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Pemphigus Vegetans

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1. Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease (PubMed)

Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease Pemphigus vegetans is a rare variant of deep acantholytic pemphigus which usually presents with vesiculobullous rash and vegetative plaques on the folds. We report a case of pemphigus vegetans patient who presented with rashes on tips of fingers and toes resembling paronychia and onychomadesis that misled the diagnosis for months. The final diagnosis of Hallopeau-type pemphigus (...) vegetans was made based on histopathology and direct immunofluorescence studies. Interestingly, not only the clinical presentation was atypical, but blood tests for anti-desmoglein 1 and 3 antibodies by ELISA technique were also negative. Thus, the rare unusual manifestation of pemphigus vegetans in this patient may associate with different autoantibodies to desmosomal proteins compared with those of classic pemphigus patients.

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2018 Case reports in medicine

2. Elevated serum eosinophil cationic protein and transforming growth factor-α levels in a patient with pemphigus vegetans. (PubMed)

Elevated serum eosinophil cationic protein and transforming growth factor-α levels in a patient with pemphigus vegetans. Pemphigus vegetans (PVeg) is a rare variant of pemphigus, characterized by vegetating lesions mainly with antidesmoglein 3 antibodies. However, the pathomechanisms for PVeg is still unknown. We present a patient with PVeg mainly associated with antidesmocollin (Dsc)3 antibodies, who originally developed pemphigus foliaceus. Serum levels of eosinophil cationic protein

2018 Clinical & Experimental Dermatology

3. The Rare Case of Pemphigus Vegetans in Association with Malnutrition Children in the Multidisciplinary Management (PubMed)

The Rare Case of Pemphigus Vegetans in Association with Malnutrition Children in the Multidisciplinary Management Pemphigus vegetans is a clinical variant of pemphigus vulgaris, accounting for 1-2% of all very rare pemphigus cases in children. The involvement of the oral mucosa in this disease is usually accompanied by severe pain that aggravates the patient's malnourished condition. Conversely, malnutrition may also reduce vulnerability towards autoimmune diseases. Although pemphigus vegetans (...) has never been reported to develop in a child with marasmus before, we encountered a case of pemphigus vegetans in a severely malnourished patient. A 12-year-old boy in marasmic condition presented with painful, clear, fluid-filled blisters, accompanied by erosions, crusts, and vegetative lesions on almost all parts of the body. Histopathological examination of the lesions revealed a suprabasal cleft, and direct immunofluorescence staining showed deposits of immunoglobulin G in the epidermal

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2017 Case reports in dermatology

5. Pemphigus Vegetans

Pemphigus Vegetans Pemphigus Vegetans Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pemphigus Vegetans Pemphigus Vegetans Aka (...) : Pemphigus Vegetans , Familial Benign Pemphigus , Hailey-Hailey Disease From Related Chapters II. Epidemiology inherited condition III. Pathophysiology Benign variant of Suprabasal cell Exacerbating factors Superficial Warm weather IV. Signs Mouth mucosal lesions absent Large confluent vegetative s Center with moist granular tissue Border composed of s and s Distribution Form in intertriginous areas (groin, axillae) Also affects neck folds and scalp or face V. Labs Immunofluorescence shows no antibodies

2018 FP Notebook

6. Successful monotherapy of pemphigus vegetans with minocycline and nicotinamide. (PubMed)

Successful monotherapy of pemphigus vegetans with minocycline and nicotinamide. Pemphigus vegetans is a rare variant of pemphigus vulgaris, accounting for 1-2% of all pemphigus diseases. Systemic corticosteroids are the therapy of first choice in combination with immunosuppressants as steroid-sparing agents.To highlight the exceptional but successful use of minocycline/nicotinamide monotherapy in pemphigus vegetans.A review of the literature to date about pemphigus vegetans with special (...) emphasis on therapy was performed. Due to its rarity, multiple anecdotal reports without long-term follow-up are available and prospective controlled trials are lacking. Only one retrospective study from Tunisia includes 17 patients with pemphigus vegetans.We present a 76-year-old woman with pemphigus vegetans achieving complete response to a minocycline/nicotinamide monotherapy at onset and at relapse of the disease. Treatment has been discontinued after repeated direct immunofluorescence (DIF

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2016 Journal of the European Academy of Dermatology and Venereology

