hybridization. Int J Immunopathol Pharmacol (...) of spread of penile squamous cell carcinoma. Am J Surg Pathol, 2004. 28: 384. 69. Mahesan, T., et al. Advances in Penile-Preserving Surgical Approaches in the Management of PenileTumors. Urol Clin North Am, 2016. 43: 427. 70. Bertolotto, M., et al. Primary and secondary malignancies of the penis: ultrasound features. Abdom Imaging, 2005. 30: 108. 71. Lont, A.P., et al. A comparison of physical examination and imaging in determining the extent of primary penilecarcinoma. BJU Int, 2003. 91: 493. 72
of Urological Pathology renal tumour grading system was recommended, and the definition of renal papillary adenoma was modified. The new WHO classification of penile squamous cell carcinomas is based on the presence of human papillomavirus and defines histologic subtypes accordingly. Germ cell neoplasia in situ (GCNIS) of the testis is the WHO-recommended term for precursor lesions of invasive germ cell tumours, and testicular germ cell tumours are now separated into two fundamentally different groups (...) : those derived from GCNIS and those unrelated to GCNIS. Spermatocytic seminoma has been designated as a spermatocytic tumour and placed within the group of non-GCNIS-related tumours in the 2016 WHO classification.The 2016 World Health Organization (WHO) classification contains new renal tumour entities. The classification of penile squamous cell carcinomas is based on the presence of human papillomavirus. Germ cell neoplasia in situ of the testis is the WHO-recommended term for precursor lesions
of imiquimod, 145 PDT 79,80 and CO 2 laser ablation. 146 12.2 Penile intraepithelial neoplasia PIN is a term that has been used to encompass the three pre- malignant clinical entities of EQ, Bowen’s disease of the penis (BDP) and bowenoid papulosis (BP). 147,148 Although EQ and BDP are sometimes used interchangeably, they are clinically distinct. EQ presents as one or more red, moist plaques on the mucosal surfaces of the glans and inner aspect of the foreskin, while BDP should be used to describe red (...) cancer with Bowen’s disease. A population-based study. JAMA 1991; 266:816–19. 8 Eedy DJ, Gavin AT. Thirteen-year retrospective study of Bowen’s disease in Northern Ireland. Br J Dermatol 1987; 117:715–20. 9 Cox NH. Body site distribution of Bowen’s disease. Br J Dermatol 1994; 130:714–16. 10 Jaeger AB, Gramkow A, Hjalgrim H et al. Bowen disease and risk of subsequent malignantneoplasms: a population-based cohort study of 1147 patients. Arch Dermatol 1999; 135:790–3. 11 Hansen JP, Drake AL, Walling
Predictive factors for local recurrence after glansectomy and neoglans reconstruction for penile squamous cell carcinoma. To investigate predictive pathological factors for local recurrence (LR) after glansectomy for penile squamous cell carcinoma (SCC) and to develop a risk score for prediction of LR after glansectomy.In this retrospective study, we analyzed 117 patients operated between February 2005 and January 2016 in a supraregional penilecancer center in the UK for LR after glansectomy (...) were the presence of perineural invasion, carcinoma in situ, positive margin on definitive pathology, and high-grade disease. Based on Kaplan-Meier analysis stratified by number of factors present, we defined 3 risk groups for LR: low (0,1 risk factors) as reference, intermediate (2,3 risk factors) with HR of 13.9 (95% CI: 1.81-107.04, P = 0.0115), or high risk (all 4 risk factors present) with a HR of 34.2 (95% CI: 3.07-381.81, P = 0,0041). Limitations include the retrospective design and low
cancers. 9 About 91% of all head and neck cancers are squamous cell carcinomas, 2% are sarcomas and the other 7% are adenocarcinomas, melanomas and not well specified tumours. 10 KCE Report 305 Quality indicators for the management of HNSCC 23 Head & neck cancers occur preferentially in males. In 2016, there were 2 694 new diagnoses of head and neck cancer in Belgium, 2 005 in males and 689 in females. 11 In Belgium, head and neck cancer is the 4 th most frequent tumour in males (6% of all (...) and neck (DS-3) 60 5.1.4 FDG-PET(/CT) before treatment (DS-4) 62 5.2 QUALITY OF TREATMENT IN SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK 64 5.2.1 Single modality treatment in stage I-II (T-1) 64 5.2.2 Total laryngectomy in T4a laryngeal cancer (SX-1) 66 5.2.3 Timeliness postoperative radiotherapy (RT-1) 67 5.2.4 Primary chemoradiotherapy for locally-advanced non-metastatic disease (RT-2) 69 5.2.5 Neck imaging after primary (chemo)radiotherapy (LN-1) 71 5.2.6 Elective neck dissection in cN0M0 squamous
