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Pemphigus Foliaceus

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41. Increased serum levels of vascular endothelial growth factor in pemphigus foliaceus patients with erythroderma. (Abstract)

Increased serum levels of vascular endothelial growth factor in pemphigus foliaceus patients with erythroderma. Erythroderma is a clinical skin syndrome shared by patients with cutaneous disorders of distinct aetiologies as a result of the combined actions of chemokines, adhesion molecules, and cytokines, such as vascular endothelial growth factor (VEGF).To evaluate the profile of serum levels of VEGF and soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) in pemphigus foliaceus (...) (PF) patients with erythroderma.We conducted a retrospective study, which included (i) a chart review of all PF patients from the Autoimmune Blistering Clinic, University of Sao Paulo, Brazil, from January 1991 to December 2014, together with an evaluation of demographic variables, hospitalization duration and complications and (ii) analysis of the circulating VEGF and sVEGFR-1 levels in PF patients with erythroderma by ELISA. The controls included patients with pemphigus vulgaris or psoriasis.We

2016 Journal of the European Academy of Dermatology and Venereology

42. Overlapping IgG4 responses to self and environmental antigens in endemic pemphigus foliaceus Full Text available with Trip Pro

Overlapping IgG4 responses to self and environmental antigens in endemic pemphigus foliaceus The etiology of human autoimmune diseases in general remains largely unknown, although the genetic and environmental interplay may be relevant. This applies to the autoimmune diseases of the skin such as the pemphigus phenotypes and others. In this group, there is an endemic form of pemphigus foliaceus (also known as fogo selvagem [FS]) in which the pathogenic IgG4 autoantibody response to the self

2016 Journal of immunology (Baltimore, Md. : 1950)

43. Pemphigus foliaceus associated with Hypericum perforatum Full Text available with Trip Pro

Pemphigus foliaceus associated with Hypericum perforatum 27579342 2016 08 31 2019 02 26 2352-5126 2 4 2016 Jul JAAD case reports JAAD Case Rep Pemphigus foliaceus associated with Hypericum perforatum. 326-8 10.1016/j.jdcr.2016.06.008 Imbernón-Moya Adrián A Department of Dermatology, Hospital Universitario Severo Ochoa, Madrid, Spain. Burgos Fernando F Department of Pathology, Hospital Universitario Severo Ochoa, Madrid, Spain. Vargas-Laguna Elena E Department of Dermatology, Hospital (...) immunostimulatory effect pemphigus photosensitizing effect 2016 9 1 6 0 2016 9 1 6 0 2016 9 1 6 1 epublish 27579342 10.1016/j.jdcr.2016.06.008 S2352-5126(16)30058-3 PMC4992013 Arch Dermatol. 2002 Feb;138(2):232-42 11843645 Eur J Clin Pharmacol. 1998 Oct;54(8):589-94 9860144 Actas Dermosifiliogr. 2005 Jul-Aug;96(6):329-56 16476253 J Eur Acad Dermatol Venereol. 2011 Apr;25(4):492-3 20561124 Arch Dermatol. 2004 Jun;140(6):723-7 15210464 J Cosmet Laser Ther. 2001 Sep;3(3):159-60 12006194 Br J Dermatol. 2000 Nov;143

2016 JAAD Case Reports

44. A 3’UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility Full Text available with Trip Pro

A 3’UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility Genetic variations mapping to 3' untranslated regions (3'UTRs) may overlap with microRNA (miRNA) binding sites, therefore potentially interfering with translation inhibition or messenger RNA (mRNA) degradation. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) located within the 3'UTRs of six (...) candidate genes and predicted to interfere with miRNA ligation could account for disease-relevant differential mRNA levels. Focusing on pemphigus foliaceus (PF) - an autoimmune blistering skin condition with unique endemic patterns - we investigated whether nine 3'UTR SNPs from the CD1D, CTLA4, KLRD1, KLRG1, NKG7, and TNFSF13B genes differentially expressed in PF were disease-associated. The heterozygous genotype of the KLRG1 rs1805672 polymorphism was associated with increased predisposition to PF (A/G