7. A case of concurrent pemphigoid vegetans and pemphigus vegetans remitted without oral corticosteroid. (PubMed)

A case of concurrent pemphigoid vegetans and pemphigus vegetans remitted without oral corticosteroid. 24359309 2015 01 12 2014 05 20 1365-2133 170 5 2014 May The British journal of dermatology Br. J. Dermatol. A case of concurrent pemphigoid vegetans and pemphigus vegetans resolving without oral corticosteroid. 1192-4 10.1111/bjd.12802 Hatano Y Y Department of Dermatology, Faculty of Medicine, Oita University, Hasama, Yufu, 879-5593, Japan. Ishikawa K K Koga H H Ishii N N Hashimoto T T Takeo N (...) therapy Pemphigus complications drug therapy 2013 12 24 6 0 2013 12 24 6 0 2015 1 13 6 0 ppublish 24359309 10.1111/bjd.12802

2013 British Journal of Dermatology

8. British Association of Dermatologists guidelines for the management of pemphigus vulgaris

British Association of Dermatologists guidelines for the management of pemphigus vulgaris GUIDELINES BJD British Journal of Dermatology British Association of Dermatologists’ guidelines for the management of pemphigus vulgaris 2017* K.E. Harman, 1 D. Brown, 2 L.S. Exton, 3 R.W. Groves, 4 P.J. Hampton, 5 M.F. Mohd Mustapa, 3 J.F. Setter?eld 4,6 and P.D. Yesudian 7 1 University Hospitals Leicester, Leicester Royal In?rmary, In?rmary Square, Leicester, LE1 5WW, U.K. 2 St John’s Institute (...) of pemphigus vulgaris (PV). The document aims to update and expand on the previous guidelines by (i) offering an appraisal of all relevant literature from January 2000 up to May 2016, focusing on any key developments; (ii) addressing important, practical, clinical questions relating to the primary guideline objective; (iii) providing guideline recommendations with, where appropriate, some health economic implications and (iv) discussing potential developments and future directions. The guideline

2017 British Association of Dermatologists

9. Two cases of pemphigus vegetans with IgG anti-desmocollin 3 antibodies. (PubMed)

Two cases of pemphigus vegetans with IgG anti-desmocollin 3 antibodies. Pemphigus vegetans shows clinically vegetating and/or pustular skin lesions mainly on the intertriginous areas and histopathologically neutrophilic and eosinophilic pustules in the epidermis. Pemphigus vegetans shows IgG reactivity mainly with desmoglein (Dsg) 3, but also with other autoantigens, including Dsg1 and desmocollins (Dscs).We examined antigen profiles in 2 cases of pemphigus vegetans. (1) A women in her 80s (...) in her 70s presented with pustular skin lesions on the left fingers with typical histopathological features. Immunoblotting and ELISAs did not detect antibodies to either Dsg1 or Dsg3. Conversely, immunoblotting detected IgG antibodies to Dscs, cDNA transfection method revealed IgG reactivity only with Dsc3, and findings from ELISAs showed that IgG reacted weakly with Dsc2 and strongly with Dsc3.Autoantibodies to Dscs, particularly to Dsc3, may play a pathogenic role in some cases of pemphigus

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2013 JAMA dermatology (Chicago, Ill.)

10. Pemphigus Vegetans

Pemphigus Vegetans Pemphigus Vegetans Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pemphigus Vegetans Pemphigus Vegetans Aka (...) : Pemphigus Vegetans , Familial Benign Pemphigus , Hailey-Hailey Disease From Related Chapters II. Epidemiology inherited condition III. Pathophysiology Benign variant of Suprabasal cell Exacerbating factors Superficial Warm weather IV. Signs Mouth mucosal lesions absent Large confluent vegetative s Center with moist granular tissue Border composed of s and s Distribution Form in intertriginous areas (groin, axillae) Also affects neck folds and scalp or face V. Labs Immunofluorescence shows no antibodies

2015 FP Notebook

11. Pemphigus Vegetans treated with Aureomycin (PubMed)

Pemphigus Vegetans treated with Aureomycin 15440774 2004 09 30 2018 12 01 0035-9157 43 7 1950 Jul Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Pemphigus vegetans treated with aureomycin. 555-6 BARBER H W HW YORKE A A eng Journal Article England Proc R Soc Med 7505890 0035-9157 0 Organic Chemicals 105478-66-8 vegetan WCK1KIQ23Q Chlortetracycline OM Chlortetracycline Organic Chemicals Pemphigus 5019:31504:18:182 AUREOMYCIN PEMPHIGUS 1950 7 1 1950 7 1 0 1 1950 7 1 0 0 ppublish

