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1. Penile Cancer

Penile Cancer EAU Guidelines: Penile Cancer | Uroweb › Penile Cancer Penile Cancer To access the pdfs & translations of individual guidelines, please as EAU member. Non-EAU members can view the web versions. To become an EAU member, click . O.W. Hakenberg (Chair), E.Compérat, S. Minhas, A. Necchi, C. Protzel, N.Watkin (Vice-chair) Guidelines Associate: R. Robinson TABLE OF CONTENTS REFERENCES 1. Hakenberg, O.W., et al. EAU guidelines on penile cancer: 2014 update. Eur Urol, 2015. 67: 142. 2 (...) . Robinson, R.N., et al. What are the risks and benefits of adjuvant radiotherapy after inguinal lymphadenectomy for penile cancer? PROSPERO, 2015. 3. Clark, P.E., et al. Penile cancer: Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw, 2013. 11: 594. 4. Souillac, I., et al. [Penile cancer in 2010: update from the Oncology Committee of the French Association of Urology: external genital organs group (CCAFU-OGE)]. Prog Urol, 2011. 21: 909. 5. Van Poppel, H., et al. Penile cancer: ESMO

2019 European Association of Urology

2. Penile Cancer

Penile Cancer Penile Cancer | Uroweb › Penile Cancer Penile Cancer To access the pdfs & translations of individual guidelines, please as EAU member. Non-EAU members can view the web versions. To become an EAU member, click . O.W. Hakenberg (Chair), E.Compérat, S. Minhas, A. Necchi, C. Protzel, N.Watkin (Vice-chair) Guidelines Associate: R. Robinson TABLE OF CONTENTS REFERENCES 1. Hakenberg, O.W., et al. EAU guidelines on penile cancer: 2014 update. Eur Urol, 2015. 67: 142. 2. Robinson, R.N., et (...) al. What are the risks and benefits of adjuvant radiotherapy after inguinal lymphadenectomy for penile cancer? PROSPERO, 2015. 3. Clark, P.E., et al. Penile cancer: Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw, 2013. 11: 594. 4. Souillac, I., et al. [Penile cancer in 2010: update from the Oncology Committee of the French Association of Urology: external genital organs group (CCAFU-OGE)]. Prog Urol, 2011. 21: 909. 5. Van Poppel, H., et al. Penile cancer: ESMO Clinical Practice

2018 European Association of Urology

3. Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer. (PubMed)

Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer. To evaluate the expression of COX-2, E-cadherin, vimentin, 14-3-3σ, and Phosphatase and tensin homolog (PTEN) tumor-related proteins in equine penile papillomas (ePP) and squamous cell carcinomas (ePSCC), the occurrence of epithelial-mesenchymal transition (EMT) at the invasion front (IF) and compare our findings with current knowledge on human penile squamous cell carcinoma (hPSCC).We analyzed (...) , by immunohistochemistry in 45 equine penile proliferative epithelial lesions, the expression of COX-2, E-cadherin, vimentin, 14-3-3σ, and PTEN using monoclonal antibodies. Tumors were histopathologically classified as well-differentiated or poorly differentiated using the IF grading scheme. Semiquantitative analysis was performed to determine down or up-regulation of the proteins and association with histopathological characteristics were statistically investigated using Mann-Whitney U test and/or Spearman's

2018 Urologic oncology

4. Risks and Benefits of Adjuvant Radiotherapy After Inguinal Lymphadenectomy in Node-positive Penile Cancer: A Systematic Review by the European Association of Urology Penile Cancer Guidelines Panel. (PubMed)

Risks and Benefits of Adjuvant Radiotherapy After Inguinal Lymphadenectomy in Node-positive Penile Cancer: A Systematic Review by the European Association of Urology Penile Cancer Guidelines Panel. Management of men with penile squamous cell carcinoma (PSCC) who have high-risk features following radical inguinal lymphadenectomy (ILND) remains controversial. European Association of Urology guidelines state that adjuvant inguinal radiotherapy (AIRT) is "not generally recommended". Despite (...) practice.Men with penile cancer who have involvement of the inguinal lymph nodes are at a high risk of cancer recurrence and death. We reviewed the literature to see if radiation treatment after removal of the nodes provided benefit. We did not find any good-quality evidence supporting this treatment, and hence it cannot be recommended.Copyright © 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved.

