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Pelvic Nerve Innervation

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1. Pelvic Nerve Innervation

Pelvic Nerve Innervation Pelvic Nerve Innervation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pelvic Nerve Innervation Pelvic (...) Nerve Innervation Aka: Pelvic Nerve Innervation From Related Chapters II. Anatomy: Spinal Level - S2-S4 Organ Perineum Lower and upper vagina and Low Posterior Trigone Lower ureter Rectosigmoid colon Nerves Pudendal Nerve Inguinal Nerve Genitofemoral Nerve Posterior femoral Nerve Pelvic and s III. Anatomy: Spinal Level - T11-T12 Organ Uterine Fundus Proximal third fallopian tube Broad ligament Upper Cecum, appendix and terminal Nerves s via hypogastric plexus IV. Anatomy: Spinal Level - T9-T10 Organ

2018 FP Notebook

2. Periprostatic innervation: New issues based on segmental analysis of 10 human cadaver pelvic blocs. (PubMed)

Periprostatic innervation: New issues based on segmental analysis of 10 human cadaver pelvic blocs. The exact paths of periprostatic nerves have been under debate over the last decades. In the present study, the topographic distribution of nerves around the prostate and their relative distances from the prostatic capsule were analyzed in male cadaver visceral blocs.The pelvic organs from ten fresh male cadavers were removed and serial sectioned en bloc for histological investigation (...) . The macroslices was divided into four sectors. Each sector was centrally covered with a raster dividing each sector in three subsectors numbered clockwise. The prostatic capsule was identified, and distances of 2.5 and 5 mm from the prostate were demarked with lines. We quantified the number of nerve fibers present in each subsector of each slide and recorded their position relative to the prostatic capsule.In general, the topographic analysis revealed that the majority of nerves were identified in sectors 4

2017 Prostate

3. Impaired contraction and decreased detrusor innervation in a female rat model of pelvic neuropraxia (PubMed)

Impaired contraction and decreased detrusor innervation in a female rat model of pelvic neuropraxia Bilateral pelvic nerve injury (BPNI) is a model of post-radical hysterectomy neuropraxia, a common sequela. This study assessed the time course of changes to detrusor autonomic innervation, smooth muscle (SM) content and cholinergic-mediated contraction post-BPNI.Female Sprague-Dawley rats underwent BPNI or sham surgery and were evaluated 3, 7, 14, and 30 days post-BPNI (n = 8/group). Electrical (...) post-BPNI.Bilateral pelvic nerve injury increased bladder size, impaired contractility, and decreased SM and autonomic innervation. Therapeutic strategies preventing nerve injury-mediated decline in neuronal input and SM content may prevent the development of a neurogenic bladder and improve quality of life after invasive pelvic surgery.

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2016 International urogynecology journal

4. Pelvic and hypogastric nerves are injured in a rat prostatectomy model, contributing to development of stress urinary incontinence (PubMed)

intervention. Incontinence has a profound impact on patient quality of life and a critical unmet need exists to develop novel and less invasive SUI treatments. During prostatectomy, the cavernous nerve (CN), which provides innervation to the penis, undergoes crush, tension, and resection injury, resulting in downstream penile remodeling and erectile dysfunction in up to 85% of patients. There are other nerves that form part of the major pelvic ganglion (MPG), including the hypogastric (HYG, sympathetic (...) ) and pelvic (PN, parasympathetic) nerves, which provide innervation to the bladder and urethra. We examine if HYG and PNs are injured during prostatectomy contributing to SUI, and if Sonic hedgehog (SHH) regulatory mechanisms are active in the PN and HYG nerves. CN, PN, HYG and ancillary (ANC) of uninjured, sham and CN crush/MPG tension injured (prostatectomy model) adult Sprague Dawley rats (n = 37) were examined for apoptosis, sonic hedgehog (SHH) pathway, and intrinsic and extrinsic apoptotic

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2018 Scientific reports

5. Pilot Study of Measurement Agreement Between Morphological and Diffusion Tensor Imaging MRI for Pelvic Nerve Cartography

Pilot Study of Measurement Agreement Between Morphological and Diffusion Tensor Imaging MRI for Pelvic Nerve Cartography Pilot Study of Measurement Agreement Between Morphological and Diffusion Tensor Imaging MRI for Pelvic Nerve Cartography - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Pilot Study of Measurement Agreement Between Morphological and Diffusion Tensor Imaging MRI for Pelvic Nerve Cartography (NERVWATCH) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our

