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Pemphigus Foliaceus

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21. Sporadic pemphigus foliaceus and class II human leucocyte antigen allele associations in the white British and Indo-Asian populations in the UK. (PubMed)

Sporadic pemphigus foliaceus and class II human leucocyte antigen allele associations in the white British and Indo-Asian populations in the UK. Pemphigus foliaceus (PF) has both genetic and environmental susceptibility factors. Current data on human leucocyte antigen (HLA) in patients with sporadic PF are limited.To better define the distribution of HLA alleles in patients with PF in the UK.We recruited 36 patients [26 of white British (WB) descent, 10 of Indo-Asian (IA) descent] with PF who

2018 Clinical & Experimental Dermatology

22. Patients affected by a new variant of endemic pemphigus foliaceus have autoantibodies colocalizing with MYZAP, p0071, desmoplakins 1-2 and ARVCF, causing renal damage. (PubMed)

Patients affected by a new variant of endemic pemphigus foliaceus have autoantibodies colocalizing with MYZAP, p0071, desmoplakins 1-2 and ARVCF, causing renal damage. We have previously reported that about 30% of patients affected by a new variant of endemic pemphigus foliaceus (EPF) in El Bagre, Colombia (termed El Bagre-EPF or pemphigus Abreu-Manu) have systemic compromise. In the current study, we focused on studying autoreactivity to the kidney and its pathological correlations.To

2018 Clinical & Experimental Dermatology

23. Beta-adrenoceptor expression in pemphigus foliaceus. (PubMed)

Beta-adrenoceptor expression in pemphigus foliaceus. 29730879 2018 11 29 1468-3083 32 12 2018 Dec Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Beta-adrenoceptor expression in pemphigus foliaceus. e459-e461 10.1111/jdv.15057 Miyamoto D D Department of Dermatology, University of São Paulo Medical School, São Paulo, São Paulo, Brazil. MUHC - McGill University Ocular Pathology & Translational Research Laboratory, Montreal, QC, Canada. Dias A B

2018 Journal of the European Academy of Dermatology and Venereology

24. Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region. (PubMed)

Differential HLA class I and class II associations in pemphigus foliaceus and pemphigus vulgaris patients from a prevalent Southeastern Brazilian region. Genetic factors, particularly those concerning HLA class II, have been associated with the pathogenesis of pemphigus. Taking advantage of an area where pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are prevalent in the northeastern region of the state of São Paulo, Southeastern Brazil, we have studied the HLA class I (A, B and C (...) and the HLA-DRB1*01-DQA1*01-DQB1*05 haplotype in PF patients and the HLA-DRB1*04:02 and *14:01 alleles and the HLA-DRB1*14-DQA1*01-DQB1*05 haplotype in PV patients were related with the highest etiologic fraction values. Distinct genetic patterns and not yet described HLA susceptibility/protection alleles/haplotypes profiles have been observed in this series. Our findings corroborate the differential genetic markers in PF and PV in an area where pemphigus is prevalent but not yet reported.Copyright © 2016

2016 Journal of Autoimmunity

25. A Safety and Dose-Finding Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus)

A Safety and Dose-Finding Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) A Safety and Dose-Finding Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. A Safety and Dose-Finding Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03075904 Recruitment Status : Recruiting

2017 Clinical Trials

26. Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF. (PubMed)

Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF. We identified a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America, which we term El Bagre-EPF, and observed reactivity to arrector pili muscle (APM), thus we tested for autoimmunity to APM.We took skin biopsies from 30 patients with El Bagre-EPF and 30 healthy controls (HCs) matched by age, sex

2017 Clinical & Experimental Dermatology

27. Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil. (PubMed)

Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil. Black fly and sandfly bites are related to the endemicity of pemphigus foliaceus (PF); however, an immune reaction against the salivary proteins from these flies still requires confirmation in the case of PF patients living in southeastern Brazil.To georeference the distribution of Simuliidae (Diptera: Simuliidae) and Phlebotominae (Diptera: Psychodidae) and of PF cases

2017 Acta Tropica

28. HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus. (PubMed)

HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus. 28977698 2019 02 19 1365-2133 178 3 2018 03 The British journal of dermatology Br. J. Dermatol. HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus. e212-e214 10.1111/bjd.16022 de Sena Nogueira Maehara L L 0000-0002-4113-1379 Department of Dermatology, Federal University of São Paulo, São Paulo, Brazil. Center for Blistering Diseases, Department