2018 European Urology

5. Prevalence of human papillomavirus DNA and p16<sup>INK4a</sup> in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis. (PubMed)

Prevalence of human papillomavirus DNA and p16INK4a in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis. Although previous meta-analyses have examined human papillomavirus (HPV) DNA prevalence in penile cancer, none, to our knowledge, have assessed pooled HPV DNA prevalence in penile intraepithelial neoplasia or p16INK4a percent positivity in penile cancer and penile intraepithelial neoplasia. Therefore, we aimed to examine the prevalence (...) of HPV DNA and p16INK4a positivity in penile cancer and penile intraepithelial neoplasia worldwide.In this systematic review and meta-analysis, we searched PubMed, Embase, and the Cochrane Library until July 24, 2017, for English-language articles published from Jan 1, 1986, onwards reporting the prevalence of HPV DNA and p16INK4a positivity, either alone or in combination, in at least five cases of penile cancer or penile intraepithelial neoplasia. Only studies that used PCR or hybrid capture

2018 Lancet Oncology

6. Penile Sparing Surgery for Penile Cancer: A Multicenter International Retrospective Cohort. (PubMed)

Penile Sparing Surgery for Penile Cancer: A Multicenter International Retrospective Cohort. We evaluated recurrence outcomes of penile sparing surgery in what is to our knowledge the largest multicenter cohort of patients to date.We retrospectively identified patients treated with penile sparing surgery from May 1990 to July 2016 at 5 tertiary referral institutions. Treatments consisted of circumcision, wide local excision, laser therapy with or without local excision, partial or total (...) clinical approach.Penile sparing surgery can provide excellent local control for superficial penile tumors as well as for appropriately selected invasive lesions. Strict followup in the early postoperative period is highly recommended.Copyright © 2018 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

2017 Journal of Urology

7. Penile Cancer Treatment (PDQ®): Patient Version

Penile Cancer Treatment (PDQ®): Patient Version Penile Cancer Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf Warning: The NCBI web site requires JavaScript to function. Search database Search term Search NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): ; 2002-. Search term (...) Penile Cancer Treatment (PDQ®) Patient Version PDQ Adult Treatment Editorial Board . Published online: October 12, 2018. Created: July 14, 2006 . This PDQ cancer information summary has current information about the treatment of penile cancer. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care. Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards

2018 PDQ - NCI's Comprehensive Cancer Database

8. Penile Cancer Treatment (PDQ®): Health Professional Version

Penile Cancer Treatment (PDQ®): Health Professional Version Penile Cancer Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf Warning: The NCBI web site requires JavaScript to function. Search database Search term Search NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): ; 2002 (...) -. Search term Penile Cancer Treatment (PDQ®) Health Professional Version PDQ Adult Treatment Editorial Board . Published online: February 6, 2019. This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of penile cancer. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions. This summary

2018 PDQ - NCI's Comprehensive Cancer Database

9. Quality of life and sexual function outcomes after primary treatment in patients with penile cancer: a systematic review

Quality of life and sexual function outcomes after primary treatment in patients with penile cancer: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any

2019 PROSPERO

10. Dose to the penile bulb and individual patient anatomy are predictive of erectile dysfunction in men treated with <sup>125</sup>I low dose rate brachytherapy for localized prostate cancer. (PubMed)

Dose to the penile bulb and individual patient anatomy are predictive of erectile dysfunction in men treated with 125I low dose rate brachytherapy for localized prostate cancer. To evaluate the occurrence of erectile dysfunction at 3 years (3yED) after prostate brachytherapy (BT) and to predict 3yED after treatment based on patients and treatments characteristics.From September 2007 to July 2015, 117 men with mild or no ED [International Index of Erectile Function (IIEF-5) > 16 (...) ] underwent 125Iodine real-time ultrasound-guided low-dose rate BT to a total dose of 160 Gy for low-risk or favorable intermediate-risk prostate adenocarcinoma, and were followed prospectively during 3 years. Median age was 63 years (51-79). The post-implant dosimetric parameters on the postoperative computer tomography were derived from the dose-volume histogram of the prostate and the penile bulb (PB), crura, neurovascular bundles (NVBs) and internal pudendal arteries (IPAs). Potential clinical