2017 Clinical Trials

6. Chronic Pelvic Pain

and how to excise vaginal mesh. Curr Opin Obstet Gynecol, 2016. 28: 311. 207. Khatri, G., et al. Diagnostic Evaluation of Chronic Pelvic Pain. Phys Med Rehabil Clin N Am, 2017. 28: 477. 208. Bendavid, R., et al. A mechanism of mesh-related post-herniorrhaphy neuralgia. Hernia, 2016. 20: 357. 209. Hahn, L. Treatment of ilioinguinal nerve entrapment - a randomized controlled trial. Acta Obstet Gynecol Scand, 2011. 90: 955. 210. Antolak, S.J., Jr., et al. Anatomical basis of chronic pelvic pain syndrome (...) colpopexy: management of postoperative pudendal nerve entrapment. Obstet Gynecol, 1996. 88: 713. 218. Fisher, H.W., et al. Nerve injury locations during retropubic sling procedures. Int Urogynecol J, 2011. 22: 439. 219. Moszkowicz, D., et al. Where does pelvic nerve injury occur during rectal surgery for cancer? Colorectal Dis, 2011. 13: 1326. 220. Ashton-Miller, J.A., et al. Functional anatomy of the female pelvic floor. Ann N Y Acad Sci, 2007. 1101: 266. 221. Amarenco, G., et al. [Perineal neuropathy

2019 European Association of Urology

7. Vasa nervorum in rat major pelvic ganglion are innervated by nitrergic nerve fibers. (PubMed)

Vasa nervorum in rat major pelvic ganglion are innervated by nitrergic nerve fibers. The vasa nervorum comprises a network of small diameter blood vessels that provide blood supply to nerves and ganglia. The cell bodies of autonomic nerves innervating the urogenital organs are housed in the major pelvic ganglia (MPG) in rats. The vasa nervorum of rat MPG have not been characterized previously, and it is not known whether these blood vessels are innervated by neuronal nitric oxide synthase (nNOS (...) were observed. The extra-capsular arterioles and venules, but not the capillaries were innervated by nNOS-positive nerve fibers.This study, to our knowledge, is the first to demonstrate the blood vessel distribution pattern and their nitrergic innervation in the rat MPG. While similar studies in human pelvic plexus are warranted, these results suggest that the blood flow in the MPG may be regulated by nitrergic nerve fibers and reveal a reciprocal relationship between nerves and blood vessels.©

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2013 Journal Of Sexual Medicine

8. Pelvic Nerve Innervation

Pelvic Nerve Innervation Pelvic Nerve Innervation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pelvic Nerve Innervation Pelvic (...) Nerve Innervation Aka: Pelvic Nerve Innervation From Related Chapters II. Anatomy: Spinal Level - S2-S4 Organ Perineum Lower and upper vagina and Low Posterior Trigone Lower ureter Rectosigmoid colon Nerves Pudendal Nerve Inguinal Nerve Genitofemoral Nerve Posterior femoral Nerve Pelvic and s III. Anatomy: Spinal Level - T11-T12 Organ Uterine Fundus Proximal third fallopian tube Broad ligament Upper Cecum, appendix and terminal Nerves s via hypogastric plexus IV. Anatomy: Spinal Level - T9-T10 Organ

2015 FP Notebook

9. The Innervation of the Pelvic and adjoining Viscera: Part II. The Bladder. Part III. The External Generative Organs. Part IV. The Internal Generative Organs. Part V. Position of the Nerve Cells on the Course of the Efferent Nerve Fibres (PubMed)

The Innervation of the Pelvic and adjoining Viscera: Part II. The Bladder. Part III. The External Generative Organs. Part IV. The Internal Generative Organs. Part V. Position of the Nerve Cells on the Course of the Efferent Nerve Fibres 16992335 2007 02 05 2009 10 27 0022-3751 19 1-2 1895 Dec 30 The Journal of physiology J. Physiol. (Lond.) The Innervation of the Pelvic and adjoining Viscera: Part II. The Bladder. Part III. The External Generative Organs. Part IV. The Internal Generative Organs (...) . Part V. Position of the Nerve Cells on the Course of the Efferent Nerve Fibres. 71-139 Langley J N JN Anderson H K HK eng Journal Article England J Physiol 0266262 0022-3751 1895 12 30 0 0 1895 12 30 0 1 1895 12 30 0 0 ppublish 16992335 PMC1512652

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1895 The Journal of physiology

10. The Innervation of the Pelvic and adjoining Viscera: Part VI. Histological and Physiological Observations upon the Effects of Section of the Sacral Nerves (PubMed)

The Innervation of the Pelvic and adjoining Viscera: Part VI. Histological and Physiological Observations upon the Effects of Section of the Sacral Nerves 16992329 2007 02 05 2008 11 20 0022-3751 19 4 1896 May 05 The Journal of physiology J. Physiol. (Lond.) The Innervation of the Pelvic and adjoining Viscera: Part VI. Histological and Physiological Observations upon the Effects of Section of the Sacral Nerves. 372-84 Langley J N JN Anderson H K HK eng Journal Article England J Physiol 0266262