2017 British Journal of Dermatology

29. Cell junction protein armadillo repeat gene deleted in velo-cardio-facial syndrome is expressed in the skin and colocalizes with autoantibodies of patients affected by a new variant of endemic pemphigus foliaceus in Colombia (PubMed)

Cell junction protein armadillo repeat gene deleted in velo-cardio-facial syndrome is expressed in the skin and colocalizes with autoantibodies of patients affected by a new variant of endemic pemphigus foliaceus in Colombia We previously described a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America (El Bagre-EPF, or pemphigus Abreu-Manu). El Bagre-EPF differs from other types of EPF clinically, epidemiologically, immunologically and in its target antigens. We

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2017 Dermatology practical & conceptual

30. Refractory pemphigus foliaceus associated with herpesvirus infection: case report (PubMed)

Refractory pemphigus foliaceus associated with herpesvirus infection: case report Pemphigus foliaceus (PF) is an autoimmune disease characterized by blistering of the skin. Infections caused by members of the herpesviridae family have been suggested as a possible triggering factor for pemphigus vulgaris (PV), but not for PF. The present study aimed to investigate the presence of Human herpesvirus (types 1, 2, 3) in corticosteroid refractory skin lesions from a patient with PF, by a Polymerase

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2017 Revista do Instituto de Medicina Tropical de São Paulo

31. Divergent Specificity Development of IgG1 and IgG4 Autoantibodies in Endemic Pemphigus Foliaceus (Fogo Selvagem) (PubMed)

Divergent Specificity Development of IgG1 and IgG4 Autoantibodies in Endemic Pemphigus Foliaceus (Fogo Selvagem) We have shown that although the IgG response in fogo selvagem (FS) is mainly restricted to desmoglein (Dsg) 1, other keratinocyte cadherins are also targeted by FS patients and healthy control subjects living in the endemic region of Limão Verde, Brazil (endemic controls). Evaluating nonpathogenic IgG1 and pathogenic IgG4 subclass responses to desmosomal proteins may reveal important

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2017 ImmunoHorizons

32. Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem) (PubMed)

Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem) The endemic form (fogo selvagem-FS) of pemphigus foliaceus is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-1. Despite the array of findings, the role of chemokines and cytokines that dictate the immune response and disease outcome is still poorly investigated.Serum from 64 patients diagnosed with FS was used to draw and establish the levels

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2017 Frontiers in immunology

33. Putative contact ketoconazole shampoo-triggered pemphigus foliaceus in a dog (PubMed)

Putative contact ketoconazole shampoo-triggered pemphigus foliaceus in a dog A 10-year-old spayed female cocker spaniel dog was referred for an evaluation of acute-onset generalized pustular cutaneous lesions following application of ketoconazole shampoo. Cytologic and histopathologic examinations of the lesions revealed intra-epidermal pustules with predominantly neutrophils and acantholytic cells. This is the first description of putative contact ketoconazole shampoo-triggered pemphigus (...) foliaceus in a dog.

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2017 The Canadian Veterinary Journal

34. The Use of Intralesional Steroids in a Case of Localized Pemphigus Foliaceus (PubMed)

The Use of Intralesional Steroids in a Case of Localized Pemphigus Foliaceus A 37-year-old South-Asian male presented to our clinic with a crusty, verrucous-like, scaly plaque of the left ala of the nose. After ruling out infectious and other epidermal bullous diseases, we finalized a diagnosis of localized pemphigus foliaceus, an exceptionally rare disorder with only 15 cases reported in the literature to date. The hyperkeratotic lesions responded favorably to a 3-week regimen of triamcinolone

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2017 Case reports in dermatology

35. A 3’UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility (PubMed)

A 3’UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility Genetic variations mapping to 3' untranslated regions (3'UTRs) may overlap with microRNA (miRNA) binding sites, therefore potentially interfering with translation inhibition or messenger RNA (mRNA) degradation. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) located within the 3'UTRs of six (...) candidate genes and predicted to interfere with miRNA ligation could account for disease-relevant differential mRNA levels. Focusing on pemphigus foliaceus (PF) - an autoimmune blistering skin condition with unique endemic patterns - we investigated whether nine 3'UTR SNPs from the CD1D, CTLA4, KLRD1, KLRG1, NKG7, and TNFSF13B genes differentially expressed in PF were disease-associated. The heterozygous genotype of the KLRG1 rs1805672 polymorphism was associated with increased predisposition to PF (A/G