2016 Biochimica et biophysica acta

45. Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. Full Text available with Trip Pro

Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. Pemphigus foliaceus (PF) is an autoimmune blistering disease caused by autoantibodies (Abs) against desmoglein 1 (Dsg1). PF sera contain polyclonal Abs which are heterogeneous mixture of both pathogenic and non-pathogenic Abs, as shown by isolation of monoclonal Abs (mAbs).To investigate how pathogenic and non-pathogenic anti

2016 Journal of dermatological science

46. Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. (Abstract)

Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. A 65-year-old woman had undergone a thymectomy for thymoma and 1 year after surgery she developed scattered erosive erythema with scaling and crusting. Examination findings exhibited the elevation of anti-dsDNA antibody, anti-desmoglein 1 antibody, anti-acetylcholine receptor antibody and anti-thyroglobulin antibody. A skin biopsy showed intraepidermal blisters (...) containing neutrophils and acantholytic keratinocytes and direct immunofluorescence revealed the deposition of immunoglobulin G in the epidermis and on the basement membrane. These findings indicated the presence of systemic lupus erythematosus (SLE), myasthenia gravis, pemphigus foliaceus and chronic thyroiditis. Only 1% of SLE patients have three other autoimmune diseases according to previous publications. Our case is rare because she suffered four autoimmune diseases after the thymectomy.© 2016

2016 Australasian Journal of Dermatology

47. Epitope analysis of anti-desmoglein 1 autoantibodies from pemphigus foliaceus patients across different activity stages. Full Text available with Trip Pro

Epitope analysis of anti-desmoglein 1 autoantibodies from pemphigus foliaceus patients across different activity stages. Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are closely related, but clinically distinct, autoimmune blistering diseases caused by autoantibodies against desmoglein (Dsg)1 and Dsg3, respectively. Using ethylenediaminetetraacetic acid (EDTA)-treated Dsg3 enzyme-linked immunosorbent assay (ELISA) we have shown that the proportion of anti-Dsg3 antibodies against calcium

2015 British Journal of Dermatology

48. CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus Full Text available with Trip Pro

CTLA4 overexpressing adipose tissue-derived mesenchymal stem cell therapy in a dog with steroid-refractory pemphigus foliaceus Canine pemphigus foliaceus is an autoimmune antibody-mediated skin disease characterized by acantholysis. The objective of this case report is to present the successful management of steroid refractory pemphigus foliaceus with cytotoxic T-lymphocyte antigen 4 (CTLA4)-overexpressing adipose tissue mesenchymal stem cells (ATMSCs).A 10-year-old, 12.3-kg, castrated male (...) Shih Tzu presented with severe pruritus and anorexia. The diagnosis of pemphigus foliaceus was made based on its history, physical examination, and histopathology results of a skin biopsy. Treatment with prednisolone and combination therapy of other immunosuppressive drugs had failed; therefore, immunosuppressive gene, CTLA4 overexpressing ATMSCs (CTLA4-ATMSCs) and/or naive ATMSCs administration was performed with the consent of the owner. ATMSCs were administered 21 times over a period of 20

2015 BMC veterinary research

49. Increased risk of severe course of pemphigus in patients with pemphigus-associated alopecia: a prospective observational study. (Abstract)

pemphigus-associated alopecia. Alopecia was observed in 11/52 patients with pemphigus and scalp involvement: [0/28 (35.7%) with pemphigus vulgaris and 1/24 (4.2%) with pemphigus foliaceus. The clinical and immunological characteristics of these patients were analysed.Patients with pemphigus-associated alopecia had a significantly higher Pemphigus Disease Area Index total activity score compared with patients who had no pemphigus-associated alopecia (21.8 ± 18.6 and 11.0 ± 20.5, respectively; P = 0.02 (...) Increased risk of severe course of pemphigus in patients with pemphigus-associated alopecia: a prospective observational study. Pemphigus-associated alopecia is considered rare, and has not been studied in detail.To evaluate the clinical and immunological characteristics of patients with pemphigus-associated alopecia.This prospective observational study included 80 consecutive patients with histopathologically and immunopathologically confirmed pemphigus, of whom 11 (13.8%) were found to have