2019 Acta Oncologica

11. Dual Prosthetic Implantation After Radical Cystoprostatectomy and Neobladder: Outcomes of the Inflatable Penile Prosthesis and Artificial Urinary Sphincter in Bladder Cancer Survivors. (PubMed)

Dual Prosthetic Implantation After Radical Cystoprostatectomy and Neobladder: Outcomes of the Inflatable Penile Prosthesis and Artificial Urinary Sphincter in Bladder Cancer Survivors. To determine the impact of radical cystectomy and orthotopic neobladder (NB) diversion on device-related outcomes in patients who undergo subsequent placement of both, an artificial urinary sphincter (AUS) and 3-piece inflatable penile prosthesis.Using an institutional prosthetic database, we identified 39 (...) an infection of their penile prosthesis and 4 patients developed an erosion of their AUS. In each case, the infection did not involve the other device. Two patients required revision surgery of their penile prosthesis due to mechanical failure (reservoir leak, n = 1; cylinder aneurysm, n = 1). Twenty-one patients underwent elective revision surgery to improve continence (cuff downsizing, n = 18; pressure-regulating balloon exchange, n = 3). There were 6 cases of AUS mechanical failure. No reservoir-related

2019 Urology

12. Mean treatment cost of incident cases of penile cancer for privately insured patients in the United States. (PubMed)

Mean treatment cost of incident cases of penile cancer for privately insured patients in the United States. The aims of this study were to estimate the short-term cost of treating newly diagnosed penile cancer and determine the correlates of penile cancer treatment cost in the United States.The Truven MarketScan database was used to identify commercially insured patients with penile cancer newly diagnosed during 2011 to 2014. A control group without HPV-related cancer diagnosis was selected (...) by matching to the case group by the propensity score method. Total healthcare costs in the 2 years after the cancer diagnosis index date were measured for each patient. The mean difference between case and control groups was considered the cancer-related cost. For patients without complete 2-year data, a generalized linear regression was performed to predict cost for censored months and identify predictors associated with monthly cost.A total of 250 patients with newly diagnosed penile cancer and 250

2019 Urologic oncology

13. Organ-sparing surgery of penile cancer: higher rate of local recurrence yet no impact on overall survival. (PubMed)

Organ-sparing surgery of penile cancer: higher rate of local recurrence yet no impact on overall survival. To report on the oncological outcome of organ-sparing surgery (OSS) compared to (total or partial) penectomy regarding recurrence patterns and survival in squamous cell carcinoma (SCC) of the penis.This was a retrospective study of all patients with penile SCC and eligible follow-up data of at least 2 years at our institution. Patients with tumors staged ≥ pT1G2 underwent invasive lymph

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2019 World journal of urology

14. Updates in the molecular epidemiology and systemic approaches to penile cancer. (PubMed)

Updates in the molecular epidemiology and systemic approaches to penile cancer. Penile cancer is a rare, but increasingly more common diagnosis. Although more there are more cases of penile cancer being diagnosed (the incidence is increasing), mortality (or conversely overall survival) has not changed. A detailed discussion of current treatments, along with potential therapeutic targets, and ongoing clinical trials is presented. This review gives insight to treatment strategies and novel

2019 Urologic oncology

15. Management of the Clinically Negative (cN0) Groin Penile Cancer Patient: A Review. (PubMed)

Management of the Clinically Negative (cN0) Groin Penile Cancer Patient: A Review. To determine the role of noninvasive, minimally invasive diagnostic modalities and current management recommendations for cN0 PNC, a literature review using PubMed and Web of Science search engines were conducted. We found that for predicting ILN+: physical exam has limitations, nomograms are not validated, conventional computerized tomography/magnetic resonance imaging/positron imaging tomography scans have

2019 Urology

16. Comparison of clinical feasibility and oncological outcomes between video endoscopic and open inguinal lymphadenectomy for penile cancer: A systematic review and meta-analysis. (PubMed)

Comparison of clinical feasibility and oncological outcomes between video endoscopic and open inguinal lymphadenectomy for penile cancer: A systematic review and meta-analysis. To compare the clinical feasibility and oncological outcomes of video endoscopic inguinal lymph node dissection (VE-ILND) and open inguinal lymph node dissection (O-ILND) in the management of penile cancer.We searched published articles in the PubMed, Embase, Cochrane Library, Web of science, China National Knowledge