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1950 Proceedings of the Royal Society of Medicine

12. Pemphigus Vegetans (PubMed)

Pemphigus Vegetans 14812408 2004 02 15 2018 12 01 0008-4409 64 4 1951 Apr Canadian Medical Association journal Can Med Assoc J Pemphigus vegetans treated by fulguration. 343 McLELLAN D D eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Organic Chemicals 105478-66-8 vegetan OM Electrocoagulation Humans Organic Chemicals Pemphigus 5120:44008:136 PEMPHIGUS VEGETANS 1951 4 1 1951 4 1 0 1 1951 4 1 0 0 ppublish 14812408 PMC1822027

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1951 Canadian Medical Association Journal

13. Pemphigus Vegetans (Neumann) (PubMed)

Pemphigus Vegetans (Neumann) 20896746 2011 03 29 2011 03 29 0959-5287 72 1889 Medico-chirurgical transactions Med Chir Trans Pemphigus Vegetans (Neumann). 233-256.1 Crocker H R HR eng Journal Article England Med Chir Trans 0156105 0959-5287 2010 10 5 6 0 1889 1 1 0 0 1889 1 1 0 1 ppublish 20896746 PMC2121543

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1889 Medico-chirurgical transactions

14. Probable Pemphigus Vegetans (PubMed)

Probable Pemphigus Vegetans 19974215 2010 06 24 2010 06 24 0035-9157 3 Dermatol Sect 1910 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Probable Pemphigus Vegetans. 23-6 Abraham P S PS eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1910 1 1 0 0 1910 1 1 0 1 ppublish 19974215 PMC1960897

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1910 Proceedings of the Royal Society of Medicine

15. Pemphigus Vegetans affecting the Larynx and Fauces, Nasal Cavities, Tongue, Cheek, and Lips of a Woman aged 40 (PubMed)

Pemphigus Vegetans affecting the Larynx and Fauces, Nasal Cavities, Tongue, Cheek, and Lips of a Woman aged 40 19974446 2010 06 24 2010 06 24 0035-9157 3 Laryngol Sect 1910 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Pemphigus Vegetans affecting the Larynx and Fauces, Nasal Cavities, Tongue, Cheek, and Lips of a Woman aged 40. 78 Davis H J HJ eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1910 1 1 0 0 1910 1 1 0 1 ppublish 19974446 PMC1961355

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1910 Proceedings of the Royal Society of Medicine

16. Pemphigus Vegetans (PubMed)

Pemphigus Vegetans 19978538 2010 06 24 2010 06 24 0035-9157 8 Dermatol Sect 1915 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Pemphigus Vegetans. 155-6 Pringle J J JJ eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1915 1 1 0 0 1915 1 1 0 1 ppublish 19978538 PMC2004510

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1915 Proceedings of the Royal Society of Medicine

17. Pemphigus Vegetans (PubMed)

Pemphigus Vegetans 19978624 2010 06 24 2010 06 24 0035-9157 8 Dermatol Sect 1915 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Pemphigus Vegetans. 70-5 Pringle J J JJ eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1915 1 1 0 0 1915 1 1 0 1 ppublish 19978624 PMC2004482

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1915 Proceedings of the Royal Society of Medicine

18. Case of Pemphigus Vegetans (PubMed)

Case of Pemphigus Vegetans 19980936 2010 06 24 2010 06 24 0035-9157 13 Dermatol Sect 1920 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Case of Pemphigus Vegetans. 144 Little E G EG eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1920 1 1 0 0 1920 1 1 0 1 ppublish 19980936 PMC2152230

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1920 Proceedings of the Royal Society of Medicine

19. Pemphigus Vegetans (PubMed)

Pemphigus Vegetans 19981641 2010 06 24 2010 06 24 0035-9157 14 Dermatol Sect 1921 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Pemphigus Vegetans. 6-7 Davis H H eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1921 1 1 0 0 1921 1 1 0 1 ppublish 19981641 PMC2153425

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1921 Proceedings of the Royal Society of Medicine

20. Pemphigus Vegetans Complicated by Peripheral Vascular Disease (PubMed)

Pemphigus Vegetans Complicated by Peripheral Vascular Disease 19994046 2010 06 25 2010 06 25 0035-9157 53 4 1960 Apr Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Pemphigus Vegetans Complicated by Peripheral Vascular Disease. 298 Garretts M M eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1960 4 1 0 0 1960 4 1 0 1 ppublish 19994046 PMC1871235

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1960 Proceedings of the Royal Society of Medicine

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