margins (median follow-up: 17-37 months), in men with pT1-3N0-2 distal urethral carcinoma treated with well-defined penis-preserving surgery and additional iliac/inguinal lymphadenectomy for clinically suspected LN disease [ ]. This suggests that prognosis is mainly determined by nodal stage. Similar results for the feasibility of penile-preserving surgery have also been reported in recent series [ , ]. However, a series on patients treated with penis-preserving surgery for distal urethral cancer (...) cancer burden in Europe. Eur J Cancer, 2011. 47: 2493. 9. Brierley, J.D., et al., TNM classification of malignanttumors. UICC International Union Against Cancer. 2017, Wiley/Blackwell. p. 208. 10. Visser, O., et al. Incidence and survival of rare urogenital cancers in Europe. Eur J Cancer, 2012. 48: 456. 11. Swartz, M.A., et al. Incidence of primary urethral carcinoma in the United States. Urology, 2006. 68: 1164. 12. Medina Perez, M., et al. [Squamous carcinoma of the male urethra, its presentation
Reports 2017 11 06 United States JAAD Case Rep 101665210 2352-5126 HPV, human papilloma virus MGUS, monoclonal gammopathy of undetermined significance PIN, penile intraepithelial neoplasia SCCIS, squamous cell carcinoma in situ genital neoplasia human papilloma virus medical dermatology oncology squamous cell carcinoma squamous cell carcinoma in situ 2017 12 22 6 0 2017 12 22 6 0 2017 12 22 6 1 epublish 29264387 10.1016/j.jdcr.2017.07.017 S2352-5126(17)30166-2 PMC5728716 Cochrane Database Syst Rev (...) p16+ Squamous cell carcinoma in situ masquerading as genital psoriasis 29264387 2019 02 26 2352-5126 3 6 2017 Nov JAAD case reports JAAD Case Rep p16 + Squamous cell carcinoma in situ masquerading as genital psoriasis. 542-545 10.1016/j.jdcr.2017.07.017 Worley Brandon B Division of Dermatology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Glassman Steven J SJ Division of Dermatology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. eng Case
or de novo gain-of-function mutation in the RET proto-oncogene associated with multiple endocrine neoplasia (MEN) type 2, either MEN2A or MEN2B, depending on the specific mutation.[ ] When occurring in patients with the MEN syndromes, thyroid cancer may be associated with the development of other types of malignanttumors. (Refer to the section of the PDQ summary on for more information.) Family history. For thyroid carcinomas of follicular cells, only 5% to 10% are familial cancers. Of those, most (...) tumor or enlarged lymph nodes of the neck. Nasopharyngeal carcinomas must be distinguished from all other cancers that can present with enlarged lymph nodes and from other types of cancer in the head and neck area. Thus, diseases such as thyroid cancer, rhabdomyosarcoma, non-Hodgkin lymphoma including Burkitt lymphoma, and Hodgkin lymphoma must be considered, as well as benign conditions such as nasal angiofibroma, which usually presents with epistaxis in adolescent males, infectious lymphadenitis
Follow-up for Clinically Localized Renal Neoplasms Follow-up for Clinically Localized Renal Neoplasms - American Urological Association advertisement Toggle navigation About Us About the AUA Membership AUA Governance Industry Relations Education AUAUniversity Education Products & Resources Normal Histology and Important Histo-anatomic Structures Urinary Bladder Prostate Kidney Renovascular Diseases Andrenal Gland Testis Paratesticular TumorsPenis Retroperitoneum Cytology Online Learning (...) by Thompson et al, 13% of tumors measuring 4cm or less and 16.5% of tumors measuring 3cm or less were benign. 35 In addition, some tumors known to be malignant but resected at a smaller size are more likely to behave in an indolent manner. For example, in a recent study by Przybycin et al, only 1 of 74 Chromophobe carcinomas resected with a size of 4 cm or less developed metastatic disease, with a median clinical follow-up period of over six years. 36 Thus, it is logical that attempts should be made