2018 Clinical & Experimental Dermatology

50. British Association of Dermatologists guidelines for the management of pemphigus vulgaris

intraepithelial, mucocutaneous blistering. Desmoglein 3 is the major antigen, but 50–60% of patients have additional antibodies to desmoglein 1, the antigen targeted in pemphigus foliaceus (PF). 3–5 Although the pathogenesis of PV is complex, involving multiple pathways, 6 the underlying antibody pro?le is a major determinant of the clinical phenotype of PV. 5,7,8 The average mortality of PV was 75% before the introduc- tion of corticosteroids in the early 1950s. 9 This ?gure may be an underestimate due (...) British Association of Dermatologists guidelines for the management of pemphigus vulgaris GUIDELINES BJD British Journal of Dermatology British Association of Dermatologists’ guidelines for the management of pemphigus vulgaris 2017* K.E. Harman, 1 D. Brown, 2 L.S. Exton, 3 R.W. Groves, 4 P.J. Hampton, 5 M.F. Mohd Mustapa, 3 J.F. Setter?eld 4,6 and P.D. Yesudian 7 1 University Hospitals Leicester, Leicester Royal In?rmary, In?rmary Square, Leicester, LE1 5WW, U.K. 2 St John’s Institute

2017 British Association of Dermatologists

51. Pemphigus. (Abstract)

often originates with painful oral erosions, and pemphigus foliaceus, which is characterised by exclusive skin lesions. Pemphigus is diagnosed on the basis of either IgG or complement component 3 deposits (or both) at the keratinocyte cell membrane, detected by direct immunofluorescence microscopy of a perilesional biopsy, with serum anti-Dsg1 or anti-Dsg3 antibodies (or both) detected by ELISA. Corticosteroids are the therapeutic mainstay, which have recently been complemented by the anti-CD20 (...) Pemphigus. Pemphigus consists of a group of rare and severe autoimmune blistering diseases mediated by pathogenic autoantibodies mainly directed against two desmosomal adhesion proteins, desmoglein (Dsg)1 and Dsg3 (also known as DG1 and DG3), which are present in the skin and surface-close mucosae. The binding of autoantibodies to Dsg proteins induces a separation of neighbouring keratinocytes, in a process known as acantholysis. The two main pemphigus variants are pemphigus vulgaris, which

2019 Lancet

52. Prognostic factors in pemphigus vulgaris and pemphigus foliaceus. (Abstract)

Prognostic factors in pemphigus vulgaris and pemphigus foliaceus. Pemphigus typically has a chronic course, although there is great variability in disease duration (DD) and time taken to disease remission (DR) between individuals with the disease. The reasons for this are unclear.To explore the prognostic influence of epidemiological, clinical, immunological and genetic factors on disease course and remission in pemphigus vulgaris (PV) and pemphigus foliaceus (PF).This was a retrospective study (...) anti-Dsg 3 levels at baseline were associated with a longer total DD (P = 0.03).Ethnic group, age at presentation, initial intercellular antibody titre and initial Dsg 3 antibody levels all had a significant impact on prognosis of pemphigus.© 2013 British Association of Dermatologists.

2013 British Journal of Dermatology

53. Direct immunofluorescence of the outer root sheath in anagen and telogen hair in pemphigus vulgaris and pemphigus foliaceus. (Abstract)

Direct immunofluorescence of the outer root sheath in anagen and telogen hair in pemphigus vulgaris and pemphigus foliaceus. Direct immunofluorescence of peri-lesional skin is the gold standard in the diagnosis of pemphigus. A specific immunofluorescence pattern may also be demonstrated in the outer root sheath of anagen and telogen hair. We demonstrated an intercellular reticular deposition of immunoglobulin G in the outer root sheath of plucked anagen and telogen hair in all pemphigus (...) vulgaris patients with active disease and for the first time in all patients with active pemphigus foliaceus. Moreover, we demonstrated for the first time that plucked hair samples may be kept at -20°C for at least 2 weeks before immunofluorescent staining and analysis. © 2013 The Authors. Australasian Journal of Dermatology © 2013 The Australasian College of Dermatologists.

