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Penicillinase-Resistant Penicillin

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1. Penicillinase-Resistant Penicillin

Penicillinase-Resistant Penicillin Penicillinase-Resistant Penicillin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Penicillinase (...) -Resistant Penicillin Penicillinase-Resistant Penicillin Aka: Penicillinase-Resistant Penicillin , Penicillinase-Resistant Semisynthetic Penicillin , Cloxacillin , Dicloxacillin , Methicillin , Nafcillin , Oxacillin From Related Chapters II. Indications Infection epidermidis Specific Infections Soft tissue infection Lymphatic infection Bone infection Joint infection III. Mechanism Same action to s Prevents ase hydrolysis of Beta lactam ring IV. Mechanism: Bacterial Resistance mechanisms Alteration of l

2018 FP Notebook

2. Penicillin

section [Cochrane Protocol]. PROSPERO 2015:CRD42015020474 Available from Review question(s) To provide the best available evidence of different regimens (including different drugs, different doses, different intervals between doses, and different 2015 18. Penicillinase-Resistant Penicillin Penicillinase-Resistant Penicillin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures (...) Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Penicillinase (...) -Resistant Penicillin Penicillinase-Resistant Penicillin Aka: Penicillinase-Resistant Penicillin , Penicillinase-Resistant Semisynthetic Penicillin , Cloxacillin , Dicloxacillin , Methicillin , Nafcillin , Oxacillin From Related Chapters II

2018 Trip Latest and Greatest

3. Penicillinase-Resistant Penicillin

Penicillinase-Resistant Penicillin Penicillinase-Resistant Penicillin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Penicillinase (...) -Resistant Penicillin Penicillinase-Resistant Penicillin Aka: Penicillinase-Resistant Penicillin , Penicillinase-Resistant Semisynthetic Penicillin , Cloxacillin , Dicloxacillin , Methicillin , Nafcillin , Oxacillin From Related Chapters II. Indications Infection epidermidis Specific Infections Soft tissue infection Lymphatic infection Bone infection Joint infection III. Mechanism Same action to s Prevents ase hydrolysis of Beta lactam ring IV. Mechanism: Bacterial Resistance mechanisms Alteration of l

2015 FP Notebook

4. Susceptibility of the "penicillinase-resistant" penicillins and cephalosporins to penicillinase of Staphylococcus aureus. Full Text available with Trip Pro

Susceptibility of the "penicillinase-resistant" penicillins and cephalosporins to penicillinase of Staphylococcus aureus. The activities of some semisynthetic penicillins and cephalosporins have been tested against clinical strains of Staphylococcus aureus. The apparent activity in vitro varies with the method of testing used. Determination of MICs using light inocula fails to detect the destructive effect of penicillinase on the antibiotic. This was, however, demonstrated reproducibly (...) , cephalothin, and cephalexin were intermediate. Cephradine was the least hydrolysed by staphylococcal penicillinase. It is recommended that the activities of all penicillins and cephalosporins against staphylococci should be tested by diffusion at 37 degrees C with pre-incubation of the culture for two hours at this temperature.

1977 Journal of Clinical Pathology

5. Penicillinase-Resistant Penicillins Plus Gentamicin in Experimental Enterococcal Endocarditis Full Text available with Trip Pro

Penicillinase-Resistant Penicillins Plus Gentamicin in Experimental Enterococcal Endocarditis Previous in vitro studies demonstrating that the penicillinase-resistant penicillins act synergistically in combination with gentamicin against some enterococci have suggested that these combinations might be effective therapy for enterococcal infections in vivo. To determine the in vivo effectiveness of such combinations, we treated rabbits with enterococcal endocarditis with gentamicin and either (...) nafcillin, oxacillin, or methicillin. Despite doses of the penicillins equivalent to 12 or 24 g/day in a 70-kg patient, the percentage of animals in each treatment group with sterile valves at autopsy after spontaneous death or sacrifice after 21 days of therapy was low. High-dose therapy with the penicillins did not significantly increase survival over the low-dose treatment groups. Thus, it seems prudent to include penicillin with a penicillinase-resistant penicillin and gentamicin as the initial

1977 Antimicrobial Agents and Chemotherapy

6. Effect of Temperature on the In Vitro Susceptibility of Staphylococcus aureus to Penicillinase-Resistant Penicillins Full Text available with Trip Pro

Effect of Temperature on the In Vitro Susceptibility of Staphylococcus aureus to Penicillinase-Resistant Penicillins Heteroresistant (methicillin-resistant) and nonheteroresistant strains of Staphylococcus aureus were tested for their susceptibility to penicillinase-resistant penicillins at incubation temperatures of 37, 35, and 30 C. Susceptibilities were determined by agar dilution and by the standard Kirby-Bauer agar diffusion tests. Minimal inhibitory concentrations were higher at 35 and 30