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1896 The Journal of physiology

11. CRACKCast 107 – Peripheral Nerve Disorders

Asymmetrical proximal and distal peripheral neuropathies: Brachial plexopathy Open Direct plexus injury (knife or gunshot wound) Neurovascular (plexus ischemia) Iatrogenic (central line insertion) Closed Traction injuries “Stingers” Traction neurapraxia Partial or complete nerve root avulsion Radiation Neoplastic Idiopathic brachial plexitis Thoracic outlet Lumbosacral plexopathies Open Closed Traction injuries Pelvic double vertical shearing fracture Posterior hip dislocation Retroperitoneal hemorrhage (...) to compressive neuropathy. Caused when the radial nerve is trapped between the humeral shaft and some hard surface, as seen in deep drunk sleep. “Bridegroom’s palsy” = radial nerve may be compressed by the bride’s head resting on the groom’s arm during sleep Rare: Radial neuropathy secondary to improper crutch use causing compressive neuropathy at the level of the axilla! Look for wrist +/- finger drop. Also seen is paresthesia of dorsum of 1st digit space. [11] Describe the motor and sensory innervation

2017 CandiEM

12. Galanin Administration Partially Restores Erectile Function After Cavernous Nerve Injury and Mediates Endogenous Nitrergic Nerve Outgrowth In Vitro. (PubMed)

Galanin Administration Partially Restores Erectile Function After Cavernous Nerve Injury and Mediates Endogenous Nitrergic Nerve Outgrowth In Vitro. Previously, we found that the neuropeptide galanin was strongly upregulated soon after bilateral cavernous nerve injury (BCNI) and that galanin and its receptors were expressed in nitrergic erectile innervation. Galanin has been observed to exert neuroregenerative effects in dorsal root ganglion neurons, but evidence for these effects in the major (...) pelvic ganglion (MPG) after BCNI is lacking.To evaluate the neurotropic effects of galanin receptor agonists and antagonists in vitro in nitrergic neurons and MPG and in vivo in rats after BCNI.Male Sprague-Dawley rats underwent BCNI and sham surgery. Organ culture and single-cell neuron culture of the MPG were performed. Osmotic pump treatment with the galanin agonist in vivo and measurement of erectile response to electrostimulation after BCNI, immunohistochemical localization of galanin

2018 Journal Of Sexual Medicine

13. Direct Administration of Nerve-Specific Contrast to Improve Nerve Sparing Radical Prostatectomy (PubMed)

Direct Administration of Nerve-Specific Contrast to Improve Nerve Sparing Radical Prostatectomy Nerve damage remains a major morbidity following nerve sparing radical prostatectomy, significantly affecting quality of life post-surgery. Nerve-specific fluorescence guided surgery offers a potential solution by enhancing nerve visualization intraoperatively. However, the prostate is highly innervated and only the cavernous nerve structures require preservation to maintain continence and potency (...) . Systemic administration of a nerve-specific fluorophore would lower nerve signal to background ratio (SBR) in vital nerve structures, making them difficult to distinguish from all nervous tissue in the pelvic region. A direct administration methodology to enable selective nerve highlighting for enhanced nerve SBR in a specific nerve structure has been developed herein. The direct administration methodology demonstrated equivalent nerve-specific contrast to systemic administration at optimal exposure

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2017 Theranostics

14. Electrophysiological properties of lumbosacral primary afferent neurons innervating urothelial and non-urothelial layers of mouse urinary bladder (PubMed)

Electrophysiological properties of lumbosacral primary afferent neurons innervating urothelial and non-urothelial layers of mouse urinary bladder Pelvic nerve (PN) bladder primary afferent neurons were retrogradely labeled by intraparenchymal (IPar) microinjection of fluorescent tracer or intravesical (IVes) infusion of tracer into the bladder lumen. IPar and IVes techniques labeled two distinct populations of PN bladder neurons differentiated on the basis of dorsal root ganglion (DRG) soma

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2016 Brain research

15. Anatomical study of pelvic nerves in relation to seminal vesicles, prostate and urethral sphincter: immunohistochemical staining, computerised planimetry and three-dimensional reconstruction. (PubMed)

Anatomical study of pelvic nerves in relation to seminal vesicles, prostate and urethral sphincter: immunohistochemical staining, computerised planimetry and three-dimensional reconstruction. Studies of male pelvic neuroanatomy are mandatory to improve functional outcome after radical prostatectomy. We performed a topographical investigation of nerves on the course from the seminal vesicles along the prostate toward the striated urethral sphincter.Serial whole mount sections (1 mm intervals (...) ) of pelvic blocks of human adult male autopsy cadavers were investigated after immunohistochemical nerve staining. Computerized nerve quantification and planimetry of the total nerve surface area were performed within defined regions (ventral, ventrolateral, dorsolateral and dorsal) at the levels of the seminal vesicles and prostate, and at the striated urethral sphincter. The distance between the seminal vesicles and the nerves was measured. For improved topographical understanding 3-dimensional

