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Pemphigus Vegetans

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41. Pemphigus Herpetiformis (Diagnosis)

pemphigus, acantholytic herpetiform dermatitis, pemphigus controlled by sulfapyridine, and mixed bullous disease. Because pemphigus herpetiformis is a clinical variant of pemphigus, it may be more appropriately described with a term that begins with the general group term (pemphigus), followed by a term for the variant subset (herpetiformis), similar to the terms for other pemphigus variants, such as , , , and pemphigus vegetans. [ , ] Next: Pathophysiology Pemphigus herpetiformis appears to be mediated (...) affected with pemphigus herpetiformis. At least 2 cases of pemphigus herpetiformis have been reported to occur in association with lung cancer. Whether this association was coincidental is not clear. [ , ] In addition, pemphigus herpetiformis has been associated with prostate cancer development in one case. [ ] Previous References Joly P, Litrowski N. Pemphigus group (vulgaris, vegetans, foliaceus, herpetiformis, brasiliensis). Clin Dermatol . 2011 Jul-Aug. 29(4):432-6. . Laws PM, Heelan K, Al

2014 eMedicine.com

42. Pemphigus Herpetiformis (Treatment)

) patients are responding clinically to prescribed medications and (2) patients experience no serious adverse effects that require a change of medications. Typically, follow-up visits are not needed for patients in clinical remission and not on treatment. Previous References Joly P, Litrowski N. Pemphigus group (vulgaris, vegetans, foliaceus, herpetiformis, brasiliensis). Clin Dermatol . 2011 Jul-Aug. 29(4):432-6. . Laws PM, Heelan K, Al-Mohammedi F, Walsh S, Shear NH. Pemphigus herpetiformis: a case (...) Pemphigus Herpetiformis (Treatment) Pemphigus Herpetiformis Treatment & Management: Medical Care, Activity, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2NDU1MC10cmVhdG1lbnQ= processing > Pemphigus

2014 eMedicine.com

43. Pemphigus, IgA (Overview)

clinical presentation is similar, these variants have distinct autoantibody target proteins. Hashimoto et al described an alternative classification for IgA pemphigus, terming the disease “intracellular IgA dermatosis (IAD)”. [ ] In addition to the SPD and IEN types, four disease subtypes have been described. Patients with vegetating lesions and pemphigus vegetans–like histology are classified as IgA-pemphigus vegetans (IgA-PVeg). Those with desmoglein-1 or desmoglein-3 target antigens are diagnosed (...) Pemphigus, IgA (Overview) IgA Pemphigus: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2Mzc3Ni1vdmVydmlldw== processing > IgA Pemphigus Updated: Apr 18, 2017 Author

2014 eMedicine.com

44. Pemphigus Erythematosus (Overview)

Updated: Mar 02, 2018 Author: Rakesh Bharti, MD, MBBS; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Pemphigus Erythematosus Overview Background The various types of pemphigus include pemphigus erythematosus, pemphigoid, pemphigus vegetans, pemphigus vulgaris, and . Pemphigus erythematosus, also known as Senear-Usher syndrome, is an overlap syndrome with features of lupus erythematosus (LE) and pemphigus foliaceus. Pemphigus is demonstrated by acantholysis (...) Pemphigus Erythematosus (Overview) Pemphigus Erythematosus: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2Mzg4MS1vdmVydmlldw== processing > Pemphigus Erythematosus

2014 eMedicine.com

45. Pemphigus Herpetiformis (Overview)

pemphigus, acantholytic herpetiform dermatitis, pemphigus controlled by sulfapyridine, and mixed bullous disease. Because pemphigus herpetiformis is a clinical variant of pemphigus, it may be more appropriately described with a term that begins with the general group term (pemphigus), followed by a term for the variant subset (herpetiformis), similar to the terms for other pemphigus variants, such as , , , and pemphigus vegetans. [ , ] Next: Pathophysiology Pemphigus herpetiformis appears to be mediated (...) affected with pemphigus herpetiformis. At least 2 cases of pemphigus herpetiformis have been reported to occur in association with lung cancer. Whether this association was coincidental is not clear. [ , ] In addition, pemphigus herpetiformis has been associated with prostate cancer development in one case. [ ] Previous References Joly P, Litrowski N. Pemphigus group (vulgaris, vegetans, foliaceus, herpetiformis, brasiliensis). Clin Dermatol . 2011 Jul-Aug. 29(4):432-6. . Laws PM, Heelan K, Al

2014 eMedicine.com

46. Pemphigus Herpetiformis (Follow-up)

) patients are responding clinically to prescribed medications and (2) patients experience no serious adverse effects that require a change of medications. Typically, follow-up visits are not needed for patients in clinical remission and not on treatment. Previous References Joly P, Litrowski N. Pemphigus group (vulgaris, vegetans, foliaceus, herpetiformis, brasiliensis). Clin Dermatol . 2011 Jul-Aug. 29(4):432-6. . Laws PM, Heelan K, Al-Mohammedi F, Walsh S, Shear NH. Pemphigus herpetiformis: a case (...) Pemphigus Herpetiformis (Follow-up) Pemphigus Herpetiformis Treatment & Management: Medical Care, Activity, Prevention Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2NDU1MC10cmVhdG1lbnQ= processing > Pemphigus

2014 eMedicine.com

47. Pemphigus Vegetans. ? Epithelioma Full Text available with Trip Pro

Pemphigus Vegetans. ? Epithelioma 19990578 2010 06 24 2010 06 24 0035-9157 29 3 1936 Jan Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Pemphigus Vegetans. ? Epithelioma. 248-50 Klaber R R eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1936 1 1 0 0 1936 1 1 0 1 ppublish 19990578 PMC2075621

1936 Proceedings of the Royal Society of Medicine

48. Immunofluorescence of the outer root sheath: an aid to diagnosis in pemphigus. (Abstract)

samples were also collected from 50 controls.Immunological deposits characteristic of pemphigus were found in the ORS of anagen and telogen hairs in all 50 patients, but in none of the 50 controls. Positive DIF findings were seen in scalp hair irrespective of the presence of scalp lesions. Of the 50 patients with pemphigus, 46 were diagnosed with pemphigus vulgaris, 2 with pemphigus vegetans, and 1 each with pemphigus foliaceus and pemphigus erythematosus, based on the clinical, histopathological (...) Immunofluorescence of the outer root sheath: an aid to diagnosis in pemphigus. The direct immunofluorescence (DIF) pattern of the outer root sheath (ORS) of the hair follicle in patients with pemphigus resembles that of perilesional skin. We performed DIF on anagen and telogen hair ORS from patients with pemphigus and compared the findings with those of perilesional skin.To assess the sensitivity of DIF in the ORS of anagen and telogen hair in patients with pemphigus with positive DIF results

2010 Clinical & Experimental Dermatology

49. Autoimmune skin disease among dermatology outpatients in Botswana: a retrospective review. Full Text available with Trip Pro

erythematosus (SLE) with cutaneous involvement, dermatomyositis, systemic sclerosis, lichen sclerosus, bullous pemphigoid, pemphigus foliaceus, pemphigus vulgaris, and pemphigus vegetans were identified. Demographic data were recorded, and incidence was determined.A total of 262 patients were diagnosed with autoimmune skin disease (4% of all new patients) with an incidence rate of 28.8 (per 1,000,000). Cutaneous lupus was the most common diagnosis with discoid lupus occurring most frequently (12.6 (...) ). The incidence of systemic sclerosis (2.2), morphea (1.6), lichen sclerosus (1.5), SLE with cutaneous involvement (1.3) and dermatomyositis (1.2) was relatively lower. Bullous pemphigoid was the most common bullous disease (3.8). Pemphigus foliaceus (0.9), pemphigus vulgaris (0.6), and pemphigus vegetans (0.2) were observed at a lower rate. At least 19.8% of these patients were also HIV positive.The incidence of autoimmune skin diseases in Botswana is lower compared to other published studies in other

2018 International Journal of Dermatology

50. Conjunctivitis, mucosal erosions, and moist cutaneous plaques Full Text available with Trip Pro

pemphigus vegetans pemphigus vulgaris 2018 1 20 6 0 2018 1 20 6 0 2018 1 20 6 1 epublish 29349113 10.1016/j.jdcr.2017.04.017 S2352-5126(17)30103-0 PMC5767905 J Am Acad Dermatol. 1998 Nov;39(5 Pt 2):872-5 9810919 J Eur Acad Dermatol Venereol. 2011 Oct;25(10):1160-7 21198951 Arch Dermatol. 2005 Jun;141(6):680-2 15967912 J Am Acad Dermatol. 1992 Aug;27(2 Pt 2):281-4 1387657 Br J Dermatol. 2015 Jul;173(1):59-68 25640111

2018 JAAD Case Reports

51. Clinical and immunological studies of 49 cases of various types of intercellular IgA dermatosis and 13 cases of classical subcorneal pustular dermatosis examined at Kurume University. Full Text available with Trip Pro

, we selected 49 cases of various types of intercellular IgA dermatosis (IAD) and 13 cases of classical subcorneal pustular dermatosis (SPD), for which sera and information were available. We studied these cases clinically and immunologically.There were 17 SPD-type IAD, 12 intraepidermal neutrophilic IgA dermatosis (IEN)-type IAD, two IgA-pemphigus vegetans, four IgA-pemphigus foliaceus, six IgA-pemphigus vulgaris and eight unclassified IAD cases. There was no sex predominance, and the average age

2016 British Journal of Dermatology

52. Vegetating Inguinal and Perianal Lesions: A Quiz. Full Text available with Trip Pro

Vegetating Inguinal and Perianal Lesions: A Quiz. 25325567 2016 01 04 2015 04 15 1651-2057 95 4 2015 Apr Acta dermato-venereologica Acta Derm. Venereol. Vegetating inguinal and perianal lesions: a quiz. Pemphigus vegetans, Hallopeau type. 507-8 10.2340/00015555-1984 Salah Louai A LA Department of Dermatology and Venereology, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden. eng Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 IM Aged Female Groin Humans (...) Pemphigus diagnosis Tongue Diseases diagnosis 2014 10 18 6 0 2014 10 18 6 0 2016 1 5 6 0 ppublish 25325567 10.2340/00015555-1984

2014 Acta Dermato-Venereologica

53. Benign Vulvar Lesions (Follow-up)

sclerosus Squamous cell hyperplasia (with and without atypia) (localized neurodermatitis) Primary irritant dermatitis Fixed drug eruption Reiter disease Lupus erythematosus Darier disease Aphthosis and Behçet disease Pyoderma gangrenosum Plasma cell vulvitis Vulvar vestibulitis Blistering diseases involving the vulvar region include the following: Familial benign chronic pemphigus (Hailey-Hailey disease) Pigmentary changes involving the vulvar region include the following: , lentiginosis, and benign (...) estrogen. [ ] The use of oral contraceptives might be a contributing factor by increasing the sensitivity of the vestibular mucosa. [ ] Blistering diseases Familial benign chronic pemphigus (Hailey-Hailey disease) Hailey-Hailey disease is a rare autosomal dominant acantholytic disorder due to a mutation on band 3q21-q24 and is characterized from late adolescence or adulthood by recurrent eruptions of vesicles and blisters typically located on the neck, axillae, and groin. Intrinsic desmosomal fragility

2014 eMedicine.com

54. Nonneoplastic Epithelial Disorders of the Vulva (Diagnosis)

the following: Lichen sclerosus Squamous cell hyperplasia (with and without atypia) (localized neurodermatitis) Primary irritant dermatitis Fixed drug eruption Reiter disease Lupus erythematosus Darier disease Aphthosis and Behçet disease Pyoderma gangrenosum Plasma cell vulvitis Vulvar vestibulitis Blistering diseases involving the vulvar region include the following: Familial benign chronic pemphigus (Hailey-Hailey disease) Pigmentary changes involving the vulvar region include the following (...) estrogen. [ ] The use of oral contraceptives might be a contributing factor by increasing the sensitivity of the vestibular mucosa. [ ] Blistering diseases Familial benign chronic pemphigus (Hailey-Hailey disease) Hailey-Hailey disease is a rare autosomal dominant acantholytic disorder due to a mutation on band 3q21-q24 and is characterized from late adolescence or adulthood by recurrent eruptions of vesicles and blisters typically located on the neck, axillae, and groin. Intrinsic desmosomal fragility

2014 eMedicine.com

55. Oral Manifestations of Systemic Diseases (Diagnosis)

coincide with exacerbations of the colonic disease. Lesions in the colon consist of areas of hemorrhage and ulceration, along with abscesses. Cutaneous involvement consists of similar ulcerations that may arise on the buttocks, abdomen, thighs, and face, although in rare cases patients may develop pyoderma vegetans. [ , ] In the oral cavity, aphthous ulcers or angular stomatitis occurs in as many as 5-10% of patients, although hemorrhagic ulcers can occur. [ ] Rarely, patients can develop pyostomatitis (...) vegetans (PSV), the oral counterpart of pyoderma vegetans. Also see . Crohn disease Crohn disease is an idiopathic inflammatory disorder that can involve the entire GI tract with transmural inflammation and noncaseating granulomas. The prevalence of Crohn disease varies significantly between populations. In North America, the incidence of Crohn disease can be as high as 20.2 cases per 100,000 population. [ ] Although formerly considered a disease of Western nations, the incidence is rising in Asia

2014 eMedicine.com

56. Onycholysis (Diagnosis)

Pellagra Pemphigus vulgaris Pleural effusion Porphyria cutanea tarda Pregnancy Psoriatic arthritis Reiter syndrome Sarcoidosis Scleroderma Shell nail syndrome Syphilis Yellow nail syndrome Dermatologic diseases in onycholysis are as follows: Pachonychia congenita Congenital ectodermal defect Pemphigus vegetans Congenital abnormalities of the nail Neoplastic disorders in onycholysis are as follows: Squamous cell carcinoma (of nail bed) Carcinoma (lung) Exogenous factors in onycholysis Nonmicrobial

2014 eMedicine.com

57. Nonneoplastic Epithelial Disorders of the Vulva (Overview)

the following: Lichen sclerosus Squamous cell hyperplasia (with and without atypia) (localized neurodermatitis) Primary irritant dermatitis Fixed drug eruption Reiter disease Lupus erythematosus Darier disease Aphthosis and Behçet disease Pyoderma gangrenosum Plasma cell vulvitis Vulvar vestibulitis Blistering diseases involving the vulvar region include the following: Familial benign chronic pemphigus (Hailey-Hailey disease) Pigmentary changes involving the vulvar region include the following (...) estrogen. [ ] The use of oral contraceptives might be a contributing factor by increasing the sensitivity of the vestibular mucosa. [ ] Blistering diseases Familial benign chronic pemphigus (Hailey-Hailey disease) Hailey-Hailey disease is a rare autosomal dominant acantholytic disorder due to a mutation on band 3q21-q24 and is characterized from late adolescence or adulthood by recurrent eruptions of vesicles and blisters typically located on the neck, axillae, and groin. Intrinsic desmosomal fragility

2014 eMedicine.com

58. Cutaneous Manifestations of HIV Disease (Overview)

Multiple dermatofibromas [ ] Recurrent neutrophilic eccrine hidradenitis Pemphigus vegetans Lichen scrofulosorum Cutaneous mucinosis Papulonecrotic tuberculide Kawasaki disease Eruptive dysplastic nevi Dissemination of vaccinia Ofuji disease [ ] Angiomyolipomas Glucan-induced keratoderma [ ] Disseminated superficial porokeratosis [ ] Previous Next: Workup Histopathologic examination is useful to diagnose cutaneous manifestations of HIV disease with atypical clinical features and Kaposi sarcoma (KS

2014 eMedicine.com

59. Cutaneous Manifestations of HIV Disease (Treatment)

Multiple dermatofibromas [ ] Recurrent neutrophilic eccrine hidradenitis Pemphigus vegetans Lichen scrofulosorum Cutaneous mucinosis Papulonecrotic tuberculide Kawasaki disease Eruptive dysplastic nevi Dissemination of vaccinia Ofuji disease [ ] Angiomyolipomas Glucan-induced keratoderma [ ] Disseminated superficial porokeratosis [ ] Previous Next: Workup Histopathologic examination is useful to diagnose cutaneous manifestations of HIV disease with atypical clinical features and Kaposi sarcoma (KS

2014 eMedicine.com

60. Bullous Pemphigoid (Treatment)

. Both Th1 and Th2 chemokines are elevated in sera of patients with autoimmune blistering diseases. Arch Dermatol Res . 2006 Jun. 298(1):38-45. . Niimi Y, Pawankar R, Kawana S. Increased expression of matrix metalloproteinase-2, matrix metalloproteinase-9 and matrix metalloproteinase-13 in lesional skin of bullous pemphigoid. Int Arch Allergy Immunol . 2006. 139(2):104-13. . Asashima N, Fujimoto M, Watanabe R, et al. Serum levels of BAFF are increased in bullous pemphigoid but not in pemphigus (...) in Patients With Diabetes: Estimating the Risk of the New Agents and Characterizing the Patients. JAMA Dermatol . 2018 Aug 8. . Langan SM, Smeeth L, Hubbard R, Fleming KM, Smith CJ, West J. Bullous pemphigoid and pemphigus vulgaris--incidence and mortality in the UK: population based cohort study. BMJ . 2008 Jul 9. 337:a180. . . Gajic-Veljic M, Nikolic M, Medenica L. Juvenile bullous pemphigoid:the presentation and follow-up of six cases. J Eur Acad Dermatol Venereol . Jan/2010. 24:69-72. . Zhou XP, Liu B

2014 eMedicine.com

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