2019 Medicine

17. Optical biopsy of penile cancer with in vivo confocal laser endomicroscopy. (PubMed)

Optical biopsy of penile cancer with in vivo confocal laser endomicroscopy. Surgical management of penile cancer depends on accurate margin assessment and staging. Advanced optical imaging technologies may improve penile biopsy and organ-sparing treatment. We evaluated the feasibility of confocal laser endomicroscopy for intraoperative assessment of benign and malignant penile tissue.With institutional review board approval, 11 patients were recruited, 9 with suspected penile cancer, and 2 (...) squamous epithelium could be identified.We report the initial feasibility of intraoperative confocal laser endomicroscopy for penile cancer optical biopsy. Pending further evaluation, confocal laser endomicroscopy could serve as an adjunct or replacement to conventional frozen section pathology for management of penile cancer.Copyright © 2019 Elsevier Inc. All rights reserved.

2019 Urologic oncology

18. Making surgery safer by centralization of care: impact of case load in penile cancer. (PubMed)

Making surgery safer by centralization of care: impact of case load in penile cancer. Penile cancer is a rare but aggressive disease, often requiring a rapid and extensive surgical treatment of the primary tumor and staging or treatment of the inguinal lymph node basins. Current management and guidelines of the disease are mainly based on retrospective data, as there is a lack of controlled trials or large series. The purpose of this work is to review contemporary data on the impact (...) of centralization and formation of rare disease networks on penile cancer care and outcomes.This narrative, non-systematic review is based on publications retrieved by a PubMed and EMBASE search and on the current guidelines of the European Association of Urology, the National Institute for Health and Care Excellence, and the National Comprehensive Cancer network.The low case load, particularly in non-specialized centres, combined with limited evidence regularly results in a disparity between the treatment

2019 World journal of urology

19. Penile Cancer

Penile Cancer Guidelines on Penile Cancer O.W. Hakenberg (Chair), E. Compérat, S. Minhas, A. Necchi, C. Protzel, N. Watkin © European Association of Urology 2015 2 PENILE CANCER - UPDATE APRIL 2014 TABLE OF CONTENTS PAGE 1. INTRODUCTION 4 1.1 Panel composition 4 1.2 Available publications 4 1.3 Publication history 4 2. METHODS 4 2.1 Data identification 4 2.2 Review 4 3. EPIDEMIOLOGY, AETIOLOGY AND PATHOLOGY 4 3.1 Definition of penile cancer 4 3.2 Epidemiology 4 3.3 Risk factors and prevention 5 (...) 3.4 Pathology 6 3.4.1 Gross handling 7 3.4.2 Pathology report 7 3.4.3 Grading 7 3.4.4 Pathological prognostic factors 7 3.4.5 Penile cancer and HPV 8 3.4.6 Molecular biology 8 3.4.7 Penile biopsy 8 3.4.8 Intra-operative frozen sections and surgical margins 9 4. STAGING AND CLASSIFICATION SYSTEMS 9 4.1 TNM classification 9 5. DIAGNOSTIC EVALUATION AND STAGING 10 5.1 Primary lesion 10 5.2 Regional lymph nodes 11 5.2.1 Non-palpable inguinal nodes 11 5.2.2 Palpable inguinal nodes 11 5.3 Distant

2015 European Association of Urology

20. Penile preserving and reconstructive surgery in the management of penile cancer. (PubMed)

Penile preserving and reconstructive surgery in the management of penile cancer. A major paradigm shift has occurred in the clinical management of penile cancer: the adoption of alternative, less-invasive surgical strategies to address the primary tumour. Such penile-preserving approaches aim to retain aspects of penile function and improve quality of life outcomes by reducing penile alterations and sexual dysfunction incurred by historical surgical approaches without compromising oncological (...) control. Novel options include wide local excision, glansectomy, and glans resurfacing, and these strategies are now included in the spectrum of interventions available to treat penile cancer. Surgical reconstructive techniques have also advanced to include primary closure, closure using skin flaps and grafts, penile lengthening and/or enhancement, and neophalloplasty. All of these options can be readily applied in the risk-informed patient after establishing disease-risk variables and instituting

2016 Nature reviews. Urology

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