1973 Antimicrobial Agents and Chemotherapy

7. Penicillinase-resistant Penicillins and Cephalosporins Full Text available with Trip Pro

Penicillinase-resistant Penicillins and Cephalosporins 14160224 1996 12 01 2018 12 01 0007-1447 2 5405 1964 Aug 08 British medical journal Br Med J PENICILLINASE-RESISTANT PENICILLINS AND CEPHALOSPORINS. 344-9 BARBER M M WATERWORTH P M PM eng Journal Article England Br Med J 0372673 0007-1447 0 Anti-Bacterial Agents 0 Cephalosporins 0 Penicillins EC 3.5.2.- Penicillinase Q91FH1328A Methicillin R72LW146E6 Cephalothin OM Anti-Bacterial Agents Cephalosporins Cephalothin Drug Resistance Drug (...) Resistance, Microbial Enterobacteriaceae Escherichia coli Haemophilus influenzae Klebsiella Methicillin Neisseria Penicillinase Penicillins Proteus Salmonella Shigella Staphylococcus Streptococcus ANCILLIN ANTIBIOTICS CEPHALOTHIN DRUG RESISTANCE, MICROBIAL ENTEROBACTERIACEAE ESCHERICHIA COLI HAEMOPHILUS INFLUENZAE KLEBSIELLA METHICILLIN NEISSERIA PENICILLIN PROTEUS SALMONELLA SHIGELLA STAPHYLOCOCCUS STREPTOCOCCUS 1964 8 8 1964 8 8 0 1 1964 8 8 0 0 ppublish 14160224 PMC1816326 Nature. 1954 Nov 27;174(4439

1964 British medical journal

8. The Use of the Penicillinase-Resistant Penicillin in the Pneumonias of Children Full Text available with Trip Pro

The Use of the Penicillinase-Resistant Penicillin in the Pneumonias of Children 14246828 1996 12 01 2018 12 01 0032-5473 40 1964 Dec Postgraduate medical journal Postgrad Med J THE USE OF THE PENICILLINASE-RESISTANT PENICILLIN IN THE PNEUMONIAS OF CHILDREN. SUPPL:127-31 YOW M D MD SOUTH M A MA HESS C G CG eng Journal Article England Postgrad Med J 0234135 0032-5473 0 Penicillins EC 3.5.2.- Penicillinase OM Child Drug Therapy Humans Infant Penicillinase Penicillins adverse effects toxicity (...) Pneumonia Toxicology CHILD DRUG THERAPY INFANT PENICILLIN PENICILLIN TOXICOLOGY PENICILLINASE PNEUMONIA TOXICOLOGIC REPORT 1964 12 1 1964 12 1 0 1 1964 12 1 0 0 ppublish 14246828 PMC2483081

1964 Postgraduate medical journal

9. Penicillinase Resistant Penicillins in the Treatment of Surgical Staphylococcal Infections Full Text available with Trip Pro

Penicillinase Resistant Penicillins in the Treatment of Surgical Staphylococcal Infections 14246830 1996 12 01 2018 12 01 0032-5473 40 1964 Dec Postgraduate medical journal Postgrad Med J PENICILLINASE-RESISTANT PENICILLINS IN THE TREATMENT OF SURGICAL STAPHYLOCOCCAL INFECTIONS. SUPPL:132-40 RUTENBURG A M AM eng Journal Article England Postgrad Med J 0234135 0032-5473 0 Penicillins EC 3.5.2.- Penicillinase OM Drug Therapy Geriatrics Humans Penicillinase Penicillins adverse effects toxicity (...) Staphylococcal Infections Surgical Wound Infection Toxicology DRUG THERAPY GERIATRICS PENICILLIN PENICILLIN TOXICOLOGY PENICILLINASE STAPHYLOCOCCAL INFECTIONS SURGICAL WOUND INFECTION TOXICOLOGIC REPORT 1964 12 1 1964 12 1 0 1 1964 12 1 0 0 ppublish 14246830 PMC2483124 Antimicrob Agents Chemother (Bethesda). 1963;161:231-6 14274901

1964 Postgraduate medical journal

10. Factors Influencing the Outcome of Experimental Canine Endocarditis Treated with Penicillinase-Resistant Penicillins Full Text available with Trip Pro