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2016 Biochimica et biophysica acta

36. Pemphigus foliaceus associated with Hypericum perforatum (PubMed)

Pemphigus foliaceus associated with Hypericum perforatum 27579342 2016 08 31 2019 02 26 2352-5126 2 4 2016 Jul JAAD case reports JAAD Case Rep Pemphigus foliaceus associated with Hypericum perforatum. 326-8 10.1016/j.jdcr.2016.06.008 Imbernón-Moya Adrián A Department of Dermatology, Hospital Universitario Severo Ochoa, Madrid, Spain. Burgos Fernando F Department of Pathology, Hospital Universitario Severo Ochoa, Madrid, Spain. Vargas-Laguna Elena E Department of Dermatology, Hospital (...) immunostimulatory effect pemphigus photosensitizing effect 2016 9 1 6 0 2016 9 1 6 0 2016 9 1 6 1 epublish 27579342 10.1016/j.jdcr.2016.06.008 S2352-5126(16)30058-3 PMC4992013 Arch Dermatol. 2002 Feb;138(2):232-42 11843645 Eur J Clin Pharmacol. 1998 Oct;54(8):589-94 9860144 Actas Dermosifiliogr. 2005 Jul-Aug;96(6):329-56 16476253 J Eur Acad Dermatol Venereol. 2011 Apr;25(4):492-3 20561124 Arch Dermatol. 2004 Jun;140(6):723-7 15210464 J Cosmet Laser Ther. 2001 Sep;3(3):159-60 12006194 Br J Dermatol. 2000 Nov;143

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2016 JAAD Case Reports

37. Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. (PubMed)

Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering. Pemphigus foliaceus (PF) is an autoimmune blistering disease caused by autoantibodies (Abs) against desmoglein 1 (Dsg1). PF sera contain polyclonal Abs which are heterogeneous mixture of both pathogenic and non-pathogenic Abs, as shown by isolation of monoclonal Abs (mAbs).To investigate how pathogenic and non-pathogenic anti

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2016 Journal of dermatological science

38. Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. (PubMed)

Systemic lupus erythematosus associated with myasthenia gravis, pemphigus foliaceus and chronic thyroiditis after thymectomy. A 65-year-old woman had undergone a thymectomy for thymoma and 1 year after surgery she developed scattered erosive erythema with scaling and crusting. Examination findings exhibited the elevation of anti-dsDNA antibody, anti-desmoglein 1 antibody, anti-acetylcholine receptor antibody and anti-thyroglobulin antibody. A skin biopsy showed intraepidermal blisters (...) containing neutrophils and acantholytic keratinocytes and direct immunofluorescence revealed the deposition of immunoglobulin G in the epidermis and on the basement membrane. These findings indicated the presence of systemic lupus erythematosus (SLE), myasthenia gravis, pemphigus foliaceus and chronic thyroiditis. Only 1% of SLE patients have three other autoimmune diseases according to previous publications. Our case is rare because she suffered four autoimmune diseases after the thymectomy.© 2016

2016 Australasian Journal of Dermatology

39. Overlapping IgG4 responses to self and environmental antigens in endemic pemphigus foliaceus (PubMed)

Overlapping IgG4 responses to self and environmental antigens in endemic pemphigus foliaceus The etiology of human autoimmune diseases in general remains largely unknown, although the genetic and environmental interplay may be relevant. This applies to the autoimmune diseases of the skin such as the pemphigus phenotypes and others. In this group, there is an endemic form of pemphigus foliaceus (also known as fogo selvagem [FS]) in which the pathogenic IgG4 autoantibody response to the self

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2016 Journal of immunology (Baltimore, Md. : 1950)

40. Pemphigus Foliaceus

Pemphigus Foliaceus Pemphigus Foliaceus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pemphigus Foliaceus Pemphigus Foliaceus Aka (...) : Pemphigus Foliaceus , Superficial Pemphigus , Pemphigus erythematosus , Senear-Usher Syndrome , Fogo selvagem , Pemphigus herpetiformis From Related Chapters II. Definition Less common, milder and superficial form of III. Signs Onset on skin of face in butterfly distribution May also involve scalp, chest or upper back Rarely involves absent IV. Variants Pemphigus erythematosus (Senear-Usher Syndrome) Localized variant of Pemphigus Foliaceus Associated with positive Fogo selvagem Variant of Pemphigus

2018 FP Notebook

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