2013 Australasian Journal of Dermatology

54. Reviewing putative industrial triggering in pemphigus: cluster of pemphigus in the area near the wastewater treatment plant Full Text available with Trip Pro

Reviewing putative industrial triggering in pemphigus: cluster of pemphigus in the area near the wastewater treatment plant A range of pemphigus is relatively rare potentially fatal group of autoimmune blistering dermatoses. Usually, there is no apparent triggering, while in some predisposed patients there are alleged environmental/industrial inducing factors. In a short time period (4 years), we diagnosed 3 novel cases of pemphigus (1 pemphigus vulgaris, 1 pemphigus foliaceus and 1 shift from (...) pemphigus foliaceus into pemphigus vulgaris) at a clinical and laboratory level (ELISA, immunofluorescence studies). We discuss a possible common inducing mechanism as these patients inhabit one estate of the Poznan suburbia (Kozieglowy, population < 12,000), Greater Poland district, Poland, and review literature data on alleged pemphigus triggers. To the best of our knowledge, this is the first report exploring the putative association between pemphigus diseases and wastewater treatment plant

2017 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

55. A patient with pemphigus foliaceus and myasthenia gravis treated by a cortisol secreting adrenal adenoma. (Abstract)

A patient with pemphigus foliaceus and myasthenia gravis treated by a cortisol secreting adrenal adenoma. 24931108 2015 09 21 2018 12 02 1365-2133 172 1 2015 Jan The British journal of dermatology Br. J. Dermatol. A patient with pemphigus foliaceus and myasthenia gravis treated by a cortisol-secreting adrenal adenoma. 280-2 10.1111/bjd.13185 Topham L L Department of Dermatology, Queen Elizabeth Hospital, Lewisham and Greenwich NHS Trust, Stadium Road, London, SE18 4QH, U.K. Chapman A A Gibbs C (...) C Saha M M eng Case Reports Letter 2014 11 14 England Br J Dermatol 0004041 0007-0963 WI4X0X7BPJ Hydrocortisone IM Adenoma complications metabolism Adrenal Gland Neoplasms complications metabolism Adult Cushing Syndrome etiology Female Humans Hydrocortisone metabolism Myasthenia Gravis complications Pemphigus complications Remission, Spontaneous 2014 6 17 6 0 2014 6 17 6 0 2015 9 22 6 0 ppublish 24931108 10.1111/bjd.13185

2014 British Journal of Dermatology

56. Rituximab therapy in pemphigus foliaceus: report of 12 cases and review of recent literature. (Abstract)

Rituximab therapy in pemphigus foliaceus: report of 12 cases and review of recent literature. 25496559 2016 02 01 2015 05 12 1365-2133 172 5 2015 The British journal of dermatology Br. J. Dermatol. Rituximab therapy in pemphigus foliaceus: report of 12 cases and review of recent literature. 1420-3 10.1111/bjd.13586 de Sena Nogueira Maehara L L Centre for Blistering Diseases, Department of Dermatology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen (...) . eng Case Reports Letter Research Support, Non-U.S. Gov't Review 2015 03 31 England Br J Dermatol 0004041 0007-0963 0 Dermatologic Agents 4F4X42SYQ6 Rituximab IM Adult Aged Aged, 80 and over Chronic Disease Dermatologic Agents therapeutic use Epidemiologic Methods Female Humans Male Middle Aged Pemphigus drug therapy Rituximab therapeutic use Treatment Outcome 2014 12 16 6 0 2014 12 17 6 0 2016 2 2 6 0 ppublish 25496559 10.1111/bjd.13586

2014 British Journal of Dermatology

57. Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. (Abstract)