Factors Influencing the Outcome of Experimental Canine Endocarditis Treated with Penicillinase-Resistant Penicillins 14296485 1996 12 01 2018 12 01 0065-7778 76 1964 Transactions of the American Clinical and Climatological Association Trans. Am. Clin. Climatol. Assoc. FACTORS INFLUENCING THE OUTCOME OF EXPERIMENTAL CANINE ENDOCARDITIS TREATED WITH PENICILLINASE-RESISTANT PENICILLINS. 115-23 HAMBURGER M M GARANCIS J C JC BEASLEY J S JS SCOTT N J NJ eng Journal Article United States Trans Am Clin (...) Climatol Assoc 7507559 0065-7778 0 Penicillins EC 3.5.2.- Penicillinase UH95VD7V76 Oxacillin OM Animals Blood Dogs Endocarditis Endocarditis, Bacterial Oxacillin Penicillinase Penicillins Pharmacology Research Staphylococcal Infections Statistics as Topic BLOOD DOGS ENDOCARDITIS, BACTERIAL EXPERIMENTAL LAB STUDY OXACILLIN PENICILLIN PHARMACOLOGY STAPHYLOCOCCAL INFECTIONS STATISTICS 1964 1 1 1964 1 1 0 1 1964 1 1 0 0 ppublish 14296485 PMC2279474 Am Heart J. 1960 Feb;59:184-90 14417445 J Am Med Assoc

1965 Transactions Of The American Clinical And Climatological Association

11. Semisynthetic Penicillin 6-[d(—)-α-Carboxy-3-Thienylacetamido] Penicillanic Acid Active Against Pseudomonas In Vitro Full Text available with Trip Pro

tested, 87% Enterobacter and 87% of Proteus mirabilis strains were inhibited by 25 mug/ml or less. Indole-positive Proteus were inhibited by 10 mug/ml or less. Fifty-five per cent of ampicillin-resistant Escherichia coli were inhibited by 100 mug/ml. Klebsiella were uniformly resistant. BRL2288 is not hydrolyzed by most resistant Pseudomonas, but it is destroyed by the beta-lactamases of E. coli and P. mirabilis. The antibiotic shows synergy with gentamicin but not with penicillinase-resistant (...) Semisynthetic Penicillin 6-[d(—)-α-Carboxy-3-Thienylacetamido] Penicillanic Acid Active Against Pseudomonas In Vitro The activity of 6-[d(-)-alpha-carboxy-3-thienylacetamido] penicillanic acid, BRL2288, was determined against Pseudomonas aeruginosa and various gram-negative bacilli. The majority of Pseudomonas strains (89%) were inhibited by 100 mug of the antibiotic per ml. BRL2288 is twofold more active than carbenicillin against Pseudomonas at 100 mug/ml or less. Among Enterobacteriaceae

1971 Applied microbiology

12. An enzyme preparation inactivating all penicillins and cephalosporins Full Text available with Trip Pro

An enzyme preparation inactivating all penicillins and cephalosporins Commercial penicillinases vary in their capacity to destroy penicillinase-resistant penicillins and cephalosporins. A new freeze-dried preparation containing both beta-lactamase I and II was found to inactivate all penicillins and cephalosporins at levels above those likely to be encountered in clinical specimens.

1973 Journal of Clinical Pathology

13. Effect of β-Lactamase Location in Escherichia coli on Penicillin Synergy Full Text available with Trip Pro

Effect of β-Lactamase Location in Escherichia coli on Penicillin Synergy Resistance to ampicillin in Escherichia coli is due generally to the presence of a beta-lactamase (penicillinase). Resistant strains have been found to fall into two groups: those with high-level resistance (1,000 mug/ml or greater) and those with low-level resistance (8 to 250 mug/ml). Most of the high-level resistant organisms posses beta-lactamases whose synthesis is episomally mediated. These strains release (...) penicillinase from the cell when they are subjected to osmotic shock. Low-level resistant strains do not release the enzyme with osmotic shock. High-level resistant strains are not susceptible to the synergistic action of a penicillinase-resistant penicillin with ampicillin. Seventy eight per cent of low-level resistant strains are susceptible to the synergistic action of ampicillin and oxacillin. The two types of beta-lactamases are similar in regard to most properties; both enzymes are subject

1969 Applied microbiology

14. Effect of Protein Binding on the Activity of Penicillins in Combination with Gentamicin Against Enterococci Full Text available with Trip Pro

. In broth the combinations of nafcillin plus gentamicin and oxacillin plus gentamicin were synergistic against 10 of 10 strains and 4 of 10 strains, respectively. However, in serum, nafcillin plus gentamicin was synergistically bactericidal against only two strains and oxacillin plus gentamicin against none. Methicillin plus gentamicin was synergistic against none of the enterococci in either medium. Thus, the semisynthetic, penicillinase-resistant penicillins are unlikely to be effective in the therapy (...) Effect of Protein Binding on the Activity of Penicillins in Combination with Gentamicin Against Enterococci To assess the effect of protein binding by human serum on the synergistic interaction of penicillins with gentamicin, time-kill curves were determined for four penicillins alone and in combination with gentamicin against 10 blood isolates of enterococci. Killing curves demonstrated synergism with penicillin G plus gentamicin against all 10 strains in either broth or 50% human serum

1979 Antimicrobial Agents and Chemotherapy

15. THE NEWER PENICILLINS Full Text available with Trip Pro

THE NEWER PENICILLINS The newer penicillins give high promise of overcoming some of the few disadvantages of penicillin-G. THEY FALL INTO THREE GROUPS: The alpha-phenoxy-penicillins; the penicillinase resistant penicillins; and the penicillins with enhanced activity against gram-negative bacteria. The newer alpha-phenoxy-penicillins offer little over alpha-phenoxy methyl penicillin (penicillin-V). As the length of the side chain is increased, absorption and attainable serum concentration (...) is also increased, but these are questionable benefits and probably not significant for therapeusis. The penicillinase-resistant penicillins have once more brought almost all severe staphylococcal infections within therapeutic range. One of them, methicillin, must be administered parenterally. It is the agent of choice for the treatment of severe, penicillin-G resistant staphylococcal infections, and this is its only clinical indication. Another, oxacillin, which may be administered orally

1962 California Medicine

16. Penicillins

drugs Ampicillin Oral or parenteral Ampicillin plus sulbactam Parenteral Amoxicillin Oral Amoxicillin plus clavulanate Oral Penicillinase-resistant penicillins Dicloxacillin Oral Nafcillin Oral or parenteral Oxacillin Oral or parenteral Broad-spectrum (antipseudomonal) penicillins Carbenicillin Oral Piperacillin Parenteral Piperacillin plus tazobactam Parenteral Ticarcillin Parenteral Ticarcillin plus clavulanate Parenteral Resistance Some bacteria produce beta-lactamases, which inactivate beta (...) infections Listeria Some and typhoid carriers Penicillinase-resistant penicillins These drugs are used primarily for Penicillinase-producing methicillin-sensitive Staphylococcus aureus These drugs are also used to treat some Streptococcus pneumoniae , group A streptococcal, and methicillin-sensitive coagulase-negative staphylococcal infections. Broad-spectrum (antipseudomonal) penicillin These drugs have activity against Bacteria susceptible to ampicillin Some strains of and spp Many strains

2013 Merck Manual (19th Edition)

18. Guidelines on Prevention, Diagnosis and Treatment of Infective Endocarditis Full Text available with Trip Pro

outpatient parenteral antibiotic therapy PBP penicillin binding protein PCR polymerase chain reaction PET positron emission tomography PVE prosthetic valve endocarditis SOFA Sequential Organ Failure Assessment SPECT single-photon emission computed tomography TOE transoesophageal echocardiography TTE transthoracic echocardiography WBC white blood cell 1. Preamble Guidelines summarize and evaluate all available evidence on a particular issue at the time of the writing process, with the aim of assisting (...) . for adults or 50 mg/kg i.v. for children, cefazolin or ceftriaxone 1 g i.v. for adults or 50 mg/kg i.v. for children. Cephalosporins should not be used in patients with anaphylaxis, angio-oedema, or urticaria after intake of penicillin or ampicillin due to cross-sensitivity. Table 6 Recommended prophylaxis for high-risk dental procedures in high-risk patients a Alternatively, cephalexin 2 g i.v. for adults or 50 mg/kg i.v. for children, cefazolin or ceftriaxone 1 g i.v. for adults or 50 mg/kg i.v

2015 European Society of Cardiology

19. Persistent Pain with Breastfeeding

and phototherapy (UVB) are safe to use. 20,48 Immunomodulating agents should not be used on thenippleduetotheriskofinfantoralabsorption. 47 Super?cial bacterial infection associated with skin trauma Persistent cracks, ?ssures Weeping, yellow crusted lesions especially in conjunction with other skin conditions Cellulitis Topical mupirocin or bacitracin ointment. Oral antibiotics such as a cephalosporin or penicillinase-resistant penicillin 18,49 (I) Bacterial dysbiosis Bilateral dull, deep aching bilateral

2016 Academy of Breastfeeding Medicine

20. Antibiotic Prophylaxis in Oral Surgery for Prevention of Surgical Site Infection

the oral cavity extending onto the skin The pathogenic organisms involved in surgical site infections for surgery extending onto the skin may also include methicillin sensitive Staphylococcus aureus in addition to the oral organisms. The penicillinase resistant antibiotics cloxacillin and cefazolin (1 st generation cephalosporin) would be the drugs of choice. Cloxacillin needs to be prescribed together with penicillin as it is effective only against Staphylococcus aureus and not the oral organisms (...) -control analytic studies, preferably from more than one centre or research group ll-3 Evidence obtained from multiple time series with or without the intervention. Dramatic results in uncontrolled experiments (such as the results of the introduction of penicillin treatment in the 1940s) could also be regarded as this type of evidence lll Opinions or respected authorities, based on clinical experience; descriptive studies and case reports; or reports of expert committees Source: Adapted from U.S

2015 Ministry of Health, Malaysia

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