2014 Journal of Urology

16. An unusual complication of sacral nerve root injury following bone marrow harvesting: a case report. (PubMed)

superior iliac spine (PSIS) as the puncture site. Pelvic magnetic resonance image (MRI) showed enhancement around the left S2 nerve root in T1 and T2-weighted images. Nerve conduction studies (NCS) revealed normal conduction velocity and amplitude on both lower extremities. Electromyography (EMG) presented abnormal spontaneous activity and neurogenic motor unit potentials on the S2-innervated intrinsic foot muscle and gastrocnemius, soleus muscle on the left. The patient was treated with pregabalin (...) for pain control. The patient was followed up after 3, 6, and 12 months. Neuropathic pain improved to Visual Analogue Scale (VAS) 1, and recovery state was confirmed by re-innervation patterns of motor unit potentials in electromyography.Bone marrow harvesting is a relatively safe procedure. However, variable complications may occur. Accurate anatomical knowledge and carefulness are required to avoid sacral nerve root injury when performing the bone marrow harvesting procedure.

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2019 BMC Cancer

17. Superior Hypogastric Plexus Block Versus Pulsed Radiofrequency for Chronic Pelvic Cancer Pain

innervating pelvic organs travel with sympathetic nerves, trunks, ganglia, and rami; thus, interrupting the sympathetic chain at this level can be used to treat pelvic cancer pain. Several studies examined the use of superior hypogastric plexus block in the treatment of pelvic cancer pain. Although the authors reported a mean reduction in pain of 70%, neither the follow-up period nor the proportion with a successful prognostic block were noted. Radiofrequency utilizes a high-frequency alternating current (...) to 1 week or 10 days to achieve neurolysis . Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 40 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Care Provider) Masking Description: prospective interventional Primary Purpose: Treatment Official Title: Superior Hypogastric Plexus Block and Pulsed Radiofrequency on Dorsal Root Ganglia of Sacral Nerves for Chronic Pelvic Cancer Pain

2017 Clinical Trials

18. Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury. (PubMed)

Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury. What's known on the subject? and What does the study add? With the present study, we aimed to provide a global picture of the molecular processes that are activated by CN injury. The present study used genomic expression profiling to identify candidate genes that might be useful targets in the CN recovery process and, thus, the ultimate preservation (...) take as long as 2 years. There are gaps in our understanding of the autonomic pelvic innervation of the penis that still need to be addressed for the development of an adequate treatment strategy for post-prostatectomy ED. The molecular mechanisms of the intrinsic ability of CN to regenerate after an injury have not been elucidated.We analyzed global gene expression in the major pelvic ganglion 48 h and 14 days after CN injury. Overall, a comparative analysis showed that 325 genes changed at the 48

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2012 BJU international

19. Another Component of the Pelvic Plexus That Innervates the Penis in the Rat. (PubMed)

Another Component of the Pelvic Plexus That Innervates the Penis in the Rat. To determine whether the small plexus located at the base of the penis, consisting of nerves arising from the major pelvic ganglion, connecting with the sensory branch of the pudendal nerve, contains postganglionic neurons innervating the erectile tissue and urethra of the penis.A total of 22 adult male Wistar rats 3-4 months of age (weight 250-350 g) were used. The features, distribution, and topography of the small (...) agglutinin after the tracer was injected in the penile structures.In the male rat, the small plexus located at the base of the penis contains postganglionic neurons innervating the penile structures. These neurons can contribute to the regulation of the sexual and urinary function of the genitourinary tract. Because the rat is the main laboratory animal used in urologic studies, it is important to consider, when designing experiments or discussing results, that in addition to the major pelvic ganglion

2011 Urology

20. Pudendal nerve in pelvic bone fractures. (PubMed)

Pudendal nerve in pelvic bone fractures. Pelvic ring injuries rank among the most serious skeletal injuries. According to published data, pelvic fractures constitute 3-8% of all fractures. There has been a threefold increase in the number of these fractures over the last 10 years. A significant factor determining the choice of the therapeutic procedure, timing and sequence of individual steps, and also the prognosis of the patient with a fractured pelvis, are associated injuries defined (...) as injuries to the organs and anatomical structures found in the pelvic region. Published data describes the incidence of injury to neurogenic structures as ranging between 9 and 21%, to the urogenital tract between 5 and 11%, to the gastrointestinal tract in 3-17% and to the gynecologic organs up to 1%. The pathway of the pudendal nerve may be affected in types B and C fractures where the root fibers emerge from the foramina sacralia and plexus sacralis is formed, on the one hand, and in types A, B and C

2013 Injury

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