Presence of autoimmune regulator and absence of desmoglein 1 in thymoma associated with a pemphigus foliaceus patient. 25523433 2016 04 12 2015 07 15 1365-2133 173 1 2015 Jul The British journal of dermatology Br. J. Dermatol. Presence of autoimmune regulator and absence of desmoglein 1 in a thymoma in a patient with pemphigus foliaceus. 268-71 10.1111/bjd.13617 Tsuchisaka A A Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell (...) Autoantigens 0 Desmoglein 1 0 Transcription Factors IM Aged, 80 and over Autoantigens metabolism Desmoglein 1 deficiency Female Humans Keratinocytes metabolism Pemphigus immunology Thymoma immunology Thymus Neoplasms immunology Transcription Factors metabolism 2014 12 20 6 0 2014 12 20 6 0 2016 4 14 6 0 ppublish 25523433 10.1111/bjd.13617

2014 British Journal of Dermatology

58. Erythema annulare-like acantholytic dermatosis: A subset of pemphigus foliaceus. (Abstract)

Erythema annulare-like acantholytic dermatosis: A subset of pemphigus foliaceus. 24836841 2015 08 18 2014 12 19 1365-2133 171 6 2014 Dec The British journal of dermatology Br. J. Dermatol. Erythema annulare-like acantholytic dermatosis: a subset of pemphigus foliaceus. 1558-9 10.1111/bjd.13115 Holahan H M HM Rutgers New Jersey Medical School, Newark, NJ, U.S.A.; Department of Dermatology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, U.S.A. Farah R S RS (...) Selby J C JC Fairley J A JA eng Case Reports Letter Research Support, U.S. Gov't, Non-P.H.S. 2014 11 09 England Br J Dermatol 0004041 0007-0963 Annular Erythema IM Acantholysis pathology Biopsy, Needle Diagnosis, Differential Erythema pathology Female Humans Middle Aged Pemphigus pathology Skin Diseases, Genetic pathology 2014 5 20 6 0 2014 5 20 6 0 2015 8 19 6 0 ppublish 24836841 10.1111/bjd.13115

2014 British Journal of Dermatology

59. Exacerbation of Pemphigus Foliaceus After Electron-beam Radiation. Full Text available with Trip Pro

Exacerbation of Pemphigus Foliaceus After Electron-beam Radiation. 24626406 2015 07 07 2014 10 23 1651-2057 94 6 2014 Nov Acta dermato-venereologica Acta Derm. Venereol. Exacerbation of pemphigus foliaceus after electron-beam radiation. 729-30 10.2340/00015555-1811 Kikuchi Kazuhiro K Department of Dermatology, Sapporo City General Hospital North 11, West 13, Chou-ku, Sapporo 060-8604, Japan. kikku@med.hokudai.ac.jp. Inokuma Daisuke D Moriuchi Reine R Koguchi-Yoshioka Hanako H Yasui Chikako C (...) Shimizu Satoko S eng Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 0 Adrenal Cortex Hormones 0 Ointments IM Administration, Cutaneous Adrenal Cortex Hormones administration & dosage Disease Progression Female Humans Middle Aged Ointments Paget Disease, Extramammary diagnosis radiotherapy Pemphigus diagnosis drug therapy etiology Radiation Injuries diagnosis drug therapy etiology Radiotherapy adverse effects Recurrence Remission Induction Skin Neoplasms diagnosis radiotherapy

2014 Acta Dermato-Venereologica

60. Pemphigus Foliaceus Masquerading as IgA Pemphigus and Responding to Dapsone Full Text available with Trip Pro

Pemphigus Foliaceus Masquerading as IgA Pemphigus and Responding to Dapsone A 14-year-old male presented with seven years history of recurrent episodes of fluid filled, itchy and eroded lesions over the body not responding to oral corticosteroids and azathioprine. Dermatological examination revealed crusted plaques and erosions in a seborrheic distribution. Histopathology of skin lesions and direct immunofluorescence were characteristic of pemphigus foliaceus. He was treated with dexamethasone (...) pulse therapy with inadequate response. However, relapsing skin lesions revealed a circinate arrangement with a predilection to trunk and flexures. In view of clinical features suggestive of IgA pemphigus, he was started on dapsone, to which he responded dramatically in four weeks. However, repeat biopsy continued to reveal features of pemphigus foliaceus and ELISA for anti-desmoglein 1 antibodies was positive.

2012 Indian journal